QIAGEN Presents: An Investor/Analyst Event 9 QIAGEN Presents: An Investor/Analyst Event June 29, 2006

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  • Patients Growth People

    QIAGEN Presents: An Investor/Analyst Event

    Quest Diagnostics and QIAGEN Relationship

    Michael A. Lewinski, Ph.D., D(ABMM) Director, Infectious Diseases

    Quest Diagnostics Nichols Institute

    2QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    Objectives

    Who is Quest Diagnostics? Mission, Vision, Values Laboratories Industry Trends (Challenges)

    Why QIAGEN? Questions?

  • 3QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    Who is Quest Diagnostics?

    Mission: We will be the undisputed world leader in diagnostic testing, information and services

    Vision: Dedicated people improving the health of patients through unsurpassed diagnostic insights and innovation

    Values: Quality, Integrity, Innovation, Accountability, Collaboration, Leadership

    4QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    Quest Diagnostics

    • Leader in Providing Healthcare Insights and Solutions • Comprehensive Diagnostic Testing

    Routine ——» Esoteric Diagnose Monitor Predict Prevent

    Advanced Information Technology Solutions Improve Care and Efficiency

    Facilitate Introduction of New Therapeutics Clinical Trials Testing

    • Touching 145 Million Patients Annually

  • 5QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    Quest Diagnostics: The Leader

    US Diagnostic Testing Market: >$40 B

    Source: Washington G-2 Reports and company estimates

    6QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    Quest Diagnostics

    • 35 Regional Laboratories • 150 Rapid Response Laboratories • 2000 Patient Service Centers • 2 Esoteric Testing (Reference) Laboratories

    Nichols Institute, San Juan Capistrano, California Nichols Institute, Chantilly, Virginia*

    • Announced agreement to acquire Focus Diagnostics

    *HLA and Donor Screening Laboratories in Chantilly, VA

  • Quest Diagnostics Nichols Institute San Juan Capistrano, CA

    8QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    Quest Diagnostics Nichols Institute San Juan Capistrano, CA

    • One of two Reference Laboratories for Quest Diagnostics

    • ISO 9001 Certified (International Organization for Standards)

    • Six Sigma Quality • Center of Research and Development activities for

    various subspecialties • Subspecialties

    Endocrinology/Toxicology Genetics Hematology/Oncology Immunology/Coagulation Infectious Diseases

  • 9QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    INFECTIOUS DISEASES Nichols Institute, SJC

    • Microbiology Bacteriology Mycobacteriology Mycology Parasitology

    • Virology • Molecular Microbiology • Infectious Disease Serology

    • Research and Development

    10QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    MOLECULAR INFECTIOUS DISEASES Nichols Institute, SJC

    • One of the largest commercial molecular infectious disease labs in country

    • Automated molecular diagnostic laboratory Nucleic acid extraction Nucleic acid amplification/detection Gene sequencing

    • Qualitative and Quantitative assays • Gene sequencing for identification, drug resistance, and strain

    typing. • Strain typing by PFGE • Employ various nucleic acid amplification/detection methods • Oligonucleotide synthesis laboratory

  • 11QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People Key Industry Trends

    Lab tests influence >70% of healthcare decisions

    Molecular diagnostics expanding >20%/year versus

  • 13QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People Why QIAGEN?

    • Quality- Established provider of quality reagents for nucleic acid extraction.

    • Innovation and Leadership- One of the first to provide Quest Diagnostics with an automated solution for nucleic acid extraction (BioRobot in 1999)

    • Collaboration- Under an NDA, our companies worked together to adapt BioRobots to fit the Quest Diagnostics paradigm

    • Accountability- Rapidly resolved unexpected issues

    14QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People Why Automation?

    • Improved quality • Increased throughput capacity • Reduced anxiety time • Reduce repetitive motion injuries associated with

    manual procedures

  • 15QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    QIAGEN BioRobots used by Quest Diagnostics

    • EZ1 • 8000 • M48 • M96 • 9604 • MDx

    16QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People

    Principal Uses of BioRobots within Quest Diagnostics

    • Total nucleic acid extraction (DNA and RNA) from whole blood, plasma or cells.

    • DNA extraction from whole blood, plasma or cells. • RNA extraction from whole blood, plasma or cells. • Qualitative and quantitative assays • Infectious diseases

    HIV HCV HBV

  • 17QIAGEN Presents: An Investor/Analyst Event June 29, 2006

    Patients Growth People Select Abstracts

    1. Baumann, R.E., and M.A. Lewinski. Evaluation of a COBAS TaqMan Hepatitis B quantitative assay. Clinical Virology Symposium (19th), Clearwater Beach, Florida. April 27 – April 30, 2003. S17.

    2. Baumann, R.E. and M.A. Lewinski. Performance evaluation of a semi- automated HIV-1 RNA assay using QIAGEN BioRobot RNA isolation and AMPLICOR HIV-1 MONITOR, version 1.5 detection. 102nd General Meeting, American Society for Microbiology, Salt Lake City, Utah. May 19 – 23, 2002. C-214.

    3. Baumann, R.E., H. Hamdan, and M.A. Lewinski. Evaluation of a COBAS TaqMan Hepatitis C quantitative assay. Clinical Virology Symposium (18th), Clearwater Beach, Florida. April 28 – May 1, 2002. S17.

    4. Baumann, R.E. and M.A. Lewinski. Evaluation of semi-automated Hepatitis C RNA quantitative assays using QIAGEN BioRobot RNA isolation and COBAS AMPLICOR HCV MONITOR detection. 15th Annual Meeting of AACC, San Diego, California. November 2000. 25.

    Patients Growth People