Introduction of LivactorDLG]_Vitamin stabilization... · 2014-12-17 · Pigment cell: makes melanin which effects on skin color decision ... UV rays, pollution, severe weather, and

Introduction of Vitamin Stabilization Technology of C-SEM

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DAELIM GLOBAL Co., Ltd, 14F Noonnoppi Daejeon Center 1028 Doonsan 2-dong, Seo-gu Daejeon, South Korea 302-828

http://www.daelimglobal.com T : F : E:

82. 42. 476. 9400 82. 42. 476. 9401 [email protected]

2

Solution Provider with Value Creation & Innovation Copyright DAELIM GLOBAL All rights reserved.

Skin is consisted with various layers and each layer has various cells. So understanding roles of each cell is needed to find right solution of various skin problems

1

Epi- dermis

Dermis

Hypo-dermis

The most outer part of skin

Stratum basal: cell division & replacement

Pigment cell: makes melanin which

effects on skin color decision

Fibroblast: makes Collagen & Elastin

which keep skin elasticity

Sebaceous glands: emits sebum to

protect virus invasion & moisture dry

Ground substance: contains plenty of

moisture and fills among cells

Located between Dermis and muscle &

bones

It contains thick fat layer to protect from

outer impact and keep body temperature

Elastin

Fibroblast

Background Knowledge - (1) Understanding of Skin

(1) Skin’s Structure & Role1)

Hypo-dermis

Pigment cell(melanocyte)

Sebaceous glands

Follicles Sweat pore Blood Vessel

Collagen

Ground substance

Stratum basal

Epi- dermis

Dermis

3


Skin aging causes various skin problems and it is divided unavoidable Intrinsic Factor and restorable Extrinsic Factor by functional cosmetics

Causes of Skin aging1) Major Skin Problems by Skin Aging

(2) Causes & Results of Skin aging

Intrinsic Factor

Extrinsic Factor

Natural aging by time and mostly decided by

genetic factor

Oxygen free radical is known as a direct reason

to generate skin aging

Aging generated by extrinsic factor such as

UV rays, pollution, severe weather, and

cigarette smoke etc.

Photoaging by UV rays is the typical case

UV rays A>B>C (Longer wavelength in order)

UV-A & B have bad influence on skin problems

Background Knowledge - (2) Causes & Results of Skin aging 1

Decrease of skin depth & elasticity, wrinkle

Destruction and decrease of collagen & elastin

1

Pigmentation & spot generation

Over generation of melanin by exposure to UV

2

Dryness skin

Decreased sebum to protect virus & moisture loss

3

Skin infection and skin cancer increase

Increase skin disease factors by decreased immunity

4

Abnormal calcium metabolic activity

Decrease of Vitamin D to accumulate calcium on bones

5

Areas to be improved by functional cosmetics

“Not easy to overcome by effort”

“Possible to improve by effort”

4


Vitamin is an organic compound required by an organism as a vital nutrient in limited amounts

1

(3) Relation between vitamin & skin

Background Knowledge - (3) Relation between vitamin & skin

Vitamins

Vitamin A Vitamin B Vitamin C Vitamin D Vitamin E

• Roles : 1) Callus Prevention 2) Skin Elasticity Increase 3) Anti Infectious Ability

• Deficiency : 1) Hypodermis Atrophy 2) Skin Dryness 3) Thick Skin

• Foods : Spinach, Carrot, Cabbage

• Roles : 1) Immune Sys. Protection 2) UV Protection 3) Anti-skin Cancer

• Deficiency : 1) Skin Cancer

• Foods : Peanut, Salmon, Bean

• Roles : 1) Activated O2 Removal 2) Sun-ray Protection 3) Collagen Generation 4) Whitening

• Deficiency : 1) Stains 2) Freckles

• Foods :

Apple, Apricot, Strawberry

• Roles : 1) Skin Dryness Prevention

• Deficiency : 1) Skin Aging

• Foods : Milk, Cheese, Mushroom

• Roles : 1) Anti-vaporizing 2) Skin Reproduction 3) Moisturizing

• Deficiency : 1) Skin Aging

• Foods : Vegetable oil, Grain

5


Skin Problem Cause Solution Principle of improvement

Intrinsic Aging • Cell damage by oxygen free radical

Vitamin C Vitamin E

• Vitamin C & E removes Oxygen free radical and maximize anti-oxidant activity by both interaction

Extrinsic Aging • Cell damage by UV A, B Vitamin C Vitamin E

• Vitamin C protects cell damage by UV & skin cancer • Vitamin E protects cell damage by fat oxidation

Skin depth & elasticity decrease • Collagen & elastin decrease

Vitamin A Vitamin C

• Vitamin A’s retinol keeps fibroblast healthy • Vitamin C motivates collagen & elastin generation

Wrinkle Generation

• MMP1) enzyme increase which demolishes protein which is composing ground substance

Vitamin A • Vitamin A’s retinol restrains MMP enzyme generation not to demolish protein

Pigmentation & spot generation

• Irregular pigment dispersion & maturity by melanin cell generation

Vitamin C • Vitamin C restrains melanin generation and revivify generated melanin & get paled the color

Dryness skin • Increase moisture loss by sebum secretion decrease

Vitamin B Vitamin E

• Vitamin B’s panthenol keeps skin moisture & shine • Vitamin E restrains fat oxidation and moisture evaporation

Vitamin is used to solve skin problems especially Vitamin-C is used for various skin problems

(4) Solutions of skin problem

1) Matrix metalloproteinase,

Background Knowledge - (4) Solutions of skin problem 1

6


Vitamin C is very beneficial for skin care but pure Vitamin C is very difficult to use as a raw material of cosmetic so far

(5) Pros & Cons of Vitamin C

1) phosphate ester, fatty acid ester

Background Knowledge - (5) Pros & Cons of Vitamin C 1

Effectiveness of Vitamin-C Limitation of Vitamin-C

Anti-aging

Wrinkle

Care

• Prevents generation of activated oxygen which

affects on skin barrier damage, pigmentation

and aging

Whitening

Skin Problem

Care

1

2

3

4

• Restricts melanin synthetic and restores skin

tone clearly & whitely through oxidized melanin

reduction

• Stabilizes collagen which affect on skin elasticity

& moisturizing for pore tightening, wrinkle free

skin and elastic skin

• Strengthens skin’s defense mechanism against

germs and skin barrier to solve skin problems

such as an atopic dermatitis

Easy decomposition by heat & air

Pure Vitamin C can’t be used as raw materials of

cosmetic even it has strong antioxidant ability

2

Body can’t synthesize Vitamin C

Vitamin C must be supplied out of the body through

eating foods which contains Vitamin C

1

Unclear effectiveness of derivatives

Vitamin derivative1) is for supporting weakness of pure

Vitamin C but conversion efficiency is not clear

3

“Using Vitamin C as raw material

of cosmetic is difficult so far”

7


Product Comparison - (1) Cellex-C - A. Introduction

Cellex-C is the best selling skin care cosmetic world widely and it owns head quarter in Canada & manufacturing plant in USA

2

A. Introduction

1) www.cellex-c.com

“ The best selling

Vitamin-C cosmetic

in the world

BUT

Is it perfect product

as much as

its fame & price?”

8


“FAQ of Cellex-C from Korean Official Website”

Cellex-C has asked questions frequently regarding discoloration, make-up scrubbing, skin sting, and dryness skin. BUT all causes are explained as nature of Vitamin-C

B. Quality issue

1) www.cellex-c.co.kr

Q: Why is the color of CelleX-C is different from others which bought before? A: It because of different date of raw material collecting → QC standard must be applied equally so we can guess it because of discoloration & decomposition

Q: Why Moisturizer & make-up is scrubbed like dead skin after using Vitamin C & Hydra 5-B Complex? A: It because of inharmony between water based Cellex-C and other oil based product. → We can guess it because of low absorption ability of Vitamin-C product of Cellex-C

Q: Why skin is stung and dried when using Vitamin-C of Cellex-C especially using Cream product? A: It is natural phenomenon when Vitamin-C is penetrating Skin, Cream type has slower absorption ability so it stays longer on the skin. → It is natural thing of Vitamin-C, BUT it can be improved according to Vitamin-C stabilization tech. like ours

Product Comparison - (1) Cellex-C - B. Quality issue 2

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Not only Cellex-C but also other Vitamin based products have similar problems as well BUT these problems can be improved by our VITAMIN STABILIZATION TECHNOLOGY

Own Patent1)

Definition of Stabilization Tech

Product Comparison - (2) C-SEM - A. Vitamin Stabilization Tech. (1) 2

Coated antioxidant particle, Composition comprising the particle and Method for preparing the particle (2009.07.07 10-0907660)

Coated antioxidant particle, Composition comprising the particle and Method for preparing the particle (2009.11.25 10-0929703)

Aqueous cosmetic composition comprising coated antioxidant particle and Method for preparing the particle (2010.06.22 10-0966919)

1) http://eng.kipris.or.kr

Stabilization Technology

Definition

Capsule Structure

Effectiveness

• Pure Vitamin C can be existed in cosmetic stably

without oxidization from light, heat and air

• Thus skin penetration of Vitamin C is increased

• Uses stabilizer which can be polymer by itself as

a capsule material to encapsulate pure Vitamin C

and protect the Vitamin C from decomposition

Vitamin C Stabilizer

Silica Bio Polymer

Applied patent to Vitamin C stabilization

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Our capsulated Vitamin C showed higher residual contents and lower discolor ability compare to pure Vitamin C

Residual contents test in cosmetic Vitamin C discoloration test

Residual contents test & discoloration test

1) Korea Health Supplement Institute, www.khsi.re.kr

0

20

40

60

80

100

Time(week)

0

1

2.5

10

25

Vitam

in

Conce

ntr

ate(

%)

Product Comparison - (2) C-SEM - A. Vitamin Stabilization Tech. (2) 2

1 Week 2 Week 3 Week 4 Week 0 Week

Pure VC

Our VC

1) More effectiveness by pure VC penetration

2) Bio contents helps moisturizing & skin penetration

3) It showed over 94% stability at 50℃ (Clinical test)

1) Decomposed Vitamin causes skin stimulation

2) Pure VC was discolored even stored in refrigerator

3) Our VC kept initial color for 4 weeks

Pure VC Capsulated VC

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Capsulated pure Vitamin C showed twice higher skin penetration ability than non-capsulated vitamin C

Skin penetrate test

2 Product Comparison - (2) C-SEM - A. Vitamin Stabilization Tech. (3)

Pure Vitamin C skin penetration test

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Cellex-C is the best Vitamin C but it can’t solve fundamental problems of Vitamin C BUT we solved this problems with our stabilization technology

Comparison Cellex-C and C-SEM comparison

Product Comparison - (3) Comparison 2

Cellex(5%Vc) C-SEM(5%Vc)

Case Image

Quantity 15ml 20ml

Issues

• Discolor and decomposition generation • Skin stimulus generation • Dryness skin generation • Make-up scrubbing generation • Lack of clinical data • Expensive

• Non-preservative, Non-pigment, Non-perfume (Natural oil use)

• Owns Vitamin Stabilization Tech. patent • Maximized skin penetration using natural vegetable oil

Discolor and

Residue contents1)

Normal Spoid Case

Pump type high-end case

Side window to check inside

1) Measuring for 4 weeks at 50℃

0 Week 100%

(Initial Stage)

4 Week

62%

0 Week 100%

(Initial Stage)

4 Week

94.2%

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Pure Vitamin C based Serum

Normally pure vitamin c is good to skin problem but it has low ph than skin’s ph

So the gap of pH can cause skin stimulus(BUT Our serum has solved this problem)

This serum is effective for whitening, wrinkle free, moisturizing and dead cell removal

with its strong anti-oxidant activity

Vitamin C stabilization is possible through our own stabilization technology

To prove our Vitamin stabilization tech. we compared pure Vitamin based sample A and vitamin derivative based sample B

(1) Comparison

-

-

Age Planner

Warming Serum

(Sample A)

Muriel White

Perfection Vitamin C

Serum (Sample B)

Recognized the best Vitamin C Derivative AA2G

Vitamin C Derivative has 80% similar effectiveness of pure Vitamin C

But Vitamin C Derivative has normal pH level enough to supplement Pure Vitamin C

So it is widely applied to make cosmetics as the alternative of unstable Pure Vitamin C

This serum was approved as a functional cosmetic by MDFA1)

Appendix - Pure Vitamin C & Vitamin Derivatives - (1) Comparison 3

1) Ministry of Food and Drug Safety, www.mfds.go.kr

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Both pure Vitamin and Vitamin Derivatives can be effective solutions for skin problems BUT pure Vitamin showed better effectiveness than Vitamin Derivatives

(2) Clinical Test

3 Appendix - Pure Vitamin C & Vitamin Derivatives - (2) Clinical Test

63.0 62.5 62.0 61.5 61.0 60.5 60.0 59.5 59.0 58.5 58.0

Sample B Sample A

0 W 3 W 6 W

Skin color change (higher is better)

Wrinkle depth (Lower is better) 63.0 62.5 62.0 61.5 61.0 60.5 60.0 59.5 59.0 58.5 58.0 0 W 3 W 6 W

Sample A Sample B

62.5

62.0

61.5

61.0

60.5

60.0

59.5 0 W 3 W 6 W

Dead skin Qt. (lower is better) 63.0 Sample B Sample A

205.0

200.0

195.5

190.0

185.5

180.0

175.5

170.0 0 W 3 W 6 W

Melanin level (Lower is better)

Sample B Sample A

Moisturizing (Higher is better) 66.0 64.0 62.0 60.0 58.0

54.0 52.0 50.0

56.0

0 W 3 W 6 W

Sample B Sample A

15


Pure Vitamin C based Age Planner Warming Serum showed its effectiveness for facial blemishes removal through 6 weeks test

(3) Facial blemishes

“Facial blemishes are decreased through 6 weeks test by stabilized Vitamin C”

Product Image 0 W 3 W 6 W

Sample (A)

Cross-polarized

Black component

Appendix - Pure Vitamin C & Vitamin Derivatives - (3) Facial blemishes 3

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Through our stabilization technology, pure Vitamin C can be used as cosmetic material WITHOUT existing problems so the customers can expect improved effectiveness

(4) Conclusion

“ Through our Stabilization technology, direct use of Vitamin-C is possible”

Sample A : Stabilized Vitamin C

Sample B : Vitamin Derivatives

AA2G [KFDA approval] Results

Skin Color Very Effective Effective Sample A showed better result than Sample B

in skin color improvement

Melanin Level Very Effective Effective Sample A showed better result than Sample B

in decrease of blemished and spots

Wrinkles Very Effective Effective Sample A showed better result than Sample B

in wrinkle decrease

Moisturizing Effective Effective Sample A showed better result than Sample B

In moisturizing

Dead Skin Removal

Effective Effective Sample A showed better result than Sample B

In dead skin decrease

Skin Stimulus No Stimulus No Stimulus Clinical Test Success

Appendix - Pure Vitamin C & Vitamin Derivatives - (4) Conclusion 3

Documents

Introduction of LivactorDLG]_Vitamin stabilization... · 2014-12-17 · Pigment cell: makes melanin which effects on skin color decision ... UV rays, pollution, severe weather, and