QIAGEN Presents: An Investor/Analyst Event · 9 QIAGEN Presents: An Investor/Analyst Event June 29, 2006 Patients Growth People INFECTIOUS DISEASES Nichols Institute, SJC • Microbiology

Patients Growth People

QIAGEN Presents: An Investor/Analyst Event

Quest Diagnostics and QIAGEN Relationship

Michael A. Lewinski, Ph.D., D(ABMM)Director, Infectious Diseases

Quest Diagnostics Nichols Institute

2QIAGEN Presents: An Investor/Analyst Event June 29, 2006


Objectives

Who is Quest Diagnostics?Mission, Vision, Values

Laboratories

Industry Trends (Challenges)

Why QIAGEN?

Questions?



Who is Quest Diagnostics?

Mission:We will be the undisputed world leader in diagnostic testing, information and services

Vision:Dedicated people improving the health of patients through unsurpassed diagnostic insights and innovation

Values:Quality, Integrity, Innovation, Accountability, Collaboration, Leadership



Quest Diagnostics

• Leader in Providing Healthcare Insights and Solutions

• Comprehensive Diagnostic TestingRoutine ——» Esoteric

Diagnose

Monitor

Predict

Prevent

Advanced Information Technology SolutionsImprove Care and Efficiency

Facilitate Introduction of New TherapeuticsClinical Trials Testing

• Touching 145 Million Patients Annually



Quest Diagnostics: The Leader

US Diagnostic Testing Market: >$40 B

Source: Washington G-2 Reports and company estimates



Quest Diagnostics

• 35 Regional Laboratories

• 150 Rapid Response Laboratories

• 2000 Patient Service Centers

• 2 Esoteric Testing (Reference) LaboratoriesNichols Institute, San Juan Capistrano, California

Nichols Institute, Chantilly, Virginia*

• Announced agreement to acquire Focus Diagnostics

*HLA and Donor Screening Laboratories in Chantilly, VA

Quest Diagnostics Nichols Institute San Juan Capistrano, CA



Quest Diagnostics Nichols InstituteSan Juan Capistrano, CA

• One of two Reference Laboratories for Quest Diagnostics

• ISO 9001 Certified (International Organization for Standards)

• Six Sigma Quality• Center of Research and Development activities for

various subspecialties • Subspecialties

Endocrinology/ToxicologyGeneticsHematology/OncologyImmunology/CoagulationInfectious Diseases



INFECTIOUS DISEASESNichols Institute, SJC

• MicrobiologyBacteriologyMycobacteriologyMycologyParasitology

• Virology• Molecular Microbiology• Infectious Disease Serology

• Research and Development



MOLECULAR INFECTIOUS DISEASESNichols Institute, SJC

• One of the largest commercial molecular infectious disease labs in country

• Automated molecular diagnostic laboratoryNucleic acid extractionNucleic acid amplification/detectionGene sequencing

• Qualitative and Quantitative assays• Gene sequencing for identification, drug resistance, and strain

typing.• Strain typing by PFGE• Employ various nucleic acid amplification/detection methods• Oligonucleotide synthesis laboratory


Patients Growth PeopleKey Industry Trends

Lab tests influence >70% of healthcare decisions

Molecular diagnostics expanding >20%/year versus <5% for most other laboratory methods [G-2 Industry Outlook]

Molecular diagnostics becoming standard-of-care

Molecular methods are supplanting traditional methods in Microbiology

NAAT’s rapidly replacing culture-based methods (eg, Bordetella pertussis and HSV)

Only way to confirm diagnosis in some settings (eg, detection ofnoncultivable microorganisms)


Patients Growth PeopleKeys to Success (Challenges)

• Be the early provider of esoteric testing services (Industry Leader)

Intellectual property to promote and sustain leadership positionRelationships that provide access to innovative technology

• Be a rapid responder to industry demands (Rapid Follower)“Better, Faster, Cheaper”

• Automate, standardize, and regionalize SOC molecular diagnostic testing services to improve quality and deliver rapidresults

• Champion information technology services to rapidly deliver complex patient information in a secure manner


Patients Growth PeopleWhy QIAGEN?

• Quality- Established provider of quality reagents for nucleic acid extraction.

• Innovation and Leadership- One of the first to provide Quest Diagnostics with an automated solution for nucleic acid extraction (BioRobot in 1999)

• Collaboration- Under an NDA, our companies worked together to adapt BioRobots to fit the Quest Diagnostics paradigm

• Accountability- Rapidly resolved unexpected issues


Patients Growth PeopleWhy Automation?

• Improved quality

• Increased throughput capacity

• Reduced anxiety time

• Reduce repetitive motion injuries associated with manual procedures



QIAGEN BioRobots used by Quest Diagnostics

• EZ1

• 8000

• M48

• M96

• 9604

• MDx



Principal Uses of BioRobots withinQuest Diagnostics

• Total nucleic acid extraction (DNA and RNA) from whole blood, plasma or cells.

• DNA extraction from whole blood, plasma or cells.

• RNA extraction from whole blood, plasma or cells.

• Qualitative and quantitative assays

• Infectious diseasesHIV

HCV

HBV


Patients Growth PeopleSelect Abstracts

1. Baumann, R.E., and M.A. Lewinski. Evaluation of a COBAS TaqMan Hepatitis B quantitative assay. Clinical Virology Symposium (19th), Clearwater Beach, Florida. April 27 – April 30, 2003. S17.

2. Baumann, R.E. and M.A. Lewinski. Performance evaluation of a semi-automated HIV-1 RNA assay using QIAGEN BioRobot RNA isolation and AMPLICOR HIV-1 MONITOR, version 1.5 detection. 102nd General Meeting, American Society for Microbiology, Salt Lake City, Utah. May 19 – 23, 2002. C-214.

3. Baumann, R.E., H. Hamdan, and M.A. Lewinski. Evaluation of a COBAS TaqMan Hepatitis C quantitative assay. Clinical Virology Symposium (18th), Clearwater Beach, Florida. April 28 – May 1, 2002. S17.

4. Baumann, R.E. and M.A. Lewinski. Evaluation of semi-automated Hepatitis C RNA quantitative assays using QIAGEN BioRobot RNA isolation and COBAS AMPLICOR HCV MONITOR detection. 15th

Annual Meeting of AACC, San Diego, California. November 2000. 25.


Documents

QIAGEN Presents: An Investor/Analyst Event · 9 QIAGEN Presents: An Investor/Analyst Event June 29, 2006 Patients Growth People INFECTIOUS DISEASES Nichols Institute, SJC • Microbiology