Recent Developmentsin Toxicology:Trends, Methodsand ProblemsProceedings of theEuropean Societies of ToxicologyMeeting Held in Leipzig. Septemhcr 12-14. WO

Edited by

Philip L. Chambers. Claire M. Chambers.

Woll Pielher Wie/orek ami Sieulried (iolbs

W i l h ()X l - i i i i i r e s a n i l ( O ' I a M c s

Springer-Yei lag

Berlin Heidelhcn: NewLondon Paris Iok\oI long Kong B;IKVIOII;I

Budapest

Contents

Neurotoxicology of different noxious compounds

In vitro assessment of antidotes to organophosphorus toxicityS. DAS GUPTA 3

Primary cultures of adult mammalian sensory neurons and other in vitrosystems of use in neurotoxicological studiesR. A. SMITH 8

Animal models in behavioural toxicology and teratologyR. LHUHRFK, J. ELSNO, and G, ZBINDFN 15

Cytotoxic brain oedema as a model in the examination ofcercbroprotectivc substancesK. ANDKI-AS . - 25

Neurochemical characterisation of hexachlorophcne induced brainoedemaK . A N I ' K I ' A S , M . B l .ASCMKF, F . Bl : R<iSIKASSl ; K. I I. I ) . F l S C I M K ,

and J. ScuMinr 3D

The effects of organophosphorus compounds on the central nervoussystem of ratsI. DI';SI, L. NACiVMA.nr':Nvi, R. LORKNCZ. and Z. Moi NAK 33

The effects of n-hexane and its metabolites on erythroeyteand synaptosome membrane aeetylcholinesterease in vitroS. RANTANI-N, S. HYPONI'N, I. AHONF.N. and H. TAHII 38

New Aspects and Methods in Toxicopathology

Assessment of toxicopathologic;il effects in ageing laboratory rodentsG. J. KRINKI:. L. P. A. PI:RRIN, and R. Hiss 43

New microtechniques in toxicopathologyK. AufiSinN, and .1. GOTINI-K 50

wi Contents

Tumor Registry Data Base: Systematized nomenclatureof preneoplastic and neoplastic lesions in rat gonadsS. QUERESHI, and R. A. ETTLIN 5 5

Mortality and neoplastic lesions in untreated Sprague Dawlcy ratsJ. KASPAREIT-RITTTNGHAUSEN, and F. DEERBERG 58

Investigations on the sensitivity of several biochemical and histologicalmethods after liver intoxication induced by pentaehlorophenol andcarbon tetrachlorideCH. ELLINGER, W. SKFFNER, and F. SCHILLER . ^3

The glutathione system in rat liver chronically injured by thioaeetamideM. KRETZSCHMAR, H. FRANKS, G. MAOHNIK, T. ZSMMLRMANN,

R. DARGKL, and W. KLINGKR 6 8

Hitherto unknown additive growth effects of fluorene and2-acetylaminofluorene on bile dvict epithelium and hepatoeytes in ratsM. DANZ, A. HARTMANN, M. OTTO, and H. BI.AS/.VK 71

Morphological lesions of pancreas and bile ducts in rats induced bydibutyltin dichlorideJ. MERKORD, L. JONAS, and G. HENNIGIIAUSEN 75

Toxic action of platinum coordination complexes on the endocrinepancreas of the ratH. G. HILLESHEIM, K. D. KOHNERT, F. FAIT, W. BFSCH,H. P. SCHROER, and H. HOFFMANN 80

Investigations of myelotoxic effects in ratsT. A. MOELLER . 83

The effect of aluminium loading on bones of miceG. SAHIN, A. ISIMER, A. TEMIZER, A. SAYAL, R. SUNAL, and S. DURU • 88

Cobalt particles, identified by energy dispersive X ray microanalysis,in diamond polisher's lungD. DINSDALE, E. VERBEKFN, M. DEMEDTS, and B. NEMERY . . . - . • • 9 2

Density of gastroendocrine cells in cynomolgus monkey and otherspeciesK. TUCH, D. OCKERT, U. HUBEL, and D. HAUSCHKE • • %

Computerised analysis of pathological findings in longtcrm trials ofphenylmercuric acetate in ratsR. SOLECKI, L. HOTHORN, M. HOLZWEISSIG, and V. HEINRICH 1 ( ) 0

Contents VII

Cardiovascular Toxicology

Preclinical assessment of the eardiotoxic potential of anthraeyclineantibiotics: N-L-leucyl-doxorubicinG. ZBINDKN, D. DFCAMPFNFFRF, and R. BAHRAIN 107

Hypertension is not exacerbated by chronic carbon monoxide exposure,with or without added salt, in the borderline hypertensive ratD. G. PENNEY, and R. M. SKIKUN 118

Cardiovascular system and kidney as specific targets of chronicexposure to vanadate in the rat: functional and morphological findingsM. CARMIGNANI, P. BOSCOI.O, A. R. VOLPE, G. TOGNA, L. MASCIOCCO.

and P. PRI'ZIOSI 124

Acute effects of dichloromethanc on arrhythmia development duringthe early phase of myocardial ischemia and rcperfusion in the ratJ. SCHOLZ, M. KLAPPERSTOCK, M. WEISE, and P. HOFFMANN 128

Pharmacokinetics of total and free digoxin imd Fab fragments in fiveintoxicated patients after administration of specific anti-digoxin FabfragmentsM. URTIZBEREA, A. SABOURAUD, M. LACIIAISK, O. CHAPPFY.

V. COSSON, F. J. BAUD, and J. M. SCHEKKMANN 132

Use of spontaneously beating heart muscle cells differentiating frompluripotential embryonic stem cells for testing of chronotropic agentsG. WAU.UKAT. and A. M. Wom/s 136

Characterization of the hypotensive side effects of macrolidc antibioticsin animalsA. HAKTL, F. KIRCHNI'.R, and H. HOFFMANN 140

Toxic Effects on Haemostasia

Toxic influence on platelet systemE. SCHROR 147

Hereditary and acquired disturbances of haemostasis in animalsP. GUTTNHR 153

Effects of snake venoms on tissue-type plasminogen activator releaseH. P. KNOCKING, and A. HOFFMANN 157

Metabolic and toxicological studies on the anticoagulant rodentieide,floeoumafenG. E. VEENSTRA, D. E. OWFN, and K. R. HUCKLE 160

Contents

Influence of natural humic acids and synthetic phenolic polymers onhacmostasisH. P. KLOCKING ! 6 6

A comparison of the thrombogenic activity of prothrombin complexconcentrates using stasis and non-stasis modelsM. RICHTER, H. P. KLOCKING, G. DORNHEIM, J. GOTTNER,

and R. WULKOW 1 7 0

Inhibition of platelet aggregation and thromboxane A2 production bychlorophenoxy acid herbicidesP. YLITALO, M. YT.IHAKOLA, H. A. Ei.o, H.-M. KOPONF.N, E. SFPPAFA,

and H. VAPAATALO 174

Toxic Effects on Liver and Kidney

The effect of paracetamol on the hepatic uptake of microparticles in vivoand in vitroS. BUHRING, G. HFNNIGHAUSEN, and L. JONAS 181

Influence of iron chelators, I,2-diaikyl-3-hydroxypyridin-4-ones,on the lipid pcroxidation and glutathionc level in the liver of miceV. EYBL, D. CAISOVA, J. KOUTENSKY, and G. J. KONTOGHIORGHES . . . 185

The influence of cytochromc P 450 inducers on carbonyl-rcduction inmouse liverE. MASFR, B. HAHNFMANN, W. LKGRUM, U. OPPFRMANN,

and K. J. NKITER 188

Influence of inducers of cytochromc P 450on dcalkylation of 7-alkoxyeoumarinsD. MUFI.FR, TH. GROH, and F. K. SPLINTER 193

The effect of monoclonal antibodies on dipyrone-induccd rat livercytochrome P 450H. KRAUL, M. PASANI-N, and O. PELKONEN 197

Antipyrinc metabolism in coke oven workersP. ARVFFA, O. PFFKONHN, L. PYY, E. SOTANIFMI, K. VAHAKANGAS,

and E. YRJANKIKKI 201

Influence of bile acids on the development of hepatic transport oforganic anionsA. BARTH 205

Compara t ive nephrotoxicity studies of cisplatin and its iodinizedderivative in rats

D. A P P E N R O T H , S. KFSSLI .R , K. W I N N E F E L D , and H. BRAUNLICH . . . . 209

Contents IX

Inhibitory effects of a platelet activating factor antagonist 48740 RP incyclosporin-induced nephrotoxicity in the rat as assessed by renalglutathionc metabolism parametersF. MASSICOT, C. PHAM IIUY, C. MARTIN, M. THFVFNIN, J.-M. WARN FT.and J. R. CI.AUDF 213

The urinary excretion of specific proteins in workers exposed to leadA . VVSKOCIL, Z . FlALA, J. SALANDOVA, A. POPLFR, B. liTII.FROVA,and S. EMMINGF.R 2I<S

Miscellaneous Toxic Effects

Reduction of arsenic trioxide toxicity in mice by repeated treatmentwith glucoseF. X. RFICHL, H. KRLPPFL, L. SZINICZ, B. FICHTL, and W. FORTH . . . 225

Effect of oral treatment with BAL, DMPS or DMSA on arsenic inorgans of mice injected with arsenic trioxideB. SCHAFER, H. KRIJPPEL, F. X. RFICHHL, B. FICHTL, and W. FORTH . . 228

Cyanide antagonism in a rodent modelR. BHATIACHARYA, K. JEHVARATNAM, S. K. RAZA, and S. DAS GUPTA . 231

The quantitative determination of cadmium in turkish cigarettesN. Oro and S. DURU ^ 236

Modifying role of plasma glucose in acute carbon monoxide poisoningD. G. PENNEY . 240

Effect of pyra/ole on diehloromethane metabolism to carbon monoxideD. PANKOW. S. KRLTSCHMI-R, and M. WFISF 24d

Fthylene oxide distribution in human bloodB. GANSFWFNDT, U. FOFSI, B. MAK<:ZVNSKI, K. GOLKA, E. HALMI:R.

and II. PI-TER 249

Distribution of mcthylcne chloride in human bloodR. THIFR, U. FOFST, S. DFUISCHMANN, K. R. SCHROFI>I:,R,

G. WESTPHAL, E. HAI I.IHK, and II. PJTFR 254

Acute experimental exposures to acetone and ethyl acetateR. R. VANGALA, M. BFASZKFWK/, H. M. Boi i, K. GOLKA,

E. KiFSSWi.rtFR. and A. SFFHFR 259

Toxic effects of carbon tetrachlonde during short and long term ethannlintake in ratsE. KNIFPFRT, A. SiLGi-MtfND, M. ROSFNKKANZ. and V. GoRtscH . . . . 263

X Contents

Effects of pyridinium-1 {[(4-carbamoyl-pyridinio)mcthoxy]mcthyl}-2-(hydroxyiminomethyl) dichloride monohydrate (HI 6) and atropinc onthe circulation and respiration of anaesthetized guinea pigsS. Dr. LA MOTTF, and L. SZINICZ 266

The mechanism of the anaesthetic action of organic solvents studiedwith different membrane models in vitroH. TAHTI, and A. VALAJA 269

An in vivo method to assess the local tolerability of intranasallyadministered drugsD. FRATIOLA, C. SORINI, V. ALIVERTI, and M. LOSA 272

Studies on the penetration of tetanus toxoid through the nasal mucosaE. SPRANZ, B. SIFGLMUND, J. FRFVHRT, and H. E. KNOFFI 276

Stobadine toxicity and transplacental movementA. KRISTOFOVA, B. UJHAZY, S. BFZFK, T. BALONOVA, and R. NOSAL . . 280

Some effects of furazolidone, humic acid and a combination of both onmale reproduction in ratsH. ZIMMFRMANN, S. GOLBS, and G. GUTTE 284

Residues of carbadox metabolites in edible pork productsA. J. BAARS, L. P. JAGER, TH. J. SPIFRFNBURG, G. J. DE GRAAF,

and J. W. SFINHORST 288

Pharmacological-toxicological investigations with a furan derivativeproduced from sugar cane on laboratory animalsS. GOLBS, M. KUEHNERT, H. ZIMMFRMANN, and J. A. P. DONATO . . . . 293

Influence of the degree, position and nature of halidc substitution onthe rate of photobleaching of xanthene dyesW. LEGRUM 298

Toxicological investigations of waste products from the plasma etchingprocess in the semiconductor industryS. BAUER, I. WOLFF, N. WKRNER, P. HOFFMANN, R. HILI.IG, R. VOIGT,

B. MERTFN, K. OFMUS, and F.-W. RATH 303

Sister chromatid exchanges in furniture workers exposed to unsaturatedpolyester resinsA. E. KARAKAYA, S. SARDAS, and M. SUN 307

Acute intoxication as a cause of wild bird mortality in the Netherlandsfrom 1975-1989A. J. BAARS, P. E. F. ZOUN, TH. J. SPIERENBURG, and TH. SMIT . , . . 311

Author Index 317

Subject Index 319