Results

The opthalmological examination revealed keratoid opacity,mild increase ofkeratoid diameter (12.5mm) and increased endocular pressure in the left oculus(23 mm Hg) that confirmed congenital glaucoma diagnosis. The infantunderwent fistulation surgery on the left oculus with the use of Mitromycin —

C and peripheral iridectomy with regular post surgical progress.

Conclusions

Congenital glaucoma, though extremely rare as a disease, is describedfor its catastrophical consequences on vision. Surgery must be performedimmediately after diagnosis, as increased endocular pressure causes rapidatrophy of the optic nerve and blindness. The pediatrician should be sen-sitive enough to acknowledge symptoms and clinical manifestations of thedisease, so as to refer the infant to a specialized ophthalmologist as soon aspossible.

doi:10.1016/j.earlhumdev.2008.09.074

Abstract UENPS.59Correlation of the weight, serum levels of sodium and potassium innewborns with high risk of bronchopulmonary dysplasia

Peter Krcho⁎, Katarína VilcekováNICU, Kosice, Slovakia

Background and aim

The effective prevention of bronchopulmonary dysplasia (BPD) requiresan understanding of the possible side effects of various interventions.Authors hypothesize that BPD may result from not only prematurity,ventilation strategies, and cytokine-related lung injury, but also frommanagement during the transition period, fluid and energy intake, andmineral homeostasis.

Materials and methods

The authors compared weight gain and mineral homeostasis in 50newborns under 1500 g during the 30 day period after delivery while theywere treated in the neonatal intensive care unit Košice during 2006. The datacollected were weight gain, and serum levels of Na and K. The incidence ofcomplications, days of mechanical ventilation, and days of bubble CPAP. Afterthe data collection period, the newborns were divided to two groups basedon the presence or absence of BPD. Data were analyzed by multi-regressionanalysis, with significance if p<0.05.

Results

The occurrence of BPD in the whole group was 24%. The newborns withBPD had lower birth weight and gestational age, more days of ventilation,and had also slower weight gain. The weight during the first seven daysdecreased significantly in newborns with BPD, and the newborns with BPDwere able to regain birth weight at a mean age of 24 days, while thenewborns without BPD did so on at an average of 15 days. The average dailyweight gain was significantly higher in newborns without BPD. The level ofsodium on the 7th day was significantly lower in newborns without BPD, thelevel of potassium on 7th day was significantly lower in newborns with BPD,the levels of sodium and potassium from the 7th until the 30th day of lifewere not significantly different in the two groups.

Conclusions

Future research might be directed toward refining the critical periodduring which water intake must be controlled in order to achieve a reductionin BPD. It would also be valuable to develop models for predicting optimalwater and mineral balance that take into account the most importantdeterminants, such as birth weight, gestational age, postnatal age, andambient humidity. Finally, future studies should target the most vulnerablegroup for BPD, extremely premature infants, and what is most important for

them — ventilation strategy, fluid and mineral homeostasis, infection, andcytokine-mediated injury, among others.

doi:10.1016/j.earlhumdev.2008.09.075

Abstract UENPS.60Incontinentia pigmenti — Case report

Theodora Syriopouloua, Eleni Fourlani⁎,b, Eleni Polykarpouc,Evaggelos MichailaaGeneral Hospital of Kalamata, Kalamata, Greeceb“Agia Sofia” University Hospital, Athens, Greecec“Alexandra” Hospital, Athens, Greece

Background and aim

Incontinentia Pigmenti is a rarehereditary disease that is inherited asX-linkeddominant characteristic and causes thedeath ofmale infants. It is characterizedbyerythematous exanthema on the limbs and torso, that can be altered inpapulovasicular or hyperkeratic during its exacerbation and odd shaped dermalhyperpigmentation (in a circular or zonular arrangement) when is fully induced.Theabnormality can coexistwithother abnormalities of different systems andhasthe tendency to be automatically correctedwhile the personmatures.We presentthe case of a female infant with incontinentia pigmenti.

Materials and methods

Neonatal term female, with birth weight 2.360 g, born with caesareansection (due todisproportion) byprimiparamotherwith anobstetrical historyofplacenta detachment during the third month of pregnancy, shows, while being20 days of age, erythematous based vesiculae in linear arrangement distally tothe torso and along the pelvic limbs. Laboratory testing was performed: bloodtesting, biochemical testing, serological testing (TORCH), dermal culture andblood culture. Imaging evaluation (cerebrum, ultrasound of kidney–urinarybladder) and fundoscopy were performed, as well.

Results

Blood testing revealed eosinophilia (E: 40%), while the rest of the testresults were within normal ranges. Imaging evaluation and fundoscopyshowed no pathological findings. Taking into consideration the circumfer-ential blood eosinophilia and with the suspicion of incontinentia pigmenti,there was a careful examination of the mother, which revealed the existenceof indistinct dermal damage on the pelvic limb — an indistinct linear scarwith the absence of hair follicles, indicative of the disease. The newbornwas transferred to a tertiary pediatric hospital for further evaluation. Localanti-inflammatory treatment with glucocorticoids was applied in order toavoid bacterial infections. Dermal biopsy distinguished a histologicalimage compatible with incontinentia pigmenti in erythematous/vesicularstage.

Conclusions

The case is presented because of its rarity. Given that dermal damage ofthe disease does not always appear since birth, or does not undergo throughall 4 phases in all the cases, and abnormalities of other systems do not alwaysappear from the beginning of the diagnosis (as it is in our case), the need oflong following up of these patients is inflicted, so as coexisting damages fromother organs to be diagnosed early.

doi:10.1016/j.earlhumdev.2008.09.076

Abstract UENPS.61Listeria monocytogenes infection: Clinical case

Filipa Neiva, Albina Silva, Antonio Matos Marques, Carla Sa, Eduarda Abreu,Fernandes Bernardete, Almerinda Pereira⁎Hospital S. Marcos, Braga, Portugal

AbstractsS30