PHOTOACOUSTIC IMAGING TO DETECT TUMOR HAIFENG WANG SUBHASHINI PAKALAPATI VU TRAN Department of...
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PHOTOACOUSTIC IMAGING TO DETECT TUMOR HAIFENG WANG SUBHASHINI PAKALAPATI VU TRAN Department of Electrical and Computer Engineering University of Massachusetts
PHOTOACOUSTIC IMAGING TO DETECT TUMOR HAIFENG WANG SUBHASHINI
PAKALAPATI VU TRAN Department of Electrical and Computer
Engineering University of Massachusetts Lowell HAIFENG WANG
SUBHASHINI PAKALAPATI VU TRAN Department of Electrical and Computer
Engineering University of Massachusetts Lowell 1
Slide 2
OUTLINE Introduction Brief Principle of Photoacoustic (PA)
Different Techniques of PAI Comparison of Various Imaging
Techniques Advantages and Disadvantages Tasks Reference 2
Slide 3
Brief Conversion of photons to acoustic waves due to absorption
and localized thermal excitation. Pulses of light is absorbed,
energy will be radiated as heat. Heat causes detectable sound waves
due to pressure variation. 3
Principle of photoacoustic Optical fiber Energy absorption
layer Laser excitation Acoustic signals The light energy is
converted into thermal energy via energy absorption layer; The
thermal energy converts into mechanical wave because of thermal
expansion; An acoustic wave is generated.
Slide 7
Principle of photoacoustic by gold nanoparticle Optical fiber
Energy absorption layer Gold nanoparticle Laser pulse Sound pulse
Laser excitation Acoustic signals
Slide 8
Principle of photoacoustic by cells or tissues[1]
Slide 9
Experimental set up of photoacoustic molecular imaging[2]
Slide 10
10 Angiogenesis
Slide 11
Tumor Detection Using Endogenous Contrast Xueding Wang, William
W. Roberts, Paul L. Carson, David P. Wood and J. Brian Fowlkes,
Photoacoustic tomography: a potential new tool for prostate cancer,
2010 :Vol. 1, No. 4 : Biomedical Optics Express 1117
Slide 12
Slide 13
Using Exogenous Contrast 3-D photoacoustic imaging Evans Blue
acted as a contrast agent. Deep lying blood vessels in real tissue
samples were imaged at depths of 5 mm and at 9 mm from the plane of
detection. The sensitivity of the technique was proven by
photoacoustic detection of single red blood cells upon a glass
plate C.G.A Hoelen et.al,1998
Slide 14
PAImaging Using Gold Nano Particles 14 Qizhi Zhang
et.al,2010
Slide 15
15 Qizhi Zhang et.al.,2010
Slide 16
COMPARISON OF DIFFERENT IMAGING TECHNIQUES: ULTRASOUND
Transducer emit ultrasound wave and get signals back from object D=
t.v Scan volume to get image 16
Slide 17
COMPUTED TOMOGRAPHY Use X-ray to collect data Detector collects
the sum of absorption factors in one direction Using the computing
algorithms, the absorption factor of each voxel will be calculated.
3D image will be constructed based on these factors. 17
Slide 18
MRI A powerful magnetic field is used to align the
magnetization of Hydrogen atoms in the body Radio frequency fields
are used to alter the alignment of this magnetization Nuclei to
produce a rotating magnetic field detectable by the scanner 18
Slide 19
POSITRON EMISSION TOMOGRAPHY Positron-emitting radionuclide
(tracer) is introduced into the body on a biologically active
molecule System detects pairs of gamma rays emitted indirectly by a
tracer Three-dimensional images of tracer concentration within the
body are then constructed by computer analysis 19
Slide 20
SINGLER PHOTON EMISSION COMPUTED TOMOGRAPHY A gamma-emitting
radioisotope is injected into the bloodstream of the patient A
marker radioisotope has been attached to a special radioligand
(chemical binding properties to certain types of tissues) The
ligand concentration is detected by a gamma-camera 20
Slide 21
ADVANTAGES 1.Ability to detect deeply situated tumor and its
vasculature 2.Monitors angiogenesis 3.High resolution 4.Compatible
to Ultra Sound 5.High Penetration depth 6.No radioactive 7.Small
size 8.Easy to clean and maintenance 9.No noise 1. Limited Path
length 2. Temperature Dependence 3. Weak absorption at short
wavelengths DISADVANTAGES 21
Slide 22
TASKS To Refine and improve the paper. 22
Slide 23
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