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infection detected by PCR

and real-time PCR in

childhood community-acquired pneumonia: A

meta-analysis

 Journal Reading divisi Respirologi

  Min ang! "eng Cai! #iaodong u! $ing u! #in %u! and &i %hiPenya'i : (ursal R) %iregarPembimbing : dr) isman *alimunthe!M)+ed,Ped! %p)A,+%upervisor : dr) Rid.an M) *aulay! %p)A,+

  dr) isman *alimunthe! M)+ed,Ped!%p)A,+

  dr) Rini %avitri *aulay! M)+ed,Ped!%p)A

  dr) "athia Meirina! M)+ed,Ped! %p)A

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P/0*A1232A0

Community

AcquiredPneumon

ia

MasalahKesehat

an

Morbiditas

Mortalitas

Antibiotik

?

Diagnosis

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[Data WHO Community Acquired Pneumonia!CAP" # Masalah kesehatan yang menyebabkankematian se$erlima anak di dunia

? Penyebab% &irus' (akteri

? Metode diagnosis% Kultur' PC)

? Pemakaian antibiotik' anti*irus?

 Penelitian Meta+Analisisuntuk menentukan

insiden in,eksi *irusmelalui deteksiPolymerase Chain)eaction !PC)" $ada

$asien $ediatri dengan

Penelitian Meta+

Analisis untukmela$orkan insidenberbagai *irusres$iratori

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M/$4*/

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- Pubmed- .mbase

+/&4R* /community+acquired $neumonia0'/*irus0' /$ediatric0' /children0'

/childhood0' /PC)0' /$olymerasechain reaction0' /real+time PC)01

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I0+32%I  Penelitian Cross 23ectional Case control atau Kohort 4sia 3ub5ect ≤ 67 tahun Penyebab% &irus  Metode% PC) atau )ealtime

PC)  8ull te9t bahasa :nggris

ataubahasa China

/+%+32%I4sia 3ub5ect%de;asa  Metode%

Kon*ensional  Penelitian satu

 5enis*irus tertentu

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Pengolahan Data< =abel 36

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Pengolahan Data< =abel 36

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  A0A3I%A %$A$I%$I+ 

Meta-Analisis *er%imonian-3aird

# /$ooled0 insiden in,eksi *irus[C:% 7> Mcochran 6 ,1eterogenitas

7

Statistik 7,1eterogenitasmoderate

# 45i HeterogenitasAnalisis metaregresiunivariate

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# (ias antar PenelitianPiranti luna9: %tata 7)

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1A%I3; "igur

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1A%I3; $abel

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1A%I3; "igur 7

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1A%I3; $abel 7

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1A%I3; $abel <

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1A%I3; "igur <

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1A%I3; $abel =

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1A%I3; "igur =

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1A%I3; "igur %

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1A%I3; "igur %

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*I%+2%I

$/M2A0 2$AMA

>irus respiratori dapat

terdete9si pada hampir ??@pasien CAP pediatri! dan lebihdari separuhnya merupa9aninfe9si campuran denganRhinovirus! R%>! dan bocavirussebagai patogen tersering

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*I%+2%I

$/M2A0

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3am$ai saat ini' $engalaman $enggunaan anti*irusuntuk tatalaksana CAP *iral masih sangat sedikit

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*I%+2%I

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Dibutuhkan anti*irus dan *aksin yang lebihaman dan e@sien untuk tatalaksana dan

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*I%+2%I

A0A3I%I% 1/$/R4(/0I$A% 

$emuan Penting % insiden in,eksi *irus$ada $enelitian yang meneliti lebih banyak

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*I%+2%I

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*I%+2%I

+/$/R5A$A%A0 

E6 Penelitian ini hanya mencaku$ $enelitianyang ditulis dalam bahasa inggris dan china

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+/%IMP23A0

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penyebab atau fa9torpendu9ung 9e'adian CAP ana9 

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%ARA0

Penelitian lan5utan di$erlukan untukmenentukan metode standar untukkoleksi s$esimen dan identi@kasi

*irus res$iratori