Alexander FarleyU. Pennsylvania - B.A. Biology, B.A. Fine ArtsCalifornia Institute of Technology - Ph.D. expected

Candidate for Master of Architecture I

self portraitmedium: graphite on papersize: 24” x 18”year: 1997

Table of Contents

1. Design and Sculpture

2. Figure Drawing

3. Cityscapes

4. Curriculum Vitae

Design and Sculpture

urban narrative bookmedium: gouachesize: 12” x 60”year: 1999

Alexander Farley

Fig 1. Fig 2.

Fig 3. Fig 4.

Sprague and Bjorkman Farley and Bjorkman

Farley and BjorkmanFarley and Bjorkman

Fig 1. Bipolar bridging complex of an anti-HSV IgG (green) bound to a membrane-bound HSV antigen (brown) and mediated by HSV gE-gI (blue and red)

Fig 2. (A) Schematic of an antibody bipolar bridged complex containing gE-gI, anti-gD-hFc, and gD. (B) Schematic of anti-gDmFc bound to gD, but not gE-gI. (C) Schematic of 2G12 bound to gE-gI, but not gD.

Fig 3. HeLa cells transiently transfected with the gD-CerFP expression vector and then fixed and processed for immunofluores-ence. anti-gDmFc (green) and intracellular marker(red); EEA1 (left), Rab11 (middle), or LAMP2 (right).

Fig 4. Quantitative colocalization analysis to compare gD-CerFP localization in gE-gI-nega-tive cells in the presence and absence of anti-gD antibodies.

Doctoral Thesis Figures

Alexander Farley

polymorphisms and mutations

illuminated phage logosmedium: wood and frosted acrylicsize: 48” x 48”year: 2009

spider material: douglas firsize: 48” x 48” x 36”year: 2009

Figure Drawing

shoulder anatomymedium: intagliosize: 18” x 24”year: 2000

Alexander Farley

figuremedium: conte crayon on papersize: 24” x 24”year: 1997

Alexander Farley

womanmedium: charcoal on papersize: 24” x 18”year: 2000

womanmedium: charcoal on papersize: 18” x 24”year: 2000

Cityscapes

blue line subwaymedium: oil on boardsize: 12” x 19.4”year: 2000

2100 chestnut streetmedium: oil on boardsize: 12” x 19.4”year: 2001

Alexander Farley

Alexander Farley

spruce street marketmedium: oil on linen | size: 36” x 48” | year: 2000 - 2007

Alexander Farley

30th street stationmedium: oil on boardsize: 12” x 48”year: 2001

sansom streetmedium: oil on boardsize: 12” x 19.4”year: 2001

pyramid building Imedium: oil on boardsize: 12” x 19.4”year: 2006

pyramid building IImedium: oil on boardsize: 12” x 19.4”year: 2006

Alexander Farley

Curriculum Vitae

ALEXANDER FARLEY900 Orlando Place, San Marino, CA 91180 / 626.429.2280 / afarley@gmail.com

EDUCATION

California Institute of Technology, Pasadena, CA 2003 – 2010 PhD (expected) in Biology, Specialization: Virology, Biochemistry, and Cell Biology (Intracellular trafficking of a bipolar bridged complex of HSV-1 gE-gI, IgG, and a viral antigen) University of Pennsylvania, Philadelphia, PA 1997 – 2001 Bachelor of Arts in Fine Arts and Bachelor of Arts in Biology with Honors

HONORS

Group Exhibitions: New Artist Summer Group Show, Gross McCleaf Gallery; Senior Thesis, Cityscapes, Meyerson Gallery Awards: Dean’s Prize (Fine Arts); Rose Undergraduate Research Award; Neysa Cristol Adams Prize in Biology Fellowships and Grants: College Alumni Society Research Grant; Department of Energy - Energy Research Undergraduate Laboratory Fellowship; Bristol-Myers Squibb Research Fellowship

PROFESSIONAL EXPERIENCE

Bjorkman Laboratory, California Institute of Technology, Pasadena, CA — Graduate Student 2004 – Present Researched viral-encoded receptors responsible for Herpes Simplex Virus immune evasion Created human cell line to inducibly express HSV glycoproteins gD, gE, and gI Showed that HSV receptors gE and gI are able to internalize antibodies Measured binding affinity of herpes virus antibody receptors to different classes of antibodies

Kazazian Laboratory, University of Pennsylvania School of Medicine, Philadelphia, PA — Technician 1999 – 2003 Researched polymorphisms responsible for differences in L1 mobile DNA element length Discovered that L1 activity positively correlates with genomic insertion length Helped to analyze differences in active L1’s contribution to the human genome Helped to create germline based mouse model for L1 activity

Bunick Laboratory, Oak Ridge National Laboratory, Oak Ridge, TN — Summer Fellow 1999 – 1999 Researched high resolution 3D x-ray crystal structure of the nucleosome core particle Helped create protein expression system to produce milligrams quantities of histone H4

PUBLICATIONS

Technical Scientific Papers — Author Sprague ER, Reinhard H, Cheung EJ, Farley AH, Trujillo RD, Hengel H, Bjorkman PJ, The Human Cytomegalovirus Fc Receptor gp68 Binds the Fc CH2-CH3 Interface of Immunoglobulin G., J Virol. 2008 Apr;82(7):3490-9. Epub 2008 Jan 23

Farley AH, Luning Prak ET, Kazazian HH Jr, More Active Human L1 Retrotransposons Produce Longer Insertions. Nucleic Acids Res. 2004 Jan 23;32(2):502-10. Print 2004.

Weinzweig J, Kirschner RE, Farley A, Reiss P, Hunter J, Whitaker LA, Bartlett SP, Metopic synostosis: Defining the Temporal Sequence of Normal Suture Fusion and Differentiating It From Synostosis on the Basis of Computed Tomography Images. Plast Reconstr Surg. 2003 Oct;112(5):1211-8

Brouha B, Schustak J, Badge RM, Lutz-Prigge S, Farley AH, Moran JV, Kazazian HH Jr, Hot L1s Account for the Bulk of Retrotransposition in the Human Population. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5280-5. Epub 2003 Apr

SKILLS AND INTERESTS

Computer Skills: Linux systems administration, bash, HTML, C, Python, Max/MSP, Adobe Photoshop, InDesign, Illustrator, Microsoft Office, Ableton LiveInterests: hiking, painting, music production, DJing, travel (Japan, England, France, Netherlands, Austria, Mexico, Canada, Portugal)