HEPATITIS C PATHWAY
Aviva Product
Not a Aviva Product
Indirect effect
Another molecule, mostly chemical compound
InhibitionDissociationPhosphorylation+pDephosphorylation-p
Nucleus
Pathway diagram below is compiled from data from the Kyote
Encylopedia of Genes and GenomesKanehisa, M., Goto, S., Furumichi,
M., Tanabe, M., and Hirakawa, M.; KEGG for representation and
analysis of molecular networks involving diseases and drugs.
Nucleic Acids Res. 38, D355-D360 (2010). Kanehisa, M., Goto, S.,
Hattori, M., Aoki-Kinoshita, K.F., Itoh, M., Kawashima, S.,
Katayama, T., Araki, M., and Hirakawa, M.; From genomics to
chemical genomics: new developments in KEGG. Nucleic Acids Res. 34,
D354-357 (2006). Kanehisa, M. and Goto, S.; KEGG: Kyoto
Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27-30
(2000). 2011 Aviva Systems Biology
Outside
Hepatocyte
NS3/4A
Endosome
E2
NS5A
NS5A
NS3Core
PIP3
Ca2+
ROS
miR-122
Hepatitis C virusE2
GAGs
Core
DNA
HCV genome RNA
+p+p
+p+p+p
+p
LDLRSR-B1
OCLN
Apoptosis
IFNIL8
RNaseL
RIP1
DNADNADNA
NS3
2-5 oligo(A)
NS5A
Control of replication
Endocytosis
CD81CLDN
Translated HCV proteinsStructural proteins
Nonstructural proteins
CoreE1E2p7
NS2NS3
NS5A
F protein
NS5BNS4ANS4B
Control of translation
Cellproliferation
Controlof apoptosis
Core
Interferonstimulated genes
Steatosis
MA
PK signaling pathway
PPARsignalingpathway
Jak-STAT signaling pathw
ay
Toll-like receptorsignaling pathw
ay
RIG-I-like receptorsignaling pathway
IFN/
IFNAR1IFNAR2EGFR
Jak1/Tyk2
GRB2
P13KTRADD TRAF2
PDK1
Akt
NFkBIkB
SOS
Ras
Raf
Bad GSK3p21
STAT1/2
LXRa
PA28y
RXRa PPARa RXRa
PP2A
PIAS1
SOCS3
p53
P38JNK
ERK1/2IKKyIKKaIKK
IRF9 STAT3ISG56
eIF3 eIF2a
IRF1 IkB
NFkB
RIG-I
PKR
IPS-1TRIF
TRAF3
2-5OAS
IRF3/7
TRAF6
TBK1IKKe
TLR3
TNFR
TNFaEGF
