pupdepartments.ac.inpupdepartments.ac.in/syllabi/Academic Session 2016-17... · Web viewFundamentals of volumetric analysis: Solubility product, effect of temperature, pH and solvent

ORDINANCESExaminations for 2016-17 & 2017-18 sessions

M.Sc. (PHARMACEUTICAL CHEMISTRY) Course of Examination

Notwithstanding the integrated nature of a course spread over more than one academic year, the Ordinances in force at the time a student joins a course shall hold good only for the examination held during or at the end of the Semester. Nothing in these Ordinances shall be deemed to debar the University from amending the Ordinances subsequently and the amended ordinances, if any, shall apply to all students whether old or new. 1. The course for M.Sc. Pharmaceutical Chemistry shall be spread over two academic years and four semesters to be called M.Sc. Previous consisting of Semester I and II, and M.Sc. Final consisting of Semester III and IV. The examination for the I and III Semesters shall be held in the month of December and for the II and IV semesters in the month of May or on such other dates as may be fixed by the Academic Council. 2. The outlines of tests and syllabi shall be such as prescribed by the Academic Council from time to time. 3. (a) The last date by which admission forms and fees must reach the Registrar shall be as follows:

Examination Without With late With lateFee late fee fee of fee of

Rs. 100/- Rs. 300/-Semester I & III Sept. 30 Oct.15 Oct.31(Regular and Reappear)Semester II & IV Feb.28 March 15 March 31(Regular and Reappear)

A late fee of Rs. 500/- will be charged for submission of forms 21 days before the commencement of Semester examinations practical or theory which ever is earlier. A late fee of Rs. 1000/- will be charged for submission of forms 10 days before the commencement of Semester examination only practical or theory which ever is earlier and with prior permission of Vice- chancellor.

(b) Incomplete form or forms of candidates who have not cleared his/her all dues will not be accepted.

(c) The amount of examination fee to be paid by a candidate for each semester shall be as prescribed by the University from time to time.

(d) The I, II and III semester examinations shall consist of four theory papers each and two practical papers each as specified in the syllabus.

(e) The IV semester examination shall consist of three theory papers and one practical paper. In addition, candidates will undertake a research project work. The project work shall be of 200 marks. The project work shall be evaluated as follows: 100 marks-To be evaluated by internal examiner/guide on the basis of day-to-day work. 50 marks –To be evaluated by external examiner for the project report.

50 marks-To be evaluated by external examiner on the basis of viva-voce/ presentation of project report by the candidate. (f) Each theory paper shall be of 100 marks of which 70 marks shall be allocated to the theory papers set by the external examiner. The internal assessment in each paper shall be of 30 marks i.e. two assignments or seminar of 12 marks, I test of 12 marks

(average of two shall be taken) and 6 marks for attendance. 4 (a) The admission to Semester I in the course is based on merit in qualifying exam and entrance test. The candidates who have passed the Bachelor’s degree in Science with subjects in the faculty of Life Sciences/ Biological /Medical/Engineering are eligible to appear in the entrance test conducted by the Department. Besides, the candidates who have passed the Bachelor’s degree in the sciences with any three of the following subjects are also eligible: Mathematics/Statistics/Physics/ Chemistry.

(b) The candidates should have obtained a minimum of 50% marks (including optional subject) in the qualifying examination for all courses. The candidates who are awarded grades shall be required to produce the conversion formula of converting the scored grade in to percentage of marks.

(c) (i) Schedule Castes and Schedule Tribes. (ii) Physically handicapped candidates.

(Produce medical certificate showing at least 35% disability)Details about entrance test will be given in hand Book of Information.

(d) A candidate who has passed the first Semester examination of M. Sc. Pharmaceutical Chemistry shall be eligible to join the second Semester.

(e) A candidate who has passed the second Semester examination of M.Sc. Pharmaceutical Chemistry shall be eligible to join the third Semester.

(f) The final examination shall be open to any person who has passed in the subject offered in the previous examination in full or in part and satisfies the following requirements :

i. Has been on the rolls of the University throughout the academic year preceeding the Semester examination.

ii. Has not discontinued his/her studies for more than two continuous years after passing M.Sc. Previous examination.

iii. Has his/her name submitted to the Registrar by the Head of the Department that he/she attended 75% lectures of the full courses of theory and practicals provided that deficiency in the number of theory lectures or practicals may be condoned for special reasons by the Academic Council.

ORHas completed the prescribed course of instruction for the examination but has not

appeared or having repeated has failed and has been recommended by the head of the Department for admission to such examination as a late University student without attending a fresh course of instruction (theory and practicals) within a period of two years from the date of completion of course.

(g) A candidate who has passed the Third Semester examination of M.Sc. Pharmaceutical Chemistry shall be eligible to join the IV Semester.

(h) The candidate shall have attended not less than 75% of the full course of the lectures and practicals in each of the course /paper. A deficiency in the number of lectures and practicals may be condoned as per University rules.

(i). A candidate who having attended the prescribed number of lectures and practicals fails or does not appear in the examination held for relevant Semester shall be allowed to appear in the next examination held for that Semester.

M.Sc. PHARMACEUTICAL CHEMISTRY

PART- I

Examinations for 2016-17 & 2017-18 sessions

OUTLINES OF THE TEST1. The examination will consist of two semesters i.e. semester I and II

2. Each semester shall be of maximum 600 marks.

3. In each semester there shall be four theory papers and two practical papers.

4. Each theory paper shall be of 100 marks of which 70 marks shall be allocated to the theory

papers set by external examiner. The internal assessment in each paper shall be of 30 marks i.e.

Assignments /seminar of 12 marks, internal test of 12 marks (average of two shall be taken) and

6 marks for attendance.

SEMESTER-I (November/December)

Paper Title of paper Marks

Theory I Quantitative analytical methods 100

II Biochemistry 100

III Stereochemistry and Chemistry of heterocyclic compounds 100

IV Pharmacology 100

Practical I Quantitative analytical methods & Biochemistry 100

II Stereochemistry and Chemistry of heterocyclic compounds 100

Total 600

SEMESTER – II (April/May)

Paper Title of paper Marks

Theory V Modern analytical methods 100

VI Physical Pharmacy 100

VII Chemistry of natural products 100

VIII Bioinformatics and Biostatistics 100

Practical III Modern analytical methods & physical Pharmacy 100

IV Chemistry of natural products & Bioinformatics 100

Total 600

M.Sc. PHARMACEUTICAL CHEMISTRY (SEMESTER-I)


PAPER-I: QUANTITATIVE ANALYTICAL METHODS

Maximum Mark : 100 Time: 3 hoursi)Theory Paper : 70 Pass Marks : 35% ii)Internal Assessment : 30 Lectures to be delivered : 60

INSTRUCTIONS FOR THE PAPER SETTERS:The question paper will consist of three sections A, B and C. Section A and B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answer / objective type questions, which will cover the entire syllabus uniformly and will carry 28 marks (2 marks each).

INSTRUCTIONS FOR THE CANDIDATES:1. Candidates are required to attempt three questions each from sections A and B of the question paper

and the entire section C.2. The use of scientific calculators is allowed.

SECTION-AIntroduction: Computation of analytical results, significant figures, concept of error, precision and accuracy, standard deviation, rejection of doubtful values with special reference to volumetric and gravimetric analysis, calibration of analytical equipments.

Quantitative chemical analysis I:1. Fundamentals of volumetric analysis: Solubility product, effect of temperature, pH and solvent on

solubility of precipitates, common ion effect, Buffers, Hydrolysis of salts. Methods of expressing concentrations, primary and secondary standards.

II. Neutralization reactions: Theory of indicators and neutralization indicators.III. Oxidation-reduction titrations: Principles of oxidation reduction titrations, redox indicators,

Iodimetric and Iodometric titrations.IV. Precipitation titration: Theory of precipitation titrations, Methods of determining end point.

SECTION-BQuantitative chemical analysis II:-

I. Gravimetric analysis: Methods of gravimetric analysis, co-precipitation, post-precipitation, digestion, thermogravimetry.

II. Complexometric titrations: Principles of complexometric titrations, chelating agents, Complexometric methods using EDTA, indicators, and titrations with disodium edetate.

III. Non-aqueous titrations: General discussion and principles of titrations in non-aqueous medium, aprotic, Protophillic, Protogenic and amphiprotic solvents. Titrations with perchloric acid,and sodium methoxide.

Chromatographic analysis:- Classification of chromatographic processes, Basic principles and theory of adsorption chromatography, partition chromatography, TLC, HPLC, Gas Chromatography and ion-exchange chromatography.Pharmaceutical applications.

Books recommended:-1. A.H Becket and J.B Stenlake, Practical Pharmaceutical Chemistry, Part1,4 th edition,CBS Publishers

and Distributors, New Delhi,1997.2. G.H Jeffery, J.Bassett, J.Mendham and R.C Denney Vogel’s Text Book of Quantitative Chemical

Analysis 5th edition, ELBS, U.K, 1989.3. A.Keneth and A. Connors, A Text Book of Pharmaceutical Analysis, 3rd edition Wiley Interscience

Singapore, 1982.4. H.H. Willard, L.L. Merriet & J.A. Dean, Instrumental methods of Analysis, 5 th Edition, 1974.(Van

Nostrand Reinfold, New York, USA)

M.Sc. PHARMACEUTICAL CHEMISTRY (SEMESTER-1)


PAPER-II: BIOCHEMISTRY


INSTRUCTIONS FOR THE PAPER SETTERS:The question paper will consist of three sections A, B and C. Section A and B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answers / objective type questions, which will cover the entire syllabus uniformly and will carry 28 marks (2 marks each).



SECTION-A

Introduction to bio-molecules: Biological properties of water, pH, ionisation, biological buffers, titration of amino acids, amino acids, proteins and their three dimensional structure, weak and strong interactions. Structure and function of carbohydrates: Monosaccharides, disaccharides, polysaccharides, homopolysaccharides (starch, cellulose, chitin), heteropolysaccharides, mucopolysaccharides. Structure and function of nucleic acids: Purines, pyrimidines, nucleosides, nucleotides, internucleotide bonding, tautomerism.Structure and function of lipids, neutral lipids, phospholipids, isoprenoids, phosphotidylinositol ( intracellular messenger), Biological effectors.Vitamins: Water soluble and fat soluble.Hormones, their structure and functions.Enzymes: General properties of enzymes and co-enzymes, their nature, classification and nomenclature of enzymes, fundamentals of steady state kinetics, enzyme inhibition, isozymes.

Biological membrane and cell wall: Properties of lipid aggregates, micelles, liposomes, structure and properties; membrane proteins and their function, fluid mosaic model, membrane mediated transport, membrane equilibrium and permeability, chemical, physical composition and biosynthesis of cell wall components.

SECTION-B

Carbohydrate metabolism: Glycolysis, biochemistry of alcoholic and lactic acid fermentation , citric acid cycle and pentose phosphate pathway, EDP pathway, disaccharide and polysaccharide metabolism, gluconeogensis, regulation of carbohydrate metabolism. Oxidative phosphorylation/Respiration: Electron transport chain, photorespiration, cyanide resistant bacterial respiration,. Microtonal electron transport.Biochemistry of lipid metabolism: Biosynthesis and catabolism of fatty acids, neutral lipids, phospholipids and cholesterol, glyoxylate cycle, regulation of fatty acid metabolism.Amino acid metabolism: Biosynthesis and catabolism of amino acids, urea cycle, regulation of amino acids, nitrogen fixation and nitrogenase complex.Nucleotide metabolism: Biosynthesis and catabolism of nucleotides, regulation of nucleotide metabolism.

Books recommended1. Biochemistry, Voet, D and Voet, J.G, John Wiley and Co. 1990.2. Biochemistry: Principle of cell structure and function, by Lehninger A.L. CBS Publishers, New

Delhi,2005.3. Steyer Lubert, Berg Jeremy M. Biochemistry, 5 th edition W.H Freeman & company. New York

2002.4. M.C. Pant, Essentials of Biochemistry, 8th edition Kedar and Ram Nath & co. Publishers. Meerut,

1996.

M.Sc PHARMACEUTICAL CHEMISTRY (SEMESTER-I)


PAPER-III: STEREOCHEMISTRY AND CHEMISTRY OF HETEROCYCLIC COMPOUNDSMaximum Mark : 100 Time: 3 hoursi)Theory Paper : 70 Pass Marks : 35% ii)Internal Assessment : 30 Lectures to be delivered : 60

INSTRUCTIONS FOR THE PAPER SETTERS:The question paper will consist of three sections A, B and C. Section A and B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answers/ objective type questions, which will cover the entire syllabus uniformly and will carry 28 marks (2 marks each).

INSTRUCTIONS FOR THE CANDIDATES:1.Candidates are required to attempt three questions each from sections A and B of the question paper and the entire section C.

SECTION-AStereoisomerism: Optical isomerism, Chirality & Compounds showing optical activity (olefins, allenes & trivalent atoms), configuration, Assignment & determination of configuration (D,L,&R,S systems), Conformation (acyclic & cyclic system) . Stereoselective & stereospecific reactions.Asymmetric synthesis- Cram’s rules, Cram’s chelate rule, Felkin & Anti-felkin rules (1,2- Induction ), Prelogs generalization (1,3-Induction), Amino acid synthesis (Strecker).

Organic reactions and mechanism: Substitution reactions; bimolecular and unimolecular nucleophilic substitutions, aromatic electrophilic and nucleophilic substitutions. Elimination reactions; bimolecular and unimolecular 1, 2- elimination, syn elimination, 1, 3- elimination reactions. Addition reactions; nucleophilic addition to carbonyl group, addition involving bridged intermediates. Pericyclic reactions [cyclo addition(2+2, 2+4)], Electrocyclic reactions, Sigmatropic rearrangement.[1,3;1,5].

SECTION-BSelective organic name reactions & rearrangements: Aldol, Perkin, Dieckmann condensation, Cannizaro Reaction, Hoffman, Schmidt, Curtius, Reimer- Tiemann, Reformastsky and Grignard Reactions, Friedel craft Reaction, Oppenauer Oxidation, Michael Addition, Mannich reaction, Sharpless asymmetric epoxidation, Hoffman rearrangements and Hoffman degradation, Beckmann and Fries rearrangement, Claisen rearrangements, benzylic acid rearrangement, Bayer- Villiger reaction, Pinacol rearrangement , dienone-phenol rearrangement.

Heterocyclic compounds:- Nomenclature of heterocyclic compounds, heterocyclic ring systems with one heteroatom: Structure, synthesis and reaction of aziridine, azirines, oxiranes, thiranes, pyrrole, furan, thiophene, -lactam and pyridine.Heterocyclic ring systems with two, three & four heteroatoms: Structure, synthesis and reactions of imidazole, oxazole, thiazole, pyrazole, pyramidine , pyrazines, triazole & triazines.Fused heterocyclic systems up to two heteroatoms: Chemistry and Reactions of indole (Fisher’s synthesis),Quinolines, Isoquinolines,quinagoline, cinnoline, quinoxaline.

Books recommended:1. I.L. Finner: Organic chemistry, Vol. II, 1st Indian edn. Pearson Education Pvt. Ltd. Indian Branch, Delhi.

2002. 2. O.P. Agarwal: Chemistry of Natural Products, Vol. I and II, 7th edn., Goel Publishing House, Meerut, 1983.

3. D.C. Gautam: Heterocyclic chemistry, RBSA Publisher, Jaiput, 2004.4. E.L. Eliel Stereochemistry of carbon compounds, Tata Mc Graw Hill publishing Company, New Delhi,

1975.5. Jerry March, Advance Organic chemistry 4th edition, A Wiley- Interscience Publication, 1999.6. P.S. Kalsi, Stereochemistry Conformation and Mechanism 6th edition. New Age International Pvt, Limited

Publishers, 2005.

M.Sc PHARMACEUTICAL CHEMISTRY (SEMESTER-I)


PAPER-IV: PHARMACOLOGY




and the entire section C.

SECTION-ARoutes of drug administration, pharmacokinetics; absorption, distribution, metabolism and excretion of drugs.Pharmacodynamics: mechanism of action, site of drug action, concept of receptors and theories of drug action.

Chemotherapy: Classification, mechanism of action of drugs in following classes.* Sulfonamides* Amino – glycosides* Macrolides* Fluoroquinolones-lactam antibiotics* Antiviral* Anti-neoplastics* Anti-tubercular* Anti-malarial

SECTION-BClassification of drugs and pharmacology of prototype drugs in followings:-1. CNS – Psychosis, Anxiety, Depression, Mania.2. Autonomic-nervous system – Cholinergic drugs, Anticholinergic drugs, sympathomimetic drugs,

sympatholytic drugs.3. Gastro – intestinal system – Peptic ulcers.4. Drugs for management of pain and inflammation-NSAID,opioid analgesics.5. Cardiovascular system – Hypertension, Congestive Heart disease, Angina, Myocardial Infarction.6. Respiratory system – Bronchial Asthma7. Endocrine system – Anti- thyroid drugs, corticosteroids, oral contraceptives, Anti – diabetic agents.

Books recommended:

1. K.D. Tripathi: Essentials of Medical Pharmacology, 5th edition. Jaypee Brothers, 2004.2. S.K. Kulkarni: Experimental Pharmacology, Vallabh Prakashan, New Delhi,Edn., 1991.3. Goodman Gilman’s: The pharmacological Basis of Therapeutics, 11th edition. Mc Graw Hill, New York. USA, 1996.

M. Sc. PHARMACEUTICAL CHEMISTRY (SEMESTER-I)


Practical Paper-I: Quantitative analytical methods & Biochemistry

M. marks: 100 Time: 4 hours Total practical hours: 60

Suggested Experiments

1. Identification of amino acid using paper chromatography techniques.

2. Identification of different organic compounds using thin layer chromatographic techniques.

3. Neutralization titrations: Assay of sodium bicarbonate, borax, boric acid, aspirin.

4. Iodimetric and iodometric titrations: Assay of iodine, copper sulphate.

5. Nonaquous titrations: Assay of Ephedrine HCl tablets.

6. Preparation and standardization of Disodium EDTA solution.

7. Qualitative and quantitative analysis of reducing and total sugars by biochemical and biophysical

techniques.

8. Determination of acid value of a fat/oil.

9. Determination of cholesterol: total, free and esterified.

10. Isolation, qualitative and quantitative analysis of lipids.

11. Qualitative and quantitative analysis of protein by biochemical and biophysical techniques.

12. Immobilization of enzymes.

13. Purification of enzyme by affinity chromatography and ion exchange chromatography.

14. Factors affecting enzyme activity.

15. Titration curve for amino acids.

16. Estimation of DNA and RNAs.

Note: Any other experiment(s) may be included in support of the theoretical aspect of the course.

M.Sc. PHARMACEUTICAL CHEMISTRY (SEMESTER-I)


Practical Paper-II: Stereochemistry and Chemistry of heterocyclic compounds

M. marks: 100

Time: 4 hours Total practical hours: 60


A. Synthesis of simple organic compounds with one or two examples:

Acetylation reaction, nucleophilic substitution reaction, esterification reaction, oxidation reaction,

Grignard reaction, Borohydride reduction, Friedal crafts acylation reaction, Diazotization reaction,

Benzoin condensation and chromatographic separation of isomeric mixtures.

B. Separation of a simple mixture of organic compounds and identification of their components.

Stereomodel workshops.


M.Sc. PHARMACEUTICAL CHEMISTRY (SEMESTER-II)


PAPER-V: MODERN ANALYTICAL METHODS





SECTION –A

Ultraviolet and visible absorption spectroscopy: Introduction, fundamental laws of photometry (Lamberts Beer’s Law), Radiation sources (Hydrogen/Deuterium lamp, tungsten filament lamp, xenon lamp) monochromatic, prism ( corn, littrow), resolution of prisms, Detectors (Photovoltaic cell, phototubes, photo multiplier tubes, silicon photo diodes) Filters (glass and absorption) single and double beam spectrophotometer & sample handling.Factors affecting max, woodward-fieser rules, fieser kuhn rule & nielson rule,application of UV spectroscopy .

NMR spectroscopy: Introduction , principle, quantum description, classical description relaxation process, chemical shift, spin- splitting, continuous wave NMR spectrometer, introduction to C13 NMR spectroscopy.Factors affecting chemical shift, coupling constant, factors affecting coupling constant, C 13

Heteronuclear coupling, Non-first order spectra, methods to resolve non-first order spectra, NOE, Introduction to COSY, HOMCOR, HETCOR, TOCSY, NOESY and Hyphenation with L.C

SECTION –BInfrared spectroscopy: Introduction, requirements of molecule to absorb in IR. Calculations of fun damental frequency; molecular vibrations, radiation sources (incandescent wire source, nest glower, Globar, Mercury arc and carbon dioxide laser); Detectors (Thermal/thermocouple, bolometer, pyrolectric, golay pneumatic and photon detector) , Dispersive and nondispersive spectrophotometer ( schematic optics of double beam spectrophotometer).Vibrational frequency,factors affecting vibrational frequency, pharmaceutical applications.

Mass spectrometry: Introduction, components of mass spectrometer ionization sources- electron impact ionization, field ionization, chemical ionization. ESI, APCI, Nitrogen rule, Determination of molecular

formula, mass fragmentation of compounds belonging to different functional groups, and heterocyclic compounds. Hyphenation with G.C.

Books recommended

1. Robert M. Silverstein; Spectrometric identification of organic compounds; 6th edition, John Wiley & sons, Inc, 2005. 2. Jag Mohan; Organic spectroscopy principles & applications 2nd edn, Norosa publishing houses, 2004. 3. P.S.Kalsi; spectroscopy of organic compounds; 5Th Edn, New age international Publishers 2004.4. Y.R. Sharma; Elementry organic Spectroscopy; S.Chand & Company Ltd, 2005.

M.Sc.PHARMACEUTICAL CHEMISTRY (SEMESTER –II)


PAPER-VI: PHYSICAL PHARMACY Maximum Mark : 100 Time: 3 hoursi)Theory Paper : 70 Pass Marks : 35% ii)Internal Assessment : 30 Lectures to be delivered : 60




SECTION-A

Preformulation & Micromeritics: Factors affecting dissolution, diffusion – pH, pka, KO/W, particle size, solubility etc. Methods to increase solubility of poorly soluble drugs, drug release mechanisms.Micromeritics: Introduction, pharmaceutical importance, Particle size distribution, surface area and particle volume, derived properties of powder, flow properties of powder, angle of repose, factors affecting flow of powders.

Surface and interfacial tension: Measurement of surface and interfacial tension, spreading coefficient, general classification of surfactants, hydrophilic- lipophilic balance. Solubilization, factors affecting solubilization, micelle formation, factors affecting micelle formation, determination of Critical Micelle Concentration, detergency and wetting agents. Contact angle, flocculating agents, de-flocculating agents, foaming and antifoaming agents. Pharmaceutical applications of surfactants.

SECTION-B

Colloids: Pharmaceutical application of colloids, brief introduction to properties of colloids, coarse dispersions Preparation and evaluation of suspension and emulsions, theory of emulsification. Fundamentals of rheology, types of flow, methods of measuring viscosity, thixotropy,measurement of thixotropy, thixotropy in formulations, rheology of disperse system, Pharmaceutical applications of rheology.

Complexation: Application of complexation in pharmacy, metal complexes, organic molecular complexes, inclusion compounds, methods for analysis, protein binding. Influence of temperature, light, oxygen and methods to prevent drug degradation. Prediction of stability, accelerated stability studies.

Books recommended:

1. Martin: Physical Pharmacy, B. I. Waverly Pvt Ltd., New Delhi (1994).

2. L. Lachman, H.A. Lieberman and J.L. Kaing: theory and Practive of Industrial Pharmacy,

III edn., Varghese Publishing House, Bombay (1977).



PAPER – VII: CHEMISTRY OF NATURAL PRODUCTS


INSTRUCTIONS FOR THE PAPER SETTERS:The question paper will consist of three sections A, B and C. Section A and B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answers/ objective type questions, which will cover the entire syllabus uniformly and will carry 28 marks(2 marks each).

INSTRUCTIONS FOR THE CANDIDATES:1. Candidates are required to attempt one question each from sections A and B of the question paper

and the entire section C.

SECTION-A

General methods for isolation, purification, identification & standardization of natural products.Carbohydrates: Introduction, stereoisomerism, mutarotation, configuration & ring structure of monosaccharides (glucose), Structure elucidation of disaccharides ( Sucrose, lactose) & polysaccharides (starch).

Alkaloids: General introduction, classification, isolation, and purification. Structure elucidation of atropine, quinine, cinchonine, nicotine and morphine.

SECTION-B

Terpenoids: General introduction, isolation, purification, structure elucidation of citral, menthol & camphor. Steroids: General introduction, isolation, purification & structure elucidation of sterols with special reference to cholesterol & ergosterol.

Glycosides: Introduction, classification, general structure elucidation of Anthraquinone & Cardioglycoside.

Books recommended:1. I.L. Finner: Organic Chemistry, Vol. II, Ist Indian edn, Pearson Education Pvt. Ltd. Indian

Branch, Delhi. 2002.2. O.P. Agarwal: Chemistry of Natural Products, Vol. I and II, 7 th edn, Goel Publishing

House, Meerut, 1983.

M.Sc. PHARMACEUTICAL CHEMISTY (SEMESTER-II)


PAPER-VIII: BIO-INFORMATICS AND BIOSTATISTICS.


INSTRUCTIONS FOR THE PAPER SETTERS:The question paper will consist of three sections A, B and C. Section A and B will have four questions from the respective sections of the syllabus and will carry 07 marks each. Section C will consist of a short answers / objective type questions, which will cover the entire syllabus uniformly and will carry 28 marks (2 marks each).

INSTRUCTIONS FOR THE CANDIDATES:1. Candidates are required to attempt one question each from sections A and B of the question paper


SECTION-A

Fundamental of Computers:- Definition of Computer , History and generations of computers, Classification of computers, Hardware and Software of computers, Computer memory, input and output devices, Block Diagram, Internet, Basic Services, E. mail, FTP,Telnet, WWW,Use of internet, Web browses. Programming languages:-C++Variables, Keywords, Identifiers and constants, data types operators, if, else, loop, switch statement. Switch case, Loops.Functions: Call by Reference, Call by Value, prototyping, function over loading,recursion.Arrays: Single Dimension, Two Dimension Arrays.Structures: Defining Structure , Processing structure , structure with Array. Classes and objects, Constructors and Destructors, Constructors overloading, over riding.Pointers.

SECTION-BBio-Informatics:- Introduction to Bioinformatics, , role of bioinformatics in pharmaceutical research. Introduction to protein & biological databases (EMBL, Gene Bank, Swiss-PROT, PIR). Search Engines ( Enter and SRS),Sequence analysis, Similarity searching algorithms, Fast, BLAST, Plylogenetic Tree. Protein modeling softwares, RASMOL, MOLMOL,INSIGHT MODDELER, CERIUS ,EMBOSS and their applications. Web Servers-NCBI, EBI, PDB.

Biostatistics:-

1. Measurement of central tendency and dispersion: Standard deviation of mean and standard error.

2. Bionomial distribution, Statistical signifance:chi-square test and goodness of fit, curve fitting, regression and correlation.

3. Analysis of Variance: Principles and applications.

Books Recommended: 1. Computers Automation and Society by Edward J. Laurie, Richard D. Irwin, Ont, 1979.2. Statistics - An introductory analysis by Taro Yamane, Harper International Edn, 1994.3. Biostatistics by B. Williams, Chapman and Hall Publ., London, 1993.4. An introduction to statistical methods byC.B.Gupta, Vikas Publ, Co., Jallandhar, 1997.5. Bioinformatics concepts, skills & applications by S.C. Rastogi, Namita Mendiratta & Parag Rastogi, CBS Publishers & Distributors, New Delhi , 2006.



Practical paper – III :Modern analytical method & Physical pharmacy

M. marks: 100

Time: 4 hours Total practical hours: 60


1. Standardization of an acid with a standard solution of base using pH-meter.

2. Determine the pKa value of an amino acid by pH metry.

3. The determination of aspirin and caffeine in a proprietary analgesic by spectrophotometery.

4. Measurement of optical rotation and study of mutarotation in glucose.

5. Titration of HCI with NaOH using potentiometer.

6. Determination of water content of salt hydrate.

7. Determination of disintegration time of uncoated coated and enteric coated tablets.

8. Determination of friability of tablets.

9. Dissolution of tablets and capsules.

10. Determination of total hardness of tablets.

11. Exercises involving structure elucidation from spectral data.


M.Sc. PHARMACEUTICAL CHEMISTY (SEMESTER-II)


Practical Paper-IV: Chemistry of natural products & Bioinformatics M. marks: 100

Time:4 hours Total practice al hours : 60


1. Extraction and analysis of the following natural products:(a) Eugenol from cinnamon leaf oil or cloves.(b) Piperine from black pepper.(c) Curcumin from turmeric (d) Pectin from orange peels.(e) Carotene from carrots. (f) Alkaloid from cinchona bark.

2. Programming , mathematical and computational models and methods.3. Accession of molecular database.4. Application of Biostatistics and processing of data.

Note: Any other experiment (s) may be included in support of the theoretical aspect of the course.

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pupdepartments.ac.inpupdepartments.ac.in/syllabi/Academic Session 2016-17... · Web viewFundamentals of volumetric analysis: Solubility product, effect of temperature, pH and solvent