INFORMATION FOR CONTRIBUTORS (1991)

Aims and Scope

Genes & Development welcomes high-quality research papers of general interest and biological significance in molecular bi- ology, molecular genetics, and related areas. Publication time from acceptance of manuscript is between two and three months. For papers accepted subject to revision, only one re- vised version will be considered; it must be submitted within 2 months of the provisional acceptance.

Submission of Papers

The journal accepts papers which present original research that has not previously been published. Submission to the Journal implies that a paper is not currently being considered for an- other journal or book. Closely related papers that are in press elsewhere or that have been submitted elsewhere should be included with the submitted manuscript. It is also understood that researchers who submit papers to this journal are prepared to make available to qualified academic researchers materials needed to duplicate their research results (DNA, cell lines, an- tibodies, microbial strains, and the like). Authors should submit nucleic acid and protein sequences to the appropriate data bank.

Contributors from North and South America, Asia, and Aus- tralia should submit their papers to the Cold Spring Harbor Laboratory office. Contributors from Europe and Africa should submit their papers to the Edinburgh office. Questions regard- ing papers should be directed to Judy Cuddihy, Managing Editor, at Cold Spring Harbor Laboratory (516-367-8492).

Manuscript Preparation

1. General. Papers accepted by the journal will occupy a max- imum of 10-12 journal pages. A manuscript of 28-32 typed, double-spaced pages total (including methods, references, ta- bles, and figure legends) with six single-column figures and one single-column table will translate to this length in the journal. The entire paper (including tables, figure legends, references, footnotes) should be typed double-spaced on standard-sized Eu- ropean or American bond paper with at least 1-in (2.5 cm) mar- gins on all four sides. Computer printouts should be of letter quality, and should use a computer typeface of at least 10 point size. Each page should be labeled with the first author's name and a page number. Five copies should be submitted; at least four of these copies should have original art. A cover letter should include: {a) name, address, and telephone number of au- thor responsible for correspondence regarding the manuscript; (b) statement that the manuscript has been seen and approved by all listed authors; (c) any specific requirements for reproduc- tion of art; and (d) status of any permissions needed.

2. Submitting Papers on Computer Discs. Publication can be speeded up if accepted papers are supplied on 31/2 - or 51/4-inch floppy discs. We can accept IBM PC, AT and XT or compatible, formats. Please supply the manuscript on the disc as a "text" or ASCII file, if possible. If a word-processing file is being sent, do not use any underscoring, italic, or boldface; spell out special characters (Greek, math); use two carriage returns at the end of each paragraph, subheads, and list items. Indicate on the disc:

computer brand name, whether the disc contains a text or word- processing file (name of software), and the disc format. Five hardcopy versions should also be submitted for use by referees and editors.

3. Form. The following order is preferred: Title page, Ab- stract, Introduction, Results, Discussion, Methods, Acknowl- edgments, References, Tables, Figure legends. The Title page should include: (a) title; (b) all authors' full names; (c) all affilia- tions clearly indicated; (d) a shortened version of the title for use as a running head {maximum 45 characters); and (e) key words {up to 6) for use in indexing. The Abstract should be about 200 words long and should summarize the aim of the report, the methodological approach, and the significance of the results. Methods will appear at the end of the paper and should be detailed enough to allow any qualified researcher to dupli- cate the results.

4. Figures and Legends. Five sets of figures should be sup- plied as high-quality glossy prints. Half-tones should be high- contrast, particularly in the case of gels, for the best reproduc- tion. Line drawings, graphs, charts, and chemical formulae should be professionally prepared and labeled. Multiple-part fig- ures should be submitted as mounted, camera-ready compos- ites. Authors submitting color figures as essential data for re- view with manuscripts undertake to pay the publication costs of four-color artwork. Price estimates are supplied upon accep- tance of the paper.

The back of each figure should be labeled with the first au- thor's name, figure number, and an indication of "top." The figures should be numbered consecutively in the order to which they are referred in the text. The size of the figures will be ad- justed to fit the Journal format, therefore please try to keep labels, symbols, and other call-out devices in proportion to the figure size and detail.

Figure legends should be brief and should not contain methods. Symbols indicated in the figure should be identified in the legend text. If figures are reprinted from another source, permission to reprint is required.

5. Tables. Tabular data should be presented concisely and logically. Tables should be numbered consecutively according to the order cited in the text and each should have a title. Use only horizontal rules and make sure column headings are un- ambiguous in indicating columns to which they refer. Table legends and footnotes should be included where needed. If tables are reprinted from another source or if data included are from another source, permission to reprint is required.

6. References. References are name/date citations in text; please do not cite by number. Undated citations (unpublished, in preparation, personal communication) should include first initials and last names of authors. Bibliographic information should be supplied in the following order. For Journal articles: Author(s), year, article title, journal title, volume, inclusive page numbers. For books: Author(s), year, chapter title, book title, editors' names, volume, inclusive page numbers, pub- lisher, city of publication.

7. Proofs. Proofs are considered the final form of the paper and correction can be made only in the case of factual errors. If additional information must be added at this stage, it should be in the form of "Note added in proof," subject to the approval of the editors.

8. Reprints. A reprint order form will be included with the proofs.

To help defray the cost of publication, a charge of $25 per page will be made for publication in Genes & Development. Authors unable to meet these charges should include a letter of explanation upon acceptance for publication; inability to meet these charges wil lhave no effect on acceptance and publication of submitted papers.

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P redoc to ra l a n d P o s t d o c t o r a l Pos i t ions a t the Markey Center f o r

Molecular Genetics Univers i t y o f Vermont

The Department of Microbiology and Molecular Genetics at The University of Vermont has predoctoral and postdoctoral positions available under its Markey Center for Molecular Genetics. Positions are available for research with:

Dr. Erik Bateman Dr. John Burke

Dr. Richard Fishel

Dr. Paula Fives-Taylor Dr. Gregory Gilmartin Dr. Douglas Johnson Dr. Janet Kurjan Dr. Yoke Wah Kow Dr. Robert Melamede Dr. Joan Moehring

Dr. Thomas Moehring

Dr. Charles Novotny

Dr. David Pederson Dr. Karen Pratt

Dr. Carlene Raper

Dr. Warren Schaeffer

Dr. Susan Wallace

Mechanisms and regulation of RNA pol II transcription RNA splicing and catalytic RNA; ribozymes as antiviral agents Biochemistry and molecular biology of recombination in human cells Molecular mechanisms of cell adhesion and invasion Biochemistry and regulation of mRNA processing Control of cellular polarity in yeast Cell-cell interactions involved in yeast mating Mechanism of action of DNA repair enzymes DNA repair enzymology Genetics of resistance to toxins and viruses in mammalian cells Mechanisms of pathogenesis of toxins and viruses in mammalian cells Mating-type regulation in the fungus Schizophyllum commune Molecular analysis of initiation of transcription in chromatin Role of DNA methylation in regulation of transcription in mammalian systems Developmental genetics of fruiting in Schizophyllum commune Cytoplasmic influence in the biology and pathogenesis of mycoplasmas Molecular mechanisms of DNA damage processing

Interested candidates should submit an application by December 16, 1991 to: Dr. Janet Kurjan, Department Microbiology and Molecular Gehetics, University of Vermont, College of Medicine and College of Agriculture and Life Sciences, Burlington, VT 05405. Include a curriculum vitae, a description of your research, the names and addresses of three references, and an indication of the labs from the above list in which you would like to do research. The University of Vermont is an Equal Opportunity/Affirmative Action Employer; women and minorities are encouraged to apply.

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P H A R M. A C I A P - L B i O C H E .M I C A L S

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I, 1" -'11 V E C T 0 R

*Vector not included with kit

Isolated CeUs/Tissu

"DNA Packaged or ,etent Cells Transformed

? Host Cells Transfected

and cDNA Library Plated

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M V - " cDNA ~ V M

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Reader Service No. 694