Proteinases in Inflammation and Tumor Invasion 2012-05-22آ  Proteinases in Inflammation and Tumor Invasion

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  • Proteinases in Inflammation and Tumor Invasion Review Articles including those from an International Conference Bielefeld, Federal Republic of Germany March 14-16,1985

    Editor Harald Tschesche

    W DE G

    Walter de Gruyter • Berlin • New York 1986

  • Editor Harald Tschesche, Dr. rer. nat. Professor für Biochemie Lehrstuhl für Biochemie Fakultät für Chemie Universität Bielefeld D-4800 Bielefeld Federal Republic of Germany

    Universitäts- Bibliothek München

    Library of Congress Cataloging in Publication Data

    Proteinases in inflammation and tumor invasion

    Includes bibliographies and index. 1. Inflammation—Congresses. 2. Proteinase—Physiological effect—Congresses. Cancer invasiveness— Congresses. 4. Collagen diseases—Congresses. I. Tschesche, Harald. [DNLM: 1. Inflammation—congresses. 2. Neoplasm Invasiveness—congresses. 3. Peptide Peptidohydrolases—congresses. QZ 202 P967 1985] RB131.P77 1986 616'.0473 86-16708 ISBN 0-89925-216-8 (U.S.)

    CIP-Kurztitelaufnahme der Deutschen Bibliothek

    Proteinases in inflammation and tumor invasion : review articles including those from an international conference, Bielefeld, Fed. Republic of Germany, March 14 -16,1985 / ed. Harald Tschesche. - Berlin ; New York : de Gruyter, 1986.

    ISBN 3-11-010530-6

    NE: Tschesche, Harald [Hrsg.]

    Copyright © 1986 by Walter de Gruyter & Co., Berlin 30. All rights reserved, including those of translation into foreign languages. No part of this book may be reproduced in any form - by photoprint, microfilm or any other means nor transmitted nor translated into a machine language without written permission from the publisher. Printing: Gerike GmbH, Berlin. - Binding: D. Mikolai, Berlin. - Printed in Germany.

  • CONTENTS

    G r a n u l o c y t e P r o t e i n a s e s as M e d i a t o r s o f U n s p e c i f i c P r o t e o l y s i s i n I n f l a m m a t i o n : A R e v i e w

    H. F r i t z , M. J o c h u m , K.H. D u s w a l d , H. D i t t m e r , H. K o r t m a n n , S. Neumann, H. Lang 1

    E f f e c t o f G r a n u l o c y t e E l a s t a s e on t h e M e t a b o l i s m o f P r o t e o g l y c a n s i n I n f l a m m a t o r y J o i n t D i s e a s e s

    K. K l e e s i e k , R. R e i n a r d s , H. G r e i l i n g 25

    P r o t e i n a s e I n h i b i t o r T h e r a p y o f S e v e r e I n f l a m m a t i o n i n P i g s : F i r s t R e s u l t s w i t h E g ! i n , a P o t e n t I n h i b i t o r o f G r a n u l o c y t e E l a s t a s e and C a t h e p s i n G

    M. J o c h u m , H.F. W e l t e r , M. S i e b e c k , H. F r i t z 53

    Mast C e l l s and M a t r i x D e g r a d a t i o n i n t h e R h e u m a t o i d J o i n t

    D.E. W o o l l e y , J.R. Y o f f e , J.M. E v a n s o n 6 1

    Human C a t h e p s i n B, H and L and t h e i r E n d o g e n o u s P r o t e i n I n h i b i t o r s : S t r u c t u r e , F u n c t i o n and B i o l o g i c a l R o l e

    V. T u r k , J . B r z i n , M. K o p i t a r , M. K o t n i k , B. L e n a r c i c , T. P o p o v i c , A. R i t o n j a , M. T r s t e n j a k , B. Rozman, W. M a c h l e i d t 77

    C a t h e p s i n B: A P r o t e i n a s e L i n k e d t o M e t a s t a s i s ?

    B. F. S l o a n e , R.E. R y a n , J . R o z h i n , T.T. L a h , J.D. C r i s s m a n , K. V. Honn 93

    The C o l l a g e n s - M o l e c u l a r and M a c r o m o l e c u l a r S t r u c t u r e s

    K. Kühn 107

    P r o t e o l y t i c M o d i f i c a t i o n s o f T y p e V I C o l l a g e n

    J . R a u t e r b e r g , R. J a n d e r , D. T r o y e r 145

    D e g r a d a t i o n o f S p e c i f i c C o l l a g e n s by M a c r o p h a g e s and N e u t r o p h i 1 s

    C. L. M a i n a r d i , M.S. H i b b s , K.A. H a s t y 161

    C o n n e c t i v e T i s s u e M e t a l 1 o p r o t e i n a s e s and M a t r i x D e g r a d a t i o n

    G. M u r p h y , J . G a v r i l o v i c , Ch. M c A l p i n e 173

  • VIII

    T i s s u e I n h i b i t o r o f M e t a 1 1 o p r o t e i n a s e s

    T.E. C a w s t o n , E. M e r c e r , C. Mooney, J.K. W r i a h t 189

    C o l l a g e n D e g r a d a t i o n i n P e r i o d o n t a l D i s e a s e s

    V . - J . U i t t o 211

    I n t e r s t i t i a l C o l l a g e n a s e , G e l a t i n a s e and a S p e c i f i c T y p e I V / V ( B a s e m e n t Membrane) C o l l a g e n D e g r a d i n q P r o t e i n a s e f r o m Human L e u k o c y t e s

    H. T s c h e s c h e , J . F e d r o w i t z , U. K o h n e r t , H.W. M a c a r t n e y , J . M i c h a e l i s , K. K ü h n , H. Wiedemann 2 2 5

    The R o l e o f C e l l M o t i l i t y i n Tumor I n v a s i o n

    G. H a e m m e r l i 2 4 5

    P e r i t u m o r a l E x t r a c e l l u l a r M a t r i x D e g r a d a t i o n i n t h e L o o s e C o n n e c t i v e T i s s u e o f t h e M e s e n t e r y

    W. M ü l 1 e r - G l a u s e r 2 6 1

    P l a s m i n o g e n A c t i v a t o r s and Tumor I n v a s i o n

    L. S k r i v e r , L.R. L u n d , P.A. A n d r e a s e n , P. K r i s t e n s e n , K. Dan0 2 8 1

    The R o l e o f P r o t e i n a s e I n h i b i t o r s i n C e l l u l a r I n v a s i v e n e s s : P u r i f i c a t i o n and C h a r a c t e r i z a t i o n o f a S e r i n e P r o t e i n a s e I n h i b i t o r f r o m R a t C h o n d r o s a r c o m a

    H. L e v y , G. F e i n s t e i n 3 0 5

    C h a r a c t e r i z a t i o n o f a C o l l a g e n a s e I n h i b i t o r f r o m Human A m n i o t i c F l u i d w h i c h I n h i b i t s Tumor C e l l I n v a s i o n

    H. L e v y , P. M i g n a t t i , D.B. R i f k i n 3 2 1

    D e v e l o p m e n t o f a D i r e c t M e a s u r e m e n t A s s a y f o r C o l l a g e n a s e a g a i n s t Type I and Type IV C o l l a g e n s i n T i s s u e H o m o g e n a t e and i t s A p p l i c a t i o n i n Stomach and Lung C a n c e r s

    K. K u b o c h i , K. Maruyama, I . O k a z a k i 3 3 7

    M e t a s t a t i c A b i l i t y o f L e w i s Lung C a r c i n o m a C e l l s and E x t r a c e l l u l a r P r o t e o l y s i s . I n t e r a c t i o n s b e t w e e n Tumour C e l l s and H o s t M a c r o p h a g e s i n t h e D e g r a d a t i o n o f Type I and T y p e IV C o l l a g e n

    G. V a e s , N. H e n r y , A.L. van L a m s w e e r d e , Y. E e c k h o u t 3 5 7

  • IX

    A T-Lymphoma D e r i v e d P r o t e i n a s e , S y n e r g i z i n g w i t h an E n d o g l y c o s i d a s e i n t h e D e g r a d a t i o n o f S u l p h a t e d P r o - t e o g l y c a n s i n S u b e n d o t h e l i a l E x t r a c e l l u l a r M a t r i x

    M.D. K r a m e r , V. S c h i r r m a c h e r , M. B a r - N e r , I . V l o d a v s k y 373

    P r o t e o l y t i c A c t i v i t y i n C u l t u r e d Human Lung C a n c e r C e l l s

    O.L. S c h o e n b e r q e r , H. S c h w ö b e l , W. E b e r t , P. A u l e n b a c h e r , H.O. W e r l i n g , N. P a w e l e t z 395

    L i s t o f A u t h o r s 409

    S u b j e c t I ndex 411

  • PROTEINASE INHIBITOR THERAPY OF SEVERE INFLAMMATION IN PIGS: FIRST RESULTS WITH EGLIN, A POTENT INHIBITOR OF GRANULOCYTE ELASTASE AND CATHEPSIN G

    M. Jochum, H. F. We l t e r * , M. Siebeck* and H. F r i t z

    Dept. o f C l i n i c a l C h e m i s t r y and C l i n i c a l B i o c h e m i s t r y i n t h e *Surgery C l i n i c C i t y , U n i v e r s i t y of Munich, Munich, FRG

    I n t r o d u c t i o n

    Lysosomal enzymes r e l e a s e d d u r i n g i n f l a m m a t i o n may enhance the i n f l a m m a t o r y response by s p e c i f i c a c t i v a t i o n of humoral systems ( c l o t t i n g , f i b r i n o l y s i s , complement, k a l l i k r e i n / k i n i n system) o r by u n s p e c i f i c d e g r a d a t i o n and o x i d a t i o n o f plasma f a c t o r s and t i s s u e p r o t e i n s . R e c e n t l y , the pa t h o b i o c h e m i c a l e f f e c t s of enzymes of the a z u r o p h i l i c and s p e c i f i c g r a n u l e s o f polymorpho- n u c l e a r g r a n u l o c y t e s ( e l a s t a s e , c a t h e p s i n G, collagenase, ca- t h e p s i n B, lysozyme, myeloperoxidase etc.) were i n v e s t i g a t e d i n more d e t a i l ( f o r r e v i e w o f l i t e r a t u r e see ( 1 ) ) . N o r m a l l y , t h e p r o t e o l y t i c a c t i o n o f the lysosomal p r o t e i n a s e s i s balanced by p r o t e i n a s e i n h i b i t o r s p r e s e n t i n plasma or o t h e r body f l u i d s . D uring severe i n f l a m m a t i o n , however, these p r o t e i n a s e s may be l i b e r a t e d i n amounts exceeding the n a t u r a l i n h i b i t o r l e v e l s so t h a t d e s t r u c t i v e processes can occur e i t h e r l o c a l l y or system- i c a l l y . Evidence c o u l d be presented t h a t l e u k o c y t i c e l a s t a s e i s indeed r e l e a s e d d u r i n g s e p t i c e m i a and o t h e r i n f l a m m a t o r y pro- cesses ( 1 ) . The c o r r e l a t i o n o b s e r v e d between t h e r e l e a s e o f t h i s p r o t e i n a s e and the consumption of plasma f a c t o r s i n d i c a t e s t h a t l y s o s o m a l enzymes may s i g n i f i c a n t l y c o n t r i b u t e t o t h e consumption of plasma f a c t o r s by u n s p e c i f i c p r o t e o l y s i s . Fur- t h e r o n , a d m i n i s t r a t i o n of an exogenous i n h i b i t o r of lysosomal p r o t e i n a s e s i n an e x p e r i m e n t a l a n i m a l model ( e n d o t o x e m i a ) caused a s i