KEEPING TRACK OF YOUR MS RELAPSE SYMPTOMS

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KEEPING TRACK OF YOUR MS RELAPSE SYMPTOMSRECORD YOUR EXPERIENCE. SHARE WITH YOUR DOCTOR.

Please see the Important Safety Information on pages 911 and the accompanying full Prescribing Information.

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TRACKING YOUR MS RELAPSE SYMPTOMSIts important to keep track of any new or worsening symptoms you experience during a relapse. With a record of these symptoms, you and your healthcare provider can take quick action so you arent suffering through an MS relapse alone and untreated.

After you note your potential relapse symptoms and review the information about Acthar, be sure to discuss your treatment options with your healthcare provider to see if Acthar may be right for you.

GETTING STARTEDRemember: For an attack to be considered an MS relapse, it must meet the following criteria:1. Old symptoms of MS become worse or new symptoms appear2. New or worsening symptoms must last at least 24 hours3. Symptoms must occur at least 30 days after the last relapse4. There must be no other explanation for the symptoms

If your MS relapse symptoms last fewer than 24 hours, you may be having a pseudo-relapse. Learn more about this and other aspects of your MS journey at the following websites (additional websites are listed on page 11 of the brochure included in this kit):

mymsaa.org | nationalmssociety.org

Learn about MS relapse treatment with Acthar at ActharMSrelapse.com/info_kit.

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Use the following pages to record your new or worsening symptoms, then contact your healthcare provider immediately to discuss them.

To help guide your tracking, here is a list of common MS symptoms that may appear or worsen during an MS relapse:

Vision loss

Issues with chewing or swallowing

Hand/arm weakness

Bowel problems

Fatigue

Difficulty walking

Speech changes

Numbness/tingling

Leg/foot weakness

Sexual problems

Muscle tightness or stiffness

Coordination problems: tripping, dropping things

Dizziness/poor balance

Pain, burning, itching

Bladder problems

Memory problems

Thinking problems


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EXAMPLE

Contact your healthcare provider immediately so you can discuss any new or worsening symptoms you record on these pages

Recording new or worsening symptoms is important. Use this tool to help track symptoms as they occur and/or progress so you and your healthcare provider can take immediate action. An online version of this tracker is also available at ActharMSrelapse.com/tracker.

SYMPTOM TRACKER

Date when new or worsening symptom(s) began:

How long did the symptom(s) last?

(hours/days):

Describe your new or worsening symptom(s):

Questions or comments for your healthcare team:

1/3/2015 6 days

Tingling in my feetthis is anew symptom.I also think my coordination is getting worse.

Is this the sign of an MS relapse? What are the next steps?

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SYMPTOM TRACKER



(hours/days):




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SYMPTOM TRACKER



(hours/days):



7

SYMPTOM TRACKER



(hours/days):




8

SYMPTOM TRACKER



(hours/days):



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WHAT IS ACTHAR?H.P. Acthar Gel (repository corticotropin injection) is a prescription medication used for the treatment ofacute exacerbations of multiple sclerosis in adults. Controlled clinical trials have shown Acthar to be effective in speeding the resolution of acute relapses of multiple sclerosis. However, there is no evidencethat it affects the ultimate outcome or natural history of the disease.

IMPORTANT SAFETY INFORMATIONYou should not take Acthar if you have:

A skin condition called scleroderma Bone density loss Any infections Eye problems, such as ocular herpes simplex Had recent surgery Stomach ulcers or a history of ulcers Heart problems

High blood pressure Allergies to pig-derived proteins Been recently given a vaccine or are about to take one A condition where your adrenal glands produce either too much of certain hormones (as with Cushings syndrome), or not enough (adrenal insufficiency)

Never inject Acthar directly into a vein, and always take Acthar as prescribed by your doctor. Never stop treatment suddenly unless your doctor tells you to. Try not to miss any scheduled doctors appointments, as it is important for the doctor to monitor you while taking Acthar.

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IMPORTANT SAFETY INFORMATION (CONTINUED)

Acthar can cause side effects similar to those with steroid treatments. Tell your doctor if you have any of the symptoms listed here. Increased risk of infections. You may be more likely to get new infections. Also, old infections may become active. Signs of infection are fever, cough, vomiting, or diarrhea. Other signs may be flu or any open cuts or sores

Adrenal gland changes. Taking Acthar long term may cause symptoms of Cushings syndrome, such as upper body fat, rounded moon face, bruising easily, or muscle weakness

Increased blood pressure, body salt, and fluid. Your doctor may recommend changes to your diet

Unpredictable response to vaccines. Talk to your doctor about which vaccines are safe to use when taking Acthar

Masking other conditions. Tell your doctor if you have any infections, changes in weight, excessive tiredness, increased thirst, fast heart rate, or difficulty breathing

Stomach or intestinal problems. Acthar may put you at increased risk for bleeding from the stomach or getting stomach ulcers. Tell your doctor if you have any pain in the stomach area, vomiting, or bloody or black stools

Changes in mood or behavior. You may be irritable, have mood swings, be depressed, or have trouble sleeping

Worsening of other medical conditions, including diabetes

Eye problems, such as cataracts, glaucoma, or optic nerve damage

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Allergic reactions. Tell your doctor if you have a skin rash, swelling, or trouble breathing

Bone density loss. Acthar may cause osteoporosis at any age

Potential harm to unborn baby. Tell your doctor if you are pregnant or plan on becoming pregnant

The most common side effects are similar to those of steroids. They include:

Fluid retention

Changes in blood sugar

Increased blood pressure

Behavior and mood changes

Changes in appetite and weight

Specific side effects in children under 2 years of age include:

Increased risk of infections

Increased blood pressure

Irritability

Symptoms of Cushings syndrome

Cardiac hypertrophy (thickening of the heart muscle)

Weight gain

The above side effects may also be seen in adults and children over 2 years of age.

These are not all of the possible side effects of Acthar.

Tell your doctor about any side effect that bothers you, or that does not go away. You may report side effects to the FDA. Call 1-800-FDA-1088 or visit www.fda.gov/medwatch. You may also report side effects by calling 1-800-778-7898.

Please see accompanying full Prescribing Information.

Mallinckrodt, the M brand mark and the Mallinckrodt Pharmaceuticals logo are trademarks of a Mallinckrodt company. Other brands are trademarks of a Mallinckrodt company or their respective owners. 2015 Mallinckrodt. PM-01-01-0605(1)a 08/15 Printed in USA.

Visit ActharMSrelapse.com/info_kit to learn more about Acthar

Mallinckrodt, the M brand mark and the Mallinckrodt Pharmaceuticals logo are trademarks of a Mallinckrodt company. Other brands are trademarks of a Mallinckrodt company or their respective owners. 2015 Mallinckrodt. PM-01-01-0605(1)a 08/15 Printed in USA.

Katrina, Paul, and Christine (front cover) and Paul (at left) Acthar Ambassadors

I make the best use of my doctors appointments by keeping a list of my current issues and any new symptoms or questions. I even use the recorder app on my phone to record what he says, like instructions for taking medications.

Paul, Londonderry, NH

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KEEPING TRACK OF YOUR MS RELAPSE SYMPTOMS