DEMOSTRACION DE INMUNIDAD FRENTE A TUMORES

ANTIGENOS TUMORALES

INMUNIDAD ANTITUMORAL

INMUNIDAD ANTITUMORAL

INMUNIDAD ANTITUMORAL

INMUNIDAD ANTITUMORAL

INMUNIDAD ANTITUMORAL

INMUNIDAD ANTITUMORAL

INMUNIDAD ANTITUMORAL

INMUNIDAD ANTITUMORAL

LINFOCITOS CD8+ Y CD4+

IL10

CANCER IMMUNOSURVEILLANCE

IKDC: DC PRODUCTORA DE IFN

NKT: DC RECONOCIMIENTO GLICOLIPIDOS

CANCER IMMUNOSURVEILLANCE

NK(NKGD2)

CANCER IMMUNOSURVEILLANCE

LT

CANCER IMMUNOSURVEILLANCE

ANTICUERPOS

CANCER IMMUNOSURVEILLANCE

CANCER IMMUNOSURVEILLANCE

NK, NKT, LT

HYPOTHETICAL LINK ENDOGENOUS SUPPRESION AND IMMUNOSURVEILLANCE

CANCER IMMUNOSURVEILLANCE

MECHANISMS OF TUMOR ESCAPE FROM THE IMMUNE SYSTEM

MIELOID SUPRESSOR CELLS

INDOLEAMINE 2,3DIOXYGENASE

MECHANISMS OF TUMOR ESCAPE FROM THE IMMUNE SYSTEM

CARACTERISTICAS CELULA TUMORAL

VIAS DE SEÑALIZACION CELULAR: FACTORES CRECIMIENTO vs. FACTORES ANTICRECIMIENTO

MICROAMBIENTE TUMORAL

LAS 3 “Es” DE INMUNOEDICION

VARIANTES CELULAS TUMORALES

CELULAS TUMORALES

CITOQUINAS

LAS 3 “Es” DE INMUNOEDICION

QUIMIOQUINASBloqueaANGIOGENESIS

FASE ELIMINACION

LAS 3 “Es” DE INMUNOEDICION

LAS 3 “Es” DE INMUNOEDICION

LAS 3 “Es” DE INMUNOEDICION

DENDRITIC-CELL DEFECTS

NORMAL DC DIFFERENTIATION

FUNCTIONAL CONSEQUENCES OF ABNORMAL DIFFERENTIATION IN CANCER

FUNCTIONAL CONSEQUENCES OF ABNORMAL DIFFERENTIATION IN CANCER

STAT3-MEDIATED SIGNALLING IN ABNORMAL DIFFERENTIATION OF DCs

FUNCTIONAL CONSEQUENCES OF ABNORMAL DIFFERENTIATION IN CANCER

NFkB-MEDIATED SIGNALLING IN ABNORMAL DIFFERENTIATION OF DCs

STAT3 IN THE TUMOR MICROENVIRONMENT

STAT3 CONSTITUTIVE ACTIVATION

STAT3 IN THE TUMOR MICROENVIRONMENT

STAT3 IN THE TUMOR MICROENVIRONMENT

HEMATOPOIETIC PROGENITOR CELLS

STAT3 IN THE TUMOR MICROENVIRONMENT

STAT3 IN THE TUMOR MICROENVIRONMENT

TARGETING STAT3 FOR CANCER IMMUNOTHERAPY

INHIBITORY B7-FAMILY MOLECULES IN THE TUMOUR MICROENVIRONMENT

INHIBITORY B7-FAMILY MOLECULES IN THE TUMOUR MICROENVIRONMENT

INHIBITORY B7-FAMILY MOLECULES IN THE TUMOUR MICROENVIRONMENT

INHIBITORY B7-FAMILY MOLECULES IN THE TUMOUR MICROENVIRONMENT

INHIBITORY B7-FAMILY MOLECULES IN THE TUMOUR MICROENVIRONMENT

SUPPRESSIVE MECHANISM OF TUMOUR ENVIRONMENTAL REGULATORY T CELL

NFkB SIGNALLING PATHWAYS

NFkB SIGNALLING PATHWAYS LINKING INFLAMMATION AND IMMUNITY TO CANCER DEVELOPMENT AND PROGRESSION

NFkB SIGNALLING PATHWAYS LINKING INFLAMMATION AND IMMUNITY TO CANCER DEVELOPMENT AND PROGRESSION

NFkB TUMOUR PROMOTING FUNCTIONS

NFkB SIGNALLING PATHWAYS LINKING INFLAMMATION AND IMMUNITY TO CANCER DEVELOPMENT AND PROGRESSION

CANCER CELL NECROSIS IS AN IMPORTANT DRIVER OF TUMOUR PROGRESSION

…”not enough of a good thing” PARADIGM

NATURAL AND ADAPTIVE Tregs

…”too much of a bad thing” PARADIGM