therapy HUMAN AMNION FOR CHRONIC LEG ULCERS Excellent clinical resutts in 13 of 15 patients Prior to the surgical grafting of chronic lower leg ulcers, human amniotic membranes were applied to the ulcers of 15 patients, OOVeted witba supponive, occlusive dressing. and len for 5 days. Following surgery a good take was fou nd in 13 of the 15 patients. Four patients were initially managed by more traditional approaches, but the gross appearance of their ulcers did not change; th ey required treatment with amnion beforeautografis could be done. In most patients there was immediateand impressive pain relief when the membranes were applied. Excluding patients with complications, the average length ofhospital stay was I mo nth . Eight of the 14 ulcers which healed successfu ll y (J was sl ow to beal) have remained intact dur ing a 2- to 10- month follow-u p. In 4 of the cases whe re ulcers did recur the area of brea kdown was < 1.5cm in diameter. Treatmenl was uns u ccess ful in I patient, who required above·knee amputation. Am nion was obtained from patients at elective cesarean secti on. J .P. et al.: Lancet! : 11 Sl OL May 19&01 And good results from the laboratory. too Biopsy specimens were taken fro m the l ea ulocrs in the 15 patients reported in the previous study. Five days after application of the amnion, a clean, red, delicate layer of granulation tissue had fo r med . Histological study of the biopsy specimens showed that vessels were more numerous, evenly dispersed, thin · walled and patent afler treatment Reaction with factor VII! antiserum was ma rkedly increased by appli cation of the membranes. None of these favora bl e features was seen in the 4 patients who initially received traditional uk:er management. 'The usefulness of amnion as a bfological dressing/or burns and chronic leg ulCf:'rs suggests that It may have a broader application.' Paac FaU lk. W. et al .: Lancet , : 11 56 () 1 May 1980) 0156· 2700/ 80/ 0621-0::09 $00.50/ 0 CADIS Pr ... I NPHARMA 2\ Jun 1980 9

HUMAN AMNION FOR CHRONIC LEG ULCERS

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therapy

HUMAN AMNION FOR CHRONIC LEG ULCERS

Excellent clinical resutts in 13 of 15 patients Prior to the surgical grafting of chronic lower leg ulcers, human amniotic membranes were applied to the ulcers of 15 patients, OOVeted witba supponive, occlusive dressing. and len for 5 days. Following surgery a good take was fou nd in 13 of the 15 patients. Four patients were initially managed by more traditional approaches, but the gross appearance of their ulcers d id not

change; they required treatment with amnion beforeautografis could be done. In most patients there was immediateand impressive pain relief when the membranes were applied. Exclud ing patients with complications, the average length ofhospital

stay was I month. Eight of the 14 ulcers which healed successfully (J was slow to beal) have remained intact during a 2- to 10-month follow-u p. In 4 of the cases where ulcers did recur the area of breakdown was < 1.5cm in diameter. Treatmenl was unsuccessful in I patient, who required above·knee amputation. Amnion was obtained from patients at elective cesarean section. Beru~u. J.P. et al.: Lancet! : 11 Sl OL May 19&01

And good results from the laboratory. too Biopsy specimens were taken from the lea ulocrs in the 15 patients reported in the previous study. Five days after application of the amnion, a clean, red, delicate layer of granulation tissue had formed. Histological study of the biopsy specimens showed that vessels were more numerous, evenly dispersed, thin·walled and patent afler treatment Reaction with factor VII! antiserum was markedly increased by application of the membranes. None of these favorable features was seen in the 4 patients who initially received traditional uk:er management. 'The usefulness of amnion as a bfological dressing/or burns and chronic leg ulCf:'rs suggests that It may have a broader application.' Paac FaUlk. W. et al .: Lancet , : 1156 () 1 May 1980)

0156· 2700/ 80/ 0621-0::09 $00.50/ 0 CADIS Pr ... INPHARMA 2\ Jun 1980 9