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ilton Park

Abingdon, O

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NUK

Praise for the First Edition of

HUMAN EVO

LUTIO

NARY G

ENETICS

:

“I strongly recommend this book to anyone w

ith an interest inhum

an evolutionary genetics or anthropological genetics. It would

be an ideal choice for advanced undergraduates and graduatecourses on this topic, and w

ould also be a key reference for thoseactive in such research.”

—HUMAN GEN

OMICS

“This is an absolutely superb book! I have been recommending it

enthusiastically to professional colleagues, graduate students, andeven the occasional highly m

otivated undergraduate student, andthe response has been overw

helmingly positive. N

ot only is thebook unique in term

s of topical coverage, but it is also extremely

well executed. In fact, it is one of the best textbooks on any subject

I have ever read. It belongs on the shelves of everyone interested inthe genetic aspects of hum

an evolution.”—AMER

ICAN JO

URNAL O

F HUMAN GEN

ETICS

“I strongly recommend H

uman Evolutionary G

eneticsas an

undergraduate textbook. At the sam

e time, I recom

mend this

book to any readers with an interest in hum

an evolution or human

genetics.”—HUMAN GEN

ETICS

NEW SECOND EDITION

HEG2_UKversion_final_brochure 5/22/13 8:16 AM Page 1

Now in full-color, the Second Edition of HUMAN EVOLUTIONARY GENETICS hasbeen completely revised to cover the rapid advances in the field since publicationof the highly regarded First Edition. Written for upper-level undergraduate andgraduate students, it is the only textbook to integrate genetic, archaeological, andlinguistic perspectives on human evolution, and to offer a genomic perspective,reflecting the shift from studies of specific regions of the genome towardscomprehensive genomewide analyses of human genetic diversity.

HUMAN EVOLUTIONARY GENETICS is suitable for courses in Genetics, Evolution,and Anthropology. Those readers with a background in anthropology will find that the streamlined genetic analysis material contained in the Second Edition is more accessible. The new edition also integrates new technologies (includingnext-generation sequencing and genomewide SNP typing) and new data analysismethods, including recent data on ancient genomes and their impact on ourunderstanding of human evolution. The book also examines the subject ofpersonal genomics and its implications.

1. An Introduction to HumanEvolutionary Genetics

Section I: How Do We StudyGenetic Variation?2. Organization and Inheritance

of the Human Genome3. Human Genome Variation4. Finding and Assaying Genome

Diversity

Section II: How Do We InterpretGenetic Variation?5. Processes Shaping Diversity6. Making Inferences from

Diversity

Section III: Where and When Did Humans Originate?7. Humans as Apes8. What Genetic Changes

Have Made Us Human?9. Origins of Modern Humans

Section IV: How Did HumansColonize the World?10. The Distribution of Diversity11. The Colonization of the

Old World and Australia12. Agricultural Expansions13. Into New Found Lands14. What Happens When

Populations Meet?

Section V: How Is AnEvolutionary Perspective Helpful?15. Understanding the Past,

Present and Future ofPhenotypic Variation

16. Evolutionary Insights intoSimple Genetic Diseases

17. Evolution and Complex Diseases18. Identity and Identification

A sample chapter and detailed table of contents are available atwww.garlandscience.com/heg2. Please also visit the website to order an examination copy of the book forconsideration on your course.

NEW TO THE SECOND EDITION• Two new authors contributing additional expertise in genome

variation, infectious disease, primatology and anthropology.

• Now with a new layout and in full-color throughout, makingthe text and figures easier to read.

• Two additional chapters, reflecting developments inunderstanding the human genome in the context of otherhominid and great ape genomes, and in complex disease.

• The guest-authored ‘Opinion Boxes’ are retained, withcompletely new boxes and new guest authors to reflectcurrent issues and controversies.

• Each chapter ends with in-depth questions that are suitablefor use as homework assignments or exam questions.

• Comprehensive glossary of over 1,300 terms, doubling theterms in the first edition.

INSTRUCTOR RESOURCES• Figures in Powerpoint® and JPEG formats.

CUSTOM PUBLISHINGGarland Science Custom Publishing enables the creation of materials frommultiple sources, including Human Evolutionary Genetics in just a few clicks.Visit http://garland.sharedbook.com to learn more.July 2013 • 650 pages • 357 illustrations Paperback • 978-0-8153-4148-2 • £49.00

CONTENTS

Mark Jobling, University of Leicester, UK, Edward Hollox, University of Leicester, UK, Matthew Hurles, Wellcome Trust Sanger Institute, Hinxton, UK, Toomas Kivisild, University ofCambridge, UK, and Chris Tyler-Smith, Wellcome Trust Sanger Institute, Hinxton, UK

HUMAN EVOLUTIONARY GENETICSSecond Edition

Fulani(Cameroon)

Swedish Maasai(Kenya)

Beja(Sudan)

Bedouin Sindi(Pakistan)

Frequency of lactase persistence phenotype

0.9

0.8

0.7

0.6

0.5

0.4

0.3

0.2

0.1

14010C 13915G 13907G 13910T non-persistent

Figure 15.11: Frequency of lactase-persistence alleles in different populations.

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