Replikasi DNA Ppt

7/26/2019 Replikasi DNA Ppt

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DNA REPLICATION Dr. Ay Ly Margaret, M.Biomed.

Department of Biochemistry

School of Medicine, Atma Jaya Catholic

University Oct 2012



OVERVIEW









P ART OF CHROMOSOME



CELL CYCLE



Cell division and DNA replication

• Cells divide

Growth, Repair, Replacement

• Before cells divide they have to double cell

structures, organelles and their genetic

information



CELL CYCLE REGULATION



SEMI CONSERVATIVE DNA REPLICATION



DNA REPLICATION





DNA STRUCTURE



ORIENTATION DNA



Discovering the structure of DNA

Rosalind Franklin’s DNA image

“Chargoff’s rule”

A = T & C = G



SOMATIC VS GERM CELL MUTATION



GENETIC CODE



TRANSITION VS TRANSVERSION



T YPE OF POINT MUTATION



T YPE OF MUTATION IN GENES



INSERTION VS DELETION



T YPE OF MUTATION IN CHROMOSOME



C ASE 1 ALBINISM

Autosomal recessive disorder

Mutation on tyrosinase gene or in P gene

defect melanin productionDeficiency in

pigmentation

Tyrosinase catalyzes tyrosine melanine

Type : ocular albinism (OA) & oculocutaneous

albinism (OCA)

OCA Single base mutation (a G to A transition at

nucleotide residue 312) in the tyrosinase gene Arg

(CGG) to Gln (CAG) substitution effecting

pigmentation process

Hum Genet (1999) 105 : 200 –

210 ; THE JOURNAL OF Biological CHEMISTRY ol. 265, No.

29, Issue of October 15, pp. 17792-17797



P protein involved in the transport of tyrosine into

melanosome



EXCISION REPAIR DNA



B ASE EXCISION REPAIR DNA



MISMATCH REPAIR DNA



REFERENCES

http://genetics.com.au

Murray RK, Granner DK, Mayes PA, Rodwell VW. Biokimia 2 Edisi 25. EGC.Jakarta; 2000:391-412.

Simth C, Marks AD, Lieberman M. Mark’s Basic medical Biochemistry A Clinical Approach 2nd Edition.Lippincott William & Wilkins. Philadelphia;2005:222-234.

http://employees.csbsju.edu/hjakubowski/classes/ch331/dna/oldnastructure.html

http://academic.brooklyn.cuny.edu/biology/bio4fv/page/molecular%20biology/dna-structure.html


http://genmed.yolasite.com/fundamentals-of-genetics.php

http://www.robertlfurler.com/2012/01/09/why-is-glucose-metabolized-differently-throughout-the-cell-cycle/

http://www.nature.com/nrn/journal/v8/n6/box/nrn2097_BX2.html


http://www.britannica.com


http://www.zoology.ubc.ca/genetics/chapter14.htm

http://homepage.usask.ca/~vim458/advirol/SPCV/evolution/evolution.html

http://www.nature.com/nature/journal/v421/n6921/full/nature01408.html

Snustad DP, Simmons MJ. Principles of Genetics 3rd Edition. Wiley. USA;2003: 353-357.

http://www.phys.ksu.edu/gene/excisio3.html

http://www.web-books.com/MoBio/Free/Ch7G.htm

http://student.biology.arizona.edu/honors96/group5/mismatch.html

http://genetics.com.au/








http://www.britannica.com/



















http://www.britannica.com/




































http://genetics.com.au/

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Replikasi DNA Ppt