PREMIUM QUALITY FEED-ENHANCER

Cleaner feed, improved productivity

GENEX POULTRY

SPECIES

POULTRY

Background

With the advent of ‘greener’, more environmentally

friendly farming practices there has been a distinct

move towards the production of more natural food

stuffs for human consumption. A major aspect of this

is the inevitable trend in favour of food produced under

more acceptable conditions, including animals which

have been fed diets free from inappropriate additives.

Recently, there has been a growing concern over the

irresponsible use of antibiotics in animal production

causing cross-resistance to the generation of

antibiotics intended for use in human medicine.

The consequences for food production are serious and

the industry will have to find an alternative method of

maintaining modern levels of production and routinely

controlling microbial populations - but in a way that

is consistent with a natural and ‘green’ approach.

The answer lies in Genex Poultry – a unique blend

of organic acids, essential oils and plant extracts.

By combining all of these components, Genex Poultry provides excellent protection against feed borne pathogens, collectively known as enterobacteria such as E. coli, salmonella, campylobacter etc.

The unique blend of active ingredients used in Genex Poultry is born of intensive R&D. It is not just the ingredients themselves that give the product its unique properties, it is the ratio and balance between them that achieve the optimal synergistic effect present in Genex Poultry. By examining the potential of each material and considering how it may enhance the efficacy of the other components, the researchers at Optivite designed the ultimate formulation that makes Genex Poultry so effective.

• Multiple synergistic associations: bacteriostatic and bactericide effect in feed

• Protects intestinal mucosa and villi from harmful bacteria consumed via the feed

• Helps the animal achieve the optimal intestinal microbial balance by reducing exposure to contaminated feed

• Supports animal health and digestive function

• Phyllosilicate carrier known to adsorb mycotoxins and endotoxins

• Phyllosilicate carrier enables slow release of active components

The effects of pathogenic infection:HEALTH PROBLEMS

• Diarrhoea

• Wet litter

• Secondary infections

• Mortality

PRODUCTION PROBLEMS

• Low growth rates

• Poor FCR

• Uneven growth

• Lack of uniformity

GENEX POULTRY do?What does

GENEX

ESSENTIALS OILS

PLANT EXTRACTS

ORGANIC ACIDS PhYLLOSILICATES

Organic acids – Their effect on lactobacilli bacteria

A similar process also takes place in lactic acid producing bacteria – lactobacilli. However, our acids target the harmful bacteria, not the beneficial bacteria that contribute to a healthy gut.

GENEX POULTRY:

HOW DOES GENEX POULTRY WORK?

The ScienceThe challenge from enterobacteriaEnterobacteria such as salmonella and E. coli are a major threat to the performance of poultry. There are many possible sources of infection of which feed is one of the main route.

Intestinal wall microvilli, microscopic cellular membrane protrusions, that are responsible for a wide variety of functions including absorption of nutrients, can be seriously damaged by enterobacteria. This can lead to the malabsorption of nutrients reducing the efficiency of digestion and inhibiting animal performance.

Organic acidsOrganic acids are used to control potentially pathogenic bacteria. Genex Poultry is formulated using a unique blend of organic acids combined with a stable carrier. It’s the types of acids used in Genex Poultry that make the difference.

Why use organic acids?Organic acids are used to control potentially pathogenic bacteria due to their ability to penetrate the bacterial cell wall of Gram-negative bacteria. Once the cell has been compromised the organic acids disrupt cell metabolism, thus killing the bacteria.

The essential oils in Genex• Stimulate feed intake

• Damage microorganism cell wall structure - Cell contents lost - Disrupts cell homeostasis/genetic material replication - Allows more organic acid into cell

• Prevent flagella formation - Limits movement - Limits growth & multiplication

The plant extracts in Genex• Natural surfactants

- Coats bacteria - Damages bacterial cell wall - Cell contents lost - Allows more organic acid into cell - Enhances essential oil effect

By combining all of these components, Genex Poultry provides excellent protection against enterobacteria.

The table below demonstrates the efficacy in feed of Genex Poultry at 4kg/t against a range of pathogens.

Organic acids – their effect on Gram-negative enterobacteria e.g. E. coli:

Organic acids (AH) consist of two components, negatively charged anions (A-) and positively charged hydrogen ions or cations (H+).

CONTROL

o

20

40

60

80

100GENEX POULTRY

% S

URV

IVA

L A

FTER

48h

rs

SALMO

NELLA

ENTER

ITIDIS

ESCHERIC

HIA

COLI

STREPT

OCOCCUS

FAECALIS

STAPHYLO

COCCU

S

AUREU

S

CAMP

YLOBACTE

R

JEJUN

I

PASTEU

RELLA

MULTO

CIDA

BACTERIA

E. coli adheres to the intestinal mucosa causing the destruction of intestinal microvilli

Reference: Dr David Dean, Institute of Cell & Molecular Biosciences, University of Newcastle, UK

Healthy microvilli

Challenged microvilli

Untreated cells (control)(After Burt & Reinders, Letters in Applied Microbiology (2003) 36: 162–167)

Cells damaged after treatment with essential oil

= Hydrogen/Cations (Positively charged)

= Anions (Negatively charged)

KEY:

STEP 1 – The acid penetrates the cell wall

AH move into the cell & split, acidifying the internal cell environment.In order to maintain the neutrality of the internal environment, the cell moves to step 2.

STEP 1 – The acid penetrates the cell wall

Lactobacilli are acid tolerant, so are able to cope with a greater pH shift.

STEP 2 – Removal of cations

The cell uses energy to power the proton pumps which move H+ out of the cell.

STEP 2 – Removal of cations

Less energy used in moving H+ out of the cell.

STEP 3 – Cell dies

As the cell is using all of its available energy moving H+ out of the cell normal cell function is impaired.Inhibition of DNA replacement occurs leading to cell death.

STEP 3 – Cell survives

The energy expended is low meaning more energy is available for normal cell function and viability.

CONTROL

FCR MORTALITY (%)LIVEWEIGHT (KG)

-56KCAL/KG ME,+2KG/T GENEX 2.55

2.51

-112KCAL/KG,+4KG/T GENEX 2.52

NEGATIVE CONTROL,-112KCAL/KG 2.52

1.848

1.850

1.861

1.889

7.5

7.8

7.3

10.7

CONTROL INCAGP 2.51 1.850 7.8

NO AGP,+2KG/T GENEX 2.50 1.859 7.8

FCR MORTALITY (%)LIVEWEIGHT (KG)

Using GENEX POULTRYTo control bacterial levels in feed as part of an overall reduction strategy offers a number of

benefits as the results below demonstrate

Summary of trial results, comparing feed treated with Genex Poultry to a control feed

ConclusionsTotal birds involved -

1.5 million birdsImproved FCR -

Av -0.07 (-0.04 to -0.13)Improved liveweight -

Av 58g (7g to 150g)Reduced mortality -

Av 1.01% (-0.03% to -2.43%)Faster days to market weight -

Av 1.09 (0.8 to 1.34)

Performance benefits are reported when using Genex Poultry to treat feed.

Bacterial control of the feed leads to

• More available nutrients and energy

• Better intestinal health

The benefit of this is that additional nutrients and energy are available to the bird

Energy StudyAn energy study with growing broilers was undertaken to determine the validity of a proposed feed energy value to be given to Genex Poultry.

Replacement of Antibiotic Growth Promoters (AGPs)The ability of Genex Poultry treated feed to replace feed containing AGPs was investigated to determine if performance could be maintained or even improved.

ConclusionsGenex at 2kg/t can replace 56kCal/kg of dietary ME.

Genex at 4kg/t can replace 112kCal/kg dietary ME.

• This can be used in 2 practical ways :

(a) reduce dietary ME by 56 (or 112) kCal/kg and add 2 (or 4) kg/t Genex.

(b) give Genex an ME value of 28,000 kCal/kg and formulate the diet restricting Genex to 2 or 4 kg/t as required.

• Alternatively, Genex can be added to the diet without accounting for any energy effect and accept the improvements in performance.

ConclusionsThe results suggest that feed containing Genex Poultry at 2kg/tonne will perform as well as that containing an AGP.

Case Studypoultry

Benefits of GENEX POULTRY• To control bacteria in feed and protect it

from environmental recontamination

• Allows optimal digestibility thereby improving daily liveweight gain and feed conversion

• Anti-microbial feed treatment will reduce the potential for harmful bacterial growth in the bird’s environment and thus reduce the possibility of clinical and subclinical disease

• Will not interfere with therapeutic antibiotics

• Will leave no residues or contribute to the development of drug resistance

• Treated feed has been shown to give similar or improved performance to feeds containing antibiotic growth promoters

• Effective feed treatment helping control moulds and protect feed nutrients

• Has no withdrawal period

• All ingredients are officially approved by the European Union

• Can be included in feed without the need for special equipment

• Is stable under severe heat treatment

Inclusion rates

2-4kg/t

STARTER

2kg/t

GROWER

2kg/t

FINISHER

2kg/t

WITHDRAWAL

No. OF BIRDS

LOCATION

OBJECTIVE

CHANGEIN FCR(pts)

LIVEWEIGHTIMPROVEMENT

(g)CHANGE INMORTALITY

(%)SLAUGHTER AGEIMPROVEMENT

(days)

150K

-0.06

+34

-0.67

ME 1

MIDDLEEAST

25K

-0.04

+88

-0.25

IR 1

IRAN

120K

-0.13

+7

-0.03

SA 4

250K

-0.06

+14

-1.83

SA 3

250K

-0.05

+34

-2.43

SA 2

SOUTH AFRICA

360K

-0.06

+150

-0.89

SA 1B

360K

-0.07

+80

-0.94

SA 1A

1.341.14 - - 0.8 - -

TOP DRESS 2-4kg/t

CONTROL

FCR MORTALITY (%)LIVEWEIGHT (KG)

-56KCAL/KG ME,+2KG/T GENEX 2.55

2.51

-112KCAL/KG,+4KG/T GENEX 2.52

NEGATIVE CONTROL,-112KCAL/KG 2.52

1.848

1.850

1.861

1.889

7.5

7.8

7.3

10.7

CONTROL INCAGP 2.51 1.850 7.8

NO AGP,+2KG/T GENEX 2.50 1.859 7.8

FCR MORTALITY (%)LIVEWEIGHT (KG)

GENEX POULTRY:

The SupportOptivite distributor countries

ContactOptivite Manton Wood Enterprise Park Worksop, S80 2RS, UK www.optivite.com

Email: info@optivite.com international@optivite.com

t: +44 (0)1909 537380 f: +44 (0)1909 478919

Optivite provides cutting-edge, science based products plus the support you need. Optivite’s nutritionists and animal husbandry specialists are available with expert advice, service and product knowledge, with regional sales and technical support people on-hand to assist with day-to-day challenges. What’s more, our global distributor network is here to guide you to the right product choices wherever you are in the world.