M/s. Maitri Pharma, GIDC Jhagadia- Bharuch · M/s. Maitri Pharma, GIDC Jhagadia- Bharuch M/s. Jyoti Om Chemical Research Centre Pvt Ltd

M/s. Maitri Pharma, GIDC Jhagadia- Bharuch

M/s. Jyoti Om Chemical Research Centre Pvt Ltd

LIST OF ANNEXURES

Sr. No. Title Page No.

Annexure 1 Terms of References 12

Annexure 2 List of Products 13

Annexure 3 List of Partners 14

Annexure 4 Plant Layout 15

Annexure 5 Products With Raw Material 16

Annexure 6 Details of Manufacturing Process 19

Annexure 7 Details of Effluent Treatment Scheme and List of Plant Machinery 41

Annexure 8 Details of Water Consumption & Waste Water Generation 48

Annexure 9 Details of Energy and Fuel Consumption 51

Annexure 10 Details of Hazardous Waste 52

Annexure 11 Details of Flue Gas & Process Gas Emission 54

Annexure 12 Details of Solvent Recovery 55

Annexure 13 List of Hazardous Chemicals as per MSIHC Rules 58

Annexure 14 Land Possession Document 59

Annexure 15 NCT Membership Certificate 61



ANNEXURE-1

TERMS OF REFERENCES

• TOR prescribed by MoEF & CC for this sector will be taken into account.



ANNEXURE-2 LIST OF PRODUCTS

SR. No. Name of Product

CAS No End use of product Quantity MT / Month

1 Pharma Intermediates 5

Cinnamyl aldehyde & OR 104-55-2 Flavouring agent agent inchewing gum,

beverages

m-Phenoxy benzyl alcohol & OR 13826-35-2 used as active in pharmaceutical products P-anisaldehyde/ 4-methoxy benzaldehyde & OR 123-11-5 fragrance and flavor industry.

4-Chlorobenzophenone & OR 134-85-0 UV curing type coating, printing ink, medical

2-[4-(4-cyclopropyl carbonyl phenyl]-2-methyl propionic acid cyclohexyl amine salt & OR 153439-40-8 Fexofenadine Intermediate API

(anti allergic ) N-(2-chloro-4-methyl-3-pyridinyl)2-(cyclopropyl amine)-3-pyridinecarboxamide & OR

133627-46-0 Nevirapine API ( anti HIV drug)

Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol hydrochloride 27489-62-9 Ambroxole Hydrochloride API ( for

respiratory disease) 2 Fine Chemical 20

Benzyl alcohol 100-51-6 Used as bacteriostatic in medications, cosmetics and topical drugs

3 Anti allergic 1

2-[4-[4-chlorophenyl)phenyl methyl [1-piperazinyl] ethoxy] acetic

303-26-4 Cetrizine API (anti allergic )

4 Dye Intermediates 5

4-chlorophthalic acid mono sodium salt 56047-23-5 Dyes intermediate

Phenyl peri acid magnasium salt 18108-68-4 Dyes intermediate Total 31



ANNEXURE-3

LIST OF NAME AND ADDRESS OF PARTNERS

Sr.No. Name of Director Address Contact No. 1 Mr. Divyeshkumar Ravinbhai

Nargoriya Add : 9, Nilkanth Society, Near Gandhikutir society, Bhatar Road, Surat – 395001, Gujarat , India

9909996216

2 Ms. Maitreyee Divyeshkumar Nagoriya

Add : 9, Nilkanth Society, Near Gandhikutir society, Bhatar Road, Surat – 395001, Gujarat , India

9909996216

3 Mrs. Tarulataben Chandravadan Palsanawala

Add :B-2 Muktanand Nagar Adajan Road , Opp New Sardar Bridge, Surat 395009 Gujarat, India

9909996216



ANNEXURE-5

LIST OF PRODUCTS WITH RAW MATERIAL

Sr. No. Name of products

Quantity of

(MT/month)

Name of Raw materials CAS NO.

Quantity (MT/MT) Quantity

(MT/month)

Pharma Intermediates

1 Cinnamyl aldehyde & OR

5

Benzaldehyde 100-52-7 0.893 4.464Acetaldehyde 75-07-0 0.370 1.848Sodium hydroxide 1310-73-2 0.100 0.500

2 m-Phenoxy benzyl alcohol & OR

m-Phenoxy benzaldehyde 39515-51-0 1.143 5.714Ni catalyst 7440-02-0 0.057 0.286H2 gas 1333-74-0 0.011 0.057

3 P-anisaldehyde/ 4-methoxy benzaldehyde & OR

p-Cresol 106-44-5 1.140 5.702Dimethyl sulfate 77-78-1 1.041 5.207sodium hydroxide 1310-73-2 0.661 3.306Sulfuric acid 7664-93-9 1.349 8.082Magnesium oxide 1309-48-4 2.215 11.074Toluene (Fresh) 108-88-3 0.083 0.413

4 4-Chlorobenzophenone & OR

4-Chlorobanzoic acid 74-11-3 0.814

4.07

Thionyl chloride 7719-09-7 0.672

3.36

Dimethyl formamide 68-12-2 0.010

0.05

Benzene 71-43-2 0.448

2.24

Aluminium chloride 7446-70-0 0.724

3.62 Caustic Solution 1310-73-2

0.921 4.60

5

2-[4-(4-cyclopropyl carbonyl phenyl]-2-methyl propionic acid cyclohexyl amine salt & OR

2-methyl-2-phenyl propanoic acid 826-55-1

0.796 3.981

Thionyl chloride 7719-09-7

1.172

5.860

Sodium hydroxide 1310-73-2

0.191

0.955 Dimethyl amine 124-40-3



40% 0.818 4.092

Alluminium chloride 7446-70-0

1.303

6.513 4-Chloro butyryl chloride 4635-59-0

0.720

3.599

Dichloromethane (Fresh) 75-09-2

0.048

0.239

Hydrochloric acid 30% (Recovered) 7647-01-0

4.175

20.876

Toluene (Fresh) 108-88-3

0.088

0.438

Brine solution 7647-14-5

0.796

3.981

Methanol (Fresh ) 67-56-1

0.024

0.118

cyclohexyl amine 108-91-8

0.338

1.688

6

N-(2-chloro-4-methyl-3-pyridinyl)2-(cyclopropyl amine)-3-pyridinecarboxamide & OR

3-Amino-2-chloro-4-methyl pyridine

133627-45-9 0.776 3.881

2-Chloronicotinoyl chloride 49609-84-9 1.271 6.354Cyclopropyl amine 765-30-0 0.236 1.182Methanol (Fresh ) 67-56-1 0.036 0.181Toluene (Fresh) 108-88-3 0.072 0.361

7

Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol hydrochloride & OR

2-Aminobenzaldehyde 529-23-7 0.400 2.000Fresh Methanol

67-56-1 0.1530.763

Bromine 7726-95-6 1.058 5.289

Potassium bromide 7758-02-3 0.395 1.974

Trans-4-amino cyclohexanol 27489-62-9 0.347 1.737 Toluene (Fresh ) 108-88-3 0.189 0.947Isopropyl alcohol (Fresh ) 67-63-0

0.1680.842

HCl gas 7647-01-0 0.132 0.658Sodium borohydrate 16940-66-2 0.100 0.500

Fine Chemical

8 Benzyl alcohol 20 Benzyl chloride 100-51-6 1.337 26.738sodium carbonate 497-19-8 0.775 15.508



Anti allergic

9


1

4‐Chlorobenzophenone 134‐85‐0 0.798

0.798

sodium borohydrate 16940‐66‐2 0.160 0.160

Fresh Methanol 67-56-1 0.040

0.040

Piprizine 110-85-0 1.427 1.427

Fresh Toluene 108-88-3 0.130 0.130Hydrochloricacid 7647‐01‐0 0.701 0.701

2‐chloroethanol 107‐07‐3 0.840 0.840 sodium monochloroacetate 3926‐62‐3 0.828 0.828

Potasium hydroxide 1310‐58‐3 0.500 0.500

dimethyl formamide 68‐12‐2 2.268 2.268Dichloromethane (Fresh) 75‐09‐2 0.084 0.084

Dye Intermediates

10

4-Chloropthalic acid mono sodium salt & OR

5

Pathallic anhydride 85-44-9 0.909

4.545

Sodium hypochlorite 7681-52-9 5.455

27.273

11

Phenyl peri acid magnesium salt & OR

Aniline (Fresh) 62-53-3 0.5

2.5

Peri acid 82-75-7 0.8

4.0Magnesium sulfate 7487-88-9 0.44 2.2Sulphuric Asid 30% 7664-93-9 2.2 11

Total 31 48.446 247.317

M/s. Maitri Pharma, Jhagadia- Bharuch ANNEXURE 6


1. Cinnamylaldehyde

Process: Benzaldehyde and acetaldehyde charged in sodium hydroxide solution. Reflux reaction mixture for several hours. After completion of reaction layer separated and pure product will be collected by distillation from crude Cinnamyl aldehyde under vacuum Chemical Reaction:

Material Balance:

Input Kg Out put KgBenzaldehyde 500.0 Reaction Mass 1,886.0 Acetaldehyde 207.0

Sodium hydroxide 56.0 Water 1,123.0

TOTAL 1,886.0 TOTAL 1,886.0

Reaction Mass 1,886.0 Crude Cinnamylaldehyde 600.0 Effluent 1,286.0

TOTAL 1886 TOTAL 1,886.0

Crude Cinnamylalde 600.0 Product ‐ Cinnamylaldehyde 560.0 Evaporation Loss 40.0

TOTAL 600 TOTAL 600

STAGE‐1

Layer Separation

Dehydration

CHO

+ CH3 CHO

acetaldehydebenzaldehyde

H

O

Cinnamayl aldehyde

M.wt-44.05 M.Wt-106.12 M.Wt- 132

+NaOH

NaOH H2O+

sodium hydroxide water

M.Wt- 39.99 M.Wt - 18.01



2. m-Phenoxy benzyl alcohol

Process:

M-Phenoxy Benzaldehyde and Nickel catalyst charged to autoclave. Apply Hydrogen gas slowly and heat reaction mixture to 80-85 ºC for several hours. After completion of reaction cool reaction mass to room temperature. Catalyst separated by filtration and m-Phenoxy benzyl alcohol isolated by distillation.

Chemical Reaction:

Material Balance:

Input Qty., Kg Output Qty. Kg m-Phenoxy benzaldehyde 200.0 Reaction Mass 202.0

Ni catalyst 10.0 Catalyst recover 10.0

H2 gass 2.0 Total 212.0 Total 212.0

Reaction Mass 202.0 m-Phenoxy benzyl alcohol

175.0

Distilation Residue 10.0 Distilation loss 17.0

Total 202.0 Total 202.0

Autoclave

Distillation

OHO

m-Phenoxy Benzyl alcohol

M.Wt- 200.23

Ni cat

m-Phenoxy Benzaldehyde

M.Wt- 198.21

H2CHOO

Molecular Formula = C13H10O2 Molecular Formula = C13H12O2

+ Ni cat

Recovered cat. Catalist

M.wt -58.69 M.wt -58.69



3. P-anisaldehyde/ 4-methoxy benzaldehyde

Process : P-Cresol acid charged to SS Reactor with sodium hydroxide and water under heating dimethyl sulfate added to it slowly at elevated temperature. After completion of reaction sulfuric acid added and p-methyl anisole separated by filtration. Chemical Reaction

Material Balance:

Input Kg Output Kg p-Cresol 138.0 P-Methyl anisole 145.0

Dimethyl sulfate 126.0 Effluent 1,699.0 sodium hydroxide 80.0

Sulphuric Acid 520.0 water 980.0 Total 1,844.0 Total 1,844.0

Stage‐1 (Heating at 100ºC and filtration)



Process:

P-methyl anisole, magnesium oxide, sulfuric acid Charged in toluene. Heat reaction mass for several hours. After completion of reaction water added and layer separated. Organic acid on distillation gives 4-methyl Benzaldehyde

Chemical Reaction:

Material Balance:

4. 4-Chlorobenzophenone

Process:

P-Methyl anisol 145.0 P-anisaldehyde 121.0 Magnase oxide 268.0 Effluent 771.0

Sulfuric acid 520.0 Recovered Toluene 240.0 Toluene (F) 10.0 Vapour loss 10.0

Toluene (R ) 240.0 Methanol (Recover) 41Water 500.0 Spent Sulfuric acid 500Total 1,683.0 Total 1,683.0

Stage‐2 (Layer separation and Distillation)



4-Chlorobenzoic acid charged to GLR with thionyl chloride and DMF as a catalyst. This mass heated for several hours and cooled. Benzene added to reaction mass followed by aluminum chloride. Reaction mass heated and quench to ice water. Solid filtered and dried to give 4-chlorobenzophenone as off white powder

Chemical Reaction:

COOH

Cl

+ SOCl 2

COCl

Cl

DMF

4-chlorobenzoic acid 4-chlorobenzoyl chloride

M.wt ‐156.56 M.wt ‐118.97 M.wt ‐175.01

+ SO2

M.wt ‐64.6

Molecular Formula = C7H5ClO2 Molecular Formula = C7H4Cl2O

+

AlCl3 M.wt ‐133.34

HCl

Sulfer dioxide Hydrochloric acid

M.wt ‐36.46

M. F. -SO2 M F. -HCl

COCl

Cl

M.F.= C7H4Cl2O

M.wt ‐175.01

4-chlorobenzoyl chloride

+

O

Cl

(4-chlorobenzophenone

M.wt ‐216.66

+

M.wt ‐145.84 M.wt ‐78

Hydrochloric acid Alluminium hydroxide

Molecular Formula = C13H9ClO

+

benzene

M.F = C6H6

M.wt ‐54.034 HCl Al(OH) 33 H2O

M.wt ‐78.11



Material Balance:

InputQty., Kg

Output Qty. Kg

4-Chloro banzoic acid 236.0 4-Chlorobenzoyl Chloride 290.0 Thionyl chloride 195.0 SO2 Gas 89

Dimethyl formamide 3.0 HCl 55Total 434.0

Total434.0

Input Qty., Kg Output Qty. Kg 4-Chlorobenzoyl Chloride

(Reaction Mass) 290.0

Product- 4-

Chlorobenzophenone

290.0

Benzene 130.0 Effluent 1,100.0 Aluminium chloride 210.0 HCl 240

Water 1,000.0 Total 1,630.0 Total 1,630.0

Input Qty., Kg Output Qty. Kg HCl 295.0 Scrub Solution To ETP 1,651.0

SO2 89.0 Caustic Solution 267.0


Scrubbing

GLR

Reaction



5. 2-[4-(4-cyclopropyl carbonyl phenyl]-2-methyl propaonic acid cyclohexylamine salt

Process:

2-Methyl-2-phenyl propionic acid and thionyl chloride charged to G L Reactor than heated for several hours. After completion of reaction mass cool to room temperature and charged dimethyl amine, sodium hydroxide slowly, followed by water under cooling and thus product obtained by filtration gives N, N, 2-trimethyl-2-phenyl propanamide a solid. Chemical Reaction:

Material Balance:

Input Qty., Kg Output Qty. Kg 2-methyl-2-propionic acid

250.0 N,N-2-trimethyl-2-phenyl proanamide

279.0

Thionyl chloride 217.0 HCl gass 208.0 Sodium hydroxide 60.0 Effluent 614.0

Dimethyl amine 40% 257.0 Water 317.0

Total 1,101.0 Total 1,101.0

Stage‐1

CH3 CH3

O

OH

CH3 CH3

O

N

CH3

CH3

SOCl2

NaOH

H2O

2-methyl-2-phenylpropanoic acid N,N,2-trimethyl-2-phenylpropanamide

+ SO2 NaOHH2O+ + +

M. wt‐ 164.20 M.Wt‐ 191..26 64.06 109.38 18.01 39.99

NH

CH3

CH3

3 HCl

HCl

sulfur dioxideHydrochloric acid

Water Sodium hydroxide

Molecular Formula = C10H12O2

M.wt = 81.54462

Molecular Formula = C12H17NO

STAGE- 1



Process:

Dichloromethane and aluminum chloride was charged to GL reactor, cool the reaction mass and 4-chlorobutyryl chloride added slowly drop wise under cooling then N, N, 2-trimethyl-2-phenyl propanamide in dichloromethane was added Slowly. Reaction mixture was refluxed for several hours. After completion of reaction water added and separated and organic layer distilled out gives oily product 2-[4-(4-chlorobutanoyl) phenyl]-N, N, 2-trimethylpropanamide. Chemical Reaction:

Material Balance:

Input Qty., Kg Output Qty. Kg N,N-2-trimethyl-2-phenyl

propanamide

279.0 2-[4-(4-chlorobutanoyl)phenyl]-

N,N-2-trimethyl propanamide

460.0

Alluminium chloride 409.0 HCl gass 118.0 4-Chloro butyryl chloride 226.0 Dichloromethane (Recovered ) 630.0

Dichloromethane (Fresh ) 15.0 Vapour loss 15.0 Dichloromethane

(Recovered)630.0

Effluent 1,826.0

water 1,490.0 Total 3,049.0 Total 3,049.0

Stage‐2



Process: Dichloromethane and aluminum chloride was charged to GL reactor, cool the reaction mass and 4-chlorobutyryl chloride added slowly drop wise under cooling then N, N, 2-trimethyl-2-phenyl propanamide in dichloromethane was added Slowly. Reaction mixture was refluxed for several hours. After completion of reaction water added and separated and organic layer distilled out gives oily product 2-[4-(4-chlorobutanoyl) phenyl]-N, N, 2-trimethylpropanamide. Chemical Reaction:

Material Balance:

Input Qty., Kg Output Qty. Kg 2-[4-(4-chlorobutanoyl) phenyl]-N,N-2-trimethyl

propanamide 460.0

2-[4-(4-chlorobutanoyl)phenyl]-

N,N-2-trimethyl propanonic acid

247.0

Hydrochloric acid 30% 1,311.0 Recovered Toluene 890.0 Water 454.0 Vapour loss 10.0

Sodium hydroxide 151.0 Effluent 2,379.0 Fresh Toluene 10.0

Recovered Toluene 890.0 Brine solution 250.0

Total 3,526.0 Total 3,526.0

Stage‐3

CH3

CH3

O

NCH3

CH3O

Cl

2‐[4‐(4‐chlorobutanoyl)phenyl]‐N,N,2‐trimethylpropanamide

CH3

CH3

O

OH

O

Cl

2‐[4‐(4‐chlorobutanoyl)phenyl]‐2‐methylpropanoic acid

CH3

CH3

O

OH

O

Cl

2‐[4‐(4‐chlorobutanoyl)phenyl]‐2‐methylpropanoic acid

HCl

H2O

NaOH

H2O

CH3

CH3

O

OH

O

2‐[4‐(cyclopropylcarbonyl)phenyl]‐2‐methylpropanoic acid

295.80 268.37

268.37 232.38

NH

CH3

CH3

.HCl+

81.54

Dimethylamine hydrochloride

+ NaCl 2 H2O+

58.44 36.02

Sodium Chloride Water

Molecular Formula = C16H22ClNO2 Molecular Formula = C14H17ClO3 Molecular Formula = C2H8ClN

Molecular Formula = C14H17ClO3 Molecular Formula = C14H16O3

STAGE - 3



Process:

2-[4-(cyclopropylcarbonyl) phenyl]-2-methyl propionic acid in Toluene and methanol was charged to reactor. Cyclohexyl amide was added drop wise slowly under cooling. The reaction mixture was refluxed for several hours then cooled and filter to give 2-[4-(cyclopropylcarbonyl) phenyl] -2-methyl propionic acid Cyclohexyl amine sate Chemical Reaction:

Material Balance:

Scrubbing of HCl Gas:

Input Qty., Kg Output Qty. Kg 2-[4-(4-cyclopropyl carbonyl phenyl]-2-methyl propaonic acid cyclohexylamine salt

314.0

Recovered methanol 383.571 Fresh Toluene 17.499 Recovered Toluene 903.501

Fresh Methanol 7.429 Vapour loss 24.900 cyclohexyl amine 106.000 Drying loss 39.000

Recovered Toluene 903.501 Recovered Methanol 383.571

Total 1,665.0 Total 1,665.0

Stage‐4

2-[4-(4-chlorobutanoyl)

phenyl]-N,N-2-trimethyl

prpanoic acid

247.000

Input Qty., Kg Output Qty. Kg

HCl 326.0 HCl 30% reused in at stage 3 1,311.0 Water 985.0 Total 1,311.0 Total 1,311.0

Scrubbing



6. N-(2-chloro-4-methyl-3-pyridinyl)2-(cyclopropyl amine)-3-pyridinecarboxamide

Process:

3-Amino-2-Chloro-4-methyl pyridine and 2-Chloronicotinyl chloride charged in Toluene to Reactor and stir at ambient temperature for several hours. After completion of reaction water added, layer separated and thus product obtained is as 2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide

Chemical Reaction:

Material Balance:

Process:

2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide, cyclo propyl amine charged in methanol. Reflux reaction mixture for several hours. After completion of reaction distilled out methanol and water added to reaction mass. Obtained precipitate filtered to get N-(2-Chloro-4-methyl-3-pyridinyl)-2-cyclopropylamino)-3-pyridinecarboxamide.

3-Amino-2-chloro-4-methyl

pyridine 215.0

2-Chloro-n-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide

323.0

2-Chloronicotinoyl chloride 352.0 Recovered Toluene 230.0 Fresh Toluene 20.0 Vapour loss 20.0

Recovered Toluene 230.0 Effluent 494.0 Water 250.0 Total 1,067.0 Total 1,067.0

Stage‐1

N Cl

NH2

CH3

+N Cl

COCl

Toluene

N Cl

NH

CH3

N

ClO+ HCl

3‐Amino‐2‐chloro‐4‐methyl pyridine 2‐Chloronicotinoyl chloride 2‐Chloro‐N‐(2‐chloro‐4‐methyl‐3‐p

yridyl)‐3‐pyridinecarboxiamide

M.Wt‐ 142.5 M.Wt‐ 176 M.Wt‐ 282.12 M.Wt‐ 36.46

Hydrochloric acid

Molecular Formula = C6H7ClN2 Molecular Formula = C6H3Cl2NO Molecular Formula = C12H9Cl2N3O

STAGE - 1



Chemical Reaction:

Material Balance:

2-Chloro-n-(2-chloro-4-methyl-3-

pyridinyl)-3-pyridinecarboxamide

323.0 N-(2-chloro-4-methyl-3-pyridinyl)2-(cyclopropyl amine)-3-pyridinecarboxamide

277.0

Cyclopropyl amine 65.5 Recovered Methanol 320.0 Fresh Methanol 10.0 Vapour loss 10.0

Recovered Methanol 320.0 Efflluent 276.5 water 165.0 Total 883.5 Total 883.5

Stage‐2

N Cl

NH

CH3

N

ClO+

NH2Methanol

N Cl

NH

CH3

N

NHO

HCl+

2‐Chloro‐N‐(2‐chloro‐4‐methyl‐3‐pyridyl)‐3‐pyridinecarboxiamide

M.Wt‐ 282.12

Cyclopropyl amine

M.Wt‐ 57.09

N‐(2‐chloro‐4‐methyl)‐3‐pyridinyl)‐2‐(cyclopropylamino)‐3‐pyridinecaraxamide

M.Wt‐ 302.7 M.Wt‐ 36.46

Hydrochloric acid

Molecular Formula = C12H9Cl2N3O Molecular Formula = C3H7N Molecular Formula = C15H15ClN4O

STAGE - 2



7. Trans-4-(2-amino-3,5-dibromo benzyl amino)cyclohexanol hydrochloride (Ambroxol hydrochloride)

Process:

2-Amino Benzaldehyde charged to GL Reactor. Bromine added to it by dissolving it in water with potassium bromide. After completion of addition, mass stirred for several hours and filtered to give 2-amino-3, 5-dibromo Benzaldehyde as a solid.

Chemical Reaction:

Material Balance:

2-Aminobenzaldehyde 152 2-Amino-3,5-dibromobenzaldehyde 320

Recovered Methanol 480 KBr 204 Fresh Methanol 20 Effluent 980

Bromin 402 Recovered Methanol 480 water 800 Evaporation Loss 20

Potassium bromide 150

Total 2,004 Total 2,004

Stage ‐1



Process:

2-Amino-3,5-dibromo Benzaldehyde charged to toluene with trance-4-amino cyclohexanol in GL reactor. This mass heated for several hours and then toluene distilled under vacuum to give 4-[[(E)-2-amino-3,5-dobromophenyl) methylidiene] amino] cyclohexanol

Chemical Reaction :

Material Balance:

2-Amino-3,5-

dibromobenzaldehyde 320

4-[[(E)-(2-amino-3,5-dibromophenyl)methyledine]amino]cyclohexanol ]

370

Trans-4-amino cyclohexanol 132 Vapor loss 82 Fresh Toluene 72 Recovered Toluene 1,728

Recovered Toluene 1,728 Effluent 72 Total 2,252 Total 2,252

Stage‐2

2-amino-3,5-dibromo benzaldeyde

Br Br

NH2

CHO

+

NH2

OHNH2

Br

Br

N

OH

4[[(E)-(2-amino-3,5-dibromophenyl)methylidene]aminocyclohexanol

Trans-4-aminocycloheanol

M.Wt‐278.92 M.Wt‐115.17 M.Wt‐376.08

+ H2O

M.Wt‐18.01

Water

Heating

Molecular Formula = C7H5Br2NO

Molecular Formula = C6H13NOMolecular Formula = C13H16Br2N2O

STAGE - 2



Process:

4‐[[(E)‐2‐amino‐3, 5‐dobromophenyl) methylidiene] amino] cyclohexanol charged to methanol followed by addition of sodium borohydride in water. This mass stirred for several hours and water added to it. This mass stirred, filtered and wet cake charged to IPA. HCl gas passed to it to form solid which filtered and dried to give Trans‐4‐(2‐amino‐3,5‐dibromo benzyl amino) cyclohexanol hydrochloride ( Ambroxol hydrochloride) as a solid.

Chemical Reaction:

Material Balance:

4-[[(E)-(2-amino-3,5-dibromophenyl)methyledine]ami

no]cyclohexanol ]370

Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol hydrochloride

380

Fresh Methanol 38 Recovered Isopropyl alcohol 1,536 Fresh Isopropyl alcohol 64 Effluent 2,191

Recovered Isopropyl alcohol 1536 vapour loss 64 HCl gas 50

Sodium borohydrate 38 water 2,075 Total 4,171

Total 4,171

Stage‐3

NH2

Br

Br

N

OH

Chemical Formula: C13H16Br2N2OMolecular Weight: 376.087

4[[(E)-(2-amino-3,5-dibromophenyl)methylidene]aminocyclohexanol

NaBH4+Sodium borohydrate

Chemical Formula: BH4NaMolecular Weight: 37.833

CH3OHChemical Formula: CH4OMolecular Weight: 32.042

NH2

Br

Br

NH

OH

BH3 CH3ONaTrihybridoboron

Chemical Formula: BH3Molecular Weight: 13.835

Sodium MethoxideChemical Formula: CH3NaO

Molecular Weight: 54.024

++

STAGE - 3

.HCl

Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol hydrochloride

Chemical Formula: C13H19Br2ClN2OMolecular Weight: 414.564

Cl

Chemical Formula: ClMolecular Weight: 35.453



8. Benzyl alcohol

Process:

Benzyl chloride is hydrolyzed with dilute soda ash for 12 hours at an elevated temperature. The mass is washed and the layer is separated to get crude Benzyl Alcohol. The crude is distilled under high vacuum at normal temperature to get pure Benzyl Alcohol.

Chemical Reaction:

Material Balance:

Distillation:

9. 2-[4-[4-chlorophenyl)phenyl methyl [1-piperazinyl] ethoxy] acetic

Process:

Benzyl chloride 250.0 Benzyl alcohol 187.0 sodium carbonate 145.0 Waste water 610.0

Water 500.0 CO2 98.0

TOTAL 895.0 TOTAL 895.0

Stage‐1

Waste Water 610.0 Distilled Water 495.0 NaCl Salt 115

Total 610.0 Total 610

Distillation



4- Chloro benzophenone in methanol charged under stirring and Sodium borohydrate added lot wise at room temperature. Stir reaction mass for 4-5 hours at room temperature and after completion of reaction distilled out methanol and water added to residue on filtration gave a 4-chlorobenzhydrol as solid.

Chemical Reaction:

Material Balance:

Process:

4-Chlorobenzophenone 400.0 4-Chlorobenzhydrol 400.0 sodium borohydrate 80.0 Recovered Methanol 1,180.0

Fresh Methanol 20.0 Vapour loss 20.0 Recovered Methanol 1,180.0

Water 1,200.0 Effluent 1,280.0 Total 2,880.0 Total 2,880.0

Stage‐1



Chemical Reaction:

Material Balance:

Process:

4-Chloro Benzhydril Piperazine and toluene was charged to reactor. 2-chloro ethanol added slowly dropwise to reaction mixture. Stir reaction mass till completion of reaction. After completion of

4-chlorobenzhydrol 400.0 4-chlorobenzhydril piperazine

503.0

Piprizine 715.0 Recovered Toluene 680.0 Fresh Toluene 35.0 Vapour loss 35.0

Recover Toluene 680.0 Efflluent 2,775.0 Hydrochloricacid 351.0

water 1,812.0 Total 3,993.0 Total 3,993.0

Stage‐2



reaction water added, layer separated. Organic layer distilled to give 2-{4-[4-chlorophenyl) phenyl methyl] piperazine-1-yl) ethanol.

Chemical Reaction:

Material Balance:

Process:

4-chlorobenzhyril

piperazine

503.0

2-{4-[4-chlorophenyl)phenyl methyl] piperazine-1-yl}-ethanol

503.0

2-chloroethanol 420.8 Recovered Toluene 571.1 Fresh Toluene 30.1 vapour loss 30.1

Recovered Toluene 571.1 Effluent 2,424.8 Water 2,004.0

Total 3,529.0 Total 3,529.1

Stage‐3



2-{4-[4-chlorophenyl) phenyl methyl] piperazine-1-yl) ethanol, Dimethyl formamide, sodium monochloro acetate, potassium hydroxide was charred to Reactor. Heat reaction mass till completion of reaction. After completion of reaction dichloromethane and water added and layer separated. Dichloromethane distilled to give 2-[2-[(4—chlorophenyl) methyl [1-ppiperazinyl] ethoxy] acetic.

Chemical Reaction:

Material Balance:

2-{4-[4-chlorophenyl)phenyl

methyl] piperazine-1-yl}-ethanol 503.000


501.0

sodium monochloroacetate

414.825 Recovered dichloromethane

2,565.1

Potasium hydroxide 250.498 Vapour loss 42.1 dimethyl formamide 1,136.259 Effluent 4,008.0

Dichloromethane (Fresh)

42.084

Dichloromethane (Recoverd ) 2,565.100


Stage‐4



10. 4-chlorophthalic acid mono sodium salt

Process:

Phallic anhydride is charged in water under stirring sodium hypochlorite solution were added under stirring at moderate temperature after completion of reaction chlorinated product is isolated by diluted with water. The product is filtered; wash with brine solution and centrifuge, dried to give 4-chloropthalic acid mono so

Chemical Reaction:

Material Balance:

Input Qty., Kg Output Qty. Kg

Pthalic anhydride 500.0 Reaction Mass 3,500.0 Sodium Hypochlorite 3,000.0

Total 3,500.0 Total 3,500.0

Reaction Mass 3,500.0 Precipitated 4‐chloropthalic acid mono sodium salt

7,500.0

Water 4,000.0

Total 7,500.0 Total 7,500.0

Precipitated 4‐chloropthalic 7,500.0 4‐chloropthalic 550.0 Effluent 6,950

Total 7,500.0 Total 7,500.0

Stage‐2

Cetrifuge & Drying

Stage‐1



11. Phenyl peri acid magnesium salt

Process:

Aniline is charged to reactor under stirring peri acid dry powder is charged slowly and heat reaction mixture to 150-155°C till reaction completed the excess aniline was recovered by vacuum destination reaction mass is dumped in water and the product is isolated by magnesium sulfate product filtered and washed with water and dry.

Chemical Reaction:

Material Balance:

Input Qty., Kg Process Output Qty. Kg

Aniline (Fresh) 250.0 Phenyl peri acid 400.0 Aniline (Recovered) 950.0 Effluent 2,470.0

Peri acid 400.0 Distilled aniline 950.0 Magnasium Sulfate 220.0 Ammonia 220


Water 1000 Scrub solution 1220Ammonia 220

Total 1,220.0 Total 1,220.0

Stage‐1

Scrubbing



ANNEXURE-7 DETAILS OF EFFLUENT TREATMENT SCHEME

WASTE WATER TREATMENT SCHEME

Waste water generation, Segregation & Treatment Facility

The effluent generated from the various area will be:

• Process Waste water • Washing from plant area. • Domestic use • Utility Blow downs- Boiler, Cooling Tower, DM Plant

The Effluent will be generated from various activities, utility, Operations & domestic activities will be channeled toward common ETP. Where it will be treated in various stages. Effluent generated from plant will be divided into two categories.

• High Concentrated Stream, • Low Concentrated Stream.

Highly concentrated stream will be allowed through pass from volatile organic removal reactor where spent solvents will be remove then it will be pass through single stage evaporation process where condense generated, Condensate of evaporation process and Low concentrated effluent from utility will collected in equalization cum neutralization tank and then treat in ETP followed by Sand filter and activated carbon filter and will be send to NCT

Domestic Effluent will be disposed through Soak pit.



Quality of Process Effluent

Sr. No. Name of Products

Quantity of effluent in KL/Day

pH COD in mg/L

COD in KG/Day

BOD in mg/L

BOD in KG/Day

TSS in mg/L

TSS in KG/Day

TDS in mg/L

TDS in KG/Day

1 Cinnamyl aldehyde & OR

0.383 10-11 604 2.315 150.00 0.06 20 0.0077 400 0.153

2 m-Phenoxy benzyl alcohol & OR

0.000 5-8 --- --- --- --- --- --- --- ---

3 P-anisaldehyde/ 4-methoxy benzaldehyde & OR

3.402 4-6 380 12.948 114.18 0.39 28 0.0107 250 0.096

4 4-Chlorobenzophenone & OR

0.632 3-6 369 2.333 110.70 0.07 50 0.0191 250 0.096

5

2-[4-(4-cyclopropyl carbonyl phenyl]-2-methyl propionic acid cyclohexyl amine salt & OR

2.558 3-6 1142 29.234 342.87 0.88 25 0.0096 750 0.287

6

N-(2-chloro-4-methyl-3-pyridinyl)2-(cyclopropyl amine)-3-pyridinecarboxamide & OR

0.464 4-6 25329 117.429 7598.99 3.52 5 0.0019 3500 1.340

7

Trans-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol hydrochloride & OR

1.512 6-8 1347 20.369 404.19 0.61 10 0.0038 680 0.260



Sr. No. Name of Products

Quantity of effluent in KL/Day

pH COD in mg/L

COD in KG/Day

BOD in mg/L

BOD in KG/Day

TSS in mg/L

TSS in KG/Day

TDS in mg/L

TDS in KG/Day

8 Benzyl alcohol 0.000 6-8 0.00 15.490 0.00 0.00 0 0.0000 0 0.000

9


0.698 6-8 861 6.009 258.34 0.18 10 0.0038 150 0.057

10 4-chloropthalic acid mono sodium salt

2.106 8-10 80 1.667 23.74 0.05 15 0.0057 50 0.019

11 Phenyl peri acid magnasium salt

1.446 8-10 507 7.337 152.24 0.22 15 0.0057 350 0.134



Note:

1) COD < 5000 mg/ lit is consider as Low COD and shall be send to ETP 2) COD > 20000 mg/ lit is consider as high COD and shall be send to first VOC removal

reactor followed by single stage evaporator then its outlet will be sent to ETP.

List of ETP units

Sr. No. Name of Unit No. of Unit Capacity (m3) 1 Collection tank 2 10 2 Flash Mixture 1 0.15 3 Flocculator 1 0.5 4 Lamella type settler 1 4 5 Aeration Tank-1 1 30 6 Secondary hopper bottom settling tank-1 1 10 7 Aeration Tank-2 1 30 8 Secondary clarifier II 1 15 9 Treated Water sump 1 20

10 Sludge Drying Bed-1 Nos. 1 10 11 Sludge Drying Bed-2 Nos. 1 5 12 Pressure Send Filter 1 0.63 13 Activated Carbon Filter 1 0.63 14 Volatile organic compound removal

reactor 1 10

15 Single stage Evaporator 1 10

EFFLUENT QUALITY

Quality of High COD stream going to Volatile organic compound removal reactor

Sr.No. Parameter Unit Inlet to VOC removal reactor

Outlet of Single stage evaporator

1 pH - 6.5-8.5 7-8 2 TDS mg/lit 3000‐ 4000 400-500 3 SS mg/lit 50-100 <2 4 COD mg/lit 20000‐30000 1000-2000 5 BOD mg/lit 5000‐8000 300-500 6 Ammonical Nitrogen

(ppm) mg/lit 100‐150 --



Stage wise Quality of low COD Wastewater

Sr. No.

Parameter

Unit Inlet low COD

Outlet of Single stage evaporator

Final ETP Inlet

Primary Treatment

Outlet of Secondary settling tank-01

Outlet of secondary settling tank-02

After Sand Carbon filter

1 pH -- 5-10 7-8 7-8 7-8 7-8 7-8 7.6 2 TDS mg/li

t 4000-7000

400-500 2000-3000

2000-3000

2000-3000

2000-3000 2000-3000

3 SS mg/lit

400-600 <2 200-250

150-200 100-150 100-150 80-100

4 COD mg/lit

3000-5000

1000-2000 2000-3000

1800-2700

500-800 250-300 200-250

5 BOD mg/lit

1000-2000

300-500 1000-1200

900-1000

150-200 50-100 50-100

Process Description of Effluent Treatment Plant

VOC removal reactor & Single Stage Evaporator

High Concentrated Process Effluent from plant will be collected in Equalization Tank-1 and then it will be treated in to Volatile organic compound removal reactor.

Volatile organic compound removal reactor will reduce remaining solvent from waste water and by then single stage evaporation process will reduce maximum high COD/TDS. Condensate of single stage Evaporator will be transfer to ETP for further treatment & Evaporation salt will be send to TSDF for landfilling.

ETP

Primary Treatment:

The effluent from plant, utility and filtrate from filter press will taken to equalization tank-2, the effluent is neutralized between pH 8.5 to 9.0 and transferred to flash mixture.

Flash Mixer

Alum solution will be prepared in dosing tank I. The solution will be dosed to flash mixer tank through dosing tank.



Flocculator

Poly solution of 1 % will be prepared in Dosing tank II. The solution will be dosed to flocculator dosing tank.

Lamella Type Tube Settler

The effluent will be settled in lamella type Tube settler. The clarified water will be discharged to sump and sludge will be discharges to sludge bed or dewatered through filter press.

Aeration Tank- I

The treated effluent from tube settler by gravity line after ensuring pH between 7.5 to 8.5. The COD inlet to aeration Tank-I is always maintained below 1800-2700 mg/lit.

MLSS=4000 mg/lit OR F/M= 0.10 to 0.12

Secondary Settling Tank I (SST- I)

The effluent from Aeration Tank I is discharged to SST – I, through gravity line. The pH at this stage have to be between 7.5 to 8.5. The settled sludge is recycled to Aeration tank I. The over flow is discharged to aeration Tank II.

Aeration Tank II

The treated supernatant from SST I is discharged to aeration tank II by gravity line after ensure pH between 7.5 and 8.5 The COD inlet to Aeration Tank I is always maintained below 500-800 mg/lit.

MLSS=3500 mg/lit OR F/M= 0.10 to 0.12

Secondary Settling Tank II (SST II)

The effluent from Aeration tank - I is discharged to SST II Through gravity line. The pH at this stage shall have to be between 7.5 and 8.0. The settled sludge is recycled to aeration Tank II.

Pressure Sand Filter

The neutral effluent will be pass through pressure sand filter for further reduction in suspended solids.

Activated Carbon Filter

From pressure sand filter, effluent will be allows through activated carbon filter for to remove color of effluent & to remove partial.



ETP Diagram:



ANNEXURE – 8

DETAILS OF WATER CONSUMPTION Category

Quantity

KLD Remarks

(A) Domestic 5

(B) Gardening 3

(C) Industrial

Process 5.468 1.77 KLD will be recycle in process

Washing 2.5

Boiler 1

Cooling 2.5

Others 0.941 Water use for Scrubbing

Industrial Total 12.41

Total (A + B + C) 20.41 Total Fresh Water -18.64KLD & Internal Recycled Water – 1.77 KLD

1) Total water requirement for the project: 20.41 KLD

2) Quantity to be recycled: 1.77 KLD (Internal Recycled)

3) Total fresh water requirement: 18.64 KLD



DETAILS OF WASTE WATER GENERATION

Category Waste water

KLD

Remarks

(A) Domestic 4 Disposed through Soak pit

(B) Industrial

Process 6.895 Treated in to VOC removal

reactor & Single stage

evaporator then send to ETP

Washing 2.5

Boiler 0.002

Cooling 0.11

Others 1.389 Scrub Solution HCl , Na2SO4

& Ammonium Sulphate will

be generated and treated in to

in house ETP

Total Industrial waste

water

10.896

Total [A + B] 14.896



Water Balance Diagram



ANNEXURE 9

DETAILS OF ENERGY & FUEL CONSUMPTION

Sr.

No.

Particulars Requirement Remark

1. Electricity 140 KVA Will be met through Electricity

company

2 Bio Coal 1 MT/day Local Supplier

3. Natural Gas 45 Nm3/Hr Local Supplier

4. Diesel (in case of power

failure, DG set will be

operated)

130 Liter/ Hr. Local suppliers



ANNEXURE-10 DETAILS OF HAZARDOUS WASTE

Sr. No.

Name of Hazardous Waste

Category

Total Quanti

ty MT/Ye

ar

Source of Generation Mode of Disposal

1 Effluent Treatment Plant Sludge

35.3 296 From ETP Collection, Storage & Send to TSDF for landfilling

2 Evaporator salt 35.3 4 From Single stage Evaporator

Collection, Storage & Send to TSDF for landfilling

3 Used Oil 5.1 0.6 From Lubrication Collection, Storage, Sold to MoEF Approved Vendors.

4 Empty Barrels/ Containers/ Liners Contaminated with hazardous chemicals/ wastes

33.1 14 From Packing Material

Collection, Storage, decontami nation, Sold to GPCB, approved Vendors

5 Process Residue and wastes / Distillation Residue & NaCl Salt

28.1 154 Production process of m-Phenoxy benzyl alcohol & NaCl salt will be generated from benzyl alcohol

Collection, Storage, Send for Incineration/co- processing

6 Spent Carbon (From ETP )

28.3 1 Activated Carbon filter Collection, Storage, Send for Incineration/co- processing

7 Spent Carbon Solvent Recovery System

28.3 1 Carbon tower of Solvent recovery System


8 Spent Solvent 28.6 100 From Production process & VOC removal reactor


9 Date-expired products

28.5 50 From premises Collection, Storage, Send for Incineration/co- processing

10 Off specification products

28.4 50

Production process Collection, Storage, Send for Incineration/co- processing

11 Spent catalyst 28.2 4 Production process of Benzyl alcohol and or 4-Chlorobenzophenone

Collection, Storage, Send for authorised regenerator

12 Scrubbed Solution Na2SO4 10% to 20 %

C2 200 Scrub solution will be generates from 4-Chlorobenzophenone

Send to ETP for treatment.



13 Scrubbed Solution HCl 10% to 20 %

C2 160 Scrub solution will be generates from 4-Chlorobenzophenone


14 Scrubbed Solution HCl 30%

C2 252 Scrub solution generates from 2-[4-(4-cyclopropyl carbonyl phenyl]-2-methyl propaonic acid cyclohexylamine salt

Recycle in process

15 Scrubbed Solution Ammonium sulphate 10% to 20 %

C2 160 Scrub solution generates from Phenyl peri acid magnasium salt

Send to ETP for treatment

16 Spent Sulphuric acid C2 250 Scrub solution generates from P-anisaldehyde/ 4-methoxy benzaldehyde


OTHER NON HAZARDOUS WASTE

Sr. No. Waste Quantity Mode Of Disposal

1. Glass Waste ( Z 13) 0.1 MT/month To TSDF. 2. Paper waste (Z44) 0.5 MT/month At notified area facility. 3. Bio-Medical Waste 0.05 MT/month Will be disposed off as per Bio Medical

Waste Rules. 4. Wooden Waste 2 MT/month Authorized Scrap Vendors. 5. Used Batteries 0.1 MT / month Authorized Scrap Vendors. 6 Fly Ash 3 MT / Month Send to authorize Brick manufactures



ANNEXURE- 11

DETAILS OF FLUE GAS EMISSION

DETAILS OF PROCESS GAS EMISSION

Sr.

No.

Stack

Attached To

Stack

Height(m)

Air Pollution

Control System Parameter Permissible Limit

1 Reactor Vent 17 Water Scrubber

Followed by

Alkali Scrubber

SO2

HCl

40 mg/Nm3

30 mg/Nm3

2 Reactor Vent 17 HCl 30 mg/Nm3

3 Reactor Vent 17 Acid Scrubber Ammonia 175 mg/Nm3

Sr. No.

Stack Attached to

Fuel Consumption Stack Height

in meter

APCM

Probable Pollutants

Permissible Limit

01 Steam Boiler

1 TPH

Bio Coal 1 MT /day

12 Bag Filter PM SO2 NOX

150 mg/Nm3 100 ppm 50 ppm 02 Thermic Fluid

Heater 2 Nos. (0.5 lac Kg Cal/hr.)

Natural Gas 45 Nm3/Hr

Adequate Stack Height

03 DG Set

125 KVA

Diesel 130 Lit/ Hr.

09 Adequate Stack Height



ANNEXURE-12

DETAILS OF SOLVENT RECOVERY

A solvent recovery system comprises of two stage heat exchangers. Cooling tower water will be

circulated in primary heat exchanger and in secondary heat exchanger chilled water circulation is

done. The uncondensed solvent after the secondary heat exchanger will be diverted to water

scrubber the traces of solvent will get dissolved in water. On getting saturation, the solvent mix

water will be subjected for recovery of solvent (if feasible) and/or water will be diverted to ETP

plant for further treatment the process will ensure no VOC emission from solvent recovery

system.

The scrubbing system consists of a scrubber (packed column absorber), an exhaust blower and

scrubbing media circulation via pumps followed by carbon adsorption tower. The vapors coming

from the process vents and raw material storage area enters the primary scrubber where they are

absorbed in water. Thus, the air leaving from the scrubber is clean, which is again feed into the

secondary tower consists of carbon to trap any remaining VOC. The figure of scrubber system is

given below as figure.



FLOW DIAGRAM OF SOLVENT RECOVERY SYSTEM

Vent

Carbon Adsorption

Reactor

Primary Condenser

Cooling Tower i

Secondary Condenser

Chilled Water

i l iSpray

Water Tank

Receiver Un scrubbed VOCs

VOC



Details of Solvent Recovery

Sr. No.

Name of Representative Product

Product Quantity in MT/Month

Name of Solvent used

Solvent Recovered Quantity in MT/Month

% Recovery

31 P-anisaldehyde/ 4-methoxy benzaldehyde

5

Toluene 9.917 96

52 2-[4-(4-cyclopropyl carbonyl phenyl]-2-methyl propionic acid cyclohexyl amine salt

Methanol 28.559 96.24 Toluene 6.108 98.49 Di chloromethane 10.032 97.67

63 N-(2-chloro-4-methyl-3-pyridinyl)2-(cyclopropyl amine)-3-pyridinecarboxamide

Toluene 4.152 92

Methanol 5.776 99.9 74 Trans-4-(2-amino-3,5-dibromo

benzyl amino)cyclohexanol hydrochloride (Ambroxol hydrochloride)

Toluene 22.737 96 Methanol 6.316 89.22 Isopropylalcohol 20.211 96

95 2-[4-[4-chlorophenyl)phenyl methyl [1-piperazinyl] ethoxy] acetic

1 Methanol 2.355 98.53 Toluene 2.497 95.06 Di chloromethane 5.120 98.39


M/s. Jyoti Om Chemical Research Centre Pvt Ltd 42

ANNEXURE-13 LIST OF HAZARDOUS CHEMICALS AS PER MSIHC RULES

Sr. No. Name of Chemicals 1 Acetaldehyde 2 Sodium hydroxide 3 Hydrogen 4 p-Cresol 5 Dimethyl sulfate 6 Sulphuric Acid 7 Magnesium oxide 8 Toluene 9 Thionyl chloride 10 Dimethyl formamide 11 Benzene 12 Aluminium chloride 13 Dimethyl amine 14 4-Chloro butyryl chloride 15 Dichloromethane 16 Hydrochloric acid 30% 17 cyclohexyl amine 18 3-Amino-2-chloro-4-methyl pyridine 19 Methanol 20 Bromine 21 Potassium bromide 22 Isopropyl alcohol 23 Sodium borohydrate 24 Benzyl chloride 25 sodium carbonate 26 Piperazine 27 sodium monochloroacetate 28 Potassium hydroxide 29 Pathallic anhydride 30 Sodium hypochlorite 31 Aniline

ADMIN

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Annexure- 15

ADMIN

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M/s. Maitri Pharma, GIDC Jhagadia- Bharuch · M/s. Maitri Pharma, GIDC Jhagadia- Bharuch M/s. Jyoti Om Chemical Research Centre Pvt Ltd