PARTNERING FOR

INNOVATION - Enriching

lives, shaping the future

MIDA SEMINAR ON CAPACITY

BUILDING FOR

PHARMACEUTICALS AND MEDICAL

DEVICES INDUSTRIES

7TH SEPTEMBER 2016

ROFINA YASMIN OTHMAN ASSOC VICE CHANCELLOR (INDUSTRY & COMMUNITY NETWORKS)

Malaysia’s first & top university

Ranked 3rd in South East Asia, 27th in Asia (QS Asia 2016), 146th in the World (QS 2015)

First university in Malaysia to be awarded QS 5-Stars (2014)

Only Malaysian university in ARWU 301-400 (2015)

Situated on a 812-acre campus in the southwest of Kuala Lumpur

Status: Research Intensive, Government Supported

Faculty: ~2,000 (~300 international)

Students ~23,000 (1:1 UG to PG, 3100 international)

>50 research centres, 6 Research Clusters

Malaysia’s largest (1,200 beds) & best teaching hospital

2

Malaysia’s Best Research Univ 2015

QS Top 50 Ranked in 2 subjects QS Top 100 Ranked in 9 subjects

3,446 ISI-indexed papers

3,799 Scopus-indexed papers

8,147 Citations

2.14 Citations per paper

1.38 Field-weighted citation impact

130 Patents filed

28 Patents granted

2,049 Inbound Students

2,138 Outbound Students 3

Faculties

Medicine

Science

Engineering

Built Environment

Economics &

Administration

Business &

Accountancy

Education

Research Clusters

Wellness

Innovative Technology

Frontier Science

Equitable Society

Humanities

Sustainability Science

4

12 Faculties

2 Academies

4 Institutes

3 Academic

Centres

6 Research

Clusters

Broad-based Research-Intensive University

Sports Centre

Languages

& Linguistics

Law

Cultural Centre

Dentistry

Computer Science

& IT

Arts & Social

Sciences

Islamic Studies

Malay Studies

>100 undergrad programs >100 Masters programs 4 Doctoral programs

Institutes

Graduate

Studies

Asia-Europe

INPUMA

Educ Leadership

Centres

Foundation

Studies

Sports

Cultural

QS Top 50 Ranked in 2 subjects QS Top 100 Ranked in 9 subjects

5

Talent engagement –

invitation for industry to

register

• Student recruitment

• Practical training placements

• Strucutued internships

• Postgraduate placements and

recruitment

• Industry sponsored MSc/PhD

FOCUS FACULTY:

FACULTY OF MEDICINE (FOM)

8

Bachelor in Pharmacy

(Honours)

Students undertake broad training in:

• physical and biological sciences;

• knowledge of drugs and their effects,

• the application of this knowledge to individuals;

• the ability to provide advice and pharmacy care to

consumers;

• and a scientific approach that will permit critical appraisal

of developments in pharmaceutical sciences.

4 years course

44 core pharmacy modules

One Stop Centre for

Pharmaceutical Research

• University of Malaya also offer Postgraduate programmes by research leading to MSc and PhD degrees.

• The research programmes encompass various areas of pharmaceutical sciences, including medicinal chemistry, natural products chemistry, drug action, drug delivery, and project related to clinical and pharmacy practice.

• The department is equipped with state-of-the-art research tools for biological chemistry, analytical chemistry and formulation research such as a pharmaceutical pilot plant facility for scale up experimental production of liquid and solid dosage forms and medium throughput biomolecular assays facility.

Faculty of medicine

Bsc (biomedical sciences) Parasitology, pharmacology,

Medical microbiology,clinical

chemistry

Faculty of science

BSc Microbiology, Biohealth,

Biochemistry, Chemistry

Faculty of engineering

B.Eng (biomedical engineering)

Research & Services Opportunies at UM

University of Malaya Medical Centre

1.0 Million patients annually

Established in 1968

Statutory body under the Ministry of Education

Pioneer in Clinical Research & Teaching

Core activities – health services, teaching and research

FACILITIES AVAILABLE 1:

CLINICAL INVESTIGATION CENTRE

15

CLINICAL INVESTIGATION CENTRE

FACULTY OF MEDICINE | UNIVERSITY OF MALAYA

Focus facility 1: Clinical

Investigation Centre

Location

13th floor, Main Tower, 2nd floor RUKA building,

Oncology and Renal unit of UMMC

A dedicated unit for conducting clinical trials at

University Malaya Medical Centre (UMMC)

OBJECTIVES

To serve pharmaceutical and biotech companies in

providing a unique combination of academic

excellence and experience to expedite safe and

quality trials in Malaysia

To provide a carefully controlled research

environment, centered around patients, for doctors

and clinical scientists to conduct safe and high

quality clinical trials

OBJECTIVES

To ensure that all clinical trials are compliant with

the Malaysian and ICH Good Clinical Practice

Guidelines and observe current standards of

research ethics. CIC ensures that research

performed under its auspices is acceptable to

international regulatory authorities

To serve as a resource for apprenticeship for

young clinical investigators

Services

Point of contact to access an integrated network of

top performing clinical investigators

Feasibility surveys

Budget negotiation and Clinical Trial Agreement review

Access to UMMC’s large pool of potential research subjects

including healthy volunteers

CIC

Sponsor

Services CIC

PI

Dedicated & experienced study coordinators

Financial management & legal liaison

Provision of facilities to conduct trials

Conduct GCP training and updates

ACHIEVEMENTS

1. 2010:

Recognised by Quintiles, the world

largest CRO as the first prime site in Asia

for the conduct of clinical trials

ACHIEVEMENTS

2. May 2013: Awarded the Best Prime Site in

the world for Recruitment number at the

half-year mark of 2013 by Quintiles

3. ASIAN MANUFACTURING

AWARDS 2013 :

Best Clinical Trial Provider

4. July 2013: Awarded by Pfizer Inc as a site of INSPIRE

Program, the first in Malaysia

5. Jun 2014 : INSPIRE site for Pfizer

INSPIRE stands for Investigator Networks, Site Partnerships

and Infrastructure for Research Excellence are strategic set

of sites that are highly productive, medically relevant &

aligned to Pfizer’s business

FOCUS FACILITY 2:

ANIMAL EXPERIMENTAL UNIT (AEU)

ANIMAL EXPERIMENTAL UNIT (AEU)

FACULTY OF MEDICINE | UNIVERSITY OF MALAYA

26

The Animal Experimental Unit (AEU) of the Faculty of Medicine (FOM)

was established in 2012 and in 2014 became the first academic

institution in Malaysia to receive FULL AAALAC accreditation. FOM also

operates four satellite laboratories

FOM, UM

AEU

Rodents

Rabbits

SAF

Rodents

Parasitology

Pharmacology

Physiology

Zebrafish Biomedical

Sciences

ANIMAL EXPERIMENTAL UNIT (AEU)

FACULTY OF MEDICINE | UNIVERSITY OF MALAYA

FACILITIES

EQUIPMENT

Holding and Procedure Rooms Operating Theatre and Post Operative Recovery Room ABSL-2 Suite Specific Pathogen Free (SPF) Suite ZebraFish Laboratory

Open Cages – Rodent & Rabbit Individually Ventilated Cages (IVC) Cage Changing Station Biohazard Class II Safety Cabinet In–Vivo Imaging System

ANIMAL EXPERIMENTAL UNIT (AEU)

FACULTY OF MEDICINE | UNIVERSITY OF MALAYA

ANIMAL EXPERIMENTAL UNIT (AEU)

FACULTY OF MEDICINE | UNIVERSITY OF MALAYA

• Facility Induction Course Responsible Care Use and Laboratory Animal Course(RCULAC)

• Basic Rodent & Rabbit Handling • Veterinary Medical Care Training • AAALAC International Accreditation Consultancy • Basic Rodent & Rabbit Necropsy & Tissue Collection

Techniques

TRAININGS OFFERED

Training/consultations conducted to date: • Faculty of Medicine, Universitas Padjadjaran

Indone – Facility operation • USM – Facility Operation • Institute of Health Sciences, University of

Brunei Darussalam – MLT Training • IPHARM – Veterinary Medical Care Training • International Islamic University of Malaysia

(IIUM) – AAALAC • Sunway University – AAALAC • UPM - AAALAC

SUCCESS CASES

ANIMAL EXPERIMENTAL UNIT (AEU)

FACULTY OF MEDICINE | UNIVERSITY OF MALAYA

FOCUS FACILITY 3:

INFRA SERVICE LABORATORIES

IPPP

UMRESEARCH | UNIVERSITY OF MALAYA

INFRA Laboratories are equipped with

advanced technology facilities with

excellent technical support to fulfil our

customers’ needs.

SERVICES & FACILITIES OFFERED

• Services consist of:

1. Sample Testing

2. Training & Workshop

3. Collaboration in R&D

NMR

machine

HPLC machine

FOCUS FACILITY 4:

HIGH IMPACT RESEARCH (HIR)

HIGH IMPACT RESEARCH

UNIVERSITY OF MALAYA

RM600 MILLION FACILITY

OPEN FOR INDUSTRY USE

EQUIPMENT AVAILABLE

EQUIPMENT AVAILABLE

EQUIPMENT

AVAILABLE

EQUIPMENT AVAILABLE

CENTRES OF RESEARCH Focused, Multidisciplinary & Cross Faculty Centres – A selection from more than 50 centres on campus

WELLNESS RESEARCH CLUSTER Dean: Prof dr norhayati

Deputy dean: Dr Ivy Ching

GRAND CHALLENGE: ACTIVE AGEING

• Wellness Research Cluster (WRC) coordinates multi and

trans-disciplinary research activities that promote human

well-being and complementing the eight elements of

wellness;

• Currently, we are challenging researchers to demonstrate

new ways of thinking that go beyond traditional

frameworks and disciplines through a grand challenge

program- ACTIVE AGEING.

FOCUS:

CENTRE OF EXCELLENCE (COE)

TIDREC

45 TROPICAL INFECTIOUS DISEASES

RESEARCH & EDUCATION CENTRE

ONE-STOP RESEARCH

CENTRE FOR TROPICAL

INFECTIOUS DISEASES

• TIDREC was established in 2008

• Focal point for national and international collaborative

research for academic institutions and research industries

in Malaysia

• FIRST in country to install fully certified modular

Biosafety Level 2 & 3 Laboratories for research involving

virulent pathogens.

• ONLY centre operating a mock BSL 3 training facility

SERVICES OFFERED

• Virus detection and serotyping and serological assay

• Bacterial identification

• Antiviral Screening

• Biohazard Spill Kit

• Consultations and training modules on biosafety and biosecurity.

Centres for informatics

Centre for Medical informatics and biological microelectronics systems (CMMS)

• Innovative technology

cluster

• Faculty of Engineering

Centre of Research for Computational Sciences & Informatics for Biology, Bioindustry, Environment, Agriculture, and Healthcare (CRYSTAL)

• Frontier science cluster

• Faculty of Science

CENAR

Centre for Natural Products Research and Drug Discovery

• Dept of Chemistry, Faculty of Science

• Focus on multi-discipline research in natural

products and drug discovery

SERVICES OFFERED

Centre for Natural Products Research and Drug Discovery

• Plant identification

• Biological Screening (in-vivo and in-vitro)

• Analysis of plant active compounds

• Extraction methods for testing and commercialization

• Preparation of crude drug extract

• Standardization of products

• Consultancy in commercialization (biological and green

chemistry products)

• Extraction and isolation of active compounds

• X-ray structure determination and characterization

• Synthesis, semi-synthesis, heterocyclic and macrocyclic

synthesis

Core Activities

Synthesis & Characterization In-vivo biological applications

Structure Elucidation

Some of Our Pool of Experts &

Expertise

• Prof. Dr. Adeeba binti Kamarulzaman

• Infectious/Communicable Diseases

• Prof. Dr. Mohd Rais bin Mustafa (Pharmacologist)

• Drug screening & bioassays, flavonoids, endothelial dysfunction

• Prof. Dr. Mustafa bin Ali Mohd (Pathologist)

• Endocrine disrupters, clinical pharmacology, drugs of abuse, traditional medicine, medicinal chemistry, xenobiotcs, toxicology

• Prof. Dr. Sazaly bin Abu Bakar (Medical Microbiologist)

• Virology, Baceteriology, Biorisk Management

• Prof. Dr. Lam Sau-kuen (Physiologist)

• Systems Physiology

INDUSTRY

ENGAGEMENT

A structured system

of managing research

output, intellectual property and

Industry engagement

Providing an accessible and supporting environment for industry engagement

INTELLECTUAL PROPERTY

PATENTS, COPYRIGHTS ETC

• LIST AVAILABLE

• FAST TRACK INDUDSTRY FRIENDLY LICENSING

• DEDICATED IP MANAGEMENT OFFICE

Rank Applicant No. of Applications

2014 2015

1 Universiti Malaya 164 129

2 Universiti Teknologi Malaysia 90 101

3 MIMOS Berhad 117 98

4 Universiti Putra Malaysia 49 46

5 Universiti Malaysia Sarawak 10 36

6 Majlis Amanah Rakyat (MARA) 18 34

7 Universiti Malaysia Pahang 20 31

8 Universiti Kebangsaan Malaysia 33 28

9 Malaysian Palm Oil Board (MPOB) 15 24

10 Universiti Sains Malaysia 14 22

Sumber : KASS IP

CREATING SPACES FOR

INTERACTIONS WITH

INDUSTRY

Industry on campus

• UM has created spaces for industry on campus and will

continue to open opportunities for strategic partnerships

• Industry laboratory spaces

• Incubator facilities

• Co-working spaces

• Access to facilities

• Industry faculty

.

UM Incubators

OFFICE PREMISE

LAB AND OFFICE

SHARED FACILITIES

INNOVATION SPACE/ SHOW

ROOM RECREATIONAL

MEETING SPACE

Current

incubator in

IPPP building

11 incubatees

2 partner tenants

Idea space

PERSPEKTIF DARI BELAKANG

Floor 4

• ICT accelerator and incubator

• MSC incubator status (Whole facility pending approval)

Floor3

• Diagnostic and Life science accelerator and incubator

• GLP and GMP pilot Floor2

• Physical science E&E incubators

• Gan-on Gan LED incubator (a CREST partner with UCSB)

Floor1

• Sub surface O&G incubator and services (an MPRC partner )

Co-incubation opportunites

under ASEAN USTART

Incubate

Launching November 2016 - UNIVERSITY INNOVATION INCUBATOR COMPLEX (I2U) UNIVERSITY OF MALAYA

Professionally managed full serviced incubator . Strategic tenancy focus

Provision of high end technology services to industry

B 2 B @ UM – WORK WITH OUR

STARTUPS & SPIN OFFS

Cytus Sdn Bhd

Oleopharma

Sdn Bhd

Pharmauji Sdn Bhd in partnership with

Develop a world–class program to

• a) bring out licensable pharmaceutical drug candidates for

commercialization eventually by pharma companies;

• (b) establish a world-class biotech business environment in Malaysia, in

partnership with international partners

• (c) train and develop biotech 50-60 Scientists, drawn from University of

Malaya or other institutions of higher learning in Malaysia, and industry in

Malaysia

Tech focus

“MEDCOM

CENTRAL"

Modular work flow management

system for Surgeons and Hospital

Managers

Accessible through Mobile devices • Real Telemedicine

• Integration, storage of transmission digital visual data and other operating room data generated

• Based on off the shelf tech integrated utilising proprietary soft ware

• Independence from proprietary devices providers

• Expandeble to other critical areas of hospital and beyond.

• Developed by Surgeons

TECH

focus

“3D

Biomodel

Printing”

https://3dprint.com/tag/university-of-malayas-

centre-for-biomedical-and-technology-

integration-cbmti/

Tech focus

“DOSIMETER“

Innovative types of optical

fiber based dosimeters

Flexible in design and

manufacturing

10x higher resolution

compared to commercial alt.

Water resistance

Immune to electromagnetic

interference

– Prof. Faisal Rafiq Mahamd Adikan

DrGhafor Amouzad Mahdiraji

Winner of Rice Bowl Awards Best ASEAN University Start-up 2015

Winner of Newton-Ungku Omar Fund Dengue Tech Challenge 2016

SENSOR FOR REAL-

TIME DOSE

MONITORING

UNLOCKING

NEW

PARTNERSHIPS

• Growing portfolio of IPR presents opportunities for Malaysia industry

• Increasing demand from international market

• Would like to accelerate transfer of technologies to industry as solution provider

• Partnerships for “first in market” proof of concept in Malaysia

• Looking to have more partners for codevelopment/test bedding/marketing/coproducing/ uptake technologies

• Would like to invite more venture funding/investment/licensing partners

ENGAGE -CONNECT! THE FUTURE IS TOGETHER

Email us : director.umcic@um.edu.my

Call us: 03-79677352 Dr Yusrizam/Wan Afna/Nasrul

Visit us: Level 5, IPPP complex, University of Malaya