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Pesquisas durante e pós epidemia do virus Zika Celina Turchi Martelli

Pesquisas durante e pós epidemia do virus Zika - IPEA · Microcephaly-definition TORCH Infections: Toxoplasmosis Other (Syphilis, Varicella-zoster) Rubella, Cytomegalovirus Herpes

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  • Pesquisas durante e pós epidemia do virus Zika

    Celina Turchi Martelli

  • Public Health Emergency of International Concern

  • Notification of microcephaly cases Brazil 2015 – Feb 2016

  • Emergence and evolution of Zika virus vector-borne transmission

    Gutiérrez-BugalloGetal.Vector-bornetransmissionandevolutionofZikavirus.NatEcolEvol.2019

  • Zika virus vector-borne transmission

    Gutiérrez-BugalloGetal.Vector-bornetransmissionandevolutionofZikavirus.NatEcolEvol.2019

  • Microcephaly-definition

    TORCH Infections: Toxoplasmosis Other (Syphilis, Varicella-zoster) Rubella, Cytomegalovirus Herpes infections

    Rare neurodevelopmental disorder

    Causes Genetic Environmental Toxic exposures Foetal alcohol S. Radiation Clinical/Infections

  • Cases series studies

  • DOI:10.2105/ Miranda et al. American Journal of Public Health - 2016

  • Modeoftransmission

    Microcephaly Intracranialcalcification

    s

    Oculardisease

    Hearingdeficits

    Cytomegalovirus Persontoperson ++ + + ++

    Toxoplasmosis Food + + + -

    Rubella Persontoperson + - + ++

    Herpessimplesvirus Persontoperson + - + +

    ZikavirusVector-borneSexualTransfusion

    ++ + + +

    DOI:10.2105/Mirandaetal.AmericanJournalofPublicHealth-2016

  • DOI10.1002/ajmg.a.38170

  • Case-control study

  • Arboviroses Laboratory LaboratoryofVaccinologyandExperimentalTherapeutics

    Ø Isolation of ZIKV: Recife 2015 Ø Detection of Positive IgM for Zika virus

    30 neonates with microcephaly in Brazil Cordeiro,et al. The Lancet 387, 2016)

    Ø Reference laboratory for ZIKV

  • Funded by the Horizon 2020 Framework Programme of the European Union

  • CongenitalZikaSyndrome

    NEURO-Zika

    Non-VectorTransmission

    NEURO-Zika:Pathogenesis

    DiseaseBurdenRiskAssessment

    WEAR

    COMMUNICATIONLatin-American

    NETWORKConsortiumCoordination

    DiagnosticsEvaluation

    MODELLING

    VaccinesinADE

    ViralFitness

  • Source: Blog NE10. https://blogs.ne10.uol.com.br/social1/2019/03/14/premio-tacaruna-mulher/ Acesso em 18 de Março de 2019.

  • International Classification of Diseases The global standard for diagnostic health information

    KA62ViralinfectioninthefoetusornewbornKA62.0CongenitalZikavirusinfection

    https://icd.who.int/

    June2018

  • PubMed Search

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    84

    13911227

    659

    "Zika Virus Infection"

    1954-2015 2016 2017 2018

    “Congenital Zika Syndrome"

    0

    50

    100

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    82

    146 136

    2016 2017 2018

  • Prioritizing Severe Emerging Diseases for Research and Development

    EpidemicthreatPrioritypathogens

    1.Humantransmission2.Medicalcountermeasures3.Severityorcasefatalityrate4.Thehuman/animalinterface5.Thepublichealthcontext6.Potentialsocietalimpacts7.Evolutionarypotential

    •  Zika•  Crimean-CongoHemorrhagicFever•  EbolaViralDisease-MarburgViral•  LassaFever•  MERSandSARS•  Nipahandhenipaviraldiseases•  RiftValleyFever•  DiseaseX

    Feb.2018http://www.who.int/blueprint/priority-diseases/en/

  • UFPE

    www.cpqam.fiocruz.br/merg/

    RicardoXimenes

    LauraRodrigues

    CelinaTurchi

    ThaliaAraujo

    WaynerSouza

    FátimaMilitão

    ErnestoMarques

    MarliTenório

    EnriqueVazquez

    CynthiaBraga

    RafaelDhalia

    SinvalBrandão