Optimise the Application of CRISPR Precision Gene … · Optimise the Application of CRISPR Precision Gene Editing ... Researcher and ... Researcher, Molecular Geneticist,

Optimise the Application of CRISPR Precision Gene Editing to Drive Your R&D Innovations

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Tel: +44 (0)203 141 8700 Email: [email protected] CRISPR Precision Gene Editing

Expert speakers include:

Wendy HarwoodProfessor & Senior Scientist, Crop Genetics DepartmentJohn Innes Centre

Laurens PauwelsProject LeaderVIB Center for Plant Systems Biology, Ghent University

Ana Atanassova Global Regulatory Affairs ManagerBayer CropScience

Stefan JanssonProfessor in Department of Plant PhysiologyUmeå University

Richard Dale Herbicide Molecular Sciences Team LeaderSyngenta

Filip CnuddeEU Government Affairs and Science Policy LeaderDow AgroSciences

www.crispr-agbioeu.com

25-26 September 2017 London, UK

http://www.crispr-agbioeu.com

mailto:[email protected]

https://www.linkedin.com/groups/6792853/profile

CRISPR AgBio Precision Genome Editing Congress Europe 2017 25-26 September, 2017 | London, UK


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Improve CRISPR workflows for plants & crops

Discover EU regulations for gene editing

Enhance specificity & efficiency

Harness CRISPR as a novel breeding technique

Advance trait discovery & validation

Increase yield production

Optimise targeted screening methodologies

Enhance drought tolerance traits

Improve complex delivery

Improve disease resistance in plants & crops

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Highly interesting congress, great speakers covering a broad range of CRISPR-associated topics, and ideal setting for networking with academic experts and peers in the industry

CRISPR AgBio US Attendee, Bayer CropScience NV

CRISPR AgBio Congress allowed me understand the current status of genome editing technologies, as well as network with peers in the industry

CRISPR AgBio US Attendee,University of Arkansas

Hear what previous attendees have to say from CRISPR AgBio US:

Enhance your precision gene editing workflows to unravel the potential of this breakthrough technology

Stay up to date with this fast moving technology to advance your trait selection & discovery applicationsCRISPR AgBio Europe 2017 is the only end to end meeting bringing together Agri biotechs and academia to advance the application of CRISPR gene editing in agriculture R&D. Learn about the CRISPR technology advancements in plants, using CRISPR as a valuable trait discovery tool and commercialisation of CRISPR edited plants and crops. Discover how the industry is developing CRISPR technology as a novel breeding technique to enhance yield by advancing desired trait selection, and accurately engineer disease and drought resistant traits in crops. Uncover the current EU regulatory perspective and guidelines for the commercialisation of CRISPR generated plants and crops, and how the industry are navigating the complex regulatory environment.Learn how academia and industry are optimising CRISPR workflows to enhance specificity, efficiency and delivery in a range of plants and crops. Hear about how this breakthrough technology is transforming functional genomics in basic research and industry applications to advance your understanding of genetic traits, and how they can be manipulated for improved agricultural productivity and yields.Realise the potential of CRISPR as a novel breeding technique by learning from key industry leaders from Europe and around the world, who are driving the field forward through the discovery and development of CRISPR-enhanced plants and crops that help attain sustainable yields that meet growing demands.

Advance your understanding of CRISPR technology & uncover novel applications




Expert SpeakersWendy HarwoodProfessor & Senior Scientist, Crop Genetics DepartmentJohn Innes Centre

Stefan JanssonProfessor in Department of Plant PhysiologyUmeå University



Cécile Collonnier Academic Scientist French National Institute for Research in Agronomy (INRA)


Damiano MartignagoGenome Editing Specialist, Plant SciencesRothamsted Research


Anindya BandyopadhyayScientist II, Molecular BiologyInternational Rice Research Institute

Mariette AnderssonResearcher and Deputy Head of the Plant Breeding DepartmentSwedish Agricultural University

Abdellah BarakatePost-Doctoral Researcher, Molecular Geneticist, The James Hutton Institute

Jan SchaartScientific ResearcherWageningen Universiteit



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All speakers were outstanding. I wanted to learn more about cutting edge developments, and I did, but also wanted to know a lot more about commercialization/regulatory/consumer issues, and I learned a lot about these aspects as well

CRISPR AgBio US Attendee, University of Florida Citrus Research and Education Center




Conference Day One | Monday 25th September, 2017

8.00 Registration & Coffee

9.00 Chair’s Opening Remarks

Optimisation of CRISPR Precision Gene Editing Technology

Cécile Collonnier Academic Scientist French National Institute for Research in Agronomy (INRA)

9.10 Deciphering the DNA Repair Mechanisms Involved in CRISPR-Induced Gene Targeting: Focus on the Model Physcomitrella Patens• P. patens, an excellent model to study DNA repair pathways involved in CRISPR-

mediated gene targeting in plants• Identification of key factors involved in CRISPR-induced gene knock-in in plants• Increasing CRISPR-induced gene knock-in frequency and quality by orienting DNA

repair pathways in the cells

Abdellah BarakatePost-Doctoral Researcher, Molecular Geneticist, The James Hutton Institute

9.40 CRISPR/Cas9 Based Gene Editing in Barley & Potato: From Construct Design to Mutation Screening• Improvements of CRISPR/Cas9 gene editing protocol from construct design to

mutation (Indels) screening• Use of CRISPR/Cas9 to manipulate meiosis, lignin and other pathways in barley,

wheat and potato• Highlight encountered problems and solutions including failed experiments• Attempts to improve gene replacement efficiency

Wendy HarwoodProfessor & Senior Scientist, Crop Genetics DepartmentJohn Innes Centre

10.10 CRISPR/Cas9 Genome Editing in UK Crops• The production of targeted gene knock-outs is impacting many different areas of

research• Examples will be given in wheat, barley and Brassica crops and the latest

developments in the technologies discussed• Technologies to increase throughput and efficiency will be described• A platform has been established to provide this technology to the research

community

10.40 Speed Networking & Morning Refreshments


11.40 CRISPR Cas9 & CRISPR Cpf1 to Manipulate Stomatal Developmental Pathway in Rice• Modification of CRISPR Cas9 and Cpf1 for application in rice• Targeting of genes related to stomatal developmental pathway• Nano cargo and CRISPR-Cas interface for transient delivery

Advancing the Application of Precision Gene Editing in Agricultural R&D


12.10 Impact of Genome Editing Technologies in Crop Protection Research• Current use of genome editing technologies in crop protection research• Future applications of the technology • Specific challenges facing use of genome editing in crop protection research



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12.40 Networking Lunch


13.40 A Dual-sgRNA Approach for Functional Genomics in Arabidopsis Thaliana• Efficient generation of inheritable mutations in Arabidopsis using CRISPR/Cas9• Deleting gene fragments by a paired nuclease approach to obtain knockouts• Examples of applications in tomato and corn to study genes implicated in leaf

development

Jan SchaartScientific ResearcherWageningen Universiteit

14.10 Harnessing CRISPR/Cas9 for Functional Genomics in Trait Discovery & Selection • Optimising CRISPR multiplexing to study gene interactions• Investigating the role of genes in disease resistance• Applications of gene editing in functional genomics and trait discovery

14.40 Afternoon Refreshments & Poster Session


15.10 Interactive Workshop: Optimisation of CRISPR/Cas9 Specificity, Efficiency & Delivery within Plant CellsThis workshop will help you maximise the use of CRISPR in your research through case study-

driven discussions on optimising CRISPR application in plants and crops. You will learn the following lessons in this interactive workshop:

• Pros and cons of CRISPR/Cas9 variants and Cpf1 in off-target efficiencies

• Improving off-target detection in plants and crops

• Optimising homology-directed repair (HDR) opposed to non-homologous directed repair for gene replacement

• Utilising the gene gun (biolistics) method

• Developing agrobacterium mediated delivery into plants

• Delivery of RNPs in plant

• Nano material cargos for delivering CRISPR-Cas systems in nucleus and chloroplast

17.10 Chair’s Closing Remarks

17.15 Close of Day 1

Part of the CRISPR Event Series



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Conference Day Two | Tuesday 26th September

8.00 Registration & Coffee

9.00 Chair’s Opening Remarks

Addressing the Regulatory Perspective on CRISPR as a Novel Breeding Technologies


9.10 Review of Regulatory Developments for the Application of Genome Editing in Plant Breeding• The regulatory context for plant products developed with the application of genome

editing tools

• Examples of how regulation is evolving and what developers should keep in mind

• Addressing the key challenges and opportunities


9.30 Addressing Regulatory Pathways for Novel Breeding Techniques • Highlighting the historical regulatory environment for past novel breeding

technologies- What have we learnt?

• How are industry working with regulatory bodies to navigate the current guidelines?

Stefan JanssonProfessor in Department of Plant Physiology Umeå University



9.50 Panel Discussion: Uncovering Key Regulatory Developments for the Use of Gene Editing Technologies in Agriculture

To provide more clarity to what the current regulatory guidelines are for utilising CRISPR gene editing technology to develop commercial products the panel will discuss and answer the following questions: • How might the outcomes achieved by new technologies like CRISPRs affect the

regulatory profile in plants and animals?

• How does the scientific community need to engage the wider public on CRISPR edited commercial products?

• How to commercialise CRISPR/Cas9 agriculture products

• What can we learn from earlier novel breeding techniques?

10.35 Networking Break & Morning Refreshments

Realising the Potential of CRISPR for the Advanced Development of Modified Plant & Crops

Damiano MartignagoGenome Editing Specialist, Plant SciencesRothamsted Research

11.10 Genome Editing in Wheat: A Challenge Worth Accepting • Setup of CRISPR/Cas9 genome editing in hexaploid bread wheat (T. aestivum) and

addressing the results obtained

• Discussion on mutants characterisation and genotyping strategies

• Rice vs Wheat: What are the differences and opportunities?

Mariette AnderssonResearcher and Deputy Head of the Plant Breeding DepartmentSwedish Agricultural University

11.40 Multiallelic Mutagenesis in Tetraploid Potato by CRISPR/Cas9 Expression in Protoplast• Implementation of CRISPR/Cas9 as a new efficient breeding technology in potato • Development of a commercial product, an amylopectin potato, together with the

Swedish starch producers • Optimising CRISPR/Cas9 methodology to increase output frequency of

commercially interesting lines • Time frame from trait idea to commercial product using implemented new

breeding technology



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12.10 Networking Lunch

14.10 Networking Break & Afternoon Refreshments

Cécile Collonnier Academic Scientist INRA-IJPB

14.40 Interactive Workshop: Harnessing CRISPR Gene Editing for Functional Genomics to Advance Trait Discovery CRISPR precision editing has become a vital tool in understanding gene interactions

and the role of genes in biological processes. This interactive session will help optimise your CRISPR gene editing workflows to enhance your trait discovery and selection for advanced plant breeding. Discover the following at this focused workshop:

• Optimising CRISPR workflows for advanced trait selection and discovery

• Addressing technical challenges in applying precision gene editing for whole genome screening

• Examples of using CRISPR for manipulating genes for desired traits in plant breeding

• Future applications of CRISPR as a novel breeding technology

16.40 Chair’s Closing Remarks

16.45 Close of CRISPR AgBio Congress Europe 2017

13.10 Interactive CRISPR AgBio Roundtable Session In this session, you will have the opportunity to catch up on the latest advancements within the field and learn from

your fellow colleagues in this interactive format to optimize the use of CRISPR gene editing technology in agriculture. The topics that will be discussed are the following.



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Harnessing CRISPR gene editing to improve nutritional value

Communicating the benefits of CRISPR technology to consumers

Advancing the commercialisation of CRISPR in agriculture

Developing plant pharmaceuticals through CRISPR gene editing

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I think it is a very successful conference. I like the interactions with other attendees, very good networking opportunities with the limited number of attendees. I also like the voice from government agencies on genome editing and regulatory policy

CRISPR AgBio US Attendee, University of Maryland




TYPICAL BREAKDOWN OF AUDIENCE HERE IS WHAT CRISPR AGBIO US ATTENDEES THOUGHT

CRISPR AgBio Europe 2017 provides a unique platform to meet and collaborate with senior decision makers in this new emerging community. This is your chance to showcase your brand and ideas at the first and only European-centric meeting dedicated to help agricultural biotech and agrochemical companies leverage the power of CRISPR/Cas9 technology.

Gain commercial exposure through a unique opportunity to network and be part of the hot

topic discussions surrounding CRISPR technology in agriculture. Feed back to your business to create products and services that you know are going to be in line with what your clients are wanting now.

There is no one size fits all approach to partnership at CRISPR AgBio Congress. Your business has specific goals this year. When you work with us we will build a partnership that helps you achieve those aims.

WHY PARTNER?

agree that CRISPR AgBio Congress offers you the chance not just to listen, but to become part of the discussion

agree that CRISPR AgBio Congress is an opportunity to attend sessions of the highest quality within the industry

agree that CRISPR AgBio Congress is the place to stay up to date with the industry

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13% Scientist

11% Director

10% Professor

9% Chief/CxO

6% Project/Team Leader

5% President

2% Head

1% Senior Director

Diane McKenna

Commercial Director

T.+44 (0)20 3141 8700

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The conference is of great interest because it will cover the newest topics and the regulatory status related to CRISPR/Cas9 technology. I am especially excited for the opportunity to interact with leaders in the field and the potential for collaborations

Speaker at CRISPR AgBio US, Boyce Thomson Institute

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Optimise the Application of CRISPR Precision Gene … · Optimise the Application of CRISPR Precision Gene Editing ... Researcher and ... Researcher, Molecular Geneticist,