Overview of the Harvard Catalyst Imaging program

Randy Gollub,MD,PhD; Ron Kikinis, MD; Bruce Rosen, MD, PhD;Clare Tempany, MD;

Valerie Humblet, PhD

http://catalyst.harvard.edu April 14, 2009

Harvard Catalyst: The History and the Basics

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• GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued– BWH/MGH imaging cores

• CTSA 2007(Roadmap initiative)• HU- Response-Harvard Catalyst

– (PI Lee Nadler/Co-Director: Steve Freedman)– GCRC at BWH incorporated in Center for Clinical Investigation

• We are a pan-Harvard enterprise dedicated to improving human health by:– Creating Connections– Enabling research At the Cutting Edge of discovery– Nurturing clinical and translational researchers

National Effort in C/T Research

38 AHC/23 states

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• Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08

Source: http://www.ctsaweb.org/

Duke

Mayo Clinic

Cornell

J.Hopkins

UC Davis

Wash. U.

Northwestern

Emory U.

• Imaging programs-(Dan Sullivan/RSNA)

Institutions participating in Harvard CTSC

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 Academic Healthcare Centers• Beth Israel-Deaconess Medical

Center• Brigham and Women’s Hospital• Massachusetts General Hospital• Children’s Hospital Boston

Specialty Hospitals and Institutes• Dana-Farber Cancer Institute• Forsyth Dental Institute• Joslin Diabetes Center• Massachusetts Eye and Ear

Infirmary• McLean Hospital• Schepens Eye Research Institute

Massachusetts Institutes of Technology

Harvard University• Faculty of Arts and Sciences• Harvard Business School• Harvard School of Dental Medicine• Harvard Divinity School• Graduate School of Design• Graduate School of Education• Kennedy School of Government• Harvard Law School• Harvard Medical School• Harvard School of Public Health• Harvard School of Engineering

Community Healthcare Institutions• Cambridge Health Alliance• HMS Department of Ambulatory

Care and Prevention at Harvard Pilgrim Healthcare

Red –Imaging Consortium

Yearly budget: $38 million (23 NIH + 15 matching)

Harvard Catalyst

• Programs (Selected list)

– Development of Novel C/T Methodologies– Biomedical Informatics– Research Education, Career Development– Pilot studies– Community Engagement– Design and Biostatistics– Diversity and Health Disparities Research– Ethics– Linkages across the institutions– Regulatory Knowledge and Support

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Harvard Catalyst

• Programs– Translational Technologies and Resources

• Imaging and Genetics– increases investigator awareness and

utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies.

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Bruce Rosen, DirectorRandy Gollub, Co-DirectorGordon J. Harris, Site Co-Director

Robert Lenkinski, Site Co-DirectorNeil Rofsky, Site Co-Director

Clare Tempany, Site Co-DirectorRon Kikinis, Site Co-DirectorGordon Williams, PI for CTSC Translational Technologies

Stephan Voss, Site Co-DirectorSimon Warfield, Site Co-Director

Annick D. Van den Abbeele, Site Co-DirectorJeff Yap, Site Co-Director

Gordon J. Harris, Site Co-DirectorAnnick D. Van den Abbeele, Site Co-DirectorWilliam Hanlon, Core Manager

Valerie Humblet, Imaging LiaisonYong Gao, XNAT Engineer

Imaging Consortium Team

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Mission of the Imaging Consortium

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• Expand imaging in clinical research– Build infrastructure (software, image analysis and

visualization tools, cross-site acquisition tools)– Provide expert consultation in the use of imaging as

part of clinical translational research– Educate and advise about available imaging and

image processing capabilities in the Harvard environment.

– Provide education at the local and national level (participation in RSNA education program)

Harvard Catalyst website

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http://catalyst.harvard.edu/home.html

Harvard Catalyst website

Image Consortium Consultation Service

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Image Consortium Consultation Service

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Technologies and Expertise

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• Cancer imaging, MRI, PET, CT, fMRI, US, pediatric imaging, neuroimaging.

• Focused on assisting with planning and design of research proposals and/or methods for image analysis.

• Consultation is available for the preparation of a grant or IRB submission.

• We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies.

Examples of Imaging Consultation

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• Standardization of physiologic monitoring system for MRI.

• Development of lingual nerve imaging (MGH-BIDMC)

• Multi-site structural and functional neuroimaging (BIDMC-MGH)

Examples of Imaging Consultation

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• Study of brain-development in premature infants (CHB-BWH-MGH)

Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation

in Infants (MGH)

CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center

Medical Imaging Informatics

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• Examples:

– Clinical:• Ruling out appendicitis based on CT scans. Are

there metrics that can be found by analyzing clinical data?

• Quantitative output from Freesurfer for Alzheimer disease

– Research:• Helping TIMC get easier access to PACS system

for clinical trials

Medical Imaging Informatics

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• IT Catalyst infrastructure:– i2b2: scalable computational framework to help

translation of genomic findings. – BIRN: XNAT imaging informatics platform: large

collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.

– NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer.

XNATEnterprise

DataRepository

(CRC)

FileRepository

IdentityManagement

OntologyManagement

CorrelationAnalysis

De -Identification

Of dataNatural

LanguageProcessing

AnnotatingGenomicData #1

ProjectManagement

WorkflowFramework

AnnotatingGenomicData #2PACS PACS

i2b2 HIVE

Dr X Desktop Pediatric

rare disease

Dr YDesktop

Alzheimer

Dr ZDesktop

Chronic pain management Dr W

Desktop Quantitative

cancer biomarkers

Medical Imaging Informatics

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Educational Opportunities proposal

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• Nanocourse: – Imaging 101 to increase knowledge about imaging

• More advanced classes for radiologists:– Tumor metrics– Radiation safety issues for IRB submission– Hands-on classes on data analysis– Imaging perfusion– Example: www.na-mic.org/Wiki/images/8/8b/Slicer3Training_ChangeTracker.ppt

Pilot funds

• Eligibility:All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation.

• First round: 62 projects funded (out of 602)• Funds:

Pilot Grants will be awarded in the amount of $50,000, with an award period of one year. (80 grants expected)

• Deadlines:Letter of intent: May 13, 2009

Full application: June 12, 2009• Contact:

Harvard Catalyst Research Navigators617 432-7800

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http://catalyst.harvard.eduImage_Consult@catalyst.harvard.edu

www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC