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Functions of the
Nervous System
NERVOUS SYSTEM
CENTRAL NS PERIPHERAL NS
BRAIN SPINAL CORD CRANIAL SPINAL AUTONOMIC
NERVES NERVES NERVES (12 pairs) (31 pairs)
SYMPATHETIC PARASYMPATHETIC NERVES NERVES
GRAY MATTER WHITE MATTER
Section 1 General Function of Neuron and Neuroglia
1. Neuron
The structure and function unit of nervous system, including the soma, axon and dendrites
Classification of neuron by function
Function and Classification of Nerve Fiber
Function
Conducting AP
Nerve impulse
Nerve Fiber: Axons or Dendrites
Characteristics of Excitement Conduction
Intact
Bidirectional conduction
Not easy to be fatigue
Insulation
The affecting factors of conduction velocity
Diameter of the axon myelin sheath or no myelin sheath Thickness of myelin sheath Temperature
Fiber types
FunctionAvg. fiber diameters (μm)
Avg. cond. Velocity (m/s)
Aα Primary muscle spindle afferents, motor to skeletal muscle
15100 (70-120)
Aβ Cutaneous touch and pressure afferents 8 50 (30-70)
Aγ motor to muscle spindle 5 20 (15-30)
Aδ Cutaneous temperature and pain afferents <3 15 (12-30)
B Sympathetic preganglionic 3 7 (3-15)
C Cutaneous pain afferents sympathetic postganglionic
1 1 (02-2)
Erlanger /Gasser classification of nerve fibers
Group FunctionAvg. fiber diameters (μm)
Avg. cond. Velocity (m/s)
Ia,IbPrimary muscle spindle afferents and afferents from tendon organs
1375 (70-120)
II Cutaneous mechanoreceptors
9 55 (25-70)
III Deep pressure sensors in muscle
3 11(10-25)
IV Unmyelinated pain fibers 1 1
Lloyd/Hunt classification of nerve fibers
Axoplasmic transport of nerve fiber
Conception:: Axoplasm in axon often keep flow, the flow of axoplasm play the role to transport material, it is called axoplasmic transport.
Anterograde axoplasmic transport
~ fast
~ slow
Retrograde axoplasmic transport
Fig. Axopasmic transport Fig. The method of horseraidish peroxidase
dynein
kinesin
Conception: Nerve endings often release some trophic factors, continuously to regulate metabolic activity of the tissue that controlled by the nerve, then affecting its the structure, biochemical and physiological changes, this effect is called trophic action of nerve.Mechanism: anxoplasmic transportPhenomenon:
Trophic action of nerve
Conception: a kind of protein molecules that produced by the tissue( such as muscle ) and astrocytes, and is the necessary substance to the neuron survival and growth.Action mode: Neurotrophin enter into the terminal of axon by endocytosis, then reach to cell body by retrograde axoplasmic transport.Significance: to promote protein synthesis in the cell body. so play important roles in supporting neuron growth, development and functional integrity. Types:
Neurotrophin
Types of Neuroglia
CNS
Astrocyte
Microglia
Oligodendrocyte
Ependymal Cell
Characteristics of Neuroglia
Quantity
Protrusion:
Gap junction:
Membrane receptor
Membrane potential:
Function of Neuroglia1.Supporting and inducting neuron migration: 2. Repair and. 3: Immune response.4. Insulation and barrier:5. Metabolism and nutrition
6. Keeping the stability of potassium concentration 7.Uptaking and secreting the neurotransmitter
Section 2 synaptic transmission
1. Several important synaptic transmission *Classical synaptic transmission *Non-directed synaptic transmission *Electrical synaptic transmission 2. Neurotransmitter and receptor *Neurotransmitter *Receptor *The main transmitter and receptor system
Classical synaptic transmission Synaptic microstructure
Presynaptic membrane Voltage-gated Ca2+ channels Transmitter vesicles
Synaptic cleftPostsynaptic membrane
Receptors
Classification of SynapseMain: A-D 、 A-S 、 A-A Other: D-D 、 D-S 、 D-A 、 S-D 、 S-S 、
S-A
Classical synaptic transmission
Process of synaptic transmission1. AP
2. Ca2+ channel open
3. Neurotransmitter release Exocytosis
4. Neurotransmitter + receptor
5. Postsynaptic potential (AP)
Classical synaptic transmission
Electric - Chemical - Electric
Synaptic Transmission
• AP travels down axon to bouton.• VG Ca2+ channels open.• Ca2+ activates calmodulin, which activates
protein kinase.• Protein kinase phosphorylates synapsins.
– Synapsins aid in the fusion of synaptic vesicles.
Synaptic Transmission (continued)
• NTs are released and diffuse across synaptic cleft.
• NT (ligand) binds to specific receptor proteins in postsynaptic membrane.
• Chemically-regulated gated ion channels open.– EPSP: depolarization.– IPSP: hyperpolarization.
• Neurotransmitter inactivated to end transmission.
Postsynaptic PotentialExcitatory postsynaptic potential(EPSP)Inhibitory postsynaptic potential(IPSP)
Classical synaptic transmission
depolarization hyperpolarization
• No threshold.• Decreases resting
membrane potential.– Closer to threshold.
• Graded in magnitude.• Have no refractory
period.• Can summate.
Excitatory postsynaptic potential (EPSP)
–No threshold.
–Hyperpolarize postsynaptic membrane.
–Increase membrane potential.
–Can summate.
–No refractory period.
Inhibitory postsynaptic potential (IPSP)
Summation of EPSP or IPSP
The processes by which the multiple EPSPs (IPSPs) from presynaptic neurons summate over time and space are called temporal and spatial summation
Excitation and inhibition of postsynaptic neuron
Classical synaptic transmission
Classical synaptic transmission Modulation of synapse
Regulating NT releaseCa2+ inflow, AP frequency or amplitude, presynaptic
receptor.Regulating the uptake and inactivation Regulating the receptors
Synaptic Plasticity
Classical synaptic transmission
The types of synaptic plasticity
Posttetanic potentiation
Habituation
sensitization
long-term potentiation( LTP)
long-term depression(LTD)
Non-directed synaptic transmission
The postganglionic autonomic neuron innervate the smooth muscle and cardiac muscle .
The multiple branches are beaded with enlargements (varicosity) that are not covered by Schwann cells and contain synaptic vesicles;
Fig. : Ending of postganglionic autonomic neurons on smooth muscle
Electrical synaptic transmission • Structure: Gap junctions:
– Each gap junction is composed of 12 connexin proteins.
– The 12 connexin proteins form a water channel.
– the charged small molecules and the local current are allowed through.
• Distribution
Electrical synaptic transmission • Functional characteristics:
– the charged small molecules and the local current are allowed through the channel.
– low resistance– Rapid– Bidirectional transmission
• significance:
Electrical Synapse Chemical Synapse
NeurotransmitterConception: small molecules that synthesized by the neurons, can be released from presynaptic terminals into the synaptic cleft and combined with the receptor of postsynaptic membrane, cause postsynaptic potential.
Conception of neuromodulator: In addition to neurotransmitter, neuron can synthesize and release some chemical substances, they are not directly transmit information between neurons, but can enhance or impair neurotransmitter effects, this kind of substance is called neuromodulator.
Neurotransmitter coexistence : Two or more than two (including neuromodulator) have been found in the same neuron, this phenomenon is called neurotransmitters coexistence.
NeurotransmitterNeurotransmitter metabolism:
• Synthesis
• Storage
• Release
• Degradation
• Reuptake
ReceptorSubtype of receptor: each receptor has multiple subtypesCholinergic receptor : muscarinic receptor (M receptor) and nicotinic receptor (N receptor), N1 and N2 Adrenergic receptor: α (α1, α2) and β (β1, β2, β3)
ReceptorPresynaptic receptor: also called autoreceptor
Usually, the presynaptic receptor activation can inhibit neurotransmitter release, realize the negative feedback control.
noradrenergic receptor
noradrenalin
ReceptorMechanism of receptor :
Classification of receptor :
Activation : Binding with the neurotransmitter Signal transduction pathways Biological effects(changing postsynaptic neuron
activity or making target cells to produce effects
Ion channel receptors G protein-coupled receptor : most
Main neurotransmitter and receptor system
Acetylcholine(Ach) :
Cholinergic fiber
Somatic motor nerve fibersAll autonomic preganglionic fibersMost parasympathetic postganglionic fibersA few sympathetic postganglionic fibers
Cholinergic neuron: widely distributed in the CNS
The Life Cycle of Acetylcholine
Choline acetyltransferase
Acetylcholinesterase
Acetylcholine(Ach) receptor:
•Muscarinic receptors(M receptor):
M1 to M5, G protein-coupled receptor
•Nicotinic receptors(N receptor):
N1 and N2, ion channel receptor
According to pharmacological properties, acetylcholine receptor can be divided into two categories
G protein-coupled receptor
M receptor
Ion channel receptorN Receptor
Acetylcholine(Ach) receptor:
Receptor Distribution Antagonist
MAutonomic effector
(cardiac muscle , smooth muscle)
Atropin
N1 Autonomic ganglion Curare,
hexamethonium
N2Endplate membrane of
skeletal muscle
Curare, decamethonium
Noradrenaline(NA) or norepinephrine(NE):•Noradrenergic neuron: In both PNS and CNS
PNS: Smooth muscles, cardiac muscle and glands.
CNS: General behavior.
•Adrenergic fibers: most sympathetic postganglionic fibers
•Adrenergic receptors: G protein-coupled receptor
Distribution and antagonist of adrenergic receptor in the peripheral nervous system
1Most sympathetic
effector(excitation)Phentolamine,
Prazosin
2
Presynaptic receptor (regulate neurotransmitter
release)
Phentolamine,Yohimbine
1 cardiac muscle(excitation)Propranolol,
Practolol
2Most sympathetic effector(inhibition)
Propranolol, Butaxamine
Distribution Antagonist
Mechanism of Action ( receptor)
Dopamine and receptor:
•Dopaminergic neuron:
Distributed in the CNS:
•Dopaminergic receptors:
1.Nigrostriatal system, participate in the movement regulation.2.Mesolimbic system,participate in the mental activities.3.Tuberoinfundibular system, involved in neuroendocrine regulation.
Serotonin and receptor:
•Serotonergic neuron : mainly in the raphe nucleus of the lower brainstem •Receptors:There are 7 types of serotonin receptor: Serotonin1-7. There are 14 subtypes of Serotonin receptors:
Histamine and receptor:•Histaminergic neuron : mainly in the tuberomammillary nucleus of posterior hypothalamus, its fiber projection is very wide, almost reach all parts of CNS.•Receptors:
Histamine system has three kinds of receptors, H1,H2, and H3 All receptors are a G- protein-coupled receptor
Amino acid neurotransmitter and receptor:•Excitatory amino acid: Mainly include the glutamate and aspartate, and glutamate is the major excitatory neurotransmitter in the brain and spinal cord
•Inhibitory amino acid:
Section 3 The basic rule of reflex activity
Reflex refers to the regularity response of body to various stimulus from internal and external environment under the central nervous system involvement.
Classification of reflex
What is Reflex?
Classification Obtain Quantity Form
Unconditioned reflex innate limited fixed and low-class
Conditioned reflex acquire infinite Changeable and high-class
Section 3 The basic rule of reflex activity
Reflex arc: Receptor→Afferent neuron→CNS→ Efferent neuron→ Effector
Central Control of Reflex
Monosynaptic reflex: only a synaptic transmission in the central. This is the simplest reflected, only monosynaptic reflex in vivo is tendon reflex.
Polysynaptic reflex: Multiple synaptic transmission in the central. This is the simplest reflected, Most reflexes are polysynaptic reflex.
The basic process of reflex
Contact Ways of Central Neurons Single line connection
Divergent connection
Contact Ways of Central Neurons Convergent connection
Chain connection
Recurrent connection
Characters of Central Excitation Conduction One-way conduction Central delay
Summation of excitation. Change of excitatory rhythm After discharge Susceptibility & Fatigue
Nerve fiber conduction Synaptic transmission
Conduction direction Bidirectional monodirectional
Time delay no have
Potential change all or nothingchanges of Summation and
rhythm
After discharge no have
Integrity requirement requirement
Fatigue not easy easy
Environmental factors
insulation susceptible
Characteristics of and nerve fiber conduction and synaptic transmission
Central Inhibition and Facilitation Postsynaptic inhibition*afferent collateral inhibitionAfter afferent nerve to the central, not only can excite a interneuron though synaptic connection, but can excite a inhibitory interneuron through its collateral branch, further inhibit another neuron, this kind of inhibition is called afferent collateral inhibition.
*recurrent inhibitionWhen the central neuron is excited, the efferent impulse is conducted outward along the axon, at the same time, also can excite a inhibitory interneuron though its collateral branch, then cause the release of inhibitory neurotransmitter, which inhibit the previously excited neurons, this kind of inhibition is called recurrent inhibition.
Central Inhibition and Facilitation Presynaptic inhibition
Postsynaptic facilitation
Presynaptic facilitation