29
Section 8 Epithelial Tumor

Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Embed Size (px)

Citation preview

Page 1: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Section 8 Epithelial Tumor

Page 2: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

1. Benign epithelial tumors

(1) Papilloma

Origin: coverage epithelium

Shape: finger-like projections into the lumen or on the surface of skin

Site: commonly in skin or bladder.

Page 3: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Papilloma

Page 4: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

(2) Adenoma

Origin: adenocytes

Type① Typical adenoma

② Cystadenoma: having single or multiple cysts containing watery secretion. Commonly in ovary

Page 5: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Cystadenoma

Page 6: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

③ Fibroademoma: both adenocytes and fibrous are parenchymal compositions. commonly in breast

④ Plesmorphic adenoma: having gland, mucoid, and cartilage-like tissues. Commonly in salivary gland.

⑤ Polypous adenoma: single or multiple. commonly in gastrointestinal track.

Page 7: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

乳腺纤维腺瘤

Page 8: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

息肉状腺瘤( 黄尚文教授提供 )

Polypous adenoma

Page 9: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

2. Malignant epithehal tumors

(1) Squamous cell carcinoma

Origin: squamous cell

Morphology: grossly: cauliflower-like, polyp, mushroom-like, ulceration.

Page 10: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Histological: Well-differentiated type are similar

to normal squamous epithelial cells, with intercellular bridges and nets of keratin pearls (carcinoma pearls).

But poor-differentiated type are pleomorphism, no intercellular bridges and keratin pearls.

Page 11: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on
Page 12: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Squamous cell carcinoma

Page 13: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

(2) Basal cell carcinoma

Origin: basal cells of skin

Features: locally invasive growth, almost never metastasis commonly in face of oldster.

Page 14: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Basal cell carcinoma

Page 15: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

(3) Transitional cell carcinoma

Origin: transitional cells

Features: exoteric, finger-like, commonly in bladder, renal pelvis.

Page 16: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

膀胱移行细胞乳头状癌 100倍

Page 17: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

(4) Adenocarcinoma

Origin: adenocytes large quantities of type:

① Typical adenocarcinoma

② Mucoid carcinoma or colloid Signet-ring cell and carcinoma mucin

③ Solid carcinoma or carcinoma simplex Poor differentiation adenoma

carcinoma, and the tumor cells arrange in solid columns, or masses.

Page 18: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Adenocarcinoma

Page 19: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Signet-ring cell carcinoma

Page 20: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

carcinoma simplex

Page 21: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Type:

a. Sclerous carcinoma: dense stroma

b. Medullary carcinoma encephaloid carcinoma:

Little stroma, and large masses of tumor cells.

c. Carcinoma simplex: Poor differentiation adenocarcinoma with

equal quantities of tumor cells and stroma.

Page 22: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

3. Premalignant diseases dysplasia, and carcinoma in situ.

(1) Premalignant diseases

Definition: the benign diseases acquired the character of developing potentially into malignancy.

Page 23: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Dysplasia and carcinoma in situ (right) (Quoted from Robbins 《 Pathology Basis of disease 》 )

Page 24: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Grade 1: above changes are just limited in low 1/3 layer.

Grade 2: Above change are limited between in 1/3-2/3.

Grade 3: above changes breakthrough 3/2 layers

If above changes occupy whole layer, it is considered as carcinoma in situ.

Page 25: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

Kinds:① Leucoplakia② Chronic cervicitis with cervical erosion③ Fibrocystic disease of breast④ Familial adenomatous polyps of the

colon⑤ Chronic atrophic gastritis and chronic

peptic ulcer of stomach.⑥ Chronic ulcer of skin⑦ Others: pigmented nevus, hidden

testis, goiter, liver cirrhosis

Page 26: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

女阴粘膜白斑 (Prof. Orr 提供 )

Page 27: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

(2) Carcinoma in situ

Definition: carcinoma in situ denotes carcinomatous changes just limited in the epithelium without evidence of invasion, not breakthrough basement membrane.

Carcinoma in situ is the earliest stage of carcinoma.

Page 28: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

carcinoma in situ

Page 29: Section 8 Epithelial Tumor. 1. Benign epithelial tumors (1) Papilloma Origin: coverage epithelium Shape: finger-like projections into the lumen or on

(3) Dysplasia

Definition: a disturbance of growth which is usually considered to be premalignant.

Features: The changes are made up of pleomorphism of the cells, loss of polarity of the cells, hyperchromatic nucle, increastd mitosis, but no invasion.