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NIH Common Fund Epigenomics Program
John Satterlee PhD Epigenomics Program Co-coordinator National Institute on Drug AbuseNIH
NIH Council of Councils May 14 2013
NIH Epigenomics Working Group
Co-Chairs Nora Volkow (NIDA) Linda Birnbaum (NIEHS) James Battey (NIDCD)
Co-Coordinators John Satterlee (NIDA) Pat Mastin (NIEHS)
Christine Colvis NCATS Roderic Pettigrew NIBIB Astrid Haugen NIEHS Carol Pontzer NCCAM Carol Kasten-Sportes NICHD Jerry Heindel NIEHS Grace Ault NCI Lisa Freund NICHD Laurie Johnson NIEHS Jennifer Couch NCI Susan Taymans NICHD Kimberly McAllister NIEHS Paul Okano NCI Mark Caulder NIDA Srikanth Nadadur NIEHS Richard Piekarz NCI Genevieve deAlmeida-Morris NIDA Kristi Pettibone NIEHS
Sharon Ross NCI Donna Jones NIDA Fred Tyson NIEHS
Mukesh Verma NCI Jonathan Pollock NIDA Leroy Worth NIEHS
Hemin Chin NEI Dena Procaccini NIDA Anthony Carter NIGMS
Elise Feingold Mike Pazin
NHGRI NHGRI
Joni Rutter David Shurtleff
NIDA NIDA
Andrea Beckel-Mitchener Michelle Freund
NIMH NIMH
Weiniu Gan NHLBI Bracie Watson NIDCD Thomas Lehner NIMH
Susan Old NHLBI Lillian Shum NIDCR Roger Little NIMH
Pothur Srinivas NHLBI Kristin Abraham NIDDK Aleksandra Vicentic NIMH
Anna McCormick NIA Olivier Blondel NIDDK Robert Riddle NINDS
Suzana Petanceska Conrad Malia Nasrin Nabavi
NIA NIAID NIAID
Jessica Faupel-Badger Philip Smith Julie Wallace
NIDDK NIDDK NIDDK
Randall Stewart Stephanie Courchesne Patricia Labosky
NINDS OSC OSC
Ashley Xia William Sharrock
NIAID NIAMS
Lisa Chadwick Gwen Collman
NIEHS NIEHS
Johanna Dwyer Deborah Olster
ODS OBSSR
Guoying Liu NIBIB Christie Drew NIEHS
NIH Common Fund Epigenomics Program
68 grants $200MMapping
Centers Technology
Development
Health and Disease
Data Coord Center
In vivo Epigenetic
Imaging
NCBI Novel Marks
Discovery of Novel Epigenetic Marks
GOAL Discover potential novel epigenetic marks
bull 67 new histone modifications Lysine crotonylation (Cell Zhao)
bull Lysine proprionylation bull Lysine butyrylation bull PolyADP ribosylation bull Histone 3 Arginine 2 dimethylation
Broad Institute
Epigenomics of Human Health and Disease
GOAL Transform our understanding of the epigenomicbasis of disease
2009 CFIC split 2011 IC only
Total 33 R01s 12 ICs
Alzheimerrsquos Cardiovascular Environmental toxins Asthma Cancer Substance abuse Psychiatric Autism Insulin resistance Autoimmune Glaucoma
Altered epigenetic states associated with
bull Gestational age at birth (FeinbergFallin) bull Hepatocellular carcinoma (Meltzer) bull Breast cancer (Huang) bull Schizophrenia and bipolar disorder (Mill) bull Alzheimerrsquos disease (De JagerBennett)
Technology Development in Epigenetics
GOAL Develop revolutionary technologies with the potential to significantly change epigenetics research
2008 General epigenetic technologies 2011 Epigenetic imaging 2013 Epigenetic manipulation (new)
Gelovani lab bullHistone dynamics (Science Henikoff) bullSingle molecule epigenomics (PNAS Soloway)bullSXRT of epigenomic organization (Cell LarabellLomvardas)bullPET imaging of histone deacetylases (Neuroimage Gelovani)
NCBI
Mapping Centers
Data Coord Center
Technology Development
Health and Disease
In vivo Epigenetic
Imaging
Novel Marks
NIH Common Fund Epigenomics Program
Reference Epigenome Mapping Centers
GOAL Generate comprehensive epigenomic maps for ldquonormalrdquo human cells and tissues
First human methylomes (Nature 2009) 42 methylomes completed 79 comprehensive epigenome datasets Data publically accessible httpwwwroadmapepigenomicsorg
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
NIH Epigenomics Working Group
Co-Chairs Nora Volkow (NIDA) Linda Birnbaum (NIEHS) James Battey (NIDCD)
Co-Coordinators John Satterlee (NIDA) Pat Mastin (NIEHS)
Christine Colvis NCATS Roderic Pettigrew NIBIB Astrid Haugen NIEHS Carol Pontzer NCCAM Carol Kasten-Sportes NICHD Jerry Heindel NIEHS Grace Ault NCI Lisa Freund NICHD Laurie Johnson NIEHS Jennifer Couch NCI Susan Taymans NICHD Kimberly McAllister NIEHS Paul Okano NCI Mark Caulder NIDA Srikanth Nadadur NIEHS Richard Piekarz NCI Genevieve deAlmeida-Morris NIDA Kristi Pettibone NIEHS
Sharon Ross NCI Donna Jones NIDA Fred Tyson NIEHS
Mukesh Verma NCI Jonathan Pollock NIDA Leroy Worth NIEHS
Hemin Chin NEI Dena Procaccini NIDA Anthony Carter NIGMS
Elise Feingold Mike Pazin
NHGRI NHGRI
Joni Rutter David Shurtleff
NIDA NIDA
Andrea Beckel-Mitchener Michelle Freund
NIMH NIMH
Weiniu Gan NHLBI Bracie Watson NIDCD Thomas Lehner NIMH
Susan Old NHLBI Lillian Shum NIDCR Roger Little NIMH
Pothur Srinivas NHLBI Kristin Abraham NIDDK Aleksandra Vicentic NIMH
Anna McCormick NIA Olivier Blondel NIDDK Robert Riddle NINDS
Suzana Petanceska Conrad Malia Nasrin Nabavi
NIA NIAID NIAID
Jessica Faupel-Badger Philip Smith Julie Wallace
NIDDK NIDDK NIDDK
Randall Stewart Stephanie Courchesne Patricia Labosky
NINDS OSC OSC
Ashley Xia William Sharrock
NIAID NIAMS
Lisa Chadwick Gwen Collman
NIEHS NIEHS
Johanna Dwyer Deborah Olster
ODS OBSSR
Guoying Liu NIBIB Christie Drew NIEHS
NIH Common Fund Epigenomics Program
68 grants $200MMapping
Centers Technology
Development
Health and Disease
Data Coord Center
In vivo Epigenetic
Imaging
NCBI Novel Marks
Discovery of Novel Epigenetic Marks
GOAL Discover potential novel epigenetic marks
bull 67 new histone modifications Lysine crotonylation (Cell Zhao)
bull Lysine proprionylation bull Lysine butyrylation bull PolyADP ribosylation bull Histone 3 Arginine 2 dimethylation
Broad Institute
Epigenomics of Human Health and Disease
GOAL Transform our understanding of the epigenomicbasis of disease
2009 CFIC split 2011 IC only
Total 33 R01s 12 ICs
Alzheimerrsquos Cardiovascular Environmental toxins Asthma Cancer Substance abuse Psychiatric Autism Insulin resistance Autoimmune Glaucoma
Altered epigenetic states associated with
bull Gestational age at birth (FeinbergFallin) bull Hepatocellular carcinoma (Meltzer) bull Breast cancer (Huang) bull Schizophrenia and bipolar disorder (Mill) bull Alzheimerrsquos disease (De JagerBennett)
Technology Development in Epigenetics
GOAL Develop revolutionary technologies with the potential to significantly change epigenetics research
2008 General epigenetic technologies 2011 Epigenetic imaging 2013 Epigenetic manipulation (new)
Gelovani lab bullHistone dynamics (Science Henikoff) bullSingle molecule epigenomics (PNAS Soloway)bullSXRT of epigenomic organization (Cell LarabellLomvardas)bullPET imaging of histone deacetylases (Neuroimage Gelovani)
NCBI
Mapping Centers
Data Coord Center
Technology Development
Health and Disease
In vivo Epigenetic
Imaging
Novel Marks
NIH Common Fund Epigenomics Program
Reference Epigenome Mapping Centers
GOAL Generate comprehensive epigenomic maps for ldquonormalrdquo human cells and tissues
First human methylomes (Nature 2009) 42 methylomes completed 79 comprehensive epigenome datasets Data publically accessible httpwwwroadmapepigenomicsorg
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
NIH Common Fund Epigenomics Program
68 grants $200MMapping
Centers Technology
Development
Health and Disease
Data Coord Center
In vivo Epigenetic
Imaging
NCBI Novel Marks
Discovery of Novel Epigenetic Marks
GOAL Discover potential novel epigenetic marks
bull 67 new histone modifications Lysine crotonylation (Cell Zhao)
bull Lysine proprionylation bull Lysine butyrylation bull PolyADP ribosylation bull Histone 3 Arginine 2 dimethylation
Broad Institute
Epigenomics of Human Health and Disease
GOAL Transform our understanding of the epigenomicbasis of disease
2009 CFIC split 2011 IC only
Total 33 R01s 12 ICs
Alzheimerrsquos Cardiovascular Environmental toxins Asthma Cancer Substance abuse Psychiatric Autism Insulin resistance Autoimmune Glaucoma
Altered epigenetic states associated with
bull Gestational age at birth (FeinbergFallin) bull Hepatocellular carcinoma (Meltzer) bull Breast cancer (Huang) bull Schizophrenia and bipolar disorder (Mill) bull Alzheimerrsquos disease (De JagerBennett)
Technology Development in Epigenetics
GOAL Develop revolutionary technologies with the potential to significantly change epigenetics research
2008 General epigenetic technologies 2011 Epigenetic imaging 2013 Epigenetic manipulation (new)
Gelovani lab bullHistone dynamics (Science Henikoff) bullSingle molecule epigenomics (PNAS Soloway)bullSXRT of epigenomic organization (Cell LarabellLomvardas)bullPET imaging of histone deacetylases (Neuroimage Gelovani)
NCBI
Mapping Centers
Data Coord Center
Technology Development
Health and Disease
In vivo Epigenetic
Imaging
Novel Marks
NIH Common Fund Epigenomics Program
Reference Epigenome Mapping Centers
GOAL Generate comprehensive epigenomic maps for ldquonormalrdquo human cells and tissues
First human methylomes (Nature 2009) 42 methylomes completed 79 comprehensive epigenome datasets Data publically accessible httpwwwroadmapepigenomicsorg
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
Discovery of Novel Epigenetic Marks
GOAL Discover potential novel epigenetic marks
bull 67 new histone modifications Lysine crotonylation (Cell Zhao)
bull Lysine proprionylation bull Lysine butyrylation bull PolyADP ribosylation bull Histone 3 Arginine 2 dimethylation
Broad Institute
Epigenomics of Human Health and Disease
GOAL Transform our understanding of the epigenomicbasis of disease
2009 CFIC split 2011 IC only
Total 33 R01s 12 ICs
Alzheimerrsquos Cardiovascular Environmental toxins Asthma Cancer Substance abuse Psychiatric Autism Insulin resistance Autoimmune Glaucoma
Altered epigenetic states associated with
bull Gestational age at birth (FeinbergFallin) bull Hepatocellular carcinoma (Meltzer) bull Breast cancer (Huang) bull Schizophrenia and bipolar disorder (Mill) bull Alzheimerrsquos disease (De JagerBennett)
Technology Development in Epigenetics
GOAL Develop revolutionary technologies with the potential to significantly change epigenetics research
2008 General epigenetic technologies 2011 Epigenetic imaging 2013 Epigenetic manipulation (new)
Gelovani lab bullHistone dynamics (Science Henikoff) bullSingle molecule epigenomics (PNAS Soloway)bullSXRT of epigenomic organization (Cell LarabellLomvardas)bullPET imaging of histone deacetylases (Neuroimage Gelovani)
NCBI
Mapping Centers
Data Coord Center
Technology Development
Health and Disease
In vivo Epigenetic
Imaging
Novel Marks
NIH Common Fund Epigenomics Program
Reference Epigenome Mapping Centers
GOAL Generate comprehensive epigenomic maps for ldquonormalrdquo human cells and tissues
First human methylomes (Nature 2009) 42 methylomes completed 79 comprehensive epigenome datasets Data publically accessible httpwwwroadmapepigenomicsorg
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
Epigenomics of Human Health and Disease
GOAL Transform our understanding of the epigenomicbasis of disease
2009 CFIC split 2011 IC only
Total 33 R01s 12 ICs
Alzheimerrsquos Cardiovascular Environmental toxins Asthma Cancer Substance abuse Psychiatric Autism Insulin resistance Autoimmune Glaucoma
Altered epigenetic states associated with
bull Gestational age at birth (FeinbergFallin) bull Hepatocellular carcinoma (Meltzer) bull Breast cancer (Huang) bull Schizophrenia and bipolar disorder (Mill) bull Alzheimerrsquos disease (De JagerBennett)
Technology Development in Epigenetics
GOAL Develop revolutionary technologies with the potential to significantly change epigenetics research
2008 General epigenetic technologies 2011 Epigenetic imaging 2013 Epigenetic manipulation (new)
Gelovani lab bullHistone dynamics (Science Henikoff) bullSingle molecule epigenomics (PNAS Soloway)bullSXRT of epigenomic organization (Cell LarabellLomvardas)bullPET imaging of histone deacetylases (Neuroimage Gelovani)
NCBI
Mapping Centers
Data Coord Center
Technology Development
Health and Disease
In vivo Epigenetic
Imaging
Novel Marks
NIH Common Fund Epigenomics Program
Reference Epigenome Mapping Centers
GOAL Generate comprehensive epigenomic maps for ldquonormalrdquo human cells and tissues
First human methylomes (Nature 2009) 42 methylomes completed 79 comprehensive epigenome datasets Data publically accessible httpwwwroadmapepigenomicsorg
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
Technology Development in Epigenetics
GOAL Develop revolutionary technologies with the potential to significantly change epigenetics research
2008 General epigenetic technologies 2011 Epigenetic imaging 2013 Epigenetic manipulation (new)
Gelovani lab bullHistone dynamics (Science Henikoff) bullSingle molecule epigenomics (PNAS Soloway)bullSXRT of epigenomic organization (Cell LarabellLomvardas)bullPET imaging of histone deacetylases (Neuroimage Gelovani)
NCBI
Mapping Centers
Data Coord Center
Technology Development
Health and Disease
In vivo Epigenetic
Imaging
Novel Marks
NIH Common Fund Epigenomics Program
Reference Epigenome Mapping Centers
GOAL Generate comprehensive epigenomic maps for ldquonormalrdquo human cells and tissues
First human methylomes (Nature 2009) 42 methylomes completed 79 comprehensive epigenome datasets Data publically accessible httpwwwroadmapepigenomicsorg
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
NCBI
Mapping Centers
Data Coord Center
Technology Development
Health and Disease
In vivo Epigenetic
Imaging
Novel Marks
NIH Common Fund Epigenomics Program
Reference Epigenome Mapping Centers
GOAL Generate comprehensive epigenomic maps for ldquonormalrdquo human cells and tissues
First human methylomes (Nature 2009) 42 methylomes completed 79 comprehensive epigenome datasets Data publically accessible httpwwwroadmapepigenomicsorg
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
Reference Epigenome Mapping Centers
GOAL Generate comprehensive epigenomic maps for ldquonormalrdquo human cells and tissues
First human methylomes (Nature 2009) 42 methylomes completed 79 comprehensive epigenome datasets Data publically accessible httpwwwroadmapepigenomicsorg
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
Program Integration and Outreach
Yearly ldquoInvestigatorsrdquo Meetings Next Oct 20-21 2013 Boston MA
Workshops ENCODEEpigenomics Programs co-sponsored tutorial on using these datasets (ASHG)
International Efforts Members CF Epigenomics European Union Canada Germany Japan Italy South Korea
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
Future Transition and Translation
The Potential for Translational Epigenomics
Workshop 2011 lsquoFrom Epigenomic Discovery to Improvements in Human Healthrdquo
Diagnostics Therapeutics Prevention for IC-specific Diseases
Transition from Common Fund to NIH ICs
NICHD 2009 Epigenetic Processes in Development (R21) NINR 2010 Epigenetic Factors Associated with Complications of Chronic Disorders (R01)
NIDA 2010 Exploring Epigenomic Processes and Non-Coding RNAs in HIVAIDS (R01 and R21) NIMH 2011 Epigenomic Modifications in Neurodevelopment (R01) NIEHS 2012 Chromatin Structure Genomics and Transcriptional Responses to the Environment (R01) NIDA 2012 Drugs of Abuse and Transgenerational Phenotypes (R01) NIEHS 2012 Transgenerational Inheritance in Mammals After Environmental Exposure (R01)
NIAAA 2012 Transgenerational Effects of Alcohol (R01 and R21) NIDCR 2013 Epigenomics of Virus-Associated Oral Diseases (R01)
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
Epigenomics Program Publications to Date
350
300
250
200
150
100
50
0
Nature 10 Cell 13 Science 2 Nat Biotech 6
301
2008 2009 2010 2011 2012 2013
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
Using Epigenomics Data to Interpret GWAS Hits
Science 2012 48983-90
