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Journal of Neurology, Neurosurgery, and PsychiatryJanuary 1989 Vol. 52 No. IContents
M EThe contribution of mortality statistics to the study of multiple sclerosis in Australia SR HAMMOND, DR ENGLISH, C de WYTT,JF HALLPIKE, KS MILLINGEN, EG STEWART-WYNNE, JG McLEOD, MG McCALL page ISeverely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis IGOR GRANT,GEORGE W BROWN, TIRRIL HARRIS, W IAN McDONALD, THOMAS PATTERSON, MICHAEL R TRIMBLE page 8Quantitative magnetic resonance imaging in multiple sclerosis: the effect of high dose intravenous methylprednisolone J KESSED H MILLER, DG MacMANUS, G JOHNSON, NM MILLIGAN, N SCOLDING, DAS COMPSTON, WI McDONALD page 14A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis D BATES,NEF CARTLIDGE, JM FRENCH, MJ JACKSON, S NIGHTINGALE, DA SHAW, S SMITH, E WOOD, SA HAWKINS, JHD MILLAR, J BELIN, DM CONROXSK GILL, M SIDEY, AD SMITH, RHS THOMPSOM, K ZILKHA, M GALE, HM SINCLAIR page 18Cerebral palsy and stereotactic neurosurgery: long term results JD SPEELMAN, J VAN MANEN page 23Visual evoked potentials in the assessment of patients with non-functioning chromophobe adenomas GRAHAM E HOLDER,PETER R BULLOCK page 31The Doppler CO2 test to exclude patients not in need of extracranial/intracranial bypass surgery B WIDDER page 38Encephalopathy, deafness and blindness in young women: a distinct retinocochleocerebral arteriolopathy? JULIEN BOGOUSSLAJEAN-MARC GAIO, LOUIS R CAPLAN, FRANCO REGLI, MARC HOMMEL, THOMAS R HEDGES 111, MARCO FERRAZZINI, PIERRE POLLAK page4Classical conditioning in patients with severe memory problems IRENE DAUM, SHELLEY CHANNON, ANTHONY GM CANAVANpage47The temporal sequence of aura-sensations in patients with complex focal seizures with particular attention to ictal aphasiaK KANEMOTO, D JANZ page 52Vestibulo-ocular abnormalities in spasmodic torticollis before and after botulinum toxin injections R STELL, AM BRONSTEIN,CD MARSDEN page 57Frozen shoulder and other shoulder disturbances in Parkinson's disease D RILEY, AE LANG, RDG BLAIR, A BIRNBAUM, B REID pageAnti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body diseaGRAHAM LENNOX, JAMES LOWE, KEN MORRELL, MICHAEL LANDON, R JOHN MAYER page 67Asymmetry of substantia nigra neuronal loss in Parkinson's disease and its relevance to the mechanism of levodopa related motfluctuations PA KEMPSTER, WRG GIBB, GM STERN, AJ LEES page 72Bromocriptine in Parkinson's disease: a double-blind study comparing "low-slow" and "high-fast" introductory dosage regimesde novo patients UK BROMOCRIPTINE RESEARCH GROUP page 77Efficacy of Sinemet CR4 in subgroups of patients with Parkinson's disease SA FACTOR, JR SANCHEZ-RAMOS,WJ WEINER, ANGELA M INGENITO page 83Physiological analysis of asterixis: silent period locked averaging YOSHIKAZU UGAWA, TOMOYUKI SHIMPO, TORU MANNEN page89The extent of small fibre sensory neuropathy in diabetics with plantar foot ulceration Z ALI, M CARROLL, KP ROBERTSON,CLARE J FOWLER page 94Cerebral cortical potentials to pure non-painful temperature stimulation: an objective technique for the assessment of small fibrepathway in man GORAN A JAMAL, STIG HANSEN, ANDREW I WEIR, JOHN P BALLANTYNE page 99TECHNICAL NOTEA database of genetically determined neurological conditions for clinicians MICHAEL BARAITSER, KIYOTAKA TOMIWA, JOHNROBIN WINTER page 106Does signal-attenuation on high-field T2-weighted MRI of the brain reflect regional cerebral iron deposition? Observations on tkrelationship between regional cerebral water proton T2 values and iron levels DJ BROOKS, P LUTHERT, D GADIAN, CD MARSDENpage 108SHORT REPORTSTyrosine hydroxylase and levodopa responsive dystonia NA FLETCHER, IJ HOLT, AE HARDING, TG NYGAARD, J MALLEI. CDpage 112Multiple sclerosis following optic neuritis in Chile GONZALO ALVAREZ, MANUEL CARDENAS page 115Dual labelling of circulating CD8 cells in patients with multiple sclerosis PJ HUGHES, PF KIRK, DAS COMPSTON page 118Endocrine involvement in mitochondrial encephalomyopathy with partial cytochrome c oxidase deficiency C DORIGUZz.I,L PALMUCCI, T MONGINI, N BRESOLIN, L BET, G COMI, R LALA page 122LETTERSLumbar extradural arachnoid cyst presenting as a conus lesion in a man aged 77 years JB WINER, AE HARDING, L SYMON,DPE KINGSLEY page 126Comparison of the Westmead PTA Scale and Glasgow Coma Scale as predictors of neuropsychological outcome following cxsevere blunt head injury E ARTHUR SHORES page 126Acute encephalopathy in adult as delayed presentation of occupational lead intoxication CARLOS GUIJARRO, JUAN DE D GARCIAOLGA HERRERO, JOSE L ARANDApage 127Progressive aphasia with right-sided extrapyramidal signs: another manifestation of localised cerebral atrophy PJ GOULDING,B NORTHEN, JS SNOWDEN, N MACDERMOTT, D NEARY page 128Severe aggravation of blepharospasm in Fisher's syndrome E GARCIA-ALBEA page 130Orthostatic tremor: diagnostic entity or variant of essential tremor? LYNN CLEEVES, J COWAN, LJ FINDLEY page 130Serum vitamin E concentrations in adult-onset spinocerebellar degeneration R KAY, R TEOH, J WOO, D CHIN, YT MAK page 131Serum vitamin E concentrations in degenerative ataxias AE HARDING, CJ MACEVILLY, DPR MULLER page 132Paroxysmal choreoathetosis as presenting symptom of diabetes mellitus J HAAN, HPH KREMER, GWAM PADBERG page 133Subdural haematoma upon straining DANIEL E JACOME, GONZALO F YANEZ page 134Rapid development of occlusion hydrocephalus by intraventricular fat possibly derived from a ruptured dermoid cyst R MAIA KRONE, B SCHUKNECHT, W KUHN page 134Cerebral venous thrombosis in hereditary protein C deficiency P VIEREGGE, G SCHWIEDER, D KOMPF page 135Geometrical optics of the retinal image stabilisation device DN RUSHTON page 137Proceedings of the Joint Meeting of the Society of British Neurological Surgeons (112th Meeting), the Neurosurgical SocietyAustralia and the Neuroanaesthetists Travelling Club-Oxford, 14-15 April, 1988 page 139MATTERS ARISING page 144CORRECTION page 149BOOK REVIEWS page 150ISSN0022-3050BRITISH MEDICAL ASSOCIATION TAVISTOCK SQUARE LONDON WClI 9JR
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No I JANUARY 1989 PageThe contribution of mortality statistics to the study of multiple sclerosis in Australia SR HAMMOND, DR ENGLISH,C de WYTT, JF HALLPIKE, KS MILLINGEN, EG STEWART-WYNNE, JG McLEOD, MG McCALL .............................. ISeverely threatening events and marked life difficulties preceding onset or exacerbation ofmultiple sclerosis IGORGRANT, GEORGE W BROWN, TIRRIL HARRIS, W IAN McDONALD, THOMAS PATTERSON, MICHAEL R TRIMBLE ..... ........ 8
Quantitative magnetic resonance imaging in multiple sclerosis: the effect of high dose intravenousmethylprednisolone J KESSELRING, DH MILLER, DG MacMANUS, G JOHNSON, NM MILLIGAN, N SCOLDING, DASCOMPSTON, WI McDONALD ..................................................................................... 14A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiplesclerosis D BATES, NEF CARTLIDGE, JM FRENCH, MJ JACKSON, S NIGHTINGALE, DA SHAW, S SMITH, E WOOD, SA HAWKINS,JHD MILLAR, I BELIN, DM CONROY, SK GILL, M SIDEY, AD SMITH, RHS THOMPSOM, K ZILKHA, M GALE, HM SINCLAIR ..... 18Cerebral palsy and stereotactic neurosurgery: long term results JD SPEELMAN, J VAN MANEN..................... 23Visual evoked potentials in the assessment of patients with non-functioning chromophobe adenomas GRAHAM EHOLDER, PETER R BULLOCK .................................................................................... 31
The Doppler CO2 test to exclude patients not in need of extracranial/intracranial bypass surgery B WIDDER ..... 38Encephalopathy, deafness and blindness in young women: a distinct retinocochleocerebral arteriolopathy? JULIENBOGOUSSLAVSKY, JEAN-MARC GAIO, LOUIS R CAPLAN, FRANCO REGLI, MARC HOMMEL, THOMAS R HEDGES III, MARCOFERRAZZINI, PIERRE POLLAK................................................................................... 43Classical conditioning in patients with severe memory problems IRENE DAUM, SHELLEY CHANNON, ANTHONY GMCANAVAN .................................................................................................... 47The temporal sequence of aura-sensations in patients with complex focal seizures with particular attention to ictalaphasia K KANEMOTO, D JANZ ............................................................................... 52Vestibulo-ocular abnormalities in spasmodic torticollis before and after botulinum toxin injections R STELL,AM BRONSTEIN, CD MARSDEN................................................................................... 57Frozen shoulder and other shoulder disturbances in Parkinson's disease D RILEY, AE LANG, RDG BLAIR,A BIRNBAUM, B REID .......................................................................................... 63Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuseLewy body disease GRAHAM LENNOX, JAMES LOWE, KEN MORRELL, MICHAEL LANDON, R JOHN MAYER ..... ......... 67Asymmetry ofsubstantia nigra neuronal loss in Parkinson's disease and its relevance to the mechanism oflevodoparelated motor fluctuations PA KEMPSTER, WRG GIBB, GM STERN, AJ LEES......................................... 72Bromocriptine in Parkinson's disease: a double-blind study comparing "low-slow" and "high-fast" introductorydosage regimens in de novo patients UK BROMOCRIPTINE RESEARCH GROUP ..................................... 77Efficacy of Sinemet CR4 in subgroups of patients with Parkinson's disease SA FACTOR, JR SANCHEZ-RAMOS,WJ WEINER, ANGELA M INGENITO............................................................................... 83Physiological analysis of asterixis: silent period locked averaging YOSHIKAZU UGAWA, TOMOYUKI SHIMPO, TORUMANNEN ..................................................................................................... 89The extent of small fibre sensory neuropathy in diabetics with plantar foot ulceration Z ALI, M CARROLL, KPROBERTSON, CLARE J FOWLER .................................................................................. 94
Cerebral cortical potentials to pure non-painful temperature stimulation: an objective technique for the assessmentof small fibre pathway in man GORAN A JAMAL, STIG HANSEN, ANDREW I WEIR, JOHN P BALLANTYNE ..... ......... 99
TECHNICAL NOTEA database of genetically determined neurological conditions for clinicians MICHAEL BARAITSER, KIYOTAKATOMIWA, JOHN WILSON, ROBIN WINTER ......................................................................... 106Does signal-attenuation on high-field T2-weighted MRI of the brain reflect regional cerebral iron deposition?Observations on the relationship between regional cerebral water proton T2 values and iron levels DJ BROOKS,P LUTHERT, D GADIAN, CD MARSDEN ........................................................................... 108
SHORT REPORTSTyrosine hydroxylase and levodopa responsive dystonia NA FLETCHER, IJ HOLT, AE HARDING, TG NYGAARD,J MALLET, CD MARSDEN ....................................................................................... 112
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Multiple sclerosis following optic neuritis in Chile GONZALO ALVAREZ, MANUEL CARDENAS...................... 115Dual labelling of circulating CD8 cells in patients with multiple sclerosis PJ HUGHES, PF KIRK, DAS COMPSTON .... 118Endocrine involvement in mitochondrial encephalomyopathy with partial cytochrome c oxidase deficiencyC DORIGUZZI, L PALMUCCI, T MONGINI, N BRESOLIN, L BET, G COMI, R LALA ........................................ 122
LETITERSLumbar extradural arachnoid cyst presenting as a conus lesion in a man aged 77 years JB WINER, AE HARDING,L SYMON, DPE KINGSLEY........................................................................................ 126
Comparison of the Westmead PTA Scale and Glasgow Coma Scale as predictors of neuropsychological outcomefollowing extremely severe blunt head injury E ARTHUR SHORES................................................ 126Acute encephalopathy in adult as delayed presentation of occupational lead intoxication CARLOS GUJARRO, JUANDE D GARCiA-DiAZ, OLGA HERRERO, JOSt L ARANDA.............................................................. 127Progressive aphasia with right-sided extrapyramidal signs: another manifestation of localised cerebral atrophyP1 GOULDING, B NORTHEN, JS SNOWDEN, N MACDERMOTT, D NEARY ............................................... 128
Severe aggravation of blepharospasm in Fisher's syndrome E GARCIA-ALBEA ................................... 130Orthostatic tremor: diagnostic entity or variant of essential tremor? LYNN CLEEVES, J COWAN, LJ FINDLEY ........ 130Serum vitamin E concentrations in adult-onset spinocerebellar degeneration R KAY, R TEOH, J WOO, D CHIN,YTMAK...................................................................................................... 131Serum vitamin E concentrations in degenerative ataxias AE HARDING, CJ MACEVILLY, DPR MULLER............... 132Paroxysmal choreoathetosis as presenting symptom of diabetes mellitus J HAAN, HPH KREMER, GWAM PADBERG.. 133Subdural haematoma upon straining DANIEL E JACOME, GONZALO F YANEZ ....... .............................. 134Rapid development of occlusion hydrocephalus by intraventricular fat possibly derived from a ruptured dermoidcyst R MARTIN, A KRONE, B SCHUKNECHT, W KUHN ............................................................ 134
Cerebral venous thrombosis in hereditary protein C deficiency P VIEREGGE, G SCHWIEDER, D KOMPF ..... ........ 135Geometrical optics of the retinal image stabilisation device DN RUSHTON ...................................... 137Proceedings of the Joint Meeting of the Society of British Neurological Surgeons (112th Meeting), theNeurosurgical Society of Australia and the Neuroanaesthetists Travelling Club-Oxford, 14-15 April, 1988 ..... 139
MATTERS ARISING............................................................................................. 144
CORRECTION.................................................................................................. 149
BOOK REVIEWS................................................................................................ 150
No 2 FEBRUARY 1989Doctors' versus patients' evaluation of results after neurosurgery HANS CARLSON, LUIGI PELLETTIERI ..... ....... 153What happens in the leucotomised brain? A post-mortem morphological study of brains from schizophrenicpatients BENTE PAKKENBERG................................................................................. 156Histological differentiation of metastatic renal carcinoma in the cerebellum from haemangioblastoma in vonHippel-Lindau's disease CA CLELLAND, CS TREIP ............... ............................................... 162Clinical presentations of vascular malformations of the brain stem: comparison of angiographically positive andnegative types MASAMITSU ABE, RAYMOND N KIELLBERG, RAYMOND D ADAMS .................................... 167Magnetic resonance imaging in patients with progressive myelopathy following spinal surgery ELIESER AVRAHAMI,RINA TADMOR, DAN FRANZ COHN .............................................................................. 176Plasma serotonin in patients with chronic tension headaches MICHAEL ANTHONY, JAMES W LANCE ..... .......... 182Cortical Lewy body dementia: clinical features and classification WRG GIBB, PJ LUTHERT, I IANOTA, PL LANTOS ... 185The substantia nigra and ventral tegmental area in Alzheimer's disease and Down's syndrome WRG GIBB, CQMOUNTJOY, DMA MANN, AJ LEES................................................................................ 193Does cognitive impairment in Parkinson's disease result from non-dopaminergic lesions? BERNARD PILLON,BRUNO DUBOIS, GIULIANA CUSIMANO, ANNE-MARIE BONNET, FRANIOIS LHERMITTE, YVES AGID ..... .................. 201
A double-blind crossover comparison of Sinemet CR4 and standard Sinemet 25/100 in patients with Parkinson'sdisease and fluctuating motor performance JESSE M CEDARBAUM, MARY HOEY, FLETCHER H MCDOWELL.207
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ContentsHigh-voltage stimulation over the human spinal cord: sources of latency variation BL PLASSMAN, SC GANDEVIA 213Changes in cranial CSF volume during hypercapnia and hypocapnia R GRANT, B CONDON, J PATTERSON, DJ WYPER,MDM HADLEY, GM TEASDALE ................................................................................... 218
Implant infections and antibiotic-impregnated silicone rubber coating DN RUSHTON, GS BRINDLEY, CE POLKEY,GV BROWNING............................................................................................... 223
Subarachnoid haemorrhage of unknown cause: a long term follow-up TD HAWKINS, C SIMS, R HANKA ..... ...... 230The natural history and functional consequences of dysphagia after hemispheric stroke DH BARER ..... ......... 236Functional prognosis in stroke: use of somatosensory evoked potentials BD ZEMAN, C YIANNIKAS ..... .......... 242The investigation of Alzheimer's disease with single photon emission tomography A BURNS, MP PHILPOT,DC COSTA, PJ ELL, R LEVY ..................................................................................... 248
Humoral immune response in patients with cerebral parenchymal cysticercosis treated with praziquantel BRUNOESTAI4OL, HUMBERTO JUAREZ, MARIA DEL CARMEN IRIGOYEN, DOLORES GONZALEZ-BARRANCO, TERESA CORONA ....... 254
SHORT REPORTSAbsence of central functional cholinergic deficits in myasthenia gravis.......................................... 258Dyssynergia cerebellaris myoclonica (Ramsay Hunt syndrome): a condition unrelated to mitochondrialencephalomyopathies CA TASSINARI, R MICHELUCCI, P GENTON, JF PELLISSIER, J ROGER ...... ..................... 262An unusual familial muscle disorder WJK CUMMING, F KRISTMUNDSDOTrIR, M MAHON ...... ..................... 266Acute myeloradiculitis due to cytomegalovirus as the initial manifestation of AIDS FLORENCE MAHIEUX,FRAN,COISE GRAY, GILLES FENELON, ROMAIN GHERARDI, DAVID ADAMS, ALAIN GUILLARD, JACQUES POIRIER ........... 270Diffuse cerebrospinal gliomatosis presenting as motor neuron disease for two years MANFRED SCHMIDBAUER,CHRISTIAN MULLER, IVO PODREKA, BRUNO MAMOLI, ELFRIEDE SLUGA, LUDER DEECKE ............................... 275Massive osteolysis of the skull and its therapeutic implications: a case report CORNELIS BOUWSMA, GWAN GO,AREND PANDERS, COEN SCHOOTS, LOUK VENCKEN................................................................ 279The prevalence of the Wernicke-Korsakoff syndrome in Sydney, Australia: a prospective necropsy study CLIVEHARPER, JULIAN GOLD, MICHAEL RODRIGUEZ, MICHAEL PERDICES ................................................. 282
LETTERSStabilisation ofa severe case ofP.O.E.M.S. syndrome after tamoxifen administration JACQUES H BARRIER, HUBERTLE NOAN, JEAN-MARIE MUSSINI, JEAN-MARIE BRISSEAU ............................................................ 286Unilateral essential tremor after wrist immobilisation: a case report JD COLE, LS ILLIS, EM SEDGWICK ..... ....... 286Superior sagittal sinus thrombosis in Wegener's granulomatosis SR HAMMANS, L GINSBERG...................... 287Extrapyramidal and depressive side reactions with flunarizine and cinarizine CA MANGONE, E HERSKOVITS ....... 288Therapeutic efficacy of a novel transdermal delivery system for (+ )-PHNO in Parkinsonian squirrel monkeysNMJ RUPNIAK, SJ TYE, CA JENNINGS, AE LOPER, JV BONDI, M HICHENS, SD IVERSEN, SM STAHL ..... .................... 289
MATTERS ARISING ................... .......................................................................... 290
BOOK REVIEWS ..................... .......................................................................... 293
No 3 MARCH 1989HypothesisTrichloroethylene cranial neuropathy: is it really a toxic neuropathy or does it activate latent herpes virus?JB CAVANAGH, PH BUXTON .................................................................................... 297
The nucleus basalis of Meynert in 20 definite cases of Creutzfeldt-Jakob disease L CARTIER, R VERDUGO,C VERGARA, S GALVEZ......................................................................................... 304
Adrenoleukodystrophy: heterogeneity in two brothers GM ELRINGTON, DE BATEMAN, MJ JEFFREY, NF LAWTON .... 310
Non-familial juvenile distal spinal muscular atrophy of upper extremity JB PEIRIS, KN SENEVIRATNE,HR WICKREMASINGHE, SB GUNATILAKE, R GAMAGE............................................................... 314
A case-control study of transient global amnesia MARIO GUIDOTrI, NICOLETTA ANZALONE, ALBERTO MORABITO,GIANLUCA LANDI ................... .......................................................................... 320The Sydney Multicentre Study of Parkinson's disease: a report on the first 3 years MARIESE A HELY, JOHN GLMORRIS. DAVID RAIL. WAYNE GJ REID, DUDLEY J O'SULLIVAN, PETER M WILLIAMSON, SANDRA GENGE, GERALD A BROE.. 324
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ContentsPulmonary function in Parkinson's disease A HOVESTADT, JM BOGAARD, JD MEERWALDT, FGA VAN DER MECHt,J STIGT...................................................................................................... 329
Defective concept formation in Parkinsonians is independent from mental deterioration CARLO CALTAGIRONE,AUGUSTO CARLESIMO, UGO NOCENTINI, STEFANO VICARI .......................................................... 334
Evoked potentiais, reaction time and cognitive performance in on and off phases of Parkinson's disease SERGIO ESTARKSTEIN, MARCELO ESTEGUY, MARCELO L BERTHEER, HORACIO GARCIA, RAMON LEIGUARDA....................... 338
Visual contrast sensitivity in drug-induced Parkinsonism C BULENS, JD MEERWALDT, GJ VAN DER WILDT, CJ KEEMINK 341Ischaemic brain damage is still common in fatal non-missile head injury DI GRAHAM, I FORD, J HUME ADAMS,D DOYLE, GM TEASDALE, AUDREY E LAWRENCE, DR MCLELLAN .................................................... 346
Delayed deterioration in patients with traumatic frontal contusions PF STATHAM, RA JOHNSTON, P MACPHERSON.. 351Treatment of focal dystonias of the hand with botulinum toxin injections LEONARDO G COHEN, MARK HALLETT,BRUCE D GELLER, FRED HOCHBERG ............................................................................. 355
Interictal regional cerebral blood flow during nonspecific activation test in partial epilepsy J VALMIER, J TOUCHON,M BALDY-MOULINIER .................. ........................................................................ 364
Cerebrospinal fluid lactate in patients with diabetes mellitus and hypoglycaemic coma HIROSHI YAO, SEIZOSADOSHIMA, YUJI NISHIMURA, KENICHIRO FUJII, MITSUKO OSHIMA, TAKAO ISHITSUKA, MASATOSHI FUJISHIMA........... 372
Postural sway during retinal image stabilisation DN RUSHTON, TH BRANDT, W PAULUS, S KRAFCZYK.............. 376Retrograde pyramidal tract degeneration in a patient with cervical haematomyelia TORU YAMAMOTO, MASAHIROYAMASAKI, TERUKUNI IMAI .................................................................................... 382
SHORT REPORTS
Cerebellar degeneration in neuroleptic malignant syndrome: neuropathologic findings and review of the literatureconcerning heat-related nervous system injury S LEE, A MERRIAM, T-S KIM, M LIEBLING, DW DICKSON, GRW MOORE. 387Finger tremor in Parkinson's disease M LAKIE, WJ MUTCH ........... .......................................... 392The utility of testing tactile perception of direction of scratch as a sensitive clinical sign of posterior columndysfunction in spinal cord disorders GRAEME J HANKEY, ROBERT H EDIS......................................... 395Preparation of manual movements in hemiparkinsonism ROBERT D RAFAL, JOSEPH H FRIEDMAN, MARGARET CLANNON ..................................................................................................... 399
Initial factors predicting survival in patients with a spinal cord injury P DAVERAT, M GAGNON, JF DARTIGUES,JM MAZAUX, M BARAT......................................................................................... 403
Syndrome of cerebellar ataxia and hypogonadotrophic hypogonadism: evidence for pituitary gonadotrophindeficiency ACK FOK, MC WONG, JS CHEAH ..................................................................... 407
LETTRS
Meningoencephalopathy following iopamidol myelography DJM REYNOLDS, C FREER ...... ..................... 410Iatrogenic lumbar meningocoel after excision of a neurofibroma PETER J WARD................................ 410Recurrent localised myositis DC WILSON, SA HAWKINS ............ ............................................ 411Rhabdomyolysis associated with simultaneous Epstein-Barr virus infection and isolation of echovirus 6 frommuscle: a dual infection PJE POELS, JAPM EWALS, EMG JOOSTEN, AM VAN LOON ................................... 412Rheumatoid nodule formation within the lumbar extradural space IAN RICHMOND, ALED W JONES............... 414
NOTICE ...................................................................................................... 414
Proceedings of the meeting of the Association of British Neurologists jointly with the Association of SovietNeurologists; Leningrad, USSR. 25-28 May 1988 ............................................................. 415Proceedings of the first meeting of the British Neuropsychiatry Association held in London 8 July 1988 ..... ..... 420
MATTERS ARISING.............................................................................................. 423
BOOK REVIEWS................................................................................................ 425
No 4 APRIL 1989Editorial THE WORK OF NEUROLOGISTS CD MARSDEN........................................................... 429
Lessons for neurologists from the United Kingdom Third National Morbidity Survey ANTHONY HOPKINS ....... 430
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ContentsThe neurological content of general practice THODOROS PAPAPETROPOULOS, EVAGELIA TSIBRE, VASSILIOSPELEKOUDAS .................................................................................................. 434A record of patient encounters in neurological practice in the !Jnited Kingdom ANTHONY HOPKINS, MATTHEWMENKEN, GORDON DEFRIESE.................................................................................... 436Neurology in Gloucestershire: the clinical workload of an English neurologist DAVID L STEVENS ..... ........... 439An analysis of 7836 successive new outpatient referrals GD PERKIN ............................................ 447The development ofa disease classification system, based on the International Classification of Diseases, for use byneurologists VICTORINE A WOOD, DERICK T WADE, RICHARD LANGTON HEWER, MALCOLM J CAMPBELL ..... ........ 449
Magnetic resonance imaging of spinal cord lesions in multiple sclerosis LAWRENCE S HONIG, WILLIAM A SHEREMATA 459Vigabatrin in the treatment of epilepsy: a long-term follow-up study A TARTARA, R MANNI, CA GALIMBERTI,JP MUMFORD, A IUDICE, E PERUCCA............................................................................. 467Oxcarbazepine: a new drug in the management of intractable trigeminal neuralgia JM ZAKRZEWSKA, PN PATSALOS 472The relationship between eye-winking tics, frequent eye-blinking and blepharospasm JS ELSTON, F CAS GRANJE,AJ LEES....................................................................................................... 477
Influence of fluctuations of plasma large neutral amino acids with normal diets on the clinical response tolevodopa JOHN G NUTT, WILLIAM R WOODWARD, JULIE H CARTER, TRACI L TROTMAN............................. 481Effects of radiation therapy on neuropsychological functioning in patients with nasopharyngeal carcinomaPWH LEE, BKM HUNG, EKW WOO, PTH TAI, DTK CHOI............................................................. 488An investigation of factors affecting progress of patients on a stroke unit NB LINCOLN, M BLACKBURN, S ELLIS,J JACKSON, JA EDMANS, FM NOURI, MF WALRER, H HAWORTH...................................................... 493The non-linear relationship between nerve conduction velocity and skin temperature K TODNEM, G KNUDSEN,T RIISE, H NYLAND, JA AARLI................................................................................... 497A comparison of nerve conduction velocities and current perception thresholds as correlates of clinical severity ofdiabetic sensory neuropathy MARC S RENDELL, JEFFERSON J KATIMS, RALPH RICHTER, FAITH ROWLAND ..... ....... 502
SHORT REPORTS
Cerebrovascular disease in north-west India: a study of necropsy material AK BANERJEE, M VARMA, RK VASISTA,JS CHOPRA....... ; 512
Subcortical cerebral infarctions in sickle cell trait MARC G REYES .............................................. 516Service provision and functional independence in depressed stroke patients and the effect of social workintervention on these DEBORAH TOWLE, NADINA B LINCOLN, LOUISE M MAYFIELD................................. 519
Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy? WILSON T ASFORA,ANTONIO AF DESALLES, MASAMITSU ABE, RAYMOND N KJELLBERG .................................................. 523
Do leukocytes have a role in the cerebral no-reflow phenomenon? BS ASPEY, C JESSIMER, S PEREIRA, MJG HARRISON 526Cyclosporin A curtails the progression of free light chain synthesis in the CSF of patients with multiplesclerosis BN MCLEAN, P RUDGE, EJ THOMPSON ................................................................. 529
A giant spinal aneurysm with cord and root compression MOKHTAR A EL MAHDI, MOHAMED A RUDWAN, SALAH MKHAFFAJI, FAWZI A JADALLAH ................................................................................. 532
Peripheral neuropathy associated with mycosis fungoides MAURO COMOLA, RAFFAELLO NEMNI, GIANCARLO COMI,MASSIMO CORBO, GIANLUCA TACCAGNI, CARLO BESANA, NICHOLAS CANAL ......................................... 536
LETTERS
Ping Pong gaze in reversible coma due to overdose ofmonoamine oxidase inhibitor HC WATKINS, CJK ELLIS ..... 539Autonomic neuropathy in systemic lupus erythematosus WALTER 0 ARRUDA, HELIO AG TEIVE, RICARDO RAMINA,PAULO R WUNDER, LUIZ CARLOS A ROCHA ...................................................................... 539
Korsakoffs psychosis in the presence of multiple sclerosis: an unusual cognitive state ANTHONY FEINSTEIN,MARIA RON................................................................................................... 540
Cerebral infarction after excessive use of nasal decongestants J MONTALBAN, L IBANEZ, C RODRIGUEZ, M LOPEZ,J SUMALLA, A CODINA......................................................................................... 541
Calcitonin for pseudoclaudication in lumbar spinal stenosis JONATHAN STREIFLER, RACHEL HERING, NATANGADOTH ....................................................................................................... 543
Subcutaneous apomorphine in Parkinson's disease P POLLAK, AS CHAMPAY, M HOMMEL, JE PERRET, AL BENABID ... 544
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ContentsLethal neurotoxicity associated to azidothymidine therapy SILVANA SARACCHINI, EMANUELA VACCHER, ELENACOVEZZI, GIOVANNI TORTORICI, ANTONINO CARBONE, UMBERTO TIRELLI ........................................... 544
Two spina bifida defects in the same child OP BINITIE...................................... 545Meningioma-an unrecognised complication of fibrous dysplasia of the skull? JONATHAN FRANKEL, FAUSTOIANOTTI, MICHAEL POWELL, FREDERICK SCHON .................................................................. 546
MATTERS ARISING.............................................................................................. 547
BOOK REVIEWS............................................................................................... 548
No 5 MAY 1989Editorial WIND OF CHANGE IN NEUROSCIENTIFIC INFORMATION RAC HUGHES ..................................... 553
Results of stereotactic radiosurgery of arteriovenous malformations: an analysis of 52 cases ANDRAS A KEMENY,PALITHA S DIAS, DAVID MC FORSTER ............................................................................ 554
Randomised double blind controlled trial of cyclosporin in multiple sclerosis P RUDGE, JC KOETSIER, J MERTIN, JOMISPELBLOM BEYER, HK VAN WALBEEK, R CLIFFORD JONES, J HARRISON, K ROBINSON, B MELLEIN, T POOLE, JCJM STOKVIS,P TIMONEN................................................................................................... 559
Interferon-a and transfer factor in the treatment of multiple sclerosis: a double-blind, placebo-controlled trialJA FRITH AND CO-WORKERS (AUSTIMS RESEARCH GROUP) ......................................................... 566
Class II HLA antigens in multiple sclerosis DH MILLER, RW HORNABROOK, J DAGGER, R FONG.................... 575Antiviral IgM and IgG subclasses in varicella zoster associated neurological syndromes TIIT MATHIESEN, ANNIKALINDE, ELISABETH OLDING-STENKVIST, BRITTA WAHREN ........................................................... 578
Examination ofbrains ofAIDS cases for human immunodeficiency virus and human cytomegalovirus nucleic acidsDG WALKER, S ITAGAKI, K BERRY, PL MCGEER ................................................................... 583
Multiple pyogenic brain abscesses: an analysis of 21 patients ALI SYED BASIT, BHATIA RAVI, AK BANERJI, PN TANDON 591Histological verification of microaneurysms as a cause of cerebral haemorrhage in surgical specimens SUSUMUWAKAI, MASAKATSU NAGAI .................................................................................... 595
The cerebral vasculature in dementia pugilistica CWM ADAMS, CJ BRUTON ...................................... 600Prevention ofhydrocephalus shunt catheter colonisation in vitro by impregnation with antimicrobials R BAYSTON,N GROVE, J SIEGEL, D LAWELLIN, S BARSHAM .................................................................... 605
Mean intracranial pressure monitoring by a non-invasive audiological technique: a pilot study A REID,RJ MARCHBANKS, D BATEMAN, AM MARTIN, AP BRIGHTWELL, JD PICKARD .......................................... 610
Auditory neglect E DE RENZI, M GENTILINI, C BARBIERI......................................................... 613
Parental age and motor neuron disease CH HAWKES, PO GOLDBLATT, M SHEWRY, AJ FOX ...... ................... 618Regional cerebral blood flow and metabolism in patients with transient global amnesia: a positron emissiontomography study KENICHIRO FUJII, SEIZO SADOSHIMA, TAKAO ISHITSUKA, KENJI KUSUDA, YASUO KUWABARA, YUICHIICHIYA, MASATOSHI FUJISHIMA ................................................................................. 622Selective D-1 dopamine receptor agonist effects in hyperkinetic extrapyramidal disorders A BRAUN, MMMOURADIAN, E MOHR, G FABBRINI, TN CHASE .................................................................... 631Study of brain tissue impedance in hydrocephalic cat KENICHIRO HIGASHI, YASUTAKA NODA, SHUNRO TACHIBANA. 636
SHORT REPORTSProgressive medullary failure associated with neurofibrillary degeneration HGW LIDOV, LW DUCHEN, PK THOMAS,DC THRUSH........ 643Familial lysinuric protein intolerance presenting as coma in two adult siblings PAMELA J SHAW, GORDON DALE,DAVID BATES.................................................................................................. 648
Jaw closing spasm: a form of focal dystonia? An electrophysiological study A LAGUENY, MM DELIAC, J JULIEN,J DEMOTES-MAINARD, X FERRER ................................................................................ 652
Increased wave P 300 latency in progressive supranuclear palsy C PIERROT-DESEILLIGNY, E TURELL, C PENET,D LEBRIGAND, B PILLON, F CHAIN, Y AGID....................................................................... 656The frequency and consequences of head injury in epileptic seizures DL RUSSELL-JONES, SD SHORVON ..... ....... 659The association of hemifacial spasm and facial pain GD PERKIN, RD ILLINGWORTH.663
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ContentsNormal cerebellar glutamate dehydrogenase protein in spinocerebellar degeneration ROGER N ROSENBERG, CARLBANNER...................................................................................................... 666
Tactile sensibility in parietal lesions RICHARD TEGNER ........... ............................................. 669Magnetic resonance imaging in Leber's optic neuropathy AG KERMODE, IF MOSELEY, BE KENDALL, DH MILLER,DG MACMANUS, WI MCDONALD ................................................................................ 671
Magnetic resonance imaging in central pontine myelinolysis PD THOMPSON, D MILLER, RF GLEDHILL, MN ROSSOR.. 675
LETTERSUnilateral paresis of the abdominal wall: a radicular syndrome caused by herniation of the L 1-2 disc? FPJ BILLET,H PONSSEN, D VEENHUIZEN .................................................................................... 678
Isolated palsy of the fourth cranial nerve caused by an intracavernous aneurysm RS MAURICE-WILLIAMS,PK HARVEY................................................................................................... 679
Reversible lithium neurotoxicity at normal serum level may refer to intracranial pathology CJF KEMPERMAN,JH GERDES, JAM DE ROOIJ, LM VENCKEN ......................................................................... 679
Thirst and compulsive water drinking in medial basal limbic epilepsy: an electroclinical and neuropathologicalcorrelation GREGORY D CASCINO, THOMAS P SUTULA........................................................... 680
Single fibre and quantitative EMG study in acute stage of human trichinosis A CRUZ MARTfNEZ, J G6MEZ CEREZO,MT FERRER, J MEDRANO, MC PEREZ CONDE, J COBO, F MOLINA ..................................................... 681
Dissecting aneurysm ofmiddle cerebral artery following resection of meningioma NORBERT HEYE, JOSE R IGLESIAS,HANS HENKES, RON FERZST, KLAUS MAIER-HAUFF ................................................................ 683Hemiballismus from cerebellar metastases MARC G REYES, EDWARD T STEVENS .................................. 684
MATTERS ARISING ................... .......................................................................... 684
BOOK REVIEWS............................................................................................... 687
NOTICES...................................................................................................... 692
CORRECTION................................................................................................. 692
No 6 JUNE 1989OCCASIONAL REVIEWRecommended minimum data to be collected in research studies on Alzheimer's diseaseMRC (UK) Alzheimer's Disease Workshop Steering Committee: GK WILCOCK, RA HOPE, DN BROOKS, PL LANTOS,C OPPENHEIMER, GP REYNOLDS, MN ROSSOR, MB DAVIES .......................................................... 693A pathological study of the association between Lewy body disease and Alzheimer's disease WRG GIBB,CQ MOUNTJOY, DMA MANN, AJ LEES ............................................................................. 701
Diffuse Lewy body disease: clinical features in 15 cases E JANE BYRNE, GRAHAM LENNOX, JAMES LOWE, RICHARD BGODWIN-AUSTEN ................... .......................................................................... 709
Levodopa peripheral pharmacokinetics and duration of motor response in Parkinson's disease PA KEMPSTER, JPFRANKEL, M BOVINGDON, R WEBSTER, AJ LEES, GM STERN ......................................................... 718Major depression in Parkinson's disease and the mood response to intravenous methylphenidate: possible role ofthe "hedonic" dopamine synapse R CANTELLO, M AGUGGIA, M GILLI, M DELSEDIME, I CHIARDO CUTIN, A RICCIO,R MUTANI .................................................................................................... 724
The efficacy of (+)-4-propyl-9-hydroxynaphthoxazine (PHNO) as adjunctive therapy in Parkinson's diseaseWJ WEINER, SA FACTOR, JR SANCHEZ-RAMOS..................................................................... 732
Temporal lobe structure as determined by nuclear magnetic resonance in schizophrenia and bipolar affectivedisorder EC JOHNSTONE, DGCC OWENS, TJ CROW, CD FRITH, K ALEXANDROPOLIS, G BYDDER, N COLTER .... .......... 736
Reaction time after head injury: fatigue, divided and focused attention, and consistency of performance DT STUSS,LL STETHEM, H HUGENHOLTZ, T PICTON, J PIVIK, MT RICHARD .................................................... 742
Electrophysiological and MRI evaluation of neurological involvement in Behcet's disease C BESANA, G COMI, A DELMASCHIO, L PRADERIO, A VERGANI, S MEDAGLINI, V MARTINELLI, F TRIULZI......................................... 749
Hand muscle reflexes following electrical stimulation in choreatic movement disorders G DEUSCHL, CH LUCKING,ESCHENCK................................................................................................... 755
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ContentsIntercostal nerve conduction study in man SUNIL PRADHAN, ARUN TALY ....................................... 763Magnetic stimulation in the diagnosis of lumbosacral radiculopathy S CHOKROVERTY, R SACHDEO, J DILULLO,RC DUVOISIN.................................................................................................. 767
SHORT REPORTSA randomised controlled study of bromocriptine versus levodopa in previously untreated Parkinsonian patients: a3 year follow up JL MONTASTRUC, 0 RASCOL, A RASCOL ........................................................ 773
The effects of earlier timing of surgery and shorter bedrest on the outcome in patients with subarachnoidhaemorrhage SEPPO JUVELA, MARKKU KASTE, MATTI HILLBOM .................................................. 776
Long term survival with early childhood intracerebral tumours GRAEME J HANKEY, LLEWELYN DAVIES, SASSON SGUBBARY .................................................................................................... 778
Vestibular hyperreactivity in patients with idiopathic spasmodic torticollis PLM HUYGEN, WIM VERHAGEN, JJM VANHOOF, MWIM HORSTIN ......................................................................................... 782
Contrast sensitivity in multiple sclerosis measured by Cambridge low contrast gratings: a useful clinical test?J FAHY, D GLYNN, M HUTCHINSON .............................................................................. 786
Herpes simplex virus specific antibody determined by immunoblotting in cerebrospinal fluid of a patient with theGuillain-Barre syndrome HANS JJA BERNSEN, ANTON M VAN LOON, RIK FJ POELS, WIM IM VERHAGEN, C(* WGMFRENKEN................................................................ 788
Cheiro-oral syndrome with bilateral oral involvement: a study of pontine lesions by high-'esohxtion magneticresonance imaging SADAYUKI MATSUMOTO, MASAHIRO YAMASAKI, SHIZUMA KAKU,HABONABATAME, TERUKUNIIMAI, MASAKUNI KAMEYAMA ................................................................................... 792
Cardiac asystole associated with epileptic seizures: a case report with simultaneous EEG and ECG SIL HOWELL,LD BLUMHARDT.............................................................................................. 795
LETTERSSeasonal variation in the incidence of photoparoxysmal discharges among patients investigated after a singleseizure MA DANESI ................... ....................................................................... 799Optic neuritis, confirmed by visual evoked response, and the risk for multiple sclerosis: a prospective surveyEACM SANDERS, GHM VAN LITH................................................................................. 799No viral antigens detected in brain tissue from a case of acute encephalitis lethargica and another case of post-encephalitic Parkinsonism TS ELIZAN, J CASALS, M SWASH .................. ...................... . 800Head injury induced migraine coma simulating acute extradural intracranial haemorrhage sODERCK DUI4UAN,ALASTAIR JENKINS ............................................................................................ 801Relapsing polyneuritis following classic Miller Fisher syndrome DR KAISER-SMITH, DR BARONE .......... 802Spontaneous haemorrhage in craniopharyngioma TORU YAMAMOTO, SHUNICHI YONEDA, N OBORU FUNATSU ...... 803Normal pressure hydrocephalus and cerebrovascular disease: findings postmortem DR H NEWTON, JD PICKARD,RO WELLER .................................................................................................. 804Hypergeusia as the presenting symptom of a posterior fossa lesion S NODA, K HIROMATSU, H UMEZAKI, S YONEDA. 804Palilalia as a symptom of levodopa induced hyperkinesia H ACKERMANN, W ZIEGLER, W OERTEL................. 805Ophthalmoplegic migraine with bilateral involvement DO HUTCHINSON, I MACG DONALDSON ..... ............... 807Seizures as the initial manifestation of paralytic rabies T HEMACHUDHA, S TIRAWATNPONG, K PHANTIHUMCHINDA. 808
MATTERS ARISING............................................................................................. 810
BOOK REVIEWS................................................................................................ 814
No 6 JULY 1989OCCASIONAL REVIEW
The Odds Ratio: a useful tool in neurosciences PETER SANDERCOCK ........................................... 817Computed tomography in the diagnosis ofmalignant brain tumours: do all patients require biopsy? MS CHOKSEY,A VALENTINE, H SHAWDON, CEL FREER, KW LINDSAY ............................................................. 821Xanthochromia after subarachnoid haemorrhage needs no revisitation M VERMEULEN, D HASAN, BG BLIJENBERG,A HIJDRA, J VAN GIJN.......................................................................................... 826
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ContentsAnticoagulation-related intracranial extracerebral haemorrhage H MATTLE, S KOHLER, P HUBER, M ROHNER,KF STEINSIEPE................................................................................................. 829
Diffuse axonal injury in head trauma PETER C BLUMBERGS, NIGEL R JONES, JOHN B NORTH ...... .................. 838Laypersons' knowledge about the sequelae ofminor head injury and whiplash JOCELYN B AUBREY, ALLEN R DOBBS,BRENDAN GAIL RULE.......................................................................................... 842Risk factors for the syndrome of ventricular enlargement with gait apraxia (idiopathic normal pressurehydrocephalus): a case-control study M CASMIRO, R D'ALESSANDRO, FM CACCIATORE, R DAIDONE, F CALBUCCI,E LUGARESI................................................................................................... 847The natural history ofthe Guillain-Barre syndrome in 18 children and 50 adults RP KLEYWEG, FGA VAN DER MECHt,MCB LOONEN, J DE JONGE, B KNIP .............................................................................. 853
A fulminant case of Guillain-Barre syndrome: topographic and fibre size related analysis of demyelinatingchanges TAKASHI KANDA, HIDEAKI HAYASHI, HITOSHI TANABE, TADAO TSUBAKI, MASAYA ODA...................... 857IgG immunoadsorption in experimental allergic neuritis: effect on antibody levels and clinical course GRAHAMK HARVEY, KLAUS SCHINDHELM, JOHN D POLLARD ............................................................... 865Chronic relapsing idiopathic polyneuropathy with primary axonal lesions J JULIEN, C VITAL, A LAGUENY, X FERRER,C BRECHENMACHER............................................................................................. 871Diphtheritic neuropathy, an analysis based on muscle and nerve biopsy and repeated neurophysiological andautonomic function tests G SOLDERS, I NENNESMO, A PERSSON .......... ........................................ 876Neoplastic meningitis in malignant melanoma: diagnosis with monoclonal antibodies RP MOSELEY, AG DAVIES,SP BOURNE, C POPHAM, S CARREL, P MONRO, HB COAKHAM ....................................................... 881Developmental spinal canal stenosis and somatotype SIMON NIGHTINGALE ..................................... 887The significance of plasma phytanic acid levels in adults TC BRITTON, FB GIBBERD, ME CLEMENS, JD BILLIMORIA,MC SIDEY..................................................................................................... 891Abnormalities of the blink reflex in Gilles de la Tourette syndrome SJM SMITH, AJ LEES ...... ................... 895Blindness in eclampsia: CT and MR imaging RODERICK DUNCAN, DONALD HADLEY, IAN BONE, EM SYMONDS,BS WORTHINGTON, PC RUBIN .................................................................................. 899CT ring sign imitating tumour, disclosed as multiple sclerosis by MRI: a case report EVA GUTLING, THEODORLANDIS ....................................................................................................... 903
SHORT REPORTS
Clinical features of the exploding head syndrome IMS PEARCE................................................. 907Does idiopathic Parkinsonism in Aberdeen follow intrauterine influenza? KLAUS P EBMEIER, WILLIAM J MUTCH,SHEILA A CALDER, JOHN R CRAWFORD, LESLEY STEWART, JOHN OA BESSON ......................................... 911
LETTERS
Benign intracranial hypertension and essential thrombocythaemia AZAD ESACK, GEOFFREY THOMPSON, HUGHBURMlESTER................................................................................................... 914Epidural haematoma of the posterior fossa: good results after prompt diagnosis with CT JELIS BOITEN ..... ..... 914Disappearing CT lesions in epilepsy: is tuberculosis or cysticercosis the cause? GK AHUJA, M BEHARI, K PRASAD,RK GOULATIA, BANSI L JAILKHANI .............................................................................. 915Exercise induced diplopia as a presentation of midline cerebral tumour RA SHINTON, DG JAMIESON ..... ......... 916Effect of tropatepine, an anticholinergic drug, on regional cerebral blood flow in patients with Parkinson'sdisease P CELSIS, JL MONTASTRUC, 0 RASCOL, JM SENARD, JP MARC-VERGNES, A RASCOL ........................... 917Benign recurrent multiple mononeuropathy in Wegener's granulomatosis S KIRKER, M KEANE, M HUTCHINSON ... 918Progressive systemic sclerosis presenting as a case of trigeminal neuropathy ANDREW HEALD ..... .............. 918Another case of Creutzfeldt-Jakob like syndrome due to antidepressant toxicity J FOERSTL, F HOHAGEN, W HEWER,B POHLMANN-EDEN........................................................................................... 920Psychiatric disturbance in mitochondrial encephalomyopathy TOSHIHITO SUZUKI, JUNZO KOIZUMI, HIROYASUSHIRAISHI, KOJIRO OFUKU, MEGUMI SASAKI, TAKAFUMI HORI, NORIO OKOSHI ........................................ 920Proceedings of the 113th meeting of the Society of British Neurological Surgeons and the joint meeting with theBritish Society of Neuroradiologists, Glasgow 22-24 September 1988 .......................................... 923
MATTERS ARISING..................................................................................................... 931
BOOK REVIEWS...................................................................................................... 931
CORRECTION......................................................................................................... 932
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ContentsNo 6 AUGUST 1989OCCASIONAL REVIEW
Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study G OCHS, A STRUPPLER,BA MEYERSON, B LINDEROTH, J GYBELS, BP GARDNER, P TEDDY, A JAMOUS, P WEINMANN............................. 933Fatigue syndromes: a comparison of chronic "postviral" fatigue with neuromuscular and affective disordersS WESSELY, R POWELL.......................................................................................... 940
Immunoglobulin M in the cerebrospinal fluid: an indicator of recent immunological stimulation MK SHARIEF,EJ THOMPSON................................................................................................. 949The effect of a high protein diet on leucine and alanine turnover in acid maltase deficiency AM UMPLEBY,PStJ TREND, D CHUBB, JV CONAGLEN, CD WILLIAMS, R HESP, IN SCOBIE, CM WILES, G SPENCER, PH SONKSEN............ 954The effect of orthostatic hypotension on cerebral blood flow and middle cerebral artery velocity in autonomicfailure, with observations on the action of ephedrine DJ BROOKS, S REDMOND, CJ MATHIAS, R BANNISTER, L SYMON. 962Role of saccadic analysis in the diagnosis of multiple sclerosis in the era of magnetic resonance imagingG TEDESCHI, S ALLOCCA, A DI COSTANZO, A DIANO, V BONAVITA................................................... 967
Corticospinal potentials after transcranial stimulation in humans M INGHILLERI, A BERARDELLI, G CRUCCU,A PRIORI, M MANFREDI ................. ........................................................................ 970
Combined HIV-CMV encephalitis presenting with brainstem signs GN FULLER, RJ GUILOFF, F SCARAVILLI,JN HARCOURT-WEBSTER ................. ...................................................................... 975
EEG spectral analysis in delirium HANNU KOPONEN, JUHANI PARTANEN, ARI PAAKKONEN, ESA MATTILA,PAAVO J RIEKKINEN............................................................................................ 980
Cerebellopontine angle epidermoid cysts: a report on 30 cases CE desoUZA, ROSEMARiE desouzA, SADE DA COSTA,NEIL SPERLING, TAE H YOON, MM ABDELHAMID, RR SHARMA, A GOEL ............................................... 986
Benign symptomatic glial cysts of the pineal gland: a report of seven cases and review of the literaturePAVEL KLEIN, LUCIEN J RUBINSTEIN ............................................................................ 991
SHORT REPORTS
Recognising aponeurotic ptosis JP DEADY, AJ MORRELL, GA SUTTON............................................ 996
Epidural morphine analgesia in Guillain Barre syndrome D GENIS, C BUSQUETS, E MANUBENS, A DAVALOS, J BAR6,A OTERINO.................................................................................................... 999
Myositis during Borrelia burgdorferi infection (Lyme disease) J SCHOENEN, J SIANARD-GAINKO, M CARPENTIER,M REZNIK.................................................................................................... 1002
Neuroleptic malignant syndrome: a case report with post-mortem brain and muscle pathology ERICA M JONES,ALLAN DAWSON ............... ............................................................................... 1006
LETTERS
Cerebral venous thrombosis and dual primary infection with human immunodeficiency virus andcytomegalovirus M-C MEYOHAS, E ROULLET, C ROUZIOUX, A AYMARD, B PELOSSE, M ELIASCEIWICZ, J FROTrIER ...... 1010
Supratentorial meningeal spread from brainstem glioma EP VRIES, M DE VISSER, D TROOST....................... 1011CSF oligoclonal IgG bands in a patient with torsion dystonia SJ WROE, PD GILES, RE CULL ...... ................ 1013Tarsal tunnel syndrome secondary to intraneural ganglion M POPPI, G GIULIANI, E POZZATI, N ACCIARRI, A FORTI. 1014Neopterin:biopterin ratios in Down's syndrome RI CATTELL, CGB HAMON, IA CORBETT, J LEJEUNE, JA BLAIR....... 1015
MATTERS ARISING.............................................................................................. 1016
BOOK REVIEWS................................................................................................ 1021
NOTICE...................................................................................................... 1024
No 9 SEPTEMBER 1989Magnetic stimulation over the spinal enlargements Y UGAWA, JC ROTHWELL, BL DAY, PD THOMPSON, CD MARSDEN 1025Predictive responses in Parkinson's disease: manual keypresses and saccadic eye movements to regular stimulusevent TREVOR CRAWFORD, SUSAN GOODRICH, LESLIE HENDERSON, CHRISTOPHER KENNARD.1033
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ContentsRapid elbow movements in patients with torsion dystonia W VAN DER KAMP, A BERARDELLI, JC ROTHWELL,PD THOMPSON, BL DAY, CD MARSDEN ........................................................................... 1043
Acute hippocampal recording and pathology at temporal lobe resection and amygdalo-hippocampectomy forepilepsy CE POLKEY, CD BINNIE, I JANOTA.1050
The effect ofchorda tympani section on ipsilateral and contralateral saslivary secretion and taste in man R GRANT,S MILLER, D SIMPSON, PJ LAMEY, I BONE.1058
The effects of oral protein on the absorption of intraduodenal levodopa and motor performance JP FRANKEL,PA KEMPSTER, M BOVINGDON, R WEBSTER, AJ LEES, GM STERN.1063
Complex partial status epilepticus associated with cyclosporin A therapy RE APPLETON, K FARRELL, P TEAL,SA HASHIMOTO, PKH WONG.1068
A comparison of two methods for measuring thermal thresholds in diabetic neuropathy DAVID LEVY,RALPH ABRAHAM, GORDON REID.1072
A prospective audit of the use and costs of myelography in a regional neuroscience unit PAG SANDERCOCK,MAJOBERTS, LD BLUMHARDT.1078
The incidence and mortality of multiple sclerosis in South East Wales A HENNESSY, RJ SWINGLER, DAS COMPSTON. 1085Screening for mitochondrial cytopathies: the sub-anaerobic threshold exercise test (SATET) LINA NASHEF,RUSSELL JM LANE.1090
SHORT REPORTS
Chiasmal apoplexy: haemorrhage from a cavernous malformation in the optic chiasm L REGLI, N DE TRIBOLET,F REGLI, J BOGOUSSLAVSKY.1095
Serial cerebral CT abnormalities in relapsing acute disseminated encephalomyelitis RWH WALKER, J GAWLER 1100Sandhoff disease mimicking adult-onset bulbospinal neuronopathy PK THOMAS, ELISABETH YOUNG, RHM KING ... 1103Value of hyperventilation in pattern-reversal visual evoked potentials J BEDNARIK, 0 NOVOTNY.1107Intrathecal baclofen and the H-reflex RAL MACDONELL, A TALALLA, M SWASH, D GRUNDY.1110
LETTERS
Intradural herniated cervical disc associated with chiropractic spinal manipulation ALAIN DESTEE, FRANCIS LESOIN,FRANCISCO DI PAOLA, PIERRE WAROT. 1113
Sciatic nerve damage due to toilet seat entrapment: another Saturday night palsy PJ TYRRELL, MD FEHER,MN ROSSOR. 1113
Schizophrenic psychosis associated with benzhexol (artane) therapy P TREND, M TRIMBLE, S WESSELY. 1115The toxic effects of anticonvulsant drugs in long-term treatment of epilepsy R RAMANA, PH SILVERSTONE,WALISHMAN. 1116
BOOK REVIEWS. 1117
No 10 OCTOBER 1989The natural course of myasthenia gravis. A long term follow up study HANS JGH OOSTERHUIS. 1121Psychosocial outcome for the survivors of severe blunt head injury: the results from a consecutive series of 100patients RL TATE, JM LULHAM, GA BROE, B STRETTLES, A PFAFF.1128
Neuropsychological outcome of patients operated upon for an intracranial aneurysm: analysis of generalprognostic factors and of the effects of the location of the aneurysm A DESANTIS, M LAIACONA, R BARBAROTTO,A BASSO, R VILLANI, D SPAGNOLI, ECAPITANI. 1135
Motoneuron firing and isomyosin type of muscle fibres in prior polio KRISTIAN BORG, JORGEN BORG,GURTEJ K DHOOT, LARS EDSTROM, LENNART GRIMBY, LARS-ERIC THORNELL.1141
Investigation of facial motor pathways by electrical and magnetic stimulation: sites and mechanisms ofexcitation KM ROSLER, CW HESS, UD SCHMID.1149
The value of measuring saccadic eye movement in the investigation of non-compressive myelopathy MC PITT,JMRAWLES. 1157
Dichotic listening and manual performance in relation to magnetic resonance imaging after closed headinjury HARVEY S LEVIN, WALTER M HIGH JR, DAVID H WILLIAMS, HOWARD M EISENBERG, EUGENIO G AMPARO,FAUSTINO C GUINTO JR, JEFF EWERT ................................. ........................... 1162
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ContentsSeizures after intravenous contrast media for cranial computed tomography MICHAEL NELSON, RICHARDJV BARTLETT, JOHN T LAMB .................................................................................... 1170Electrophysiological signs of arteriovenous malformations of the spinal cord C ARMON, JR DAUBE............... 1176
SHORT REPORTS
Alleviation of acquired stuttering with human centremedian thalamic stimulation SUBHASH C BHATNAGAR,ORLANDO J ANDY............................................................................................. 1182Appearing and disappearing CT scan abnormalities in epilepsy in India-an enigma BC BANSAL, ABHA DUA,RAKESH GUPTA, MS GUPTA..................................................................................... 1185Non ischaemic causes of lacunar syndromes: prevalence and clinical findings NICOLETTA ANZALONE,GIANLUCA LANDI............................................................................................. 1188Post traumatic extracranial vertebral artery dissection with locked-in syndrome: a case with MRI documentationand unusually favourable outcome AD RAE-GRANT, F LIN, BA YAEGER, P BARBOUR, LP LEVITT, JE CASTALDO,MC LESTER.................................................................................................... 1191Soluble class I antigens in serum and CSF of patients with varicella zoster virus meningitis JC ALVAREZ-CERMENO,JM ECHEVARRiA, LM VILLAR, I LAZARO, A BOOTELLO, P GONZALEZ-PORQUt......................................... 1194Are HLA antigens implicated in the pathogenesis of non-haemorrhagic deterioration following aneurysmalsubarachnoid haemorrhage? RICHARD H LYE, PHILIP A DYER, STEPHEN SHELDON, NAGI ANTOUN ..... ............. 1197
LETTERS
Akathisia following traumatic brain injury: treatment with bromocriptine JONATHAN T STEWART ..... .......... 1200Cartilage embolism of spinal cord AK BANERJEE, SD DEODHAR ................................................. 1201Trigeminal neuralgia associated with contralateral intracranial tumour: a false localising sign caused by vascularcompression? Report of two cases R MICHELUCCI, CA TASSINARI, R PLASMATI, G RUBBOLI, F TOGNETTI, F CALBUCCI. 1202Proceedings of the meeting of the Association of British Neurologists, Glasgow 6-8 April 1989.................. 1204
MATTERS ARISING ................... .......................................................................... 1212
NOTICES...................................................................................................... 1213
BOOK REVIEWS................................................................................................ 1214
No 11 NOVEMBER 1989 4
Magnetic resonance imaging in dementia of Parkinson's disease STEVEN J HUBER, EDWIN C SHUTTLEWORTH,JEFFREY A CHRISTY, DONALD W CHAKERES, ANDREW CURTIN, GEORGE W PAULSON.................................. 1221Visuospatial working memory in Parkinson's disease VERONICA A BRADLEY, JOHN L WELCH, DAVID J DICK ....... 1228Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistryGRAHAM LENNOX, JAMES LOWE, MICHAEL LANDON, E JANE BYRNE, R JOHN MAYER, RICHARD B GODWIN-AUSTEN ....... 1236
Striatal dopamine D2 receptors in tardive dyskinesia: PET study J BLIN, JC BARON, H CAMBON, AM BONNET,B DUBOIS, C LOC'H, B MAZIERE, Y AGID.......................................................................... 1248Unilateral visual neglect overcome by cues implicit in stimulus arrays LD KARTSOUNIS, ELIZABETH K WARRINGTON 1253Rejection behaviour: a human homologue of the abnormal behaviour of Denny-Brown and Chambers' monkeywith bilateral parietal ablation ETSURO MORI, ATSUSHI YAMADORI .............................................. 1260Arm function after stroke. An evaluation of grip strength as a measure of recovery and a prognosticindicator ALAN SUNDERLAND, DEBORAH TINSON, LESLEY BRADLEY, RICHARD LANGTON HEWER ..... ............... 1267Epileptic seizures in intracerebral haemorrhage CHUNG-YANG SUNG, NAI-SHIN CHU ...... ....................... 1273Effect of the knee-chest position on cerebral blood flow in patients undergoing lumbar spinal surgery J-F PITTET,A RAMADAN, DR MOREL, A FORSTER ............................................................................ 1277Familial distal dysautonomia BRIAN ROBINSON, RALPH JOHNSON, DAVID ABERNETHY, LINDA HOLLOWAY .... ...... 1281
SHORT REPORTS
Idiopathic granulomatous meningitis AMO BAKHEIT, PGE KENNEDY, DI GRAHAM, JRS MORE ..... .................. 1286Clinicopathological correlation in a case of painful ophthalmoplegia: Tolosa-Hunt syndrome PJ GOADSBY,JW LANCE.................................................................................................... 1290
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People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction BEN SACKS,STEPHEN SMITH .................... ........................................................................... 1294
Chronic encapsulated intracerebral haematoma: pathogenetic and diagnostic considerations ETTORE FIUMARA,MARCELLO GAMBACORTA, VINCENZO D'ANGELO, MASSIMO FERRARA, CLAUDIO CORONA.............................. 1296
Two techniques for the assessment of line bisection in visuo-spatial neglect: a single case study PETER W HALLIGAN,JOHN C MARSHALL............................................................................................. 1300
Resistance to ischaemic conduction failure in chronic hypoxaemia and diabetes KK HAMPTON, SH ALANI, JI WILSON,DE PRICE..................................................................................................... 1303
LETTERS
Singing in the brain: a new form of complex partial seizure? MARIE VIDAILHET, MICHEL SERDARU, YVES AGID...... 1306Sensory neuropathy as the initial manifestation of primary biliary cirrhosis I ILLA, F GRAUS, I FERRER, J ENRIQUEZ 1307Rapid recovery after delayed myelopathy from electrical burns PD CLOUSTON, D SHARPE ..... .................. 1308Intradural spinal lipoma with enlarged intervertebral foramen KUNIAKI TSUCHIYA, MAKOTO MICHIKAWA,AKIKO FURUYA, TETSUO FURUKAWA, HIROSHI TSUKAGOSHI ....................................................... 1308
Coxsackie B5 papillitis DJ SPALTON, I MURDOCH, GE HOLDER .................................................. 1310Some historical observations on involuntary movements of the face RT ROSS................................... 1311
MATTERS ARISING ............................................................................................. 1312
NOTICES..................................................................................................... 1313
BOOK REVIEWS .................... ........................................................................... 1314
No 12 DECEMBER 1989 PageOCCASIONAL REVIEW
Whiplash injury: a reappraisal JMS PEARCE.................................................................. 1329Risk associated with heparin withdrawal in ischaemic cerebrovascular disease ANDREW SLIVKA, DAVID LEVY,ROBERT H LAPINSKI ................. .......................................................................... 1332
Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy(Binswanger's disease) T REVtSZ, CP HAWKINS, EPGH DU BAULAY, RO BARNARD, WI MCDONALD................... 1337
Regional cerebral blood flow and cerebral vasoreactivity in patients with retinal ischaemic symptomsEMILIA KERTY, DAVID RUSSELL, SOREN J BAKKE, ROLF NYBERG-HANSEN, KJELL ROOTWELL ........................... 1345
Source of pain and primitive dysfunction in migraine: an identical site? S BONUSO, E MARANO, E DI STASIO, F SORGE,F BARBIERI, E ULLUCCI ........................................................................................ 1351
Changes within the "normal" cerebral white matter of multiple sclerosis patients during acute attacks and duringhigh-dose cortisone therapy assessed by means of quantitative MRI M BRAININ, A NEUHOLD, T REISNER, E MAIDA,S LANG, L DEECKE ............................................................................................ 1355Ocular inflammatory changes in established multiple sclerosis EM GRAHAM, SA FRANCIS, MD SANDERS, P RUDGE .. 1360Pattern electroretinography in patients with delayed pattern visual evoked potentials due to distal anterior visualpathways dysfunction GRAHAM E HOLDER .................................................................... 1364The spectrum of polyneuropathies in patients infected with HIV JM LEGER, P BOUCHE, F BOLGERT, MP CHAUNU,M ROSENHEIM, HP CATHALA, M GENTILINI, JJ HAUW, P BRUNET .................................................... 1369
Fasiculations in motorneuron disease: discharge rate reflects extent and recency of collateral sprouting M JANKO,JV TRONTEL, K GERSAK........................................................................................ 1375
Long term effect of low frequency chronic electrical stimulation on the fast hind limb muscles of dystrophic miceJ DANGAIN, G VRBOVA ........................................................................................ 1382
Electrophysiological study of the Babinski sign in paraplegic patients A ROBY-BRAMI, JR GHENASSIA, B BUSSEL .... 1390Late onset recessive ataxia with Friedreich's disease phenotype G DE MICHELE, A FILLA, F BARBIERI, A PERRETTI,L SANTORO, L TROMBETTA, F SANTORELLI, G CAMPANELLA ........................................................ 1398
Regional cerebral blood flow by SPECT imaging in Sturge-Weber Disease: an aid for diagnosis C CHIRON,C RAYNAUD, N TZOURIO, C DIEBLER, 0 DULAC, M ZILBOVICIUS, A SYROTA .......................................... 1402
Liver and pituitary abnormalities in Hallervorden-Spatz disease DJ WILLIAMS, JW IRONSIDE..................... 1410
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Preservation of musical memory in Alzheimer's disease HOWARD A CRYSTAL, ELLEN GROBER, DAVID MASUR ...... 1415Magnetic resonance imaging studies in multiple sclerosis twins BMJ UITDEHAAG, CH POLMAN, J VALK, JC KOETSIER,CJ LUCAS.................................................................................................... 1417Hypothyroidism and polyneuropathy ETTORE BEGHI, MARIA L DELODOVICI, GRAZIELLA BOGLIUN, VITTORIO CRESPI,FELICE PALEARI, PIERLUIGI GAMBA, MAURIZIO CAPRA, MICHELE ZARRELLI.......................................... 1420Idiopathic dystonia and cervical spondylotic myelopathy JA WATERSON, M SWASH, ES WATKINS.................. 1424Pure sensory stroke due to midbrain haemorrhage limited to the spinothalmic pathway PL AZOURI, A TOUGERON,C HUSSONOIS, E SCHOUMAN-CLAEYS, B BUSSEL, JP HELD ........................................................... 1427
Progressive encephalomyelitis with rigidity: a case report with magnetic resonance imaging findings PA MCCOMBE,JB CHALK, JW SEARLE, AEG TANNENBERG, JJ SMITH, MP PENDER ................................................... 1429
Effect of bezafibrate on the sequelae of acute experimental focal cerebral ischaemia BS AsitEY, S EHTESHAMI,CM HURST, S PEREIRA, MJG HARRISON........................................................................... 1432Serum prolactin during status epilepticus TORBJ0RN TOMSON, ULLA LINDBOM, BENGT Y NILSSON, EVA SVANBORG,DAN EH ANDERSSON......................................................... 1435
LETTERS
Anti-Purkinje cell cytoplasmic and neuronal nuclear antibodies aid diagnosis of paraneoplastic autoimmuneneurological disorders VA LENNON........................................................................... 1438Sublingual apomorphine and Parkinson's disease AJ LEES, JL MONTASTRUC, NORA TURJANSKI, 0 RASCOL,BIRGIT KLEEDORFER, H PEYRO SAINT-PAUL, GM STERN, A RASCOL.................................................. 1439
Crying and laughing after brain damage: a confused nomenclature PETER ALLMAN............................. 1440Pontine tumour with central neurogenic hyperventilation ROLF SALVESEN...................................... 1441Isolated Schwannoma of the fourth cranial nerve RS MAURICE-WILLIAMS....................................... 1442An ependyoma involving the pituitary fossa JB WINER, H LIDOV, F SCARAVILLI.................................. 1443
Paroxysmal dysarthria and ataxia: associated MRI abnormality DA GORARD, FB GIBBERD ...... ................ 1444Development of HTLV-I associated myelopathy (HAM) in a seroconverted patient for antibody to HTLV-IYUJI SAKAI, HIROSHI YAO, SEIZO SADOSHIMA, MASATOSHI FUJISHIMA, KAZUO OKOCHI ................................ 1445
Parkinsonian symptoms in a patient with AIDS and cerebral toxoplasmosis ENRIQUE J CARRAZANA,EUGENE ROSSITCH JR, MARTIN A SAMUELS ....................................................................... 1445
Tobacco-alcohol amblyopia: magnetic resonance imaging findings AG KERMODE, GT PLANT, DH MILLER,BE KENDALL, WI MCDONALD................................................................................... 1446
Opsoclonus-myoclonus following the intranasal usage of cocaine DAVID SCHARF ....... ........................ 1447Autosomal dominant cerebellar ataxia with deafness, myoclonus and amyotrophy TERESA P MELO, JOSt M FERRO 1448Persistent primitive trigeminal artery: a possible cause oftrigeminal and abduceus nerve palsy KIYONDBU IKEZAKI,KIYOTAKA FUJII, TAKASHI KISHIKAWE .......................................................................... 1449
Norpethidine induced-myoclonus in a patient with renal failure DAVID C REUTENS, EDWARD G STEWART-WYNNE 1450Intramedullary spinal cord metastasis following a slowly progressive course JHTM KOELMAN, M DE VISSER,JAM KUSTER, JJR DREISSEN, J VALK, PA KOSTER .................................................................. 1451Management of intraventricular haemorrhage secondary to ruptured arteriovenous malformation in a child withVon Willebrand's disease RICHARD K OSENBACH, CHRISTOPHER M LOFTUS, ARNOLD H MANEZES, JOSE BILLER,RAYMOND TANNOUS, WILLIAM TC YUH.......................................................................... 1452
NOTICES.................................................. 1454
PROCEEDINGS OF THE MEETING OF THE SOCIETY OF BRITISH NEUROLOGICAL SURGEONS, SALFORD, 13-14 APRIL 1989 1455
LISTS OF ASSESSORS AND REVIEWERS ............................................................................ 1464
INDEX TO VOLUME 52, 1989.................................................................................... 1467
CONTENTS 1989
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