Joakim Dillner, M.D.Professor

Department of Laboratory MedicineKarolinska Institutet

Sweden

Biography• Joakim Dillner, M.D., is professor in infectious Disease Epidemiology at Karolinska

Institutet, Stockholm, Sweden. • He is Director of BBMRI.se (BioBanking and Molecular Resource Infrastructure of

Sweden), the Swedish national biobanking platform that is the national hub of the joint European biobanking platform BBMRI-ERIC.

• He is Director of the International Papillomavirus Reference Center, that maintains a repository of isolates of HPV, sequences them and awards new HPV type number.

• He is Director of the Swedish Cervical Screening Registry and the Karolinska Hospital Cervical Cancer Prevention Center, that performs the HPV screening and the biobanking of the organised cervical screening program in the greater Stockholm Region.

• He supervises large trials of organised HPV-based screening and Nordic follow-up studies of HPV vaccination.

• Professor Dillner has published more than 370 original research papers. The H-index is 60 and the number of citations is >13000.

Research Interests• Cancer prevention, in particular organised cancer screening

programs.• Tumor virology, in particular using biobank and registry linkages

to define study bases with prospectively followed samples that are analysed using high throughput “omics” technologies.

• Using registries to evaluate and improve cancer prevention efforts and to enrich biobank cohorts with clinical data.

• “Omics”-based studies applied to longitudinally followed biobank cohorts.

• International networking to further research on cancer prevention and advocacy for evidence-based cancer control strategies

JoakIim DillnerProfessorKarolinska InstitutetSweden

• Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry.

• Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interactions between the different types of DNA, RNA and protein biosynthesis as well as learning how these

interactions are regulated.

Introduction

Relationship to other biological sciences

Interaction b/w DNA, RNA & Protein

Techniques of molecular biology• Expression cloning• Polymerase chain reaction• Gel electrophoresis• Macromolecule blotting and probing• Southern blotting• Northern blotting• Western blotting• Eastern blotting• DNA microarray• Allele-specific oligonucleotide• Antiquated technologies

Expression Cloning

BlottingAgarose Gel Electrophoresis

Clinical Significance

• Clinical research and medical therapies arising from molecular biology are partly covered under gene therapy.

• The use of molecular biology or molecular cell biology approaches in medicine is now called molecular medicine.

• Molecular biology also plays important role in understanding formations, actions, regulations of various parts of cells which can be used efficiently for targeting new drugs, diagnosis of disease, physiology of the Cell.