Infertility Update

George R Attia, M.DDirector of IVF Program

University of Texas SouthwesternMedical Center at Dallas

Infertility

• Inability to conceive after one year of adequate unprotected intercourse (six months if the woman is over age 35)

Time Required for Conception in Couples Who Will Attain Pregnancy

25

4557

7285

93 95

0102030405060708090

100

1 month 2 months 3 months 6 months 1 Year 2 Year 3 ear

% P

regn

ant

35%

35%

20%

7% 3%

Male FactorTubal FactorOv dysfunctionUnexplainedOthers

40%

40%

10%

10%

Anovulatory

Tubal & Pelvic

Unusual factors

Unexplained

• Anovulation• Tubal Factor• Male • Pelvic Factor (Endometriosis, adhesion)• Unexplained• Uterine/cervical (fibroid)

10%

90%

PCOS

Others

Ovulation

• History• BBT• LH kits• Mid luteal phase Progesterone (cycle length

– 7)• Ultrasound• EMB (day 21-26)

• Anovulation• Tubal / Pelvic Factor• Male • Unexplained• Uterine/cervical (fibroid)

Tubal & Pelvic Factors

• Tubal disease, PID• Tubal surgery• Pelvic adhesions• Endometriosis

Tubal Factor

• Tubal infertility after PID (12%, 24%, 50%)• One-half of patients who found to have

tubal damage and/or pelvic adhesion have no history of antecedent disease

Tubal Factor

• Hysterosalpingography• Hysteroscopy / laparoscopy• Falloscopy

• Anovulation• Tubal Factor• Male • Unexplained• Uterine/cervical (fibroid)

Male Factor Infertility

• Anatomic defects (hypospadias, Retrograde ejac.)

• Genetics Causes • Trauma• Infection• Endocrine disorders• Varicocele

Male Factor Infertility

• Vol. > 2 ml, Conc. > 20x106, Mot. >50%, Morph. > 30%.

• Total motile sperm per milliliter ( sperm per ml X percent motility) > 1o x 106

Male Factor Infertility

• Screening for

* Cystic fibrosis (Bilateral congenital absence of the vas) (1%-2% of infertile males)

* Y chromosome microdeletion (7% - 10%)

* Klinefelter’s syndrome (XXY) (1 in 500)

• Anovulation• Tubal Factor• Male• Uterine/cervical (fibroid)• Unexplained

• Anovulation• Tubal Factor• Male• Uterine/cervical (fibroid)• Unexplained

Basic Work Up• Day 3 Labs (FSH,

Inhibin B, Estradiol)• Mid luteal phase

Progesterone• Semen analysis

• Hysterosalpingogram

• ??? Laparoscopy

• Anovulation

• Male

• Tubal Factor

• Uterine/cervical (fibroid)

• Unexplained

• Anovulation• Tubal Factor• Male• Unexplained• Uterine/cervical (fibroid)

1. Estrogen2.FSH

4.LHPositive

Feedback

3. Estrogen

Hypoth / Pituitary

Induction of Ovulation

1. Estrogen2.FSH

4.LHPositive

Feedback

3. Estrogen

Hypoth / Pituitary

1. Clomid2. Injection Medications

(Gonal-f, Follistim, Repronex)

Induction of Ovulation

• Clomid 80% response, less invasive, cheapLow incidence of multiple

• Injectable Multiple gestationExpensive

• Intrauterine Insemination

• Anovulation• Tubal / Pelvic Factor• Male• Unexplained• Uterine/cervical (fibroid)

• Tubal Surgery• In vitro fertilization (IVF)

Pregnancy Outcome After Tubal Surgery

0%10%20%30%40%50%60%70%

Intrauterine 70% 17% 12%Ectopic 10% 14% 4%

Mild Moderate Sever

Preg

nanc

y R

ate

( %)

10 29 56

• Anovulation• Tubal Factor• Male • Unexplained• Uterine/cervical (fibroid)

• Intrauterine Insemination• In vitro fertilization (IVF)• Intracytoplasmic Sperm Injection (ICSI)

• Anovulation• Tubal Factor• Male• Unexplained• Uterine/cervical (fibroid)

Pregnancy Rate per Cycle in Patients with Unexplained Infertility

2.7 3.8 5.68.3 7.7

17.1

30

0

5

10

15

20

25

30

NoTreatmentIUIClomipheneClomiphene & IUIHMGHMG + IUIIVF

• Anovulation• Tubal Factor• Male• Unexplained• Uterine/cervical (fibroid)

In Vitro Fertilization(IVF)

LH FSH

Hypoth / Pituitary

PositiveFeedback

Estradiol

FollisitimGonal-FPerganolRepronex

D 1 D 21 D 35SD 1

Start Lupron

Start FSHStart OC Retrieval Transfer

2 D3 wks 2wks 3 DS D

10-14

10-14 D

IVF Success Rate

• Age• Age• Age• 40 - 60%• Cost $5500 + Medications

Intracytoplasmic Sperm Injection(ICSI)

Pre Implantation Genetic Diagnosis(PGD)

Sex Selection(Microsort)