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Mendelian Genetics Dihybrid Crosses. April 2008. March 12, 2009 Mr. Bromwell. Mendel’s Law of Independent Assortment. Genes on separate chromosomes segregate randomly and independently of each other during meiosis. used when examining the inheritance of two traits simultaneously. - PowerPoint PPT Presentation
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April 2008
Mendelian GeneticsMendelian GeneticsDihybrid CrossesDihybrid Crosses
March 12, 2009March 12, 2009Mr. BromwellMr. Bromwell
Mendel’s Law of Independent AssortmentMendel’s Law of Independent Assortment
• Genes on separate chromosomes segregate randomly and independently of each other during meiosis.– used when examining the inheritance of two
traits simultaneously
Making Predictions: Blue-Eyed Freckle Juice Making Predictions: Blue-Eyed Freckle Juice
Problem:In at least one of the genes for eye color, brown eyes are dominant to blue eyes.* Having freckles is also a dominant trait.
A brown-eyed, freckle-faced couple are heterozygous for these two traits. What is the probability that they will have a blue-eyed child with freckles?
* Disclaimer: There are at least three genes that control eye color. The brown/blue gene is only one of them. Therefore it is not the only determiner of a person’s eye color.
Solution A:From the information in the problem you know that both parents have the heterozygous genotype ‘BbFf’.
B = dominant allele (brown eyes)b = recessive allele (blue eyes)F = dominant allele (freckles)f = recessive allele (no freckles)
First, determine the types of gametes that each parent can produce.
In other words, according to the Law of Independent Assortment, how many combinations of one eye color allele and one freckle allele can be made?
Alleles in Parent Cell
BbFf
gam
ete
type
s
Making Predictions: Blue-Eyed Freckle Juice Making Predictions: Blue-Eyed Freckle Juice
BF Bf bF bf
Solution A:Second, complete the Punnett square with the allele combinations for both parents.
– You will need a Punnett square that is 4 x 4 boxes.
– Be careful to list the alleles for each parent correctly.
– Place alleles for the same gene together. This makes for easier interpretation.
Making Predictions: Blue-Eyed Freckle Juice Making Predictions: Blue-Eyed Freckle Juice
BF Bf bF bf
BF BBFF BBFf BbFF BbFf
Bf BBFf BBff BbFf Bbff
bF BbFF BbFf bbFF bbFf
bf BbFf Bbff bbFf bbff
♂ male gamete types
♀ fe
mal
e ga
met
e t
ypes
Finally, create a genotype pattern.– The pattern bbF_ will result in blue
eyes and freckles.– The probability of this occurring is
3/16.
Once again… a Word About RatiosOnce again… a Word About RatiosA cross that involves two organisms that are heterozygous for two traits is called a dihybrid crossdihybrid cross.
There are nine possible genotypes in a ratio of 1:2:1:2:4:2:1:2:11:2:1:2:4:2:1:2:1.
There are four possible phenotypes in a ratio of 9:3:3:19:3:3:1.
BF Bf bF bf
BF Brownfreckles
Brownfreckle
s
Brownfreckle
s
Brownfreckle
s
Bf Brownfreckles
Brown no
freckles
Brownfreckle
s
Brown no
freckles
bF Brownfreckles
Brownfreckle
s
Blue Freckle
s
Blue Freckle
s
bf Brownfreckles
Brown no
freckles
Blue Freckle
s
Blue no
Freckles
♂ male gamete types
♀ fe
mal
e ga
met
e t
ypes
Solution B:Instead of dealing with both traits at the same time, first perform a monohybrid cross for each individual trait.
– You will need a Punnett square for each trait.
Making Predictions: Blue-Eyed Freckle Juice Making Predictions: Blue-Eyed Freckle Juice
B b
B BB Bb
b Bb bb
F f
F FF Ff
f Ff ff
Inheritance of eye color Inheritance of freckles
Solution B:Next, find the probability of each individual outcome separately, then multiply their probabilities together to determine the chance of them happening together.
Making Predictions: Blue-Eyed Freckle Juice Making Predictions: Blue-Eyed Freckle Juice
Therefore…– The probability of getting blue eyes is ¼.– The probability of getting freckles is ¾.– ¼ x ¾ = 3/16 (the probability of getting blue eyes and freckles)
B b
B BB Bb
b Bb bb
F f
F FF Ff
f Ff ff
Inheritance of eye color Inheritance of freckles
ReferencesReferencesBiggs, Alton, et. al. Biology. New York: The McGraw Hill Companies, Inc., 2007.“Freckle Juice” Kathinthehat’s Weblog. Oct 3, 2007. Retrieved Apr 7, 2008 from
<http://katinthehat.wordpress.com/2007/10/03/freckle-juice/>.