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Hematopoiesis Simplified: Part 1 Erythropoiesis
Larry Johnson Texas A&M University
Hematopoiesis Simplified: Part 1 Erythropoiesis
Objectives are to:
• Identify the developmental cells of
erythropoiesis
•Characterize developmental changes in the cytoplasm and nucleus of these cells
Bone marrow
32583
Blood vessel
Bone marrow
19761
Blood in vessel
Peripheral blood
Erythrocytes
Reticulocytes
21
Erythrocytes
Reticulocytes
Orthochromatophilic erythroblasts
Polychromatophilic erythroblasts
Basophilic erythroblasts
Proerythroblasts
No nucleus and red cytoplasm
No nucleus and blue - grey cytoplasm
Dark, small, spherical nucleus blue – grey cytoplasm
Darkening, fractured ,spherical nucleus and mixed pools of grey and blue cytoplasm
Fractured, spherical nucleus and thin rim of dark blue cytoplasm
Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm
Erythropoiesis
McGraw-Hill Companies
Orthochromatophilic erythroblasts
Erythrocytes
Polychromatophilic erythroblasts
Basophilic erythroblasts
Proerythroblasts
Reticulocytes
Erythropoiesis
Erythropoiesis
Erythrocytes
Orthochromatophilic erythroblasts
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
Polychromatophilic erythroblasts
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
Basophilic erythroblast
Orthochromatophilic erythroblast
Erythrocyte
Polychromatophilic erythroblast
Basophilic erythroblast
Proerythroblast
Reticulocytes
Erythropoiesis
Proerythroblasts
Reticulocytes
Erythrocytes Orthochromatophilic erythroblasts Erythropoiesis
Early orthochromatophilic erythroblasts
Late polychromatophilic erythroblasts
Polychromatophilic erythroblasts Early polychromatophilic erythroblasts
Basophilic erythroblasts Proerythroblasts
ut 112
Polychromatophilic erythroblast
Orthochromatophilic erythroblasts
Basophilic erythroblast
Proerythroblast
Late polychromatophilic erythroblast
Eosinophil or basophil
RBCs
platelets
Reticulocyte
Erythrocytes
Bone marrow
32583
Reticulocyte entering blood vessel
Blood vessel
The End of Hematopoiesis Simplified:
Part 1 Erythropoiesis
• Granulopoiesis is next
Hematopoiesis Simplified: Part 2 Granulopoiesis
Larry Johnson Texas A&M University
Hematopoiesis Simplified: Part 2 Granulopoiesis
Objectives are to:
• Identify the developmental cells of granulopoiesis
•Characterize developmental changes in the cytoplasm and nucleus of these cells
Bone marrow 32583
Bone marrow 19761
Blood
Blood
`
Bone marrow
32583
Developing granulocytes
21
Peripheral blood
Neutrophilic metamyelocytes
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic band or stab cells
Lobulated, dark nucleus, mature grey cytoplasm with small granules
Horse-shoe shaped, darkening nucleus, grey mature cytoplasm
Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent
Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules
Large, oval, non-indented nucleus, large amount of sky blue cytoplasm with non-specific granules
Granulopoiesis
Neutrophilic band cells
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic metamyelocytes
Granulopoiesis
ut 112
Neutrophilic myelocytes
Neutrophilic metamyelocyte
Neutrophil
Eosinophil or basophil
Platelets
Neutrophilic metamyelocytes
Neutrophilic band cells
Neutrophils
Neutrophilic myelocytes
Promyelocytes
Neutrophilic metamyelocytes
Granulopoiesis
Neutrophilic metamyelocytes
Neutrophilic band cells
Lymphocytes Neutrophilic myelocytes
Lymphocytes
Neutrophilic band cell
Unknown nuclei Promyelocyte
Neutrophilic myelocytes
Neutrophilic metamyelocytes
Neutrophilic band cells
Neutrophilic band cells
Neutrophils
Granulopoiesis
Early neutrophilic metamyelocytes
Neutrophilic metamyelocytes
Neutrophilic myelocytes
Late promyelocytes Promyelocyte
Neutrophilic metamyelocytes
Proerythroblast
Neutrophilic myelocytes
Neutrophilic metamyelocytes
Orthochromatophilic erythroblasts
Orthochromatophilic erythroblasts
Unknown nuclei
Eosinophils or basophils
Neutrophilic band cells
32583
White blood cell entering a blood vessel
Bone marrow
Blood vessel
Blood vessel
The End of Hematopoiesis Simplified: Part 2 Granulopoiesis
