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NAJAARSSYMPOSIUM 2017 – FALL SYMPOSIUM 2017

NEDERLANDSE FEDERATIE VOOR NEFROLOGIE – DUTCH FEDERATION OF NEPHROLOGY

(99STE WETENSCHAPPELIJKE VERGADERING)

Date Friday, October 13th, 2017 The NFN fall symposium is part of the Science Day (“Wetenschapsdag”), with parallel programs by:

The Dutch Federation for Nephrology (NFN)

The Dutch Kidney Patients Association (NVN)

The Dutch Kidney Foundation (NSN)

Niernieuws.nl

Venue Postillion Hotel Bunnik (http://www.postillionhotels.com/nl-nl/hotels/postillion-hotel-utrecht-bunnik) Address

Kosterijland 8 3981 AJ Bunnik The Netherlands

Detailed Directions & Public Transportation http://www.postillionhotels.com/nl-nl/hotels/postillion-hotel-utrecht-bunnik/location-directions Program and abstract book files: https://www.nefro.nl/ Registration Not required. Contact Dr. Johan van der Vlag (Johan.vandervlag@radboudumc.nl; 024-3616539 or 0614649134)

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NAJAARSSYMPOSIUM 2017 – FALL SYMPOSIUM 2017

NEDERLANDSE FEDERATIE VOOR NEFROLOGIE – DUTCH FEDERATION OF NEPHROLOGY

(99STE WETENSCHAPPELIJKE VERGADERING)

Program at a glance

Welcome 10.00-10.30 Welcome with coffee and tea

Morning session & Poster Highlights 10.30-11.00 Junior invited lecture:

FIBROBLAST GROWTH FACTOR 23 – BEYOND PHOSPHATE Dr. Martin de Borst Dept. of Nephrology, University Medical Center Groningen, Groningen

11.00-12.24 Oral abstract presentations 12.24-12.42 Short (3-minute) plenary presentations of selected posters 12.42-12.50 News from PLAN

Break & Poster Discussion 12.50-13.30 Lunch and time for discussion 13.30-14.30 Moderated parallel poster sessions A through F

Afternoon Session & Awards Session 14.30-15.54 Oral abstract presentations 16.00-16.30 Senior invited lecture:

PITFALLS AND PROSPECTS IN BIOENGINEERING STRATEGIES FOR KIDNEY REGENERATION Prof. Dr. Roos Masereeuw Dept. of Pharmaceutical Sciences, Utrecht University, Utrecht

16.30-17.00 NFN award session (joint closing session with NVN, Niernieuws.nl and NSN): Prizes will be awarded & awardees will pitch their research.

17.00 Drinks

Friday October 13th, 2017 Postillion Hotel Bunnik Kosterijland 8 3981 AJ Bunnik

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Full Program

Welcome 10.00-10.30 Welcome with coffee and tea, and mounting of posters

Morning session Location: will be indicated after entrance at the beginning of the day Chair: Prof. Dr. R.T. Gansevoort 10.30-11.00 Junior invited lecture:

FIBROBLAST GROWTH FACTOR 23 – BEYOND PHOSPHATE Dr. Martin de Borst Dept. of Nephrology, University Medical Center Groningen, Groningen

11.00-11.12 O1. DIETARY SODIUM RESTRICTION VERSUS DIURETICS FOR SALT-SENSITIVE HYPERTENSION IN CHRONIC KIDNEY DISEASE D.M. Bovée

1, A.H.J. Danser

1, R. Zietse

1, E.J. Hoorn

1

1Dept. of Nephrology,

Erasmus MC, Rotterdam, The Netherlands

11.12-11.24 O2. MAGNESIUM PREVENTS VASCULAR CALCIFICATION BY INHIBITION OF HYDROXYAPATITE CRYSTAL FORMATION Anique D. ter Braake,

1 Paul T. Tinnemans,

2 Catherine M. Shanahan,

3 Joost G. J. Hoenderop,

1

and Jeroen H. F. de Baaij1,4

1Dept. of Physiology, Radboud Institute for Molecular Life Sciences, Radboud university medical center,

Nijmegen, The Netherlands,2Institute for Molecules and Materials, Radboud University, Nijmegen, The

Netherlands,3BHF Centre of Research Excellence, Cardiovascular Division, King’s College, London,

United Kingdom 4Dept. of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom

11.24-11.36 O3. G2/M CYCLE ARREST IN HUMAN TRANSPLANTED KIDNEYS CORRELATES TO THE DEVELOPMENT OF FIBROSIS, FUNCTIONAL DECLINE AND GRAFT LOSS T.T. Pieters

1, T. Vanhove

3, T.Q. Nguyen

2, M.C. Verhaar

1, D. Kuypers

3, R. Goldschmeding

2,

M.B. Rookmaaker1

1Dept. of Nephrology and Hypertension, and

2Pathology, University Medical Center Utrecht, The

Netherlands, 3Dept. of Nephrology, University Hospitals of Leuven, Belgium

11.36-11.48 O4. VALUE-BASED EVALUATION OF DIALYSIS VERSUS CONSERVATIVE CARE IN OLDER PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE Wouter R Verberne¹, Janneke Dijkers¹, Johannes C Kelder

2, Tom B M Geers¹, Wilbert T

Jellema¹, Hieronymus H Vincent¹, Johannes J M van Delden3, Willem Jan W Bos¹

¹Dept. of Internal Medicine; 2Dept. of Clinical Epidemiology and Medical Statistics, St Antonius

Hospital, Nieuwegein, The Netherlands; 3University Medical Centre Utrecht, Julius Centre for Health

Sciences and Primary Care, Utrecht, The Netherlands

11.48-12.00 O5. GLOMERULAR ENHANCER OF ZESTE HOMOLOG-2 (EZH2) HISTONE METHYLTRANSFERASE REDUCES GLOMERULAR ENDOTHELIAL GLYCOCALYX DURING DIABETIC NEPHROPATHY BY REGULATING HYALURONAN SYNTHESIS Marloes Sol

1, Jiedong Qiu

2, Johan van der Vlag

3, Jacob van den Born

4, Benito A. Yard

2, Jan-

Luuk Hillebrands1, Jan A.A.M. Kamps

1, Guido Krenning

1

1 Dept. of Pathology and Medical Biology and

4 Dept. Internal Medicine, Div. Nephrology University

Medical Center Groningen, The Netherlands, 2 Dept. of Nephrology, University of Heidelberg,

Germany, 3 Dept. of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands

12.00-12.12 O6. A NOVEL ENDOTHELIAL CELL BASED COMPLEMENT DEPENDENT CYTOTOXICITY TEST IN KIDNEY TRANSPLANTATION R.G.M. Lammerts; J. van den Born; W.A. Dam; B.G. Hepkema; BJ Kroesen; M.R. Daha; M.A.J. Seelen; S.P. Berger Dept. Internal Medicine, Div. Nephrology, University Medical Center Groningen, The Netherlands

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12.12-12.24 O7. ANGIOTENSIN-NEPRILYSIN INHIBITION CAUSES A BLOOD-PRESSURE INDEPENDENT RENOPROTECTIVE EFFECT IN DIABETIC HYPERTENSIVE RATS Estrellita Uijl

12, Lodi C.W. Roksnoer

12, Marian C. van Groningen

3, Robert Zietse

2, Jaap A.

Joles4, Ewout J. Hoorn

2 and A.H. Jan Danser

1

1Division of Pharmacology and Vascular Medicin &

2Division of Nephrology and Transplantation, Dept.

of Internal Medicin & 3Dept. of Pathology Erasmus MC, Rotterdam, The Netherlands

4Dept. of

Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands

Poster Highlights (plenary session) Chair: Prof. Dr. R.T. Gansevoort 12.24-12.27 P1. SODIUM-SENSITIVE BLOOD PRESSURE RESPONSE IN TYPE 1 DIABETES IS

ACCOMPANIED BY IMPEDED SKIN LYMPHANGIOGENESIS E.F.E. Wenstedt

1; N.M.G. Rorije

1; R.H.G. Olde Engberink

1; B.J.H. van den Born

2; J. Aten

3; L.

Vogt1

Dept. of Internal Medicine, 1Division of Nephrology

2Division of Vascular Medicine,

3Dept. of

Pathology, Academic Medical Center, University of Amsterdam, the Netherlands

12.27-12.30 P2. NPHP1 GENE DELETIONS CAUSE ESRD IN 0.9% OF ADULT-ONSET CASES Snoek R

1*, van Setten J

2, Keating BJ

3, van der Zwaag A

1, Knoers NVAM

1, de Borst MH

4*, van

Eerde AM1*

1Dept. of Genetics and Center for Molecular Medicine,

2Dept. of Cardiolog, University Medical Center

Utrecht, The Netherlands 3Dept. of Surgery, Penn Transplant Institute, Philadelphia, PA, USA,

4 Dept. of

Nephrology, University Medical Center Groningen, The Netherlands (*TransplantLines consortium)

12.30-12.33 P3. LONG-TERM OUTCOMES OF ARTERIOVENOUS FISTULAS AND GRAFTS IN A LARGE EUROPEAN COHORT Bram M Voorzaat

1, Koen EA van der Bogt

2, Friedo W Dekker

3, Joris I Rotmans

1

Depts. of Internal 1Medicine,

2Surgery and

3Clinical Epidemiology, Leiden University Medical Center

12.33-12.36 P4. DYSLIPIDEMIA IN NEPHROTIC RATS ASSOCIATES WITH ABNORMALITIES IN HEPATIC LIPOPROTEIN RECEPTORS Pragyi Shrestha

1, Daphne Dekker

2, Wendy Dam

1, Bart van de Sluis

2, Jacob van den Born

1

1Dept. Nephrology and

2Dept Pediatrics, section Molecular Genetics, University Medical Center

Groningen, The Netherlands

12.36-12.39 P5. THE LIMITS OF COLD ISCHEMIA TIME IN KIDNEY TRANSPLANTATION OF DECEASED DONORS Hessel Peters-Sengers

1, Julia H.E. Houtzager

2, Mirza M. Idu

b, Martin B.A. Heemskerk

3, L.W.

Ernest van Heurn2, Jaap J. Homan van der Heide

1, Stefan P. Berger

4, Jesper Kers

5, Thomas

M. van Gulik2, Frederike J. Bemelman

1

1Dept. of Nephrology,

2Dept. of Surgery,

5Dept. of Pathology, Academic Medical Center, Amsterdam,

the Netherlands 3Dutch Transplant Foundation, Leiden, the Netherlands,

4Dept. of Nephrology,

University Medical Center Groningen, Groningen, the Netherlands

12.39-12.42 P6. EFFECT OF SGLT2 INHIBITION ON FIBROBLAST GROWTH FACTOR 23 AND 25(OH) VITAMIN D IN THE IMPROVE TRIAL M.A. de Jong

1, S.I. Petrykiv

2, G.D. Laverman

3, D. de Zeeuw

2, Stephan J.L. Bakker

1, H.J.L.

Heerspink2 M.H. de Borst

1

Div. of 1

Nephrology and 2Pharmacology, UMCG, Groningen, the Netherlands,

3 Dept of Nephrology,

ZGT, Almelo and Hengelo, the Netherlands

12.42-12.50 News from PLAN (NFN PLAtform young investigators Nephrology)

Break 12.50-13.30 Lunch and time for discussion

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Poster Discussion (parallel sessions) 13.30-14.30 Poster sessions A, B, C, D, E and F (maximal 7 minutes presentation & discussion)

(See page 7 – 12 of the program for details)

Afternoon Session Location: will be indicated after entrance at the beginning of the day Chair: Dr. J. van der Vlag 14.30-14.42 O8. METABOLITE-SENSING IN HUMAN PROXIMAL TUBULE EPITHELIAL CELLS

STIMULATES INDOXYL SULFATE SECRETION Jitske Jansen

1, Katja Jansen

1, Amr Othman

1, Ruben Poesen

2, Björn Meijers

2, Majorie B. van

Duursen3, Rosalinde Masereeuw

1

1Div. Pharmacology, Utrecht Institute for Pharmaceutical Sciences,

3Institute for Risk Assessment

Sciences, Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. 2Dept. of Microbiology

and Immunology, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium

14.42-14.54 O9. IN VITRO MODELS TO DETECT CIRCULATING PERMEABILITY FACTORS IN PATIENTS WITH RECURRENT FSGS Den Braanker DJW

1, Deegens JKJ

1, Maas R

1, Schreuder MF

2, Wetzels JFM

1, van der Vlag J

1,

Nijenhuis T1

1Depts. of Nephrology &

2Pediatric Nephrology, Radboud University Medical Center, Nijmegen, the

Netherlands

14.54-15.06 O10. HEPARAN SULFATE BIOSYNTHESIS ENZYMES DIFFERENTIALLY DETERMINE COMPLEMENT FACTOR H/FACTOR H-RELATED PROTEIN BINDING TO GLOMERULAR ENDOTHELIAL CELLS Markus A. Loeven

1, Simon C. Satchell

2, Toin H. van Kuppevelt

3, Johan van der Vlag

1

Depts. of 1Nephrology and

3Biochemistry, Radboud University Medical Center, Nijmegen, the

Netherlands 2

Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom

15.06-15.18 O11. PRIMARY COENZYME Q10 DEFICIENCY AND RENAL DISEASE: CASE SERIES AND REVIEW OF LITERATURE Anne M. Schijvens

1, Charlotte M.H.H.T. Bootsma-Robroeks

1, H.J. (Eric) Steenbergen

2, E.A.M.

(Marlies) Cornelissen1, Nicole C.A.J. van de Kar

1, Michiel F. Schreuder

1 Depts of

1Pediatric Nephrology, Amalia Children’s Hospital, and

2Pathology, Radboud university

medical center, Nijmegen, the Netherlands

15.18-15.30 O12. BONE MARROW DERIVED MYELOID CELLS CONTRIBUTE TO TISSUE CAPSULE FORMATION IN A RAT MODEL OF CHRONIC KIDNEY DISEASE FOR GENERATION OF IN VIVO TISSUE ENGINEERED BLOOD VESSELS T. Bezhaeva

1, W. Geelhoed

1, D. Wang

2, H. Yuan

2, F.R.Damanik

3, AJ van Zonneveld

1, P.H.A.

Quax4, L.Moroni

3, Song Li

2 and J.I. Rotmans

1

Depts. of 1Internal Medicine and Einthoven Laboratory for Experimental Vascular Medicine, and

4Vascular Surgery, Leiden University Medical Center, The Netherlands

2Dept. of Bioengineering,

University of California, Los Angeles, USA ; 3Dept. of Regenerative Medicine, Maastricht University,

The Netherlands 15.30-15.42 O13. CHROMATIN CONFORMATION LINKS DISTAL TARGET GENES TO CHRONIC

KIDNEY DISEASE LOCI Maarten M. Brandt

1 Claartje A. Meddens

2,4 Laura Louzao-Martinez

3 Noortje A.M. van den

Dungen5 Nico R. Lansu

2,4,5 Edward E.S. Nieuwenhuis

2 Dirk J. Duncker

1 Marianne C. Verhaar

3

Jaap A. Joles3 Michal Mokry

2,4,5 Caroline Cheng

1,3

1Experimental Cardiology, Department of Cardiology, Thoraxcenter Erasmus University Medical

Center, Rotterdam, The Netherlands; 2Dept. of Pediatrics, Wilhelmina Children’s Hospital,

3Dept. of

Nephrology and Hypertension, Division of Internal Medicine and Dermatology 4Regenerative Medicine

Center Utrecht 5Epigenomics facility, University Medical Center Utrecht, Utrecht, The Netherlands

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15.42-15.54 O14. DIAGNOSTIC EXOME SEQUENCING IN 254 DUTCH PATIENTS WITH FAMILIAL AND SPORADIC KIDNEY DISEASE Ilse M. Rood

1, Marlies E.A. Cornelissen

2, Jeroen K.J. Deegens

1, Tom Nijenhuis

1, Rutger J.

Maas1, Erik-Jan Kamsteeg

3, Nicole van de Kar

2, Linda Koster

2, Jeroen Schoots

3, Michiel F.

Schreuder2, Jack F.M. Wetzels

1, Ernie M.H.F. Bongers

3*, Dorien Lugtenberg

3*†

Depts. of 1Nephrology,

2Pediatrics, and

3Human Genetics, Radboud University Medical Center,

Nijmegen, The Netherlands

16.00-16.30 Senior invited lecture: PITFALLS AND PROSPECTS IN BIOENGINEERING STRATEGIES FOR KIDNEY REGENERATION Prof. Dr. Roos Masereeuw Dept. of Pharmaceutical Sciences, Utrecht University, Utrecht

NFN award session (joint closing session with Nierpatiënten Vereniging Nederland, Niernieuws.nl and Nierstichting Nederland) Location: will be indicated after entrance at the beginning of the day Chair: Prof. Dr. R.T. Gansevoort

16.30-17.00 NFN prizes will be awarded & awardees will pitch their research:

500 EURO, first prize oral presentation

250 EURO, second prize oral presentation

100 EURO, third prize oral presentation

100 EURO, poster prize 17.00 Drinks

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Poster session A (Posters selected for short plenary oral communications) Location: will be indicated after entrance at the beginning of the day Chairs: Prof. Dr. Ron Gansevoort (Science section NFN) + Maarten de Jong (PLAN member) P1. SODIUM-SENSITIVE BLOOD PRESSURE RESPONSE IN TYPE 1 DIABETES IS ACCOMPANIED BY IMPEDED SKIN LYMPHANGIOGENESIS E.F.E. Wenstedt

1; N.M.G. Rorije

1; R.H.G. Olde Engberink

1; B.J.H. van den Born

2; J. Aten

3; L. Vogt

1

Dept. of Internal Medicine, 1Division of Nephrology

2Division of Vascular Medicine,

3Dept. of Pathology, Academic Medical

Center, University of Amsterdam, the Netherlands

P2. NPHP1 GENE DELETIONS CAUSE ESRD IN 0.9% OF ADULT-ONSET CASES Snoek R

1*, van Setten J

2, Keating BJ

3, van der Zwaag A

1, Knoers NVAM

1, de Borst MH

4*, van

Eerde AM1*

1Dept. of Genetics and Center for Molecular Medicine,

2Dept. of Cardiolog, University Medical Center

Utrecht, The Netherlands 3Dept. of Surgery, Penn Transplant Institute, Philadelphia, PA, USA,

4 Dept. of

Nephrology, University Medical Center Groningen, The Netherlands (*TransplantLines consortium)

P3. LONG-TERM OUTCOMES OF ARTERIOVENOUS FISTULAS AND GRAFTS IN A LARGE EUROPEAN COHORT Bram M Voorzaat

1, Koen EA van der Bogt

2, Friedo W Dekker

3, Joris I Rotmans

1

Depts. of Internal 1Medicine,

2Surgery and

3Clinical Epidemiology, Leiden University Medical Center

P4. DYSLIPIDEMIA IN NEPHROTIC RATS ASSOCIATES WITH ABNORMALITIES IN HEPATIC LIPOPROTEIN RECEPTORS Pragyi Shrestha

1, Daphne Dekker

2, Wendy Dam

1, Bart van de Sluis

2, Jacob van den Born

1

1Dept. Nephrology and

2Dept Pediatrics, section Molecular Genetics, University Medical Center Groningen, The Netherlands

P5. THE LIMITS OF COLD ISCHEMIA TIME IN KIDNEY TRANSPLANTATION OF DECEASED DONORS Hessel Peters-Sengers

1, Julia H.E. Houtzager

2, Mirza M. Idu

b, Martin B.A. Heemskerk

3, L.W. Ernest van Heurn

2,

Jaap J. Homan van der Heide1, Stefan P. Berger

4, Jesper Kers

5, Thomas M. van Gulik

2, Frederike J. Bemelman

1

1Dept. of Nephrology,

2Dept. of Surgery,

5Dept. of Pathology, Academic Medical Center, Amsterdam, the Netherlands

3Dutch

Transplant Foundation, Leiden, the Netherlands, 4Dept. of Nephrology, University Medical Center Groningen, Groningen, the

Netherlands

P6. EFFECT OF SGLT2 INHIBITION ON FIBROBLAST GROWTH FACTOR 23 AND 25(OH) VITAMIN D IN THE IMPROVE TRIAL M.A. de Jong

1, S.I. Petrykiv

2, G.D. Laverman

3, D. de Zeeuw

2, Stephan J.L. Bakker

1, H.J.L. Heerspink

2 M.H. de

Borst1

Div. of 1

Nephrology and 2Pharmacology, UMCG, Groningen, the Netherlands,

3 Dept of Nephrology, ZGT, Almelo and

Hengelo, the Netherlands

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Poster session B (Clinical Nephrology) Location: will be indicated after entrance at the beginning of the day Chairs: Dr. H. de Jong (Science section NFN) + Sjoerd Timmermans (PLAN member) P7. DIETARY PROTEIN AND KIDNEY FUNCTION DECLINE IN OLDER POST-MYOCARDIAL INFARCTION PATIENTS: THE ALPHA OMEGA COHORT STUDY Kevin Esmeijer

1,2, Johanna M. Geleijnse

3, Johan W. de Fijter

1, Daan Kromhout

3,4, Ellen K. Hoogeveen

1,2,5

1. Dept. of Nephrology, Leiden University Medical Center, Leiden, The Netherlands, 2. Dept. of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, 3. Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands, 4. Dept. of Epidemiology,University Medical Center Groningen, Groningen, The Netherlands, 5. Dept. of Nephrology, Jeroen Bosch Hospital, Den Bosch, the Netherlands

P8. COMPARISON OF ESTIMATED VERSUS MEASURED GFR DECLINE IN THE ASSOCIATION WITH ESRD AND MORTALITY Marieke HC van Rijn, Karen Leffondre Marie Metzger, Martin Flamant, Jean-Philippe Haymann, Benedicte Sten-gel, Jan AJG van den Brand Department of Nephrology, Radboudumc, Nijmegen, The Netherlands (on behalf of the NephroTest study group)

P9. CLINICAL CONSEQUENCES OF DIFFERENT ALBUMIN MEASUREMENT METHODS IN PATIENTS WITH MEMBRANOUS NEPHROPATHY Anne-Els van de Logt

1, Coralien Vink

1, Sanna Rijpma

2, Miranda van Berkel

2, Jack Wetzels

1

1 Dept. Nephrology and

2Clinical Laboratory, Radboudumc, Nijmegen, The Netherlands

P10. EXPLAINING FACTORS FOR ETHNIC DIFFERENCES IN ESTIMATED GFR IN THE NETHERLANDS : THE HELIUS STUDY B.J.M.V. Huisman, B. Hafkamp, C. Agyemang, M.B. Snijder, R.J.G Peters, B.J.H van den Born, L.Vogt. Division of Nephrology, Academic Medical Center, Amsterdam, The Netherlands

P11. GENETIC RESEARCH IN STRUCTURAL KIDNEY MALFORMATIONS IN HUMANS: WHAT’S NEXT? Anukrati Nigam, Nine V.A.M. Knoers, and Kirsten Y. Renkema Department of Genetics, Center for Molecular Medicine, UMC Utrecht, Utrecht University, Utrecht, The Netherlands

P12. DECLINE OF KIDNEY FUNCTION DURING THE PRE-DIALYSIS PERIOD IN CHRONIC KIDNEY DIS-EASE PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS Cynthia J. Janmaat

1, Merel van Diepen

1, Cheyenne C.E. van Hagen

1, Joris I. Rotmans

2, Friedo W. Dekker

1, Olaf

M. Dekkers1,2

Departments of

1Clinical Epidemiology and

2Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Poster session C (Clinical Nephrology: Transplantation and dialysis) Location: will be indicated after entrance at the beginning of the day Chairs: Prof. Dr. Frederike Bemelmans (Science section NFN) + Laura Michielsen (PLAN member) P13. ESTIMATED GFR TO PREDICT POST-DONATION RENAL FUNCTION IN LIVING KIDNEY DONORS Marco van Londen, Jessica van der Weijden, Stephan J.L. Bakker, Stefan P. Berger, Gerjan Navis, and Martin H. de Borst Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands

P14. PREGNANCY IN RENAL TRANSPLANT PATIENTS: IS AZATHIOPRINE BETTER THAN A CALCINEURIN INHIBITOR? Dorien Feyaerts

1, Lina Rigodanzo Marins

1, Bram van Cranenbroek

1, Olivier W.H. van der Heijden

2, Henk W. van

Hamersvelt3, Irma Joosten

1, Renate G.

van der Molen

1

1Departments of Laboratory Medicine,

2Obstetrics and Gynaecology,

3Nephrology, Radboud University Medical Center,

Nijmegen, The Netherlands

P15. PERITUBULAR CAPILLARY LOSS IN THE FIRST MONTH AFTER KIDNEY TRANSPLANTATION IS MORE PRONOUNCED IN PATIENTS WITH REJECTION COMPARED TO DELAYED GRAFT FUNCTION Anke A. Keijbeck

1, Floor M.E.G. Steegh

1, Mariëlle A.C.J. Gelens

2, Ernst L.W. van Heurn

3, Maarten H.L.

Christiaans2, Carine J. Peutz-Kootstra

1

Department of 1Pathology,

2Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.

3Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands

P16. ROUTINE HEMODIALYSIS DOES NOT RESULT IN OPTIMAL PLASMA MAGNESIUM CONCENTRATIONS Niki H.J. Leenders, MD

1; Tiny Hoekstra, PhD

1; Frans J. van Ittersum, MD PhD

1; Joost G.J. Hoenderop, PhD

2; Marc

G. Vervloet, MD PhD1

1Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands

2Department of Physiology, Radboud University Medical Center, Nijmegen, The Netherlands

P17. ONLINE HEMODIAFILTRATION EFFECTIVELY REMOVES FREE LIGHT CHAIN KAPPA J. Sträter

1, S.A. Nurmohamed

1, N. van de Donk

2, F.J. van Ittersum

1,M.P.C. Grooteman

1

1 VU University medical center, department of nephrology;

2 VU university medical center; department of hematology

P18. DO HEMODIALYSIS AND PERITONEAL DIALYSIS DIFFER REGARDING THEIR EFFECT ON CORONARY ARTERY CALCIFICATION? Thijs T. Jansz

1, Franka E. van Reekum

1, Akin Özyilmaz

2,3, Marianne C. Verhaar

1, Brigit C. van Jaarsveld

3, on behalf

of the NOCTx investigators. 1Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands,

2Division of

Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, the Netherlands, 3Dialysis

Center Groningen, Groningen, the Netherlands, 4Department of Nephrology, VU University Medical Center, Amsterdam, the

Netherlands

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Poster session D (Quality of Life: Dialysis) Location: will be indicated after entrance at the beginning of the day Chairs: Dr. Maarten Raasveld (Science section NFN) + Hessel Peters-sengers (PLAN member)

P19. ANXIETY SYMPTOMS ARE INDEPENDENTLY ASSOCIATED WITH ALL-CAUSE MORTALITY IN CHRONIC DIALYSIS PATIENTS R.W. Schouten

1,2, G.L. Haverkamp

1,2,E.Nadort

1,2,C.E.H. Siegert

2, F.W. Dekker

3, A. Honig

1,4

Depts. of 1Nephrology,

2Psychiatry, OLVG, Amsterdam, The Netherlands.

3Dept. of Clinical Epidemiology, Leiden University

Medical Centre, Leiden, the Netherlands.4Hospital Psychiatry, VUmc, Amsterdam, the Netherlands. In cooperation with:

Dept. of Nephrology, VU medical centre, Amsterdam, The Netherlands. Dept. of Nephrology, MHC hospital, The Hague, The Netherlands. Dept. of Nephrology, Haga hospital, The Hague, The Netherlands

P20. ETHNIC DIFFERENCES IN DEPRESSIVE SYMPTOMS AND ITS ASSOCIATED CLINICAL OUTCOMES R.W. Schouten

1,2, G.L. Haverkamp

1,2, E.Nadort

1,2,C.E.H. Siegert

2, F.W. Dekker

3, A. Honig

1,4

Depts. of 1Nephrology,

2Psychiatry, OLVG, Amsterdam, The Netherlands.

3Dept. of Clinical Epidemiology, Leiden University

Medical Centre, Leiden, the Netherlands..4Hospital Psychiatry, VUmc, Amsterdam, the Netherlands. In cooperation with:

Dept. of Nephrology, VU medical centre, Amsterdam, The Netherlands. Dept. of Nephrology, MHC hospital, The Hague, The Netherlands. Dept. of Nephrology, Haga hospital, The Hague, The Netherlands

P21. COGNITIVE E-HEALTH THERAPY FOR DEPRESSIVE SYMPTOMS IN DIALYSIS PATIENTS: PROTOCOL FOR A RANDOMIZED CONTROLLED TRIAL ‘DIVERS-II’ R.W. Schouten

1,2, E.Nadort

1,2,C.E.H. Siegert

2, F.W. Dekker

3, P. van Oppen

4, A. Honig

1,5

Depts. of 1Nephrology,

2Psychiatry, OLVG, Amsterdam, The Netherlands.

3Dept. of Clinical Epidemiology, Leiden University

Medical Centre, Leiden, the Netherlands. 4Dept. of Clinical Psychology, GGZ-Ingeest, VUmc, Amsterdam Public Health,

Amsterdam, the Netherlands.5Hospital Psychiatry, VUmc, Amsterdam, the Netherlands. In cooperation with: Dept. of

Nephrology, VU medical centre, Amsterdam, The Netherlands. Dept. of Nephrology, MHC hospital, The Hague, The Netherlands. Dept. of Nephrology, Haga hospital, The Hague, The Netherlands

P22.SUBTYPES OF DEPRESSIVE SYMPTOMS AND THEIR ASSOCIATION WITH MORTALITY IN DIALYSIS PATIENTS Robbert W. Schouten

1,2, Victor J. Harmse

2, Carl E.H. Siegert

1, Friedo W. Dekker

3, Wouter van Ballegooijen

4,

Adriaan Honig2,5

Depts. of

1Nephrology,

2Psychiatry, OLVG, Amsterdam, The Netherlands.

3Department of Clinical Epidemiology, Leiden, The

Netherlands. 4Department of Clinical Psychology, GGZ Ingeest/VUmc/Amsterdam Public Health, Amsterdam, The

Netherlands. 5Hospital Psychiatry, VUmc, Amsterdam, the Netherlands

P23. THE IMPACT OF SYMPTOMS ON HEALTH RELATED QUALITY OF LIFE IN ELDERLY PRE-DIALYSIS PATIENTS; EFFECT AND IMPORTANCE IN THE EQUAL STUDY Pauline WM Voskamp

1, Merel v Diepen

1, Marie Evans

2, Fergus J Caskey

3, Maurizio Postorino

4, Maciej

Szymczak5, Moniek vd Luijtgaarden

6, Christoph Wanner

7, Kitty J Jager

6, Friedo W Dekker

1, on behalf of the

EQUAL Study Investigators 1Dept of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands,

2Dept of Clinical Sciences

Intervention and Technology, Karolinska University Hospital Huddinge, Stockholm, Sweden, 3UK Renal Registry, Southmead

Hospital, Bristol, UK, 4Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension, Azienda Ospedaliera

Bianchi Melacrino Morelli, Reggio Calabria, Italy, 5Dept of Nephrology and Transplantation Medicine, Wroclaw Medical

University, Wroclaw, Poland, 6ERA-EDTA registry, Dept of Medical Informatics, Academic Medical Center, Amsterdam, The

Netherlands, 7Division of Nephrology, University Hospital of Würzburg, Würzburg, Germany

P24. INVESTIGATING THE IMPACT OF HOME DIALYSIS ON QUALITY OF LIFE, CLINICAL OUTCOMES, AND COSTS: RATIONALE AND DESIGN OF THE DOMESTICO PROJECT AA Bonenkamp

1, A van Eck van der Sluijs

2, JAJ Bart

3, MH Hemmelder

4, GA de Wit

5, A Özyilmaz

6, FM van der

Sande7, FTJ Boereboom

8, AJ Luik

9, CWH de Fijter

10, FJ van Ittersum

1, FW Dekker

11, MC Verhaar

2, AC Abrahams

2

en BC van Jaarsveld1

1VU medical center, Amsterdam

2UMCU, Utrecht

3Dutch Association of Kidney Patients (NVN), Bussum

4Medical Center

Leeuwarden 5

Julius Center for Health Sciences and Primary Care, Utrecht 6Dialysis Centre Groningen

7MUMC, Maastricht

8Dianet Dialysis Center, Utrecht

9VieCuri, Venlo

10Onze Lieve Vrouwe Gasthuis, Amsterdam

11LUMC, Leiden

Part of:

Program – NFN Fall Symposium 2017

11

Poster session E (Translational Nephrology) Location: will be indicated after entrance at the beginning of the day Chairs: Kioa Wijnsma (Science section NFN) + Anne Schijvens (PLAN member)

P25.CHARACTERIZATION OF PLASMA MICROVESICLES IN PATIENTS WITH DIABETIC NEPHROPATHY Melissa Uil

1,4, Chi M. Hau

2, Mohamed Ahdi

3, Victor Gerdes

3, Sandrine Florquin

1, Rienk Nieuwland

2, Joris J.T.H.

Roelofs1

1Department of Pathology, Academic Medical Center, University of Amsterdam, the Netherlands,

2Laboratory of

experimental clinical chemistry, Academic Medical Center, the Netherlands, 3Department of internal medicine, Slotervaart

Hospital, Amsterdam, the Netherlands

P26. MOBILIZATION OF NONOSMOTICALLY STORED SODIUM AFTER WATER LOADING IN HEALTHY INDIVIDUALS Rosa D. Wouda, Shosha Dekker, Joelle Reijm, Rik H. Olde Engberink, Liffert Vogt Division of Nephrology, Academic Medical Center, Amsterdam, Netherlands

P27. CILIARY PHENOTYPING IN URINE-DERIVED PATIENT CELLS TO DETERMINE THE PATHOGENICITY OF NOVEL VARIANTS IN CILIOPATHY GENES Machteld M. Oud

1,2, Dorien Lugtenberg

1, Helger G. Yntema

1, Lisenka Vissers

1, Ronald Roepman

1,2, Ernie M.

Bongers1

1Dept. of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands;

2Radboud Institute for

Molecular Life Sciences, Nijmegen, The Netherlands

P28. QUANTIFICATION OF URINARY EXTRACELLULAR VESICLES Charles J. Blijdorp

1, Thomas Hartjes

1, Martin E. Van royen

1, Robert Zietse

1, Ewout J. Hoorn

1

1Department of Nephrology, Erasmus Medical Center, Rotterdam, Netherlands

P29. AUTOMATIC SEGMENTATION OF HISTOPATHOLOGICAL SLIDES FROM RENAL ALLOGRAFT BI-OPSIES USING ARTIFICIAL INTELLIGENCE Meyke Hermsen

1, Thomas de Bel

1, Milly van de Warenburg

1, Jimmy Knuiman

1, Eric Steenbergen

1, Geert

Litjens1, Bart Smeets

1, Luuk Hilbrands

2, Jeroen van der Laak

1

Departments of 1Pathology and

2Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands

P30. CONVERTASE-STABILIZING FACTORS IN PATIENTS WITH COMPLEMENT-MEDIATED RENAL DISEASES M.A. Michels

1, N.C. van de Kar

1, M. Okroj

2, A.M. Blom

3, S.A. van Kraaij

4, E.B. Volokhina

1,4*, L.P. van den

Heuvel1,4,5*

1Department of Pediatric Nephrology, Amalia Children Hospital, Radboud university medical center, Nijmegen, the

Netherlands. 2Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology UG-MUG, Medical University

of Gdańsk, Poland. 3Medical Protein Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden.

4Department of Laboratory Medicine, Radboud university medical center, Nijmegen, the Netherlands.

5Department of

Pediatrics, University Hospitals Leuven, Leuven, Belgium *Contributed equally

P31. DIETARY SODIUM-INDUCED CHANGES IN THE MICROCIRCULATORY SYSTEM OF THE SKIN ARE RELATED TO BLOOD PRESSURE RESPONSE IN HEALTHY MALES E.F.E. Wenstedt

1, MD; R.H.G. Olde Engberink

1, MD; N.M.G. Rorije

1, MD; B.J.H. van den Born

2, MD PhD; J. Aten

3,

PhD; L. Vogt1, MD PhD

1 Department of Internal Medicine, Division of Nephrology, Academic Medical Center, University of Amsterdam, the

Netherlands, 2 Department of Internal Medicine, Division of Vascular Medicine, Academic Medical Center, University of

Amsterdam, the Netherlands 3

Department of Pathology, Academic Medical Center, University of Amsterdam, the Netherlands

Part of:

Program – NFN Fall Symposium 2017

12

Poster session F (Experimental Nephrology) Location: will be indicated after entrance at the beginning of the day Chairs: Rachel Giles (Science section NFN) + Niki Leenders (PLAN member)

P32. RELAXIN RECEPTOR DEFICIENCY IMPAIRS OUTWARD REMODELING IN ARTERIOVENOUS FISTULAS FOR HAEMODIALYSIS T. Bezhaeva1, M.R. de Vries2, W. Geelhoed1, E.P. van der Veer1, S. Versteeg3, C.M.A. van Alem1, N. Eijkelkamp3, AJ van Zonneveld1, P.H.A. Quax2 and J.I. Rotmans1 1Departments of Internal Medicine and Einthoven Laboratory for Experimental Vascular Medicine,

2Vascular Surgery,

Leiden University Medical Center, The Netherlands; 3Laboratory for Translational Immunity, University Medical Center

Utrecht, The Netherlands

P33. TARGETED C4 INHIBITION BY AFFINITY PURIFIED IMMUNOGLOBULINS Elena Volokhina

1,2, Rianne van Sloten

1, Nicole van de Kar

1, Marloes Michels

1, Thea van der Velden

1, Marcin

Okrój3, Anna Blom

4, Lambertus van den Heuvel

1,2,5

1Department of Pediatric Nephrology, Radboud university medical center, Nijmegen, The Netherlands;

2Department of

Laboratory Medicine, Radboud university medical center, Nijmegen, The Netherlands; 3Department of Medical

Biotechnology, Intercollegiate Faculty of Biotechnology UG-MUG, Medical University of Gdańsk, Poland; 4Medical Protein

Chemistry, Department of Translational Medicine, Lund University, Malmö, Sweden; 5Department of Pediatrics, University

Hospitals Leuven, Belgium

P34. RENAL OXYGENATION DURING CHRONIC NITRIC OXIDE SYNTHASE INHIBITION AS RECORDED BY TELEMETRY Tonja W. Emans

1,2, Jaap A. Joles

2, Ben J. Janssen

3 and C.T.P. (Paul) Krediet

1

1 Internal Medicine-Nephrology, AMC-UvA, Netherlands;

2 Nephrology & Hypertension, UMC Utrecht, Netherlands;

3Pharmacology and Toxicology, University Maastricht, Netherlands

P35. HMGA1-DRIVEN LONG NON-CODING RNAS MEDIATE ENDOTHELIAL-TO-MESENCHYMAL TRANSITION IN KIDNEY FIBROSIS R. Bijkerk

1, A. Lafzi

2, W. Stam

1, J.M.G.J. Duijs

1, A. Koudijs

1, E. Lievers

1, T.J. Rabelink

1, H. Kazan

2 and A.J. van

Zonneveld1

1Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine,

Leiden University Medical Center, Leiden, the Netherlands. 2Department of Computer Engineering, Antalya International

University, Antalya, Turkey

P36. EVALUATION OF TUMORIGENIC POTENTIAL OF CONDITIONALLY IMMORTALIZED PROXIMAL TUBULE EPITHELIAL CELLS FOR BIOARTIFICIAL KIDNEY APPLICATION Milos Mihajlovic

1, Sam Hariri

1, Miriam J. Oost

1, Koen G.C. Westphal

1, Manoe J. Janssen

1, Luuk Hilbrands

2 and

Rosalinde Masereeuw1

1Div Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands;

2Department of Nephrology,

Radboudumc, Nijmegen, the Netherlands

P37.IN TWO-KIDNEY ONE-CLIP HYPERTENSIVE SHEEP CARDIAC AND CONTRALATERAL RENAL SYMPATHETIC NERVE ACTIVITY ARE DIFFERENTIALLY CONTROLLED Tycho R. Tromp

1,2, Jaap A. Joles

2, Rohit Ramchandra

1

1The University of Auckland, Auckland, New Zealand,

2University Medical Center Utrecht, Utrecht, Netherlands

P38. A PROTEOME COMPARISON BETWEEN FETAL AND MATURE RENAL EXTRACELLULAR MATRIX Laura Louzao-Martinez MSc

1,2, Christian van Dijk MSc

1, Niek Bekker

1, Caroline Cheng PhD

1,3

1Department of Nephrology and Hypertension, University Medical Center Utrecht, The Netherla nds;

2Netherlands

Heart Institute; 3Experimental Cardiology, Department of Cardiology, Erasmus University Medical Center, The

Netherlands