Meditekknology srlMeditekknology srlA CNR spin-off company operating in the field of (bio)nanotechnology and medical diagnostics

Codice Istat: Codice Istat: 7310E, "Sperimentazione in campo biologico, ricerca".K73 Ricerca e Sviluppo

MissionMission:: Research and development inthe field of biotechnology: reagents andinstruments for medical diagnostics andtherapy, new organic and inorganic

K73 Ricerca e Sviluppog g

molecules for the labeling of biologicalsystems and/or as photoemitters

http://www.cnr.it/sitocnr/IlCNR/Innovazione/SocietaSpinoffCNR.html

thiophene

The challenge:from organic from organic devices to biopolymers and and bioimaging

United States Patent 6,841,669U d s 6,8 ,66

Functionalized thiophene oligomers and their use as fluorescent markers

AbstractThiophene oligomers which are excitable in the visible and ultraviolet region and each having at least one functional group able to form a covalent bond with organic and/or biological molecules, so as not to alter

h h fl f h leither the fluorescence properties of the oligomers or the biological activity of the bound molecules, and their use as fluorescent markers in analysis techniques.

R.C. replaced by G.G.

Initial Status

O 36%BIO-D 36%CNR 25%INFM 25%G.G. 7%G.B. 7%

Merging of CNR and INFM

BIO-D sold to a biggercompany which, after the beginning of the beginning of the economic crisis, decides to abandon the field of bi t h lbiotechnology

Current Status

CNR 50%CNR 50%G.G. 25%G.B. 25%

What are we doing?

producing and selling gknow-how

producing and selling hi hthiophene

fluorophoresparticipating in national and international international projects developing a

technological platformplatform

Our platform in (bio)nanotechnology

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smart surfaces for lab-on-chip

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multifunction KKN

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multifunction thiophene fluorophores for IT

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for intracellular proteins recognition

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g(M-TFs)(Dr.se Antonella Cazzato, Francesca Di M i Il i El

Novel smart surfaces for in situ cell staining by covalent attachment of

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Maria, Ilaria Elena Palama’)

staining by covalent attachment of pH-responsive microgels on platforms dedicated to micro uidics for lab-on-chip (Dr.se Simona Argentiere, Laura Blasi)

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M-TF1

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A B C1 h 24 h

M-TF1

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D E F48 h 72 h 192 h

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M-TF2

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25 Pm 75 Pm 25 Pm

24h 48h 72h

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M-TF3

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25 Pm 25 Pm 10 PmMM

Cell�interaction�with�fluorescent�microfibers�A�and�B�after�48�h����

Live cells 1 Live cells 2 Live cells 3

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Scale bar: 50 Pm

Th f t ? The future?

Who knows?Who knows?........