Guncel Tibbin Temelleri

GNCEL TIBBIN TEMELLER

LAWRENCE M. TIERNEY, Jr.SANJAY SAINTMARY A. WHOOLEY

eviri Editr

Prof. Dr. Mehmet Akif Karan

LANGE

LANGE

GNCEL

TIBBIN TEM

ELLER

eviri Editr

Prof. Dr. M

ehmet A

kif Karan

Tierney

Saint

Whooley

GNCEL TIBBIN TEMELLERLawrence M. Tierney, MD Sanjay Saint, MD, MPH Mary A. Whooley, MD

eviri EditrProf. Dr. Mehmet Akif Karan

Klinikte ve poliklinikte mkemmel bir hzl bavuru kayna!

Klinik uygulamada en sk grlen 500den fazla hastaln tan ve tedavisi hakknda gncel bilgiler

Her sayfada bir hastalk Her hastalk iin maddeler

halinde Tan Esaslar, Ayrc Tan, Tedavi, pucu ve Kaynak

Hem ayaktan hem yatan hastalar kapsamakta

Hastalklar ile birlikte Kadn Hastalklar ve Doum, Cerrahi ve Pediatri gibi uzmanlk dallarn iermekte

Tamamyla gncellenmi klinik belirtiler, tan testleri ve tedavi seenekleri

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1 Kardiyovaskler Hastalklar

Pulmoner Hastalklar

Gastrointestinal Sistem Hastalklar

Hepatobiliyer Sistem Hastalklar

Hematolojik Hastalklar

Romatolojik ve Otoimmun Hastalklar

Endokrin Hastalklar

nfeksiyon Hastalklar

Onkolojik Hastalklar

Sv, Asit-Baz ve Elektrolit Bozukluklar

Genitoriner ve Bbrek Hastalklar

Nrolojik Hastalklar

Geriatri

Psikiyatrik Bozukluklar

Deri Hastalklar

Jinekolojik, Obstetrik ve Meme Hastalklar

Sk Karlalan Cerrahi Hastalklar

Sk Karlalan Pediatrik Hastalklar

Genetik Hastalklar

Sk Grlen Gz Hastalklar

Kulak Burun ve Boazn Sk Rastlanan Hastalklar

Zehirlenmeler

Editrler

Lawrence M. Tierney, Jr., MDProfessor of MedicineUniversity of California, San FranciscoAssociate Chief of Medical ServicesVeterans Affairs Medical CenterSan Francisco, California

Sanjay Saint, MD, MPHAssociate Chief of Medicine, Ann Arbor VA Medical CenterDirector, VAIUM Patient Safety Enhancement ProgramProfessor of Internal Medicine, University of Michigan Medical SchoolAnn Arbor, Michigan

Mary A. Whooley, MDProfessor of Medicine, Epidemiology and BiostatisticsUniversity of California, San FranciscoDepartment of Veterans Affairs Medical CenterSan Francisco, California

eviri Editr

Prof. Dr. Mehmet Akif Karanstanbul niversitesi, stanbul Tp Fakltesi, Hastalklar Anabilim Dal,Geriatri Bilim Dal

NOBEL TIP KTABEVLER

GNCELTIBBIN TEMELLER

2013 Nobel Tp Kitabevleri Ltd. ti.

Gncel Tbbn Temelleri, Drdnc Bask

eviri Editr: Prof. Dr. Mehmet Akif Karan

ISBN: 978-975-420-937-2

Current Essentials of Medicine, Fourth EditionLawrence M. Tierney, Sanjay Saint, Mary A. WhooleyISBN: 978-0-07-163790-9 2011 McGraw-Hill Companies

Bu kitabn Trkeye eviri hakk McGraw-Hill Companies tara-fndan NOBEL TIP KTABEVLERne verilmitir. 5846 ve 2936 sayl Fikir ve Sanat Eserleri yasas gerei herhangi bir blm, resmi veya yazs, yazarlarn ve yaynlaycsnn yazl izni alnmadan tek-rarlanamaz, baslamaz, kopyas karlamaz, fotokopisi alnamaz veya kopya anlam tayabilecek hibir ilem yaplamaz.

Dzenleme: NobelTpKitabevleri

HandeDalsaldaur

Kapak: Hakkakr

Bask / Cilt: NobelMatbaaclk, Hadmky-STANBUL

NOBEL TIP KTABEVLER LTD. T.

ANKARASalk Sokak No:17/C ankaya (Shhiye) Tel: (0312) 434 10 87

ANTALYAMeltem Mahallesi Dumlupnar BulvarBakent Sit. B Blok. No: 4 Meltem-Antalya Tel: (0242) 238 15 55

BURSAUluda niversitesi Grkle Kamps Kamps AVM No: 7 Nilfer-BursaTel: (0224) 224 60 21

ELAZIYahya Kemal Cad. niversite Mah. No: 36/B Tel: (0424) 233 43 43

SAMSUNUlugazi Mah. 19 Mays Bulvar 16/6 Tel: (0362) 435 08 03

APAMillet Cad. No:111 apa-stanbul Tel: (0212) 632 83 33 Fax: (0212) 587 02 17

CERRAHPAA Cerrahpaa Tp Fakltesi Kars Park ii Cerrahpaa-stanbul Tel: (0212) 586 17 58

KADIKY Rhtm Cad. Derya Merkezi No: 7 Kadky-stanbul Tel: (0216) 336 60 08

Anne babasna hayatlarnn son dneminde mutlak bir ballkla hizmet eden ve kendisini tanma bahtna sahip olan herkes iin bir model olan bir kz karde, Katherine Thirneye

Lawrence M. Tierney, Jr.

Eitime olan ballklar yeni kuaklara ilham verecek olan, babam Prem Saint ve kaynpederim James McCarthye

Sanjay Saint

Annem Mary Aquinas Whooley (1940-2003)in ansna,

Mary A. Whooley

vindekiler

Katkda Bulunanlar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .vii

nsz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi

eviriye Katkda Bulunanlar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xiii

1. Kardiyovaskler Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1

2. Pulmoner Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37

3. Gastrointestinal Sistem Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66

4. Hepatobiliyer Sistem Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92

5. Hematolojik Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109

6. Romatolojik ve Otoimmun Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147

7. Endokrin Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 178

8. nfeksiyon Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202

9. Onkolojik Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 286

10. Sv, Asit-Baz ve Elektrolit Bozukluklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309

11. Genitoriner ve Bbrek Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 325

12. Nrolojik Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 350

13. Geriatri . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 372

14. Psikiyatrik Bozukluklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 381

15. Deri Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 399

16. Jinekolojik, Obstetrik ve Meme Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . 450

17. Sk Karlalan Cerrahi Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 468

18. Sk Grlen Pediatrik Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 481

19. Genetik Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 500

20. Sk Grlen Gz Hastalklar . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 509

21. Kulak Burun ve Boazn Sk Rastlanan Hastalklar . . . . . . . . . . . . . . . . . . . . 529

22. Zehirlenmeler . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 540

ndeks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 565

vii

Katkda Bulunanlar

Timir Baman, MDCardiology Fellow, University of Michigan Medical School, Ann Arbor, MichiganCardiovascular Diseases

Alex Benson, MDFellow, Department of Pulmonary and Critical Care Medicine, University of Colorado Hospital, Aurora, ColoradoPulmonary Diseases

Aaron Berg, MDClinical Lecturer and Hospitalist, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MichiganFluid, AcidBase, and Electrolyte Disorders

Jeffrey Critchfield, MDAssociate Professor of Clinical Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco School of Medicine, San Francisco, CaliforniaRheumatologic & Autoimmune Disorders

Vanja Douglas, MDAssistant Clinical Professor, Department of Neurology, University of California, San Francisco, CaliforniaNeurologic Disorders

Rebecca A. Jackson, MDAssociate Professor & Chief, Obstetrics, Gynecology and Reproductive Sciences, San Francisco General Hospital, University of California, San Francisco, CaliforniaGynecologic, Obstetric, and Breast Disorders

Kirsten Neudoerffer Kangelaris, MDResearch Fellow, Division of Hospital Medicine, University of California, San Francisco, CaliforniaSelected Genetic Disorder

viii Katkda Bulunanlar

Helen Kao, MDAssistant Professor, Division of Geriatrics, Deparment of Medicine, University of California, San Francisco, San Francisco, CaliforniaGeriatrics

Kewchang Lee, MDAssociate Clinical Professor of Psychiatry, University of California, San Francisco; Director of Psychiatry Consultation, San Francisco Veterans Affairs Medical Center, San Francisco, CaliforniaPsychiatric Disorders

Joan C. Lo, MDResearch Scientist, Division of Research, Kaiser Permanente Northern California; Associate Clinical Professor of Medicine, University of California, San Francisco, Oakland, CaliforniaEndocrine Disorders

Michael P. Lukela, MDDirector, Medicine-Pediatrics Residency Program, University of Michigan Medical School, Ann Arbor, MichiganCommon Pedi