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Nanotechnology

Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

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Page 1: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Nanotechnology

Page 2: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Outline

Page 3: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

3

What is nano?

Page 4: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

4

Evolving landscapes

Page 5: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Nanoproducts

5

Page 6: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Nanotechnology

6

Page 7: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Benefits

7

Page 8: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Immunotherapy Toxicity

Page 9: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Vaccines

Page 10: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Toxicity

Page 11: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Immune system

Page 12: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Bidirectional communication

Page 13: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Particle size

Page 14: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Protein binding

Page 15: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Biodistribution

Page 16: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

MPS uptake

Page 17: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Hemolysis

Page 18: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Hemolysis

Page 19: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Coagulation system

Page 20: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Undesirable effects

Page 21: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Zeta potential

Page 22: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Platelets

Page 23: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Allergenicity

Page 24: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Allerginicity Complement activation

Page 25: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Allergenicity

Page 26: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Cytokine storm

Page 27: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Carrier properties

Page 28: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

IL-8 induction

Page 29: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

IL-1 Immunogenicity

Page 30: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

API properties

Page 31: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Immunogenicity

Page 32: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Anti-PEG antibody

Page 33: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Future directions

Page 34: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Take home message

Page 35: Nanotechnology - Center for Cancer Research · Nanotechnology Nanotechnology can benefit cancer therapy by improving formulation of traditional drugs (SM, biotechnology products and

Acknowledgements

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