1. YORK UNIVERSITYFACULTY OF GRADUATE STUDIESProposal for a Type 2 Diploma in Neuroscience within theGraduate Programs of Biology, Kinesiology and Health Science and Psychology Submitted to theOntario Council of Graduate Studies ???????????14 January 2008 PartVOLUME I: The DiplomaProgramTABLE OF CONTENTS

2. Neuroscience Diploma Proposal page21.INTRODUCTION...............................................................................................................31.1 The Discipline of Neuroscience .................................................................................31.2 Neuroscience in Ontario1.3 Rationale for a Diploma in Neuroscience at York......................................................32.REQUIREMENTS FOR COMPLETION...........................................................................52.1 Summary of requirements...........................................................................................52.2 First requirement.........................................................................................................52.3 Second requirement ..................................................................................................562.4 Third requirement........................................................................................................72.5 Fourth requirement......................................................................................................72.6Fifthrequirement..683. CORE FACULTY...78Table 1 ...94. ADMINISTRATION .. ......10 11 4.1 Steering Committee.1011 4.2 Admissions Process 1014.3 Record of Admission and Completion ofRequirements.....101 4.4 Resources.112 APPENDIXA.123 APPENDIXB.189 3. Neuroscience Diploma Proposalpage31. INTRODUCTION1.1 The Discipline of Neuroscience Neuroscience is the multidisciplinary study of the nervous system. It ranges from research on molecular and cellular mechanisms in nerve cells and the relationship between the elements of neural systems, to the study of behavior of whole organisms. Neuroscience is perhaps the most rapidly expanding field of science in the past decade; for example, approximately 30,000 people now attend the annual Society for Neuroscience MMeeting. Neuroscientists can be found in departments of anatomy, biology, chemistry, computer science, engineering, kinesiology, mathematics, pharmacology, philosophy, physiology, psychology and zoology, as well as a variety of medical and health profession departments. This broad range means that students often specialize in specific areas of neuroscience but, at the very least, are likely to be exposed to molecular and cell biology, neural systems and cognitive/behavioral neuroscience. Graduate programs in neuroscience, whether they are certificates, specializations, or degrees, typically offer a small number of core neuroscience courses that are team taught by faculty from the various departments affiliated with the program.1.2 Neuroscience in Ontario Ontario universities are widely recognized for their strength in neuroscience. F; for example, the first annual National Canadian Neuroscience Meeting was is being held in Toronto during May 2007. Neuroscience at the graduate level in Ontario is offered by a number of universities at both the Masters and PhD levels. These offerings generally follow the collaborative model mentioned above. Universities with medical training schools, such as the University of Toronto, McMaster, Queens and the University of Western Ontario, offer a very broad range of areas of specialization. Universities without medical schools, such as Brock, Carleton and Waterloo, offer more restricted and focused programs. For example, at the University of Waterloo, the Departments of Health Studies and Gerontology, Psychology and Kinesiology collaborate to offer a highly specialized PhD in Behavioral Neuroscience, and are planning to offer a specialized graduate diploma in computational neuroscience. York University falls into the latter category of institutions.1.3 Rationale for a Diploma in Neuroscience at York York University has individual strengths in neuroscience that are unique within the greater Toronto area and and in some cases at the international level. Many graduate students at York university are already engaged in neuroscience research, but our current graduate programs are not designed to provide the structure for a well-rounded 4. Neuroscience Diploma Proposal page 4 education or scholarly community that is specific to the field foof neuroscience. Our current neuroscience faculty and graduate students are housed in a number of programsDepartments, with the highest concentrations in Psychology, Kinesiology and Health Science and Biology. The current proposal is a venture jointly developed by the graduate faculty of these programsDepartments but its structure is open to allow faculty from other programs Departments to participate in the future, either by adopting the diploma into their gGraduate pPrograms or by cross-appointment of faculty to one of the originating programs. Overall, Yorks greatest strength is at the systems/cognitive levels of neuroscience, with applications to neurology, rehabilitation, and neuropsychology. Other neuroscience programs place a greater emphasis on the molecular/cellular level but Yorks strength will continue to lie in the former area where there is scope in Ontario for the development of a program of this nature. As this Ddiploma program may evolve eventually into an independent PhD program, its organizational structure will also allow us to identify areas where strength needs to be developed. In view of this, the time is ripe for York to harness its neuroscience strengths by developing, in the first instance, a Diploma program and, at some point in the future, a PhD program. Areas of particular strength of the proposed Diploma will be visual perception, visual- motor control and cognition and neuropsychology. In the case of visual perception and visual-motor control, many members of former case, 50% of the members of the York Centre for Vision Research, Canadas largest and strongest group in this area, are neuroscientists who will be involved with the proposed Diploma. In the case of visual perception, these faculty areFaculty in the area of visual perception are: Elder, Fallah, Hoffman, Murray, Steeves, Wilcox, Wilkinson and Wilson. In the case of visual- motor visual-motor control: Crawford, J.D., DeSouza, Harris, Henriques, Park and Sergio. In cCognition and neuropsychology is another area of strength and is represented by : Bialystock, Goel, Heinrichs, Murtha, Park, Rich, Rivest and , Rosenbaum. The new area of social cognitive neuroscience is growing in the Department of Psychology (Mar, McGregor). There is also representation in developmental neuroscience (Crawford, D.A.) and neuroendocrinology (Unnipappan). More dDetails about the faculty members associated with each of these areas are contained in Table 1 (p. 98). Their and their ccurriculum vitae s are contained in Part Volume 2. The preceding list of investigators use diverse technological approaches to neuroscience, including computation modeling, event-related potentials, brain imaging (fMRI, PET, MEG), animal neurophysiology, psychophysics, kinematics, trans-cranial magnetic stimulation, and molecular and cellular techniques. This occurs mainly at York and also through extensive local and international collaborations with hospitals and other universities. 5. Neuroscience Diploma Proposalpage 5In summary, at the present time York graduate students undertake sophisticated butindividual neuroscience research with highly qualified supervisors. However, they donot have the opportunity to put this research into a broader context, to meet on aregular basis with like-minded colleagues or to fill gaps in their neuroscienceeducation. The proposed Diploma is designed to overcome these deficiencies in theireducation. The us, the proposed Diploma can be viewed as the first step in thedevelopment of a much more comprehensive neuroscience program at York,eventually leading to a PhD in Neuroscience.2. REQUIREMENTS FOR COMPLETION2.1 Summary of Requirements1) Concurrent Successful completion of a Masters thesis or PhD dissertation in thefield of neuroscience, including a manuscript in the latter case.2) Minimum 2-year consecutive participation in the Diploma program.3) Successful completion of two half graduate courses in neuroscience.4) Regular attendance at a monthly seminar series5) Successful completion submission of a review paperfirst authored manuscript.Requirements 4 and 5 shall constitute the additional academic work, equivalent to twofull graduate courses, necessary to meet Type 2 Diploma requirements.2.2 Requirement 1: Concurrent Successful Completion of a Masters Thesis orPhD Dissertation.The thesis or dissertation will be on a topic in neuroscience and it will be under thesupervision of a core member of the Diploma Program (see Table 1 for a list of corefaculty). The Neuroscience Steering Committee (Section 4.1) shall make adetermination that the thesis or dissertation topic falls within the neuroscience area atthe time the student applies for admission to the Diploma. In order to ensure that PhDstudents have full access to the expertise of the program, at least one other member oftheir dissertation Supervisory Committee shall be a core member of the Diploma.To provide PhD students with the opportunity to develop the critical skill of preparingand submitting a manuscript for publication, the dissertation shall contain at least onefirst authored manuscript that has either been published in a recognized neurosciencejournal, accepted for publication, or is publishable in principle.Students may fulfill this requirement in two ways. First, the student may at any time 6. Neuroscience Diploma Proposal page 6submit a manuscript and editors letter, indicating either acceptance for publication orresubmission with revisions, to the Steering Committee to fulfill the requirement.Second, the student may wait until the dissertation is submitted for examination. TheSteering Committee shall obtain an opinion from the External Examiner that at leastone manuscript in the dissertation is publishable in principle. This request shall besent to the External Examiner at the time the dissertation is forwarded forexamination.If the External Examiner deems that the manuscript is not publishable in principle,then the student may petition the Steering Committee for a reassessment of thisjudgment, providing the students supervisor endorses the petition. Voting by eachmember of the Steering Committee, with the advice of non-members, if necessary,shall fall into one of three categories. Category 1: Publishable in principle, in whichcase the requirement is met. Category 2: Returned for revisions. This categoryindicates that the manuscript will be acceptable providing specified revisions areundertaken by the student. The Steering Committee shall provide a list of deficienciesto be remedied and the manuscript shall be resubmitted for a second vote, unless theSteering Committee determines that the students supervisor should take responsibilityfor ensuring that the revisions are made. Category 3: Not publishable in principle.This category indicates that the experiment is either badly flawed or so unoriginal thatit would be highly unlikely to be accepted by a recognized journal.While Masters students are strongly encouraged to include a manuscript as part oftheir thesis, it is recognized that they may not have either the time or the opportunityto do this and they are exempted from this requirement. Nevertheless, it is expectedthat the thesis will be of publishable quality.2.3 Requirement 2: Minimum 2-year consecutive participation in the Diplomaprogram.This requirement has two purposes: to maintain consistency in the studentscurriculum and to allow resource planning for requirements 3 and 4. This requirementalso sets the time window for fulfilling requirement number 4 (seminar attendance).While consecutive participation will normally be expected, students may petitionartition the Steering Committee for relief from this requirement, if there areextenuating circumstances and the students supervisor supports the petition. Underthese circumstances, the student would normally be expected to attend the requirednumber of seminars over a non-consecutive time period.2.4 Requirement 3: Successful completion of two half graduate courses in 7. Neuroscience Diploma Proposalpage 7neuroscience.The purpose of this requirement is to ensure that all students awarded the Diplomaentering the program meet a minimum requirement of basic neuroscience knowledge.Given the multidisciplinary diversity of neuroscience, this is a key feature of theprogram.As described in Section 1.1, neuroscience covers a broad range of areas from themolecular to the cognitive level. Students taking the Diploma are unlikely to have athorough grounding in basic principles across all levels. Consequently, they will berequired to take two half courses, team taught by core faculty members, which willprovide them with this grounding. Each course will at a minimum be offered inalternate years. The first course covers anatomical and cellular topics and is entitledFundamentals of Neuroscience I: Structures, Neurons and Synapses. The secondcourse covers visual-motor and cognitive topics and is entitled Fundamentals ofNeuroscience II: Circuits, Systems and Behavior.Appendix A contains the detailed outlines of these courses. They will be cross-listedbetween the Graduate Programmes in Biology, Kinesiology and Health Science andPsychology. It will therefore be possible for students to take these courses as part ofthe requirements for their Masters or PhD degree. Students not enrolled in theDiploma may take these course with permission of the instructor.2.5 Requirement 4: Attendance at a monthly seminar series. This requirement is an important part of the Diploma because it will engender interaction with like-minded colleagues, introduces students to advanced research topics in a variety of areas and provide students with an opportunity to develop their presentation skills. Students will be required to attend a monthly seminar series over the 2 years of their Diploma, for a total of 16 seminars. The series will be organized by the Steering Committee and consist of research colloquia by invited speakers from both outside and inside the university. Readings covering each topic will be assigned to the students. As part of this series, a full day will be assigned to students presenting their research in conference presentation format. This seminar series will be independent of current York seminar series to ensure that it covers the necessary diversity of topics in neuroscience research. A subcommittee of the Steering Committee is organizing the first seminar series to precede the program (2007-2008), so that we can establish a baseline infrastructure can be developed for the following year. Attendance at seminars will be kept by the organizers but students may petition for relief from attendance at a particular seminar for good reason, such as attendance at a conference or a personal emergency. 8. Neuroscience Diploma Proposalpage82.6 Requirement 5: Successful completion of a review paperfirst authoredmanuscriptTo provide an in-depth understanding of a topic in neuroscience, students shallprepare a critical review paper. The topic should be selected in consultation with thestudents supervisor. The review paper shall be approximately 6, 000 words in length,not including references. References shall be primarily to original sources and mustbe extensive enough to thoroughly cover the topic.The paper shall be submitted to the Steering Committee for assessment by twomembers, or their core faculty designates, prior to the thesis/dissertation defense.Assessment shall be on a pass/resubmit with revisions/fail basis. The review papershall be over and above any curriculum requirements for the Masters or PhD degree,including the introduction to either the Masters thesis or the PhD dissertation.However, the paper may cover a sub-area of research mentioned in the introductionthat is not reviewed in detail.The purpose of this requirement is to provide the student with the critical skill ofpreparing and submitting a manuscript for publication. Manuscripts shall be submittedto the Steering Committee for adjudication, In the case of a manuscript which hasbeen submitted to a recognized neuroscience journal, acceptance by the SteeringCommittee shall be automatic, providing the manuscript is accompanied by aneditors letter, indicating either acceptance for publication or resubmission withrevisions. In the case of a manuscript that has not been submitted to a journal, orabout which word from the journal has not been received, the Steering Committeeshall judge the manuscript by majority vote, with the advice of non-members, ifnecessary. If the students supervisor is a member of the Steering Committee, theymay not vote.Voting by each member of the Steering Committee shall fall into one of threecategories. Category 1: Publishable in principle, in which case the requirement ismet. Category 2: Returned for revisions. This category indicates that themanuscript will be acceptable providing specified revisions are undertaken by thestudent. The Steering Committee shall provide a list of deficiencies to be remediedand the manuscript shall be resubmitted for a second vote, unless the SteeringCommittee determines that the students supervisor should take responsibility forensuring that the revisions are made. Category 3: Not publishable in principle. Thiscategory indicates that the experiment is either badly flawed or so unoriginal that itwould be highly unlikely to be accepted by a recognized neuroscience journal. In thiscase the student may submit another manuscript on a different research topic forconsideration by the Steering Committee. 9. Neuroscience Diploma Proposalpage9While Masters students are strongly encouraged to submit manuscripts, it is recognized that they may not have either the time or the opportunity. In the case where it is not feasible for a Masters student to submit a research manuscript, the student may submit a review paper on a neuroscience topic in lieu of a manuscript. The reason why a manuscript is not feasible must be stated in writing to the Steering Committee, along with a short summary of the proposed topic of the review paper. The topic must be approved by the Steering Committee. The manuscript and review paper specified in this section can either be whole or part of the students Masters thesis or PhD dissertation research or a coursework requirement.3. CORE FACULTYTable 1 below contains the list of core faculty, the area of neuroscience in whichthey work and their specific research interests. Core faculty are individuals who wishto offer the Diploma to at least some of their students. The curriculum vitas of thefaculty in Table 1 are contained in Volume 2 of this proposal. Members of theSteering Committee are also indicated. These are individuals who have been guidingthe development of the Diploma and who have volunteered to actively participate inits administration. The curriculum vitae of the faculty in Table 1 are contained in Part2 of this proposal.The following list only includes faculty who volunteered after our initial recruitingwithin the Departments/Schools of Psychology, Biology, and Kinesiology & HealthSciences. It is expected that more faculty from these and other departments willbecome interested in joining the program once the proposed infrastructure is approvedand in place. Faculty wishing to become core member shall submit a CV andstatement of interest to the Steering Committee which shall determine the suitabilityof the applicants neuroscience credentials for inclusion as a core member.Table 1List of core faculty 10. Neuroscience Diploma Proposal page 10Name andDepartment Steering Neuroscience Area Research InterestsRankCommittee Bialystok, E.Psychologyno Cognition andEffect of experience on Distinguished neuropsychologycognitive ability across theResearch Prof.lifespanCrawford, J.D.Psychology yesVisual-motorEye-hand coordination, 3-D Professor and controlgaze and trans-saccadicCanada ChairintegrationCrawford, D.A.Kinesiologyyes Developmental Cellular and molecularAssistant Prof. mechanisms underlyingdevelopmental disorders DeSouza, J.Psychology yesVisual-motorNeural processing of theAssistant Prof.controloculomotor and attentionalsystems Elder, J.Psychology noVisual pPerceptionNeural mechanisms ofAssociate Prof.contour perceptionFallah, M.Kinesiologyyes Visual pPerceptionNeural mechanisms ofAssistant Prof.attention and objectprocessing Goel, V. Psychology noCognition and The role of the prefrontalAssociate Prof. neuropsychologycortex in rational and emotional processingHarris, L.Psychology no Visual-motor Mechanisms of perceivedProfessorcontrol orientation, sensoryintegration and self motionHeinrichs, W. Psychology noCognition and Neural mechanismsProfessor neuropsychologyunderlying schizophreniaHenriques, D. Kinesiologyno Visual-motor Neural mechanisms ofAssistant Prof.controlmultisensory eye, head andlimb movements Hoffman, K.Psychology no Visual perception Neural dynamics of faceAssistant Prof. and voice processing Mar, R.Psychology no Social cognitionNeural basis of empathyAssistant Prof. and personality McGregor, IPsychology no Social cognition Threat-induced frontalAssociate Prof. asymmetry and zealousextremism Murray, R. Psychology no Visual perception Computational modeling ofAssistant Prof. visual perception Murtha, S. Psychology no Cognition andChanges in attention andProfessor neuropsychology memory during normal and abnormal aging Park, N. Psychology noCognition and Memory for skilled action Associateneuropsychology after cognitive impairment 11. Neuroscience Diploma Proposal page11Professor. Rich, J. Psychology noCognition andMemory in normal andAssociate Prof. neuropsychology abnormal agingRivest, J.Psychology noCognition andNeural correlates ofAssociate Prof. neuropsychology perceptual systems and disordersRosenbaum, S. Psychology yes Cognition and Neural mechanisms ofAssistant Prof. neuropsychology remote spatial and episodic memorySergio, L.Kinesiologyyes Visual-motorNeural mechanisms ofAssociate Prof. control visually guided reaching inhealth and diseaseSteeves, J. Psychology noVisual pPerception Neural mechanismsAssistant Prof. controlling face processingUnniappan, S. Biologyno Neuroendocrinology The influence ofAssistant Prof.neuroendocrine factors onneural mechanismsWilcox, L.Psychology noVisual pPerception The neural substrate ofAssociate Prof.stereopsis Wilkinson, F.Psychology yes Visual pPerception The role of the visualProfessorsystem in migraineWilson, H.Biologyyes Visual pPerceptionPsychophysics of formProfessorvision and motion perception4. ADMINISTRATION4.1 Steering CommitteeThe Steering Committee shall be composed of individuals who are actively involved 12. Neuroscience Diploma Proposal page12 in the administration of the Program. The Committee shall be composed of no fewer than four and no more than eight members, including at least two from Psychology and at least two from Kinesiology and Health Sciences. The Chair of the Committee shall be elected on an annual basis by its members. Membership shall be by invitation or self nomination and shall be for a period of two years with the option of renewal for further terms. In the event that invitations or self nominations exceed the limit of eight members, core Diploma faculty shall vote to select members from the nominees. The Steering Committee shall be responsible for the quality of the Diploma Program and for its administration. The Chair shall convene meetings of all part of the Committee as necessary to conduct the affairs of the Program, including organizing the seminar series (Section 2.5), reviewing and approving manuscripts (Section 2.6), admitting students (Section 4.2), maintaining records (Section 4.3), reviewing student progress, determining the suitability of the neuroscience credentials of faculty applying for core membership and undertaking any other relevant business.4.2 Admissions Process Students wishing to be admitted to the Program must be enrolled as a Masters or PhD student in one of the following the Graduate Programs: of either Biology, Kinesiology and Health Science or Psychology. Normally students will participate in the home department program of the supervisor. A web-site at www.yorku.ca/neuro neurosci will be set up to advertise the diploma program and direct students to the correct supervisors and graduate programs. The student shall submit to the Steering Committee a one paragraph summary of their proposed research and a letter of endorsement from their supervisor supporting the application. The supervisor must be a core member of the Diploma Program. The Committee will make its decision to admit or reject the application on the basis of these two sources of information. It is anticipated that enrollment will be limited to 15 students/year, the limiting factor being the manageable size of the two neuroscience courses.4.3 Record of Admission and Completion of Requirements Appendix B contains the form Diploma in Neuroscience - Record of Admission and Completion which will be used to track the progress of each student enrolled in the Program. Upon admission into the Program by the Steering Committee, the Chair or designate shall complete Part A and forward the form to the home program of the student for inclusion in his/her file. It shall be the joint responsibility of the student and supervisor to obtain the relevant signatures indicating progress through the Diploma requirements in Part B of the form. Upon completion of all requirements the form shall be submitted to the Steering Committee for final approval of award of the Diploma and completion of Part C. All Diploma requirements must be completed at the same time as the degree requirements. The Diploma can only be completed once, either at the Masters level or the PhD level. Students promoted to the PhD level from 13. Neuroscience Diploma Proposalpage 13 the Masters level who have not completed all Diploma requirements will be required to meet the PhD requirements of the Diploma.4.4 Resources Additional resources are not required from York University to mount this Diploma. The two neuroscience courses will be taught in alternate years as part of the normal assigned graduate workload of the Course Directorson a voluntary basis by core faculty. This workload amount to a quarter course or less per faculty member every second year. Further, the option is available for these faculty members to include this teaching as part of their formal graduate level workload, if they so wish. The seminar series is also being conducted on a voluntary basis by members of the Steering Committee. The seminar series will not require funding from the Faculty of Graduate Studies, since the resources of the Center for Vision Research are available to cover the costs of guest speakers and refreshments. Minimal workload will be imposed on the three Graduate Program Assistants, since they will are only be required to store the Record of Admission and Completion in the file of each student taking the Diploma. It will be the joint responsibility of the supervisor and student to have all sections of Part B completed and deliver the form to the Steering Committee for completion of Part C. 14. Neuroscience Diploma Proposal page 14Appendix ANew Course ProposalDr. Dorota Anna Crawford, Ph.D., dakc@yorku.caDr. Mazyar Fallah, Ph.D., mfallah@yorku.caDr. Lauren Sergio, Ph.D., lsergio@yorku.ca 1. Course Number and TitleKAHS: 6XXX 3.0Title: Fundamentals of Neuroscience I: Structures, Neurons, andSynapses 2. Effective Date and TermTBA. 3. Calendar Course DescriptionThis course will focus on molecular and cellular mechanisms underlying the structure andfunction of the nervous system, functional neuroanatomy, and the neurophysiology ofmovement. Prerequisites: undergraduate course in neuroscience or equivalent or bypermission of course director. 4. Expanded Course DescriptionThe course will provide graduate students with an in depth analysis of the molecular andcellular mechanisms underlying the structure and function of the developing and maturenervous system. This is an advanced course that will focus on current research topics inselected areas of Neuroscience, which is the study of the biology of the nervous systemand its relationship to behavior and disease. The course includes three modules, (1)molecular and cellular neuroscience, (2) functional neuroanatomy and (3) muscle andspinal cord neurophysiology, which will introduce students to the breadth of research inNeuroscience. The molecular and cellular neuroscience module course covers topicsranging from neuronal structure and function, communication at the synapse, membranereceptors and intra- and intercellular signaling systems within the sensory, motor,memory, and speech systems. It will also cover the cellular and molecular processesunderlying neuronal development, including differentiation of nerve cells, migration ofneurons, mechanisms of axonal growth and guidance, target recognition and synapseformation, and the basis of synaptic specificity. The functional neuroanatomy module willcover the structures and functions of the brain, including the meninges, cranial nerves,spinal cord, brainstem, subcortical structures, ventricular system, and cortex. Muscle andspinal cord neurophysiology will cover neuromuscular and motor unit function in healthand disease, spinal cord function, and reflex modulation during movement.Module 1 Functional neuroanatomy Director: Dr. Mazyar Fallah 15. Neuroscience Diploma Proposalpage 151. Anatomical Organization of the CNS2. Functional Organization of Perception and Movement3. Association Areas of the Cerebral Cortex4. Internal Cellular Representation Required for Perception and ActionModule 2 Molecular and cellular neuroscience Director: Dr. Dorota A. Crawford5. Cell biology of neurons and protein trafficking6. Molecular biology of ion channels7. Membrane potential and action potential8. Synaptic Transmission, second messenger system and neurotransmitters9. Development: proliferation and migration, pathfinding and target selection,formation of synapsesModule 3 Muscle and spinal cord neurophysiology Director: Dr. Lauren Sergio10. The motor unit and muscle action11. Diseases of the motor unit12. Spinal reflexes 5. Faculty Resources The course will be taught by Drs. Dorota A. Crawford, Mazyar Fallah and Lauren Sergio who have the expertise to teach this course. Drs. Denise Henriques and Hugh Wilson can also teach the course. 6. EvaluationStudents will be evaluated based on three exams, class participations and term paper on atopic of the students choice, related to topics covered in class.Final mark will be based on: Class Exam 1 (Module 1)25% Class Exam 1 (Module 2)30% Final Exam (Module 3)20% Class discussions and attendance5% Course essay (a review of an area covered in the course) 20% 7. BibliographyThere is a textbook required for the course:Eric R. Kandel, James Schwartz, and Thomas Jessell. Principles of Neural Science4thEdition (Elsevier)Further reading will be assigned by individual instructors. 8. Resources (library/physical/other) Assigned readings will be available from the York University library system from journals, such as Nature, Science, Journal of Neuroscience, Nature Genetics, Nature Neuroscience, Brain, Brain Research, Journal of Neurobiology, Neuron, Cell, 16. Neuroscience Diploma Proposalpage 16NeuroReport and Proceedings of the National Academy of Science. 9. Integrated Courses N/A 10. Cross-listed Courses BIOL 6XXX 3.0 and PSYCH 6XXX 3.0 11. Rationale As indicated in the course outline, the purpose of the course is to examine 3 aspects of the brain: the fundamental molecular mechanisms underlying the general features of cellular neuroscience, functional neuroanatomy, and neurophysiology of movement. Students in Kinesiology and Health Science, Biology and Psychology will gain a deeper understanding of these topics in Neuroscience. This will be important for any student who is interested in pursuing a career in neuroscience research or a career in the health- care professions. This course is also important for students who wish to pursue studies in systems neuroscience or cognitive neuroscience, as well as those with a general interest in cellular and molecular biology. This course will provide an important and crucial background for students enrolled in the Neuroscience Diploma of the graduate program within the three departments.New Course ProposalDr. Joseph DeSouza, Ph.D., desouza@yorku.caDr. Kari Hoffman, Ph.D., khoffman@yorku.ca 5. Course Number and TitlePSYC: 6XXX 3.0 17. Neuroscience Diploma Proposal page 17Title: Fundamentals of Neuroscience II: Circuits, Systems, and Behavior 6. Effective Date and TermTBA. 7. Calendar Course DescriptionThis course will focus on a systems approach to specialized circuits within the centralnervous system that determine sensory, motor and cognitive systems. This course requiresas a prerequisite PSYC 6XXX 3.0, BIO 6XXX 3.0 or KAHS 6XXX 3.0 [i.e.Fundamentals of Neuroscience I: structures, neurons and synapses.], or permission fromthe Course Directors.Permission of the Course Directors is required to enroll in thecourse. 8. Expanded Course DescriptionThe course will provide graduate students with an in depth analysis of the circuits withinthe nervous system that underlying the structure and function of the developing andmature nervous system. This is an advanced course that will focus on current researchtopics in selected areas of Neuroscience, which is the study of the biology of the nervoussystem and its relationship to behavior and disease. The course includes two modules thatcover a range of topics within systems neuroscience. It is designed to complimentElements of Neuroscience I and in total will introduce students to the breadth of researchwithin the field of Neuroscience.Module 1 Director: Drs. DeSouza and Hoffman13. Neurotechniques14. Principles of neural computationModule 2 Director: Dr. DeSouza15. Visual, auditory & somatosensory systems16. Vestibular system, eye movements and other senses17. Basal Ganglia, Cerebellum and subcortical systems18. Higher cortical systemsModule 3 Director: Dr. Kari Hoffman19. Plasticity and Learning20. Sleep and Spontaneous activity21. Emotion/Motivation22. Autonomic system/ hormones and stress 5. Faculty ResourcesThe course will be taught by Drs. Joseph DeSouza and Kari Hoffman who have theexpertise to teach this course. Drs. J. Douglas Crawford, Susan Murtha, ShaynaRosenbaum, Lauren Sergio, Jennifer Steeves and Frances Wilkinson could also teach partsof this course and appear as guest lecturers. 18. Neuroscience Diploma Proposalpage18 6. EvaluationStudents will be evaluated based on two exams, class participations and term paper on atopic of the students choice (to be approved by the course instructor). Term paper willrelated to a specific topic covered in class.Final mark will be based on: Class Exam (Module 1)25% Class Exam (Module 2)25% Paper presentations20% Class discussions and attendance5% Course essay (a review of an area covered in the course) 25% 7. BibliographyEric R. Kandel, James Schwartz, and Thomas Jessell. Principles of Neural Science4thEdition (Elsevier)Selected readings from peer-reviewed journal articles will be assigned for each class. 8. Resources (library/physical/other)Assigned readings will be available from the York University library system fromjournals, such as Nature, Science, Journal of Neuroscience, Nature Genetics, NatureNeuroscience, Brain, Brain Research, Journal of Neurobiology, Neuron, Cell,NeuroReport and Proceedings of the National Academy of Science. 9. Integrated CoursesN/A 10. Cross-listed Courses BIOL 6XXX 3.0 and KAHS 6XXX 3.0 11. Rationale As indicated in the course outline, the purpose of the course is to examine three aspects of the brain: the fundamental molecular mechanisms underlying the general features of systems neuroscience and its implications when these systems fail due to systems specific disease states. Students in Psychology, Biology and Kinesiology and Health Science will gain a deeper understanding of these topics in Neuroscience. This will be important for any student who is interested in pursuing a career in neuroscience research or a career in the health-care professions. This course is also important for students who wish to pursue studies in systems neuroscience or cognitive neuroscience, as well as those with a general interest in the biological basis of behavior. This course will provide an important and crucial background for students enrolled in the Neuroscience Diploma of the graduate program within the three departments. 19. Neuroscience Diploma Proposal page 19APPENDIX BDiploma in Neuroscience Record of Admission and CompletionPART AName of Student __________________ ____________ Name ofSupervisor _______________________________ 20. Neuroscience Diploma Proposal page 20Degree Sought: MA/MSc PhDCurrently Enrolled In: Biology Kinesiology & Health Science PsychologyI certify that this student has been accepted into the Neuroscience Diploma Program:Chair of Steering Committee _________________________________ Date ___________________PART B Certification that this student has completed the following Diploma requirements:Suitable Masters or PhD Research TopicName (please print) _______________________________ Position ________________________Signature ____________________________________________Masters Thesis or PhD Dissertation with manuscriptName (please print) _______________________________ Position ________________________Signature ____________________________________________Two-year consecutive participation in the Program and Seminar SeriesName (please print) _______________________________ Position ________________________Signature ____________________________________________Two courses in NeuroscienceName (please print) ______________________________ Position NEUROSCIENCE I_______________________Signature ____________________________________________Name (please print) ______________________________ PositionNEUROSCIENCE II________________________Signature ____________________________________________First authored manuscriptReview paperName (please print) ________________________________ Position ________________________Signature ____________________________________________PART C 21. Neuroscience Diploma Proposal page 21I certify that the above student has completed all the requirements for the Diploma in Neuroscience:__________________________________________________________________ ___________________________________________Chair of Steering Committee DateMayJune 2007