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Letter to the Editor
IS MITOMYCIN C-INDUCED CHROMOSOME BREAKAGE ALWAYSREQUIRED FOR THE DIAGNOSIS OF FANCONI APLASTIC ANEMIA?
Sinasi Ozsoylu, MD h Department of Paediatrics and Haematology, FatihUniversity, Medica Faculty, Ankara, Turkey
I read with enthusiasm the brief report of Papadopoulos et al. entitledªA case of non-Fanconi anemia bone marrow dysfunction with familial in-volvementº in the May± June, 1998 issue of Pediatric Hematology and OncÈology
(1998;15:277 ± 281).The patient had almost all criteria (cafe-au-lait spots, pancytopenia with
bone marrow failure, eye, hand ® ndings, growth retardation, microcephaly,and family history) for the diagnosis of Fanconi aplastic anemia (FA) exceptlack of the characteristic chromosome breaks following clastogenic stresswhich is essential for International Fanconi Anemia Registry.
Although I completely agree with the authors statement that ªwe willprobably have to wait until all of the many FA and related genes have beencloned and their functions identi® ed,º the paper of Dokal et al. [1] stronglysuggests that positive diepoxybutane test is not essential for the diagnosisof Fanconi’s aplastic anemia. I believe the patient reported in this study isanother example for the above suggestion.
REFERENCE
1. Dokal I, Chase A, Morgan NV, et al. Positive diepoxybutane test in only one of two brothers found to
be compound heterozygotes for Fanconi’s anem ia complem entatin group C mutation. Br J Haematol.
1996;93:813 ± 816.
Received 6 August 1998; accepted 21 August 1998.
Address correspondence to SË inasi ÈOzsoylu, M D, Departm ent of Paediatrics and Haematology, Fatih
University, Medica Faculty, CË iftlik cad. No: 57, 06510 Emek-Ankara, Turkey.
Pediatric Hem atology and Oncology, 16:271, 1999
Copyright C° 1999 Taylor & Francis
0888-0018/99 $12.00 + .00 271
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