406

" XBD=126 XHG=82 YBD=217 YHG=189>in, " XBD=197 XHG=136 YBD=217 YHG=189>the " XBD=320 XHG=215 YBD=217 YHG=189>table. " XBD=419 XHG=367 YBD=216 YHG=189>Its " XBD=540 XHG=438 YBD=216 YHG=189>effect " XBD=603 XHG=559 YBD=216 YHG=198>on " XBD=683 XHG=622 YBD=217 YHG=189>the " XBD=840 XHG=701 YBD=217 YHG=191>attacks " XBD=898 XHG=860 YBD=217 YHG=191>of " XBD=1115 XHG=912 YBD=217 YHG=191>mesenteric " XBD=1264 XHG=1133 YBD=217 YHG=190>throm-

" XBD=175 XHG=83 YBD=257 YHG=228>bosis " XBD=260 XHG=190 YBD=256 YHG=238>was " XBD=338 XHG=274 YBD=256 YHG=231>not " XBD=393 XHG=355 YBD=255 YHG=231>at " XBD=455 XHG=408 YBD=256 YHG=229>all " XBD=611 XHG=471 YBD=256 YHG=228>evident " XBD=680 XHG=627 YBD=257 YHG=229>for " XBD=780 XHG=695 YBD=265 YHG=230>they " XBD=966 XHG=795 YBD=266 YHG=229>persisted " XBD=1019 XHG=981 YBD=257 YHG=238>as " XBD=1163 XHG=1036 YBD=262 YHG=229>before, " XBD=1266 XHG=1179 YBD=262 YHG=228>with" XBD=149 XHG=85 YBD=295 YHG=277>one " XBD=294 XHG=174 YBD=304 YHG=267>period " XBD=361 XHG=322 YBD=295 YHG=268>of " XBD=461 XHG=383 YBD=295 YHG=268>four " XBD=600 XHG=487 YBD=296 YHG=268>weeks " XBD=779 XHG=626 YBD=296 YHG=268>freedom " XBD=896 XHG=806 YBD=295 YHG=269>from " XBD=1019 XHG=921 YBD=295 YHG=268>them " XBD=1066 XHG=1031 YBD=295 YHG=269>in " XBD=1265 XHG=1093 YBD=304 YHG=268>January," XBD=181 XHG=88 YBD=335 YHG=308>1943. " XBD=429 XHG=228 YBD=334 YHG=307>Treatment " XBD=544 XHG=456 YBD=334 YHG=307>with " XBD=715 XHG=570 YBD=343 YHG=307>heparin " XBD=781 XHG=742 YBD=335 YHG=317>as " XBD=853 XHG=808 YBD=334 YHG=316>an " XBD=1170 XHG=880 YBD=335 YHG=307>antithrombotic " XBD=1267 XHG=1197 YBD=335 YHG=316>was" XBD=268 XHG=85 YBD=382 YHG=346>suggested " XBD=349 XHG=283 YBD=374 YHG=346>but " XBD=531 XHG=365 YBD=374 YHG=346>domestic " XBD=743 XHG=548 YBD=374 YHG=346>difficulties " XBD=932 XHG=759 YBD=382 YHG=346>appeared " XBD=984 XHG=947 YBD=373 YHG=348>to " XBD=1044 XHG=1000 YBD=374 YHG=346>be " XBD=1081 XHG=1061 YBD=374 YHG=355>a " XBD=1268 XHG=1097 YBD=383 YHG=346>complete" XBD=148 XHG=85 YBD=413 YHG=385>bar " XBD=207 XHG=168 YBD=412 YHG=387>to " XBD=289 XHG=228 YBD=412 YHG=385>the " XBD=408 XHG=311 YBD=421 YHG=388>great " XBD=644 XHG=429 YBD=413 YHG=385>elaboration " XBD=823 XHG=664 YBD=420 YHG=385>required " XBD=933 XHG=845 YBD=413 YHG=385>both " XBD=991 XHG=954 YBD=412 YHG=388>to " XBD=1218 XHG=1014 YBD=413 YHG=386>administer " XBD=1269 XHG=1240 YBD=413 YHG=386>it" XBD=156 XHG=86 YBD=457 YHG=424>and " XBD=215 XHG=176 YBD=451 YHG=426>to " XBD=372 XHG=238 YBD=452 YHG=424>control " XBD=440 XHG=393 YBD=453 YHG=424>its " XBD=592 XHG=462 YBD=453 YHG=425>effects." XBD=187 XHG=132 YBD=492 YHG=463>On " XBD=284 XHG=202 YBD=493 YHG=463>Feb. " XBD=334 XHG=304 YBD=498 YHG=465>5, " XBD=448 XHG=356 YBD=498 YHG=464>1943, " XBD=509 XHG=465 YBD=492 YHG=464>he " XBD=594 XHG=523 YBD=492 YHG=464>had " XBD=631 XHG=610 YBD=491 YHG=473>a " XBD=732 XHG=646 YBD=499 YHG=472>very " XBD=864 XHG=748 YBD=491 YHG=472>severe " XBD=1004 XHG=880 YBD=491 YHG=463>attack " XBD=1058 XHG=1020 YBD=491 YHG=464>of " XBD=1271 XHG=1071 YBD=492 YHG=464>abdominal" XBD=170 XHG=88 YBD=539 YHG=503>pain " XBD=279 XHG=185 YBD=531 YHG=504>after " XBD=323 XHG=302 YBD=531 YHG=513>a " XBD=597 XHG=347 YBD=541 YHG=503>streptococcal " XBD=849 XHG=620 YBD=539 YHG=502>pharyngitis. " XBD=944 XHG=896 YBD=530 YHG=503>At " XBD=1038 XHG=968 YBD=531 YHG=503>this " XBD=1147 XHG=1063 YBD=531 YHG=503>time " XBD=1270 XHG=1171 YBD=531 YHG=504>there" XBD=174 XHG=87 YBD=570 YHG=551>were " XBD=287 XHG=196 YBD=578 YHG=542>signs " XBD=349 XHG=310 YBD=570 YHG=543>of " XBD=412 XHG=367 YBD=570 YHG=552>an " XBD=656 XHG=432 YBD=571 YHG=542>intracranial " XBD=898 XHG=677 YBD=575 YHG=541>thrombosis, " XBD=1096 XHG=920 YBD=570 YHG=543>retention " XBD=1156 XHG=1118 YBD=570 YHG=544>of " XBD=1272 XHG=1174 YBD=571 YHG=543>urine" XBD=261 XHG=87 YBD=619 YHG=581>requiring " XBD=570 XHG=284 YBD=610 YHG=582>catheterisation " XBD=663 XHG=593 YBD=608 YHG=582>and " XBD=757 XHG=680 YBD=613 YHG=580>.also " XBD=880 XHG=781 YBD=608 YHG=580>three " XBD=1014 XHG=902 YBD=610 YHG=581>weeks " XBD=1076 XHG=1038 YBD=609 YHG=582>of " XBD=1271 XHG=1094 YBD=618 YHG=582>priapism." XBD=157 XHG=89 YBD=648 YHG=621>For " XBD=241 XHG=170 YBD=649 YHG=623>two " XBD=343 XHG=256 YBD=658 YHG=621>days " XBD=400 XHG=356 YBD=649 YHG=621>he " XBD=588 XHG=415 YBD=658 YHG=621>appeared " XBD=640 XHG=602 YBD=648 YHG=623>to " XBD=698 XHG=653 YBD=648 YHG=620>be " XBD=798 XHG=714 YBD=647 YHG=629>once " XBD=907 XHG=813 YBD=648 YHG=629>more " XBD=959 XHG=923 YBD=648 YHG=621>in " XBD=1121 XHG=974 YBD=649 YHG=621>articulo " XBD=1271 XHG=1137 YBD=654 YHG=622>mortis," XBD=155 XHG=89 YBD=690 YHG=661>but " XBD=223 XHG=180 YBD=688 YHG=660>he " XBD=350 XHG=248 YBD=689 YHG=661>made " XBD=428 XHG=375 YBD=689 YHG=660>his " XBD=554 XHG=453 YBD=689 YHG=661>usual " XBD=751 XHG=577 YBD=695 YHG=669>recovery, " XBD=941 XHG=777 YBD=696 YHG=659>finishing " XBD=1054 XHG=965 YBD=688 YHG=660>with " XBD=1099 XHG=1079 YBD=688 YHG=669>a " XBD=1212 XHG=1124 YBD=688 YHG=661>bout " XBD=1277 XHG=1239 YBD=689 YHG=660>of" XBD=347 XHG=90 YBD=728 YHG=700>haemorrhoids. " XBD=505 XHG=392 YBD=735 YHG=700>Again " XBD=562 XHG=526 YBD=727 YHG=700>in " XBD=692 XHG=583 YBD=735 YHG=699>April, " XBD=813 XHG=720 YBD=733 YHG=700>1943, " XBD=880 XHG=836 YBD=727 YHG=699>he " XBD=972 XHG=901 YBD=727 YHG=708>was " XBD=1215 XHG=995 YBD=736 YHG=700>desperately " XBD=1276 XHG=1237 YBD=727 YHG=700>ill" XBD=176 XHG=91 YBD=767 YHG=739>with " XBD=362 XHG=202 YBD=767 YHG=739>bilateral " XBD=538 XHG=389 YBD=775 YHG=739>quinsies " XBD=635 XHG=565 YBD=766 YHG=738>and " XBD=837 XHG=660 YBD=766 YHG=738>remained " XBD=900 XHG=863 YBD=766 YHG=738>in " XBD=1010 XHG=925 YBD=775 YHG=747>poor " XBD=1158 XHG=1036 YBD=766 YHG=739>health " XBD=1275 XHG=1184 YBD=766 YHG=738>until" XBD=194 XHG=91 YBD=807 YHG=778>June. " XBD=288 XHG=240 YBD=806 YHG=778>At " XBD=389 XHG=318 YBD=806 YHG=778>this " XBD=500 XHG=415 YBD=806 YHG=778>time " XBD=574 XHG=520 YBD=806 YHG=778>his " XBD=775 XHG=596 YBD=814 YHG=777>optimism " XBD=866 XHG=796 YBD=806 YHG=778>and " XBD=1025 XHG=888 YBD=814 YHG=778>general " XBD=1276 XHG=1047 YBD=806 YHG=778>cheerfulness" XBD=230 XHG=94 YBD=846 YHG=818>seemed " XBD=297 XHG=260 YBD=845 YHG=820>to " XBD=444 XHG=329 YBD=846 YHG=818>desert " XBD=548 XHG=475 YBD=845 YHG=817>him " XBD=649 XHG=579 YBD=845 YHG=817>and " XBD=724 XHG=680 YBD=845 YHG=817>he " XBD=896 XHG=756 YBD=847 YHG=817>became " XBD=1013 XHG=928 YBD=854 YHG=826>very despondent." XBD=165 XHG=93 YBD=885 YHG=857>The " XBD=462 XHG=179 YBD=885 YHG=857>administration " XBD=514 XHG=476 YBD=884 YHG=856>of " XBD=675 XHG=530 YBD=894 YHG=856>heparin " XBD=762 XHG=688 YBD=885 YHG=857>still " XBD=911 XHG=776 YBD=885 YHG=856>seemed " XBD=1195 XHG=925 YBD=893 YHG=856>impracticable, " XBD=1276 XHG=1211 YBD=885 YHG=857>but" XBD=139 XHG=93 YBD=924 YHG=906>an " XBD=309 XHG=151 YBD=924 YHG=896>editorial " XBD=356 XHG=319 YBD=924 YHG=896>in " XBD=444 XHG=367 YBD=925 YHG=896>THE " XBD=604 XHG=457 YBD=925 YHG=896>LANCET " XBD=655 XHG=617 YBD=924 YHG=897>of " XBD=745 XHG=662 YBD=933 YHG=897>May " XBD=913 XHG=758 YBD=930 YHG=897>15,1943, " XBD=1014 XHG=922 YBD=924 YHG=896>drew " XBD=1090 XHG=1027 YBD=924 YHG=905>our " XBD=1277 XHG=1099 YBD=924 YHG=896>attention" XBD=131 XHG=93 YBD=964 YHG=939>to " XBD=358 XHG=146 YBD=964 YHG=935>dicoumarol " XBD=408 XHG=372 YBD=964 YHG=945>as " XBD=469 XHG=423 YBD=963 YHG=945>an " XBD=587 XHG=484 YBD=971 YHG=939>agent " XBD=638 XHG=602 YBD=964 YHG=936>in " XBD=814 XHG=652 YBD=972 YHG=936>lowering " XBD=888 XHG=827 YBD=963 YHG=936>the " XBD=1008 XHG=902 YBD=963 YHG=935>blood " XBD=1275 XHG=1021 YBD=972 YHG=935>prothrombin," XBD=163 XHG=93 YBD=1003 YHG=975>and " XBD=305 XHG=181 YBD=1002 YHG=975>its’ use " XBD=393 XHG=322 YBD=1003 YHG=984>was " XBD=554 XHG=411 YBD=1003 YHG=975>decided " XBD=667 XHG=571 YBD=1013 YHG=984>upon " XBD=777 XHG=685 YBD=1003 YHG=975>after " XBD=813 XHG=791 YBD=1002 YHG=984>a " XBD=936 XHG=827 YBD=1010 YHG=975>study " XBD=992 XHG=954 YBD=1002 YHG=975>of " XBD=1067 XHG=1005 YBD=1002 YHG=975>the " XBD=1276 XHG=1085 YBD=1002 YHG=974>literature." XBD=167 XHG=95 YBD=1042 YHG=1014>The " XBD=406 XHG=184 YBD=1050 YHG=1014>preparation " XBD=508 XHG=423 YBD=1042 YHG=1015>used " XBD=595 XHG=525 YBD=1042 YHG=1023>was " XBD=650 XHG=614 YBD=1042 YHG=1014>in " XBD=729 XHG=668 YBD=1042 YHG=1015>the " XBD=837 XHG=747 YBD=1042 YHG=1015>form " XBD=894 XHG=855 YBD=1041 YHG=1014>of " XBD=1076 XHG=910 YBD=1050 YHG=1014>capsules, " XBD=1181 XHG=1096 YBD=1040 YHG=1013>each " XBD=1276 XHG=1199 YBD=1040 YHG=1022>con-" XBD=230 XHG=96 YBD=1089 YHG=1053>taining 0-05 " XBD=382 XHG=351 YBD=1089 YHG=1062>g. " XBD=441 XHG=402 YBD=1082 YHG=1054>of " XBD=519 XHG=458 YBD=1082 YHG=1054>the " XBD=640 XHG=541 YBD=1090 YHG=1054>drug. " XBD=752 XHG=698 YBD=1082 YHG=1054>On " XBD=863 XHG=771 YBD=1081 YHG=1054>June " XBD=942 XHG=889 YBD=1087 YHG=1053>25, " XBD=1062 XHG=969 YBD=1086 YHG=1053>1943, " XBD=1277 XHG=1085 YBD=1079 YHG=1054>treatment" XBD=166 XHG=96 YBD=1121 YHG=1102>was " XBD=308 XHG=194 YBD=1128 YHG=1092>begun " XBD=413 XHG=326 YBD=1121 YHG=1093>with " XBD=460 XHG=439 YBD=1120 YHG=1102>a " XBD=562 XHG=481 YBD=1121 YHG=1093>dose " XBD=621 XHG=582 YBD=1121 YHG=1093>of 0-05 " XBD=771 XHG=740 YBD=1129 YHG=1102>g. " XBD=897 XHG=795 YBD=1128 YHG=1093>given " XBD=962 XHG=916 YBD=1119 YHG=1101>on " XBD=1160 XHG=987 YBD=1119 YHG=1092>alternate " XBD=1276 XHG=1180 YBD=1127 YHG=1091>days." XBD=169 XHG=97 YBD=1159 YHG=1132>The " XBD=434 XHG=190 YBD=1168 YHG=1132>prothrombin " XBD=581 XHG=452 YBD=1160 YHG=1133>indices " XBD=717 XHG=600 YBD=1160 YHG=1133>before " XBD=808 XHG=738 YBD=1159 YHG=1132>and " XBD=953 XHG=828 YBD=1166 YHG=1131>during " XBD=1165 XHG=972 YBD=1158 YHG=1133>treatment " XBD=1277 XHG=1189 YBD=1158 YHG=1139>were" XBD=135 XHG=98 YBD=1199 YHG=1180>as " XBD=312 XHG=157 YBD=1199 YHG=1171>follows :

" XBD=296 XHG=216 YBD=1248 YHG=1223>Date .P’0</M’OtM&tM.- &dquo; index,

" XBD=220 XHG=137 YBD=1306 YHG=1281>June " XBD=378 XHG=236 YBD=1310 YHG=1282>25, 1943 " XBD=513 XHG=477 YBD=1305 YHG=1282>92 " XBD=710 XHG=597 YBD=1307 YHG=1282>Before " XBD=903 XHG=726 YBD=1306 YHG=1281>treatment " XBD=994 XHG=918 YBD=1306 YHG=1280>with " XBD=1216 XHG=1012 YBD=1306 YHG=1280>dicoumarol.

" XBD=217 XHG=137 YBD=1338 YHG=1311>Aug. " XBD=286 XHG=259 YBD=1339 YHG=1311>8, " XBD=380 XHG=304 YBD=1335 YHG=1311>1943 |>" XBD=542 XHG=476 YBD=1420 YHG=1310>70" XBD=220 XHG=136 YBD=1373 YHG=1341>Aug. " XBD=287 XHG=239 YBD=1368 YHG=1340>28, " XBD=380 XHG=304 YBD=1364 YHG=1340>1943 " XBD=542 XHG=476 YBD=1421 YHG=1310>62 L " XBD=792 XHG=594 YBD=1366 YHG=1341>Continuous " XBD=984 XHG=807 YBD=1365 YHG=1340>treatment " XBD=1078 XHG=999 YBD=1365 YHG=1340>with" XBD=226 XHG=137 YBD=1397 YHG=1366>Sept. " XBD=287 XHG=240 YBD=1397 YHG=1370>14, " XBD=381 XHG=304 YBD=1393 YHG=1369>1943 " XBD=532 XHG=476 YBD=1421 YHG=1370>50 J " XBD=674 XHG=670 YBD=1391 YHG=1387>. " XBD=932 XHG=726 YBD=1395 YHG=1370>dicoumarol." XBD=377 XHG=136 YBD=1426 YHG=1399>Nov. 27, 1943 " XBD=532 XHG=477 YBD=1423 YHG=1388>60

" XBD=222 XHG=140 YBD=1481 YHG=1453>This " XBD=445 XHG=253 YBD=1481 YHG=1456>treatment " XBD=517 XHG=477 YBD=1488 YHG=1456>is, " XBD=589 XHG=550 YBD=1482 YHG=1455>of " XBD=746 XHG=618 YBD=1489 YHG=1464>course, " XBD=899 XHG=780 YBD=1491 YHG=1455>vastly " XBD=1069 XHG=931 YBD=1491 YHG=1454>simpler " XBD=1188 XHG=1100 YBD=1482 YHG=1455>than " XBD=1279 XHG=1218 YBD=1482 YHG=1454>the" XBD=271 XHG=96 YBD=1521 YHG=1493>elaborate " XBD=477 XHG=315 YBD=1521 YHG=1493>methods " XBD=590 XHG=521 YBD=1521 YHG=1494>and " XBD=770 XHG=635 YBD=1522 YHG=1495>control " XBD=854 XHG=815 YBD=1523 YHG=1488>of " XBD=1177 XHG=894 YBD=1531 YHG=1494>heparinisation. " XBD=1278 XHG=1223 YBD=1522 YHG=1494>He" XBD=229 XHG=95 YBD=1563 YHG=1532>walked " XBD=270 XHG=250 YBD=1559 YHG=1541>a " XBD=372 XHG=290 YBD=1560 YHG=1533>mile " XBD=437 XHG=393 YBD=1560 YHG=1541>on " XBD=549 XHG=458 YBD=1561 YHG=1533>June " XBD=612 XHG=572 YBD=1561 YHG=1534>25 " XBD=683 XHG=630 YBD=1562 YHG=1534>for " XBD=764 XHG=703 YBD=1562 YHG=1534>the " XBD=856 XHG=779 YBD=1571 YHG=1534>first " XBD=961 XHG=876 YBD=1561 YHG=1534>time " XBD=1074 XHG=982 YBD=1562 YHG=1535>since " XBD=1277 XHG=1089 YBD=1569 YHG=1534>February," XBD=193 XHG=100 YBD=1600 YHG=1572>1942. " XBD=295 XHG=241 YBD=1599 YHG=1571>On " XBD=403 XHG=319 YBD=1608 YHG=1572>July " XBD=448 XHG=430 YBD=1599 YHG=1573>2 " XBD=515 XHG=472 YBD=1600 YHG=1573>he " XBD=609 XHG=538 YBD=1601 YHG=1573>had " XBD=679 XHG=634 YBD=1600 YHG=1582>an " XBD=827 XHG=703 YBD=1601 YHG=1568>attack " XBD=891 XHG=847 YBD=1601 YHG=1574>of " XBD=1111 XHG=910 YBD=1601 YHG=1573>abdominal " XBD=1218 XHG=1134 YBD=1610 YHG=1573>pain " XBD=1277 XHG=1242 YBD=1601 YHG=1582>so" XBD=181 XHG=94 YBD=1639 YHG=1612>mild " XBD=280 XHG=200 YBD=1639 YHG=1610>that " XBD=343 XHG=299 YBD=1639 YHG=1611>he " XBD=504 XHG=362 YBD=1648 YHG=1612>ignored " XBD=563 XHG=522 YBD=1640 YHG=1612>it. " XBD=682 XHG=609 YBD=1640 YHG=1613>The " XBD=787 XHG=701 YBD=1641 YHG=1616>next " XBD=877 XHG=807 YBD=1641 YHG=1622>was " XBD=990 XHG=898 YBD=1640 YHG=1614>after " XBD=1056 XHG=1010 YBD=1640 YHG=1622>an " XBD=1224 XHG=1075 YBD=1641 YHG=1613>interval " XBD=1283 XHG=1245 YBD=1640 YHG=1612>of" XBD=139 XHG=85 YBD=1691 YHG=1651>10 " XBD=281 XHG=159 YBD=1684 YHG=1650>weeks, " XBD=351 XHG=305 YBD=1678 YHG=1660>on " XBD=467 XHG=373 YBD=1687 YHG=1651>Sept. " XBD=543 XHG=494 YBD=1685 YHG=1652>15, " XBD=666 XHG=565 YBD=1679 YHG=1652>when " XBD=730 XHG=687 YBD=1680 YHG=1652>he " XBD=822 XHG=752 YBD=1679 YHG=1652>had " XBD=865 XHG=844 YBD=1679 YHG=1661>a " XBD=1065 XHG=885 YBD=1680 YHG=1652>moderate " XBD=1169 XHG=1084 YBD=1689 YHG=1652>pain " XBD=1278 XHG=1190 YBD=1680 YHG=1652>from" XBD=172 XHG=100 YBD=1718 YHG=1690>1.20 " XBD=249 XHG=197 YBD=1717 YHG=1698>PM " XBD=310 XHG=272 YBD=1717 YHG=1692>to " XBD=378 XHG=339 YBD=1718 YHG=1691>10 PM " XBD=548 XHG=479 YBD=1718 YHG=1691>and " XBD=676 XHG=573 YBD=1728 YHG=1694>spent " XBD=723 XHG=702 YBD=1718 YHG=1700>a " XBD=820 XHG=749 YBD=1727 YHG=1691>day " XBD=882 XHG=845 YBD=1718 YHG=1692>in " XBD=985 XHG=905 YBD=1719 YHG=1691>bed. " XBD=1106 XHG=1033 YBD=1719 YHG=1691>One " XBD=1278 XHG=1130 YBD=1719 YHG=1691>unusual" XBD=228 XHG=93 YBD=1757 YHG=1730>feature " XBD=287 XHG=248 YBD=1757 YHG=1729>of " XBD=374 XHG=302 YBD=1758 YHG=1730>this " XBD=514 XHG=391 YBD=1758 YHG=1729>attack " XBD=602 XHG=531 YBD=1758 YHG=1739>was " XBD=642 XHG=622 YBD=1758 YHG=1739>a " XBD=768 XHG=662 YBD=1766 YHG=1730>slight rigidity " XBD=988 XHG=949 YBD=1758 YHG=1730>of " XBD=1064 XHG=1003 YBD=1758 YHG=1730>the " XBD=1152 XHG=1082 YBD=1758 YHG=1730>left- " XBD=1278 XHG=1165 YBD=1758 YHG=1733>rectus" XBD=299 XHG=94 YBD=1803 YHG=1769>abdominis, " XBD=363 XHG=316 YBD=1797 YHG=1770>all " XBD=536 XHG=375 YBD=1806 YHG=1770>previous " XBD=692 XHG=550 YBD=1797 YHG=1770>attacks " XBD=834 XHG=704 YBD=1806 YHG=1770>having " XBD=967 XHG=848 YBD=1798 YHG=1770>shown " XBD=1127 XHG=980 YBD=1806 YHG=1770>varying " XBD=1278 XHG=1141 YBD=1806 YHG=1770>degrees" XBD=134 XHG=95 YBD=1837 YHG=1809>of " XBD=291 XHG=149 YBD=1845 YHG=1808>rigidity " XBD=352 XHG=313 YBD=1837 YHG=1810>of " XBD=428 XHG=368 YBD=1837 YHG=1809>the " XBD=541 XHG=447 YBD=1845 YHG=1809>right " XBD=688 XHG=561 YBD=1837 YHG=1812>rectus. " XBD=824 XHG=727 YBD=1838 YHG=1809>Since " XBD=905 XHG=844 YBD=1838 YHG=1810>the " XBD=1106 XHG=920 YBD=1846 YHG=1809>beginning " XBD=1165 XHG=1126 YBD=1837 YHG=1810>of " XBD=1276 XHG=1181 YBD=1845 YHG=1810>July," XBD=190 XHG=97 YBD=1882 YHG=1849>1943, " XBD=265 XHG=221 YBD=1876 YHG=1848>he " XBD=357 XHG=294 YBD=1877 YHG=1849>has " XBD=570 XHG=387 YBD=1876 YHG=1848>recovered " XBD=653 XHG=598 YBD=1883 YHG=1848>his " XBD=835 XHG=684 YBD=1877 YHG=1847>cheerful " XBD=1010 XHG=865 YBD=1877 YHG=1849>outlook " XBD=1116 XHG=1040 YBD=1877 YHG=1851>and. " XBD=1276 XHG=1139 YBD=1885 YHG=1849>general" XBD=260 XHG=92 YBD=1924 YHG=1888>vivacity. " XBD=372 XHG=306 YBD=1916 YHG=1889>His " XBD=527 XHG=386 YBD=1915 YHG=1888>attacks " XBD=603 XHG=548 YBD=1915 YHG=1879>of " XBD=689 XHG=604 YBD=1924 YHG=1888>pain " XBD=769 XHG=712 YBD=1915 YHG=1897>are " XBD=990 XHG=784 YBD=1924 YHG=1888>infrequent’ " XBD=1072 XHG=1001 YBD=1915 YHG=1889>and " XBD=1188 XHG=1091 YBD=1917 YHG=1889>mild. " XBD=1277 XHG=1234 YBD=1915 YHG=1888>In" XBD=260 XHG=92 YBD=1963 YHG=1926>January, " XBD=379 XHG=286 YBD=1960 YHG=1928>1944, " XBD=443 XHG=399 YBD=1954 YHG=1927>he " XBD=532 XHG=462 YBD=1955 YHG=1936>was " XBD=827 XHG=553 YBD=1962 YHG=1928>comparatively " XBD=934 XHG=845 YBD=1960 YHG=1928>well, " XBD=1023 XHG=957 YBD=1956 YHG=1927>but " XBD=1079 XHG=1042 YBD=1955 YHG=1927>in " XBD=1278 XHG=1100 YBD=1963 YHG=1927>February" XBD=150 XHG=89 YBD=1994 YHG=1966>fell " XBD=285 XHG=163 YBD=1994 YHG=1966>victim " XBD=337 XHG=300 YBD=1995 YHG=1969>to " XBD=373 XHG=352 YBD=1994 YHG=1975>a " XBD=467 XHG=387 YBD=2003 YHG=1966>long " XBD=605 XHG=482 YBD=1994 YHG=1966>attack " XBD=658 XHG=619 YBD=1994 YHG=1966>of " XBD=887 XHG=667 YBD=2003 YHG=1965>pharyngitis " XBD=971 XHG=901 YBD=1995 YHG=1967>and |>" XBD=1176 XHG=978 YBD=1994 YHG=1965>tracheitis. " XBD=1277 XHG=1220 YBD=1995 YHG=1967>He" XBD=272 XHG=89 YBD=2034 YHG=2006>recovered " XBD=344 XHG=295 YBD=2043 YHG=2006>by " XBD=427 XHG=365 YBD=2034 YHG=2006>the " XBD=517 XHG=449 YBD=2034 YHG=2006>end " XBD=579 XHG=540 YBD=2033 YHG=2006>of " XBD=726 XHG=595 YBD=2038 YHG=2005>March, " XBD=840 XHG=748 YBD=2033 YHG=2006>since " XBD=961 XHG=860 YBD=2034 YHG=2006>when " XBD=1025 XHG=980 YBD=2033 YHG=2006>he " XBD=1108 XHG=1044 YBD=2033 YHG=2006>has " XBD=1278 XHG=1131 YBD=2042 YHG=2004>enjoyed" XBD=310 XHG=89 YBD=2082 YHG=2046>remarkably " XBD=438 XHG=324 YBD=2073 YHG=2046>active " XBD=541 XHG=452 YBD=2081 YHG=2045>good " XBD=688 XHG=554 YBD=2078 YHG=2045>health, " XBD=774 XHG=704 YBD=2073 YHG=2045>and " XBD=989 XHG=791 YBD=2074 YHG=2045>abdominal " XBD=1091 XHG=1007 YBD=2082 YHG=2046>pain " XBD=1172 XHG=1109 YBD=2073 YHG=2045>has " XBD=1279 XHG=1192 YBD=2074 YHG=2046>been" XBD=298 XHG=90 YBD=2122 YHG=2078>completely " XBD=434 XHG=311 YBD=2113 YHG=2085>absent " XBD=502 XHG=448 YBD=2112 YHG=2084>for " XBD=535 XHG=517 YBD=2113 YHG=2085>3 " XBD=703 XHG=550 YBD=2112 YHG=2084>months. ‘

" XBD=179 XHG=140 YBD=2159 YHG=2130>It " XBD=271 XHG=196 YBD=2159 YHG=2130>will " XBD=335 XHG=288 YBD=2159 YHG=2130>be " XBD=505 XHG=353 YBD=2159 YHG=2129>noticed " XBD=610 XHG=522 YBD=2159 YHG=2130>that " XBD=737 XHG=627 YBD=2158 YHG=2129>while " XBD=822 XHG=756 YBD=2158 YHG=2128>the " XBD=1104 XHG=840 YBD=2165 YHG=2129>prothrombin " XBD=1278 XHG=1124 YBD=2159 YHG=2130>content" XBD=124 XHG=91 YBD=2199 YHG=2168>is " XBD=368 XHG=143 YBD=2199 YHG=2168>diminished " XBD=462 XHG=386 YBD=2198 YHG=2168>and " XBD=546 XHG=481 YBD=2198 YHG=2169>the " XBD=742 XHG=566 YBD=2198 YHG=2167>evidence " XBD=806 XHG=762 YBD=2197 YHG=2167>of " XBD=1049 XHG=820 YBD=2198 YHG=2168>thrombosis " XBD=1139 XHG=1069 YBD=2198 YHG=2169>less " XBD=1276 XHG=1157 YBD=2198 YHG=2168>under" XBD=158 XHG=93 YBD=2238 YHG=2209>the " XBD=328 XHG=178 YBD=2246 YHG=2210>present " XBD=565 XHG=347 YBD=2243 YHG=2209>treatment, " XBD=652 XHG=586 YBD=2238 YHG=2209>the " XBD=930 XHG=671 YBD=2245 YHG=2207>lymphocytic " XBD=1063 XHG=950 YBD=2237 YHG=2208>series " XBD=1144 XHG=1081 YBD=2237 YHG=2217>are " XBD=1276 XHG=1163 YBD=2245 YHG=2208>again" XBD=238 XHG=93 YBD=2285 YHG=2249>greatly " XBD=487 XHG=269 YBD=2285 YHG=2248>increasing. " XBD=628 XHG=538 YBD=2277 YHG=2248>This " XBD=823 XHG=659 YBD=2277 YHG=2247>increase " XBD=923 XHG=854 YBD=2277 YHG=2247>has " XBD=1050 XHG=953 YBD=2277 YHG=2247>been " XBD=1276 XHG=1079 YBD=2277 YHG=2257>unaccom-" XBD=230 XHG=92 YBD=2325 YHG=2288>panied " XBD=299 XHG=247 YBD=2325 YHG=2288>by " XBD=392 XHG=317 YBD=2325 YHG=2297>any " XBD=556 XHG=411 YBD=2317 YHG=2288>clinical " XBD=856 XHG=575 YBD=2322 YHG=2287>deterioration, " XBD=952 XHG=875 YBD=2316 YHG=2286>and " XBD=1027 XHG=968 YBD=2317 YHG=2287>for " XBD=1109 XHG=1044 YBD=2317 YHG=2288>the " XBD=1277 XHG=1127 YBD=2324 YHG=2288>present" XBD=124 XHG=92 YBD=2356 YHG=2327>it " XBD=178 XHG=146 YBD=2356 YHG=2326>is " XBD=275 XHG=202 YBD=2357 YHG=2328>not " XBD=473 XHG=293 YBD=2357 YHG=2327>intended " XBD=537 XHG=497 YBD=2357 YHG=2328>to " XBD=674 XHG=562 YBD=2357 YHG=2328>treat. " XBD=753 XHG=688 YBD=2356 YHG=2327>the " XBD=975 XHG=777 YBD=2355 YHG=2326>leukaemia " XBD=1052 XHG=998 YBD=2363 YHG=2327>by " XBD=1275 XHG=1075 YBD=2356 YHG=2326>radiation." XBD=238 XHG=92 YBD=2403 YHG=2366>During " XBD=481 XHG=273 YBD=2396 YHG=2367>treatment " XBD=623 XHG=517 YBD=2396 YHG=2367>there " XBD=729 XHG=659 YBD=2395 YHG=2366>has " XBD=862 XHG=766 YBD=2394 YHG=2365>been " XBD=947 XHG=899 YBD=2394 YHG=2375>no " XBD=1202 XHG=985 YBD=2402 YHG=2357>suggestion " XBD=1281 XHG=1239 YBD=2395 YHG=2366>of" XBD=347 XHG=92 YBD=2442 YHG=2405>haemorrhage " XBD=401 XHG=362 YBD=2435 YHG=2406>in " XBD=492 XHG=417 YBD=2443 YHG=2415>any " XBD=594 XHG=507 YBD=2443 YHG=2406>part " XBD=653 XHG=610 YBD=2435 YHG=2406>of " XBD=731 XHG=664 YBD=2435 YHG=2401>the " XBD=860 XHG=746 YBD=2441 YHG=2405>body. |>" XBD=1234 XHG=1230 YBD=2444 YHG=2440>," XBD=781 XHG=585 YBD=2499 YHG=2476>SUMMARY

" XBD=177 XHG=142 YBD=2547 YHG=2518>A " XBD=273 XHG=192 YBD=2548 YHG=2527>case " XBD=331 XHG=288 YBD=2548 YHG=2519>of " XBD=490 XHG=342 YBD=2549 YHG=2519>chronic " XBD=714 XHG=505 YBD=2556 YHG=2518>lymphatic " XBD=927 XHG=728 YBD=2548 YHG=2518>Ieukaemia " XBD=1016 XHG=940 YBD=2547 YHG=2527>was " XBD=1278 XHG=1032 YBD=2555 YHG=2517>complicated" XBD=149 XHG=61 YBD=2594 YHG=2556>, by " XBD=376 XHG=185 YBD=2587 YHG=2556>recurrent " XBD=644 XHG=412 YBD=2588 YHG=2559>thrombotic " XBD=919 XHG=681 YBD=2595 YHG=2558>phenomena " XBD=1204 XHG=956 YBD=2593 YHG=2557>culminating " XBD=1279 XHG=1240 YBD=2585 YHG=2557>in" XBD=208 XHG=97 YBD=2626 YHG=2597>acute " XBD=431 XHG=236 YBD=2627 YHG=2597>intestinal " XBD=708 XHG=460 YBD=2627 YHG=2597>obstruction. " XBD=827 XHG=771 YBD=2627 YHG=2597>Its " XBD=960 XHG=856 YBD=2626 YHG=2597>basic " XBD=1198 XHG=989 YBD=2626 YHG=2597>treatment " XBD=1279 XHG=1225 YBD=2633 YHG=2596>by" XBD=286 XHG=96 YBD=2665 YHG=2635>radiation " XBD=386 XHG=311 YBD=2665 YHG=2636>and " XBD=475 XHG=409 YBD=2666 YHG=2637>the " XBD=706 XHG=499 YBD=2666 YHG=2637>treatment " XBD=773 XHG=730 YBD=2666 YHG=2637>of " XBD=843 XHG=793 YBD=2666 YHG=2637>its " XBD=1135 XHG=868 YBD=2673 YHG=2635>complicating " XBD=1280 XHG=1157 YBD=2665 YHG=2635>factor" XBD=389 XHG=97 YBD=2713 YHG=2675>of’thrombosis " XBD=507 XHG=412 YBD=2706 YHG=2676>with " XBD=762 XHG=531 YBD=2706 YHG=2676>dicoumarol " XBD=848 XHG=786 YBD=2705 YHG=2685>are " XBD=1078 XHG=875 YBD=2706 YHG=2675>described.

SIGNIFICANCE OF

BLOOD HISTAMINASE IN PREGNANCY

A. AHLMARK

" XBD=440 XHG=160 YBD=2975 YHG=2937>Pharmacology " XBD=561 XHG=454 YBD=2974 YHG=2938>Dept, " XBD=802 XHG=576 YBD=2968 YHG=2936>Karolinska " XBD=1000 XHG=819 YBD=2973 YHG=2938>Institute, " XBD=1218 XHG=1018 YBD=2969 YHG=2938>Stockholm" XBD=266 XHG=146 YBD=3026 YHG=2997>SINCE " XBD=450 XHG=296 YBD=3026 YHG=2997>Marcou " XBD=555 XHG=480 YBD=3025 YHG=2996>and " XBD=941 XHG=585 YBD=3033 YHG=2998>Athanasiu-Vergu " XBD=1096 XHG=974 YBD=3032 YHG=2998>(1937) " XBD=1281 XHG=1129 YBD=3026 YHG=2997>demon-" XBD=242 XHG=96 YBD=3066 YHG=3035>strated " XBD=285 XHG=263 YBD=3063 YHG=3044>a " XBD=778 XHG=306 YBD=3072 YHG=3035>histamine-inactivating " XBD=998 XHG=798 YBD=3066 YHG=3036>substance " XBD=1060 XHG=1020 YBD=3065 YHG=3036>in " XBD=1146 XHG=1081 YBD=3065 YHG=3037>the " XBD=1283 XHG=1169 YBD=3065 YHG=3028>blood" XBD=141 XHG=97 YBD=3104 YHG=3075>of " XBD=346 XHG=160 YBD=3112 YHG=3074>pregnant " XBD=526 XHG=370 YBD=3108 YHG=3083>women, " XBD=697 XHG=554 YBD=3104 YHG=3076>several " XBD=878 XHG=721 YBD=3105 YHG=3076>authors " XBD=1000 XHG=902 YBD=3104 YHG=3075>have " XBD=1180 XHG=1027 YBD=3105 YHG=3074>studied " XBD=1283 XHG=1205 YBD=3104 YHG=3075>this" XBD=374 XHG=99 YBD=3152 YHG=3115>phenomenon." XBD=248 XHG=138 YBD=3192 YHG=3164>Zeller " XBD=329 XHG=259 YBD=3191 YHG=3163>and " XBD=553 XHG=341 YBD=3190 YHG=3162>Birkhauser " XBD=680 XHG=567 YBD=3198 YHG=3163>(1940) " XBD=874 XHG=695 YBD=3193 YHG=3164>described " XBD=907 XHG=886 YBD=3192 YHG=3173>a " XBD=1127 XHG=919 YBD=3200 YHG=3164>gasometric " XBD=1284 XHG=1139 YBD=3192 YHG=3163>method" XBD=143 XHG=95 YBD=3238 YHG=3203>by " XBD=278 XHG=164 YBD=3230 YHG=3202>which " XBD=321 XHG=299 YBD=3230 YHG=3211>a " XBD=539 XHG=343 YBD=3237 YHG=3202>significant " XBD=713 XHG=561 YBD=3230 YHG=3201>increase " XBD=776 XHG=730 YBD=3230 YHG=3205>.of " XBD=855 XHG=794 YBD=3231 YHG=3204>the " XBD=1285 XHG=878 YBD=3238 YHG=3203>histamine-destroying" XBD=199 XHG=95 YBD=3271 YHG=3242>effect " XBD=253 XHG=213 YBD=3269 YHG=3241>of " XBD=368 XHG=262 YBD=3269 YHG=3241>blood " XBD=484 XHG=382 YBD=3268 YHG=3240>could " XBD=540 XHG=498 YBD=3268 YHG=3240>be " XBD=724 XHG=555 YBD=3268 YHG=3239>observed " XBD=828 XHG=739 YBD=3269 YHG=3242>from " XBD=952 XHG=842 YBD=3269 YHG=3242>about " XBD=1027 XHG=965 YBD=3269 YHG=3241>the " XBD=1127 XHG=1045 YBD=3269 YHG=3242>13th " XBD=1235 XHG=1140 YBD=3269 YHG=3242>week " XBD=1290 XHG=1250 YBD=3268 YHG=3241>of" XBD=307 XHG=96 YBD=3318 YHG=3289>pregnancy. " XBD=455 XHG=342 YBD=3308 YHG=3280>Werle and " XBD=767 XHG=553 YBD=3307 YHG=3278>Effkemann " XBD=896 XHG=782 YBD=3315 YHG=3281>(1940) " XBD=1054 XHG=911 YBD=3318 YHG=3280>devised " XBD=1088 XHG=1068 YBD=3308 YHG=3289>a " XBD=1285 XHG=1102 YBD=3316 YHG=3280>biological" XBD=242 XHG=95 YBD=3347 YHG=3319>method " XBD=307 XHG=259 YBD=3355 YHG=3319>by " XBD=437 XHG=324 YBD=3346 YHG=3319>which " XBD=483 XHG=453 YBD=3346 YHG=3319>it " XBD=569 XHG=500 YBD=3346 YHG=3326>was " XBD=748 XHG=587 YBD=3355 YHG=3317>possible, " XBD=805 XHG=767 YBD=3346 YHG=3328>as " XBD=927 XHG=823 YBD=3354 YHG=3312>early " XBD=974 XHG=936 YBD=3346 YHG=3328>as " XBD=1052 XHG=990 YBD=3347 YHG=3319>the " XBD=1132 XHG=1070 YBD=3346 YHG=3320>3rd " XBD=1284 XHG=1148 YBD=3351 YHG=3319>month," XBD=136 XHG=97 YBD=3385 YHG=3361>to " XBD=252 XHG=157 YBD=3386 YHG=3356>show " XBD=295 XHG=274 YBD=3385 YHG=3367>a " XBD=722 XHG=316 YBD=3391 YHG=3356>histamine-destroying " XBD=847 XHG=744 YBD=3383 YHG=3357>effect 3 " XBD=1036 XHG=934 YBD=3385 YHG=3357>times " XBD=1118 XHG=1058 YBD=3385 YHG=3358>the " XBD=1284 XHG=1139 YBD=3386 YHG=3358>normal." XBD=238 XHG=99 YBD=3423 YHG=3396>Zeller’s " XBD=472 XHG=264 YBD=3432 YHG=3396>qualitative " XBD=651 XHG=494 YBD=3426 YHG=3395>method, " XBD=826 XHG=671 YBD=3421 YHG=3394>founded " XBD=893 XHG=847 YBD=3422 YHG=3404>on " XBD=978 XHG=917 YBD=3422 YHG=3395>the " XBD=1225 XHG=999 YBD=3432 YHG=3396>decolorising " XBD=1289 XHG=1251 YBD=3424 YHG=3396>of" XBD=215 XHG=99 YBD=3470 YHG=3430>indigo " XBD=482 XHG=238 YBD=3471 YHG=3434>disulphonate " XBD=554 XHG=507 YBD=3470 YHG=3435>by " XBD=670 XHG=572 YBD=3469 YHG=3433>H202 " XBD=824 XHG=690 YBD=3460 YHG=3433>formed " XBD=942 XHG=845 YBD=3460 YHG=3432>when " XBD=1152 XHG=966 YBD=3461 YHG=3433>histamine " XBD=1203 XHG=1175 YBD=3462 YHG=3435>is " XBD=1286 XHG=1229 YBD=3463 YHG=3434>de-

" XBD=1499 XHG=1327 YBD=226 YHG=190>stroyed,’ has " XBD=1689 XHG=1601 YBD=219 YHG=190>been " XBD=1803 XHG=1716 YBD=219 YHG=190>used " XBD=1889 XHG=1829 YBD=226 YHG=189>by, " XBD=2045 XHG=1918 YBD=227 YHG=199>among " XBD=2201 XHG=2073 YBD=224 YHG=190>others, " XBD=2412 XHG=2230 YBD=219 YHG=191>Neumann " XBD=2502 XHG=2437 YBD=220 YHG=190>and" XBD=1487 XHG=1328 YBD=266 YHG=229>Ebbinge " XBD=1634 XHG=1507 YBD=266 YHG=230>(1942). " XBD=1752 XHG=1679 YBD=258 YHG=229>The " XBD=2202 XHG=1766 YBD=265 YHG=225>histamine-inactivating " XBD=2383 XHG=2218 YBD=267 YHG=229>principle " XBD=2504 XHG=2398 YBD=258 YHG=229>tallies" XBD=1365 XHG=1329 YBD=296 YHG=269>in " XBD=1575 XHG=1381 YBD=305 YHG=268>important " XBD=1742 XHG=1589 YBD=305 YHG=271>respects " XBD=1837 XHG=1750 YBD=297 YHG=269>with " XBD=2077 XHG=1851 YBD=297 YHG=268>histaminase " XBD=2129 XHG=2091 YBD=297 YHG=277>as " XBD=2326 XHG=2144 YBD=305 YHG=269>originally " XBD=2504 XHG=2336 YBD=297 YHG=268>described" XBD=1378 XHG=1330 YBD=344 YHG=307>by " XBD=1484 XHG=1398 YBD=336 YHG=308>Best " XBD=1574 XHG=1502 YBD=335 YHG=307>and " XBD=1772 XHG=1592 YBD=344 YHG=306>McHenry " XBD=1906 XHG=1792 YBD=342 YHG=308>(1930) " XBD=1965 XHG=1927 YBD=335 YHG=316>or " XBD=2259 XHG=1984 YBD=336 YHG=307>diaminoxidase " XBD=2424 XHG=2279 YBD=343 YHG=306>(Zeilef).

. " XBD=1574 XHG=1380 YBD=395 YHG=359>Hitherto, " XBD=1778 XHG=1593 YBD=394 YHG=360>however, " XBD=1904 XHG=1798 YBD=389 YHG=359>there " XBD=1990 XHG=1922 YBD=389 YHG=359>has " XBD=2104 XHG=2009 YBD=388 YHG=359>been " XBD=2172 XHG=2123 YBD=388 YHG=368>no " XBD=2364 XHG=2191 YBD=389 YHG=359>accurate " XBD=2503 XHG=2382 YBD=388 YHG=367>means" XBD=1376 XHG=1333 YBD=427 YHG=398>of " XBD=1659 XHG=1403 YBD=435 YHG=398>quantitative " XBD=1906 XHG=1689 YBD=429 YHG=393>estimation " XBD=1978 XHG=1936 YBD=427 YHG=391>of " XBD=2068 XHG=2003 YBD=427 YHG=398>the " XBD=2252 XHG=2097 YBD=434 YHG=407>enzyme " XBD=2504 XHG=2280 YBD=433 YHG=397>throughout" XBD=1576 XHG=1334 YBD=475 YHG=446>pregnancy ; " XBD=1674 XHG=1606 YBD=466 YHG=446>nor " XBD=1793 XHG=1695 YBD=467 YHG=436>have " XBD=1863 XHG=1808 YBD=466 YHG=446>we " XBD=1961 XHG=1885 YBD=474 YHG=446>any " XBD=2130 XHG=1978 YBD=466 YHG=436>definite " XBD=2366 XHG=2151 YBD=472 YHG=431>knowledge " XBD=2428 XHG=2387 YBD=465 YHG=435>of " XBD=2503 XHG=2444 YBD=466 YHG=437>the" XBD=1602 XHG=1334 YBD=515 YHG=476>physiological " XBD=1831 XHG=1624 YBD=506 YHG=476>variations " XBD=1896 XHG=1854 YBD=505 YHG=476>of " XBD=2158 XHG=1913 YBD=506 YHG=476>histaminase " XBD=2220 XHG=2180 YBD=505 YHG=476>in " XBD=2306 XHG=2242 YBD=505 YHG=476>the " XBD=2504 XHG=2328 YBD=512 YHG=476>pregnant" XBD=1534 XHG=1335 YBD=553 YHG=516>organism. " XBD=1605 XHG=1586 YBD=545 YHG=516>I " XBD=1810 XHG=1625 YBD=544 YHG=515>therefore " XBD=1993 XHG=1829 YBD=552 YHG=515>thought " XBD=2043 XHG=2012 YBD=545 YHG=516>it " XBD=2244 XHG=2063 YBD=545 YHG=514>desirable " XBD=2303 XHG=2263 YBD=544 YHG=515>to " XBD=2424 XHG=2323 YBD=544 YHG=514>work " XBD=2504 XHG=2442 YBD=543 YHG=515>out" XBD=1358 XHG=1335 YBD=584 YHG=565>a " XBD=1535 XHG=1379 YBD=584 YHG=554>method " XBD=1600 XHG=1556 YBD=583 YHG=555>of " XBD=1866 XHG=1617 YBD=590 YHG=554>determining " XBD=1951 XHG=1886 YBD=583 YHG=554>the " XBD=2130 XHG=1972 YBD=584 YHG=555>amount " XBD=2194 XHG=2151 YBD=583 YHG=553>of " XBD=2449 XHG=2209 YBD=583 YHG=553>histaminase " XBD=2504 XHG=2468 YBD=582 YHG=553>in

" XBD=1366 XHG=1300 YBD=977 YHG=884>I |>" XBD=1366 XHG=1360 YBD=973 YHG=950>i" XBD=1335 XHG=1309 YBD=1071 YHG=983>t

B v" XBD=1325 XHG=1300 YBD=1197 YHG=1084>1

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" XBD=1391 XHG=1342 YBD=1593 YHG=1567>Fig. I-Blood " XBD=1727 XHG=1556 YBD=1588 YHG=1565>histaminase " XBD=1765 XHG=1740 YBD=1588 YHG=1566>in pregnancy.-Histaminolytic " XBD=2313 XHG=2212 YBD=1593 YHG=1573>power, " XBD=2467 XHG=2327 YBD=1593 YHG=1566>expressed " XBD=2512 XHG=2483 YBD=1595 YHG=1566>by" XBD=1422 XHG=1374 YBD=1618 YHG=1596>the " XBD=1550 XHG=1437 YBD=1617 YHG=1600>amount " XBD=1595 XHG=1567 YBD=1618 YHG=1595>of " XBD=1755 XHG=1611 YBD=1618 YHG=1595>histamine " XBD=1917 XHG=1772 YBD=1623 YHG=1596>destroyed " XBD=1998 XHG=1938 YBD=1624 YHG=1595>by " XBD=1998 XHG=1992 YBD=1618 YHG=1595>I ml. " XBD=2182 XHG=2084 YBD=1623 YHG=1595>plasma " XBD=2224 XHG=2198 YBD=1618 YHG=1597>in " XBD=2295 XHG=2242 YBD=1618 YHG=1603>one " XBD=2389 XHG=2314 YBD=1621 YHG=1596>hour, " XBD=2510 XHG=2407 YBD=1618 YHG=1596>charted" XBD=1476 XHG=1374 YBD=1653 YHG=1627>against " XBD=1597 XHG=1490 YBD=1648 YHG=1625>months " XBD=1639 XHG=1609 YBD=1648 YHG=1625>of " XBD=1806 XHG=1650 YBD=1653 YHG=1632>pregnancy. (a) " XBD=2034 XHG=1934 YBD=1652 YHG=1625>norrpal " XBD=2203 XHG=2055 YBD=1653 YHG=1632>pregnancy " XBD=2308 XHG=2221 YBD=1652 YHG=1625>(mean " XBD=2354 XHG=2326 YBD=1647 YHG=1625>of " XBD=2450 XHG=2369 YBD=1648 YHG=1625>about " XBD=2511 XHG=2470 YBD=1648 YHG=1626>110" XBD=1641 XHG=1375 YBD=1677 YHG=1655>blood-histaminase " XBD=1902 XHG=1655 YBD=1682 YHG=1654>determinations). " XBD=1977 XHG=1940 YBD=1682 YHG=1655>(b) " XBD=2018 XHG=1991 YBD=1674 YHG=1665>= " XBD=2173 XHG=2032 YBD=1677 YHG=1656>imminent " XBD=2313 XHG=2187 YBD=1677 YHG=1654>abortion " XBD=2355 XHG=2329 YBD=1676 YHG=1659>at " XBD=2415 XHG=2368 YBD=1677 YHG=1655>the " XBD=2513 XHG=2430 YBD=1682 YHG=1655>begin-" XBD=1437 XHG=1376 YBD=1711 YHG=1681>ning " XBD=1481 XHG=1451 YBD=1706 YHG=1684>of " XBD=1539 XHG=1491 YBD=1707 YHG=1684>the " XBD=1598 XHG=1551 YBD=1706 YHG=1684>4th " XBD=1718 XHG=1615 YBD=1706 YHG=1683>month. " XBD=1808 XHG=1752 YBD=1707 YHG=1684>The " XBD=1930 XHG=1822 YBD=1707 YHG=1685>uterine " XBD=2069 XHG=1946 YBD=1711 YHG=1684>bleeding " XBD=2197 XHG=2081 YBD=1711 YHG=1684>stopped " XBD=2282 XHG=2212 YBD=1707 YHG=1684>after " XBD=2378 XHG=2295 YBD=1706 YHG=1684>about " XBD=2406 XHG=2390 YBD=1707 YHG=1685>2 " XBD=2512 XHG=2420 YBD=1707 YHG=1684>weeks." XBD=1413 XHG=1376 YBD=1741 YHG=1714>(c) " XBD=1453 XHG=1427 YBD=1733 YHG=1724>= " XBD=1577 XHG=1469 YBD=1737 YHG=1716>uterine " XBD=1717 XHG=1593 YBD=1741 YHG=1713>bleeding " XBD=1759 XHG=1733 YBD=1736 YHG=1715>in " XBD=1823 XHG=1775 YBD=1736 YHG=1714>the " XBD=1886 XHG=1839 YBD=1736 YHG=1713>3rd " XBD=1953 XHG=1903 YBD=1736 YHG=1713>and " XBD=2017 XHG=1969 YBD=1736 YHG=1714>4th " XBD=2152 XHG=2035 YBD=1737 YHG=1714>months. " XBD=2242 XHG=2186 YBD=1736 YHG=1713>The " XBD=2307 XHG=2258 YBD=1741 YHG=1714>day " XBD=2391 XHG=2322 YBD=1736 YHG=1713>after " XBD=2452 XHG=2406 YBD=1736 YHG=1714>the " XBD=2513 XHG=2467 YBD=1736 YHG=1713>last" XBD=1545 XHG=1374 YBD=1767 YHG=1743>histaminase " XBD=1776 XHG=1565 YBD=1766 YHG=1743>determination " XBD=1845 XHG=1797 YBD=1766 YHG=1743>the " XBD=1970 XHG=1867 YBD=1772 YHG=1745>patient " XBD=2043 XHG=1990 YBD=1766 YHG=1750>was " XBD=2193 XHG=2063 YBD=1771 YHG=1743>operated " XBD=2250 XHG=2215 YBD=1766 YHG=1750>on " XBD=2314 XHG=2270 YBD=1766 YHG=1743>for " XBD=2513 XHG=2334 YBD=1766 YHG=1745>extrauterine" XBD=1533 XHG=1375 YBD=1802 YHG=1780>pregnancy.

" XBD=1391 XHG=1338 YBD=1848 YHG=1821>Fig. " XBD=1539 XHG=1404 YBD=1843 YHG=1820>2-Blood " XBD=1733 XHG=1563 YBD=1842 YHG=1820>histaminase " XBD=1781 XHG=1756 YBD=1842 YHG=1821>in " XBD=1863 XHG=1801 YBD=1842 YHG=1819>four " XBD=1989 XHG=1883 YBD=1849 YHG=1819>heatthy women " XBD=2197 XHG=2126 YBD=1842 YHG=1819>from " XBD=2260 XHG=2211 YBD=1843 YHG=1820>7th " XBD=2307 XHG=2275 YBD=1843 YHG=1825>to " XBD=2385 XHG=2327 YBD=1843 YHG=1819>!3th " XBD=2474 XHG=2399 YBD=1843 YHG=1821>week " XBD=2514 XHG=2488 YBD=1842 YHG=1821>of" XBD=1534 XHG=1376 YBD=1880 YHG=1857>pregnancy.

" XBD=1405 XHG=1340 YBD=1939 YHG=1910>the " XBD=1551 XHG=1437 YBD=1939 YHG=1909>blood " XBD=1658 XHG=1582 YBD=1938 YHG=1909>and " XBD=1730 XHG=1690 YBD=1938 YHG=1909>to " XBD=1987 XHG=1762 YBD=1945 YHG=1909>investigate " XBD=2084 XHG=2019 YBD=1938 YHG=1909>the " XBD=2270 XHG=2117 YBD=1946 YHG=1918>enzyme " XBD=2343 XHG=2303 YBD=1938 YHG=1909>in " XBD=2511 XHG=2373 YBD=1938 YHG=1910>normal" XBD=1568 XHG=1340 YBD=1986 YHG=1958>pregnancy." XBD=1541 XHG=1388 YBD=2025 YHG=1988>Briefly, " XBD=1639 XHG=1573 YBD=2017 YHG=1988>the " XBD=1917 XHG=1673 YBD=2018 YHG=1988>histaminase " XBD=2109 XHG=1955 YBD=2017 YHG=1988>content " XBD=2167 XHG=2137 YBD=2017 YHG=1988>is " XBD=2434 XHG=2204 YBD=2017 YHG=1987>determined " XBD=2512 XHG=2463 YBD=2025 YHG=1988>by" XBD=1518 XHG=1340 YBD=2064 YHG=2027>repeated " XBD=1636 XHG=1541 YBD=2057 YHG=2028>tests " XBD=1698 XHG=1658 YBD=2057 YHG=2028>in " XBD=1867 XHG=1721 YBD=2064 YHG=2028>plasma " XBD=1930 XHG=1889 YBD=2057 YHG=2028>to " XBD=2076 XHG=1953 YBD=2057 YHG=2028>which " XBD=2163 XHG=2098 YBD=2057 YHG=2028>the " XBD=2311 XHG=2186 YBD=2056 YHG=2027>amine " XBD=2400 XHG=2333 YBD=2057 YHG=2027>has " XBD=2512 XHG=2423 YBD=2057 YHG=2028>been" XBD=1476 XHG=1340 YBD=2102 YHG=2066>added, " XBD=1569 XHG=1493 YBD=2096 YHG=2067>and " XBD=1707 XHG=1584 YBD=2097 YHG=2067>which " XBD=1755 XHG=1724 YBD=2097 YHG=2068>is " XBD=1978 XHG=1775 YBD=2096 YHG=2066>incubated " XBD=2034 XHG=1993 YBD=2096 YHG=2068>at 37° C. " XBD=2295 XHG=2218 YBD=2096 YHG=2067>The " XBD=2511 XHG=2318 YBD=2096 YHG=2067>histamine" XBD=1372 XHG=1341 YBD=2136 YHG=2106>is " XBD=1637 XHG=1404 YBD=2139 YHG=2106>determined " XBD=1719 XHG=1666 YBD=2143 YHG=2107>by " XBD=1966 XHG=1749 YBD=2142 YHG=2106>comparing " XBD=2060 XHG=1994 YBD=2135 YHG=2106>the " XBD=2201 XHG=2090 YBD=2136 YHG=2106>effect " XBD=2274 XHG=2231 YBD=2135 YHG=2106>of " XBD=2512 XHG=2300 YBD=2143 YHG=2106>chemically" XBD=1490 XHG=1341 YBD=2181 YHG=2145>treated " XBD=1661 XHG=1515 YBD=2183 YHG=2146>plasma " XBD=1779 XHG=1686 YBD=2176 YHG=2146>with " XBD=1870 XHG=1805 YBD=2175 YHG=2145>the " XBD=2007 XHG=1896 YBD=2175 YHG=2145>effect " XBD=2076 XHG=2033 YBD=2175 YHG=2145>of " XBD=2120 XHG=2097 YBD=2175 YHG=2155>a " XBD=2329 XHG=2147 YBD=2175 YHG=2144>standard " XBD=2512 XHG=2354 YBD=2175 YHG=2145>solution" XBD=1384 XHG=1341 YBD=2215 YHG=2185>of " XBD=1607 XHG=1404 YBD=2215 YHG=2186>histamine " XBD=1684 XHG=1634 YBD=2215 YHG=2194>on " XBD=1868 XHG=1708 YBD=2215 YHG=2185>isolated " XBD=2006 XHG=1893 YBD=2222 YHG=2185>strips " XBD=2075 XHG=2032 YBD=2214 YHG=2185>of " XBD=2162 XHG=2097 YBD=2215 YHG=2181>the " XBD=2386 XHG=2189 YBD=2222 YHG=2185>guineapig " XBD=2512 XHG=2410 YBD=2214 YHG=2184>small" XBD=1529 XHG=1340 YBD=2255 YHG=2224>intestine. " XBD=1659 XHG=1581 YBD=2254 YHG=2225>The " XBD=1841 XHG=1680 YBD=2261 YHG=2224>activity " XBD=1905 XHG=1862 YBD=2255 YHG=2225>of " XBD=1986 XHG=1921 YBD=2254 YHG=2225>the " XBD=2251 XHG=2006 YBD=2254 YHG=2225>histaminase " XBD=2302 XHG=2271 YBD=2255 YHG=2225>is " XBD=2512 XHG=2323 YBD=2261 YHG=2223>expressed" XBD=1392 XHG=1340 YBD=2302 YHG=2264>by " XBD=1478 XHG=1413 YBD=2294 YHG=2265>the " XBD=1660 XHG=1501 YBD=2294 YHG=2265>amount " XBD=1723 XHG=1680 YBD=2293 YHG=2264>of " XBD=1946 XHG=1742 YBD=2294 YHG=2264>histamine " XBD=2294 XHG=1969 YBD=2301 YHG=2263>dihydrochloride " XBD=2512 XHG=2320 YBD=2300 YHG=2262>destroyed" XBD=1392 XHG=1340 YBD=2340 YHG=2304>by " XBD=1430 XHG=1413 YBD=2333 YHG=2305>1 " XBD=1513 XHG=1449 YBD=2333 YHG=2305>ml. " XBD=1678 XHG=1533 YBD=2340 YHG=2304>plasma " XBD=1735 XHG=1696 YBD=2333 YHG=2304>in " XBD=1819 XHG=1749 YBD=2333 YHG=2313>one " XBD=1932 XHG=1836 YBD=2333 YHG=2304>hour " XBD=1988 XHG=1946 YBD=2334 YHG=2305>at " XBD=2082 XHG=2006 YBD=2338 YHG=2304>37°, " XBD=2163 XHG=2098 YBD=2333 YHG=2304>the " XBD=2301 XHG=2178 YBD=2332 YHG=2303>initial " XBD=2512 XHG=2318 YBD=2333 YHG=2303>histamine" XBD=1666 XHG=1341 YBD=2379 YHG=2342>dihydrochloride " XBD=1979 XHG=1696 YBD=2372 YHG=2343>concentration " XBD=2118 XHG=2006 YBD=2379 YHG=2342>being " XBD=2202 XHG=2148 YBD=2372 YHG=2343>1-0 " XBD=2272 XHG=2233 YBD=2372 YHG=2344>to 2-5 " XBD=2514 XHG=2387 YBD=2375 YHG=2342>micro-," XBD=1524 XHG=1341 YBD=2418 YHG=2391>grammes " XBD=1616 XHG=1550 YBD=2418 YHG=2391>per " XBD=1815 XHG=1640 YBD=2419 YHG=2382>ml..By " XBD=1981 XHG=1840 YBD=2418 YHG=2381>adding " XBD=2166 XHG=2006 YBD=2418 YHG=2382>varying " XBD=2364 XHG=2189 YBD=2411 YHG=2382>amounts " XBD=2432 XHG=2390 YBD=2410 YHG=2381>of " XBD=2512 XHG=2452 YBD=2411 YHG=2381>the" XBD=1496 XHG=1341 YBD=2457 YHG=2420>enzyme " XBD=1573 XHG=1532 YBD=2450 YHG=2422>to " XBD=1767 XHG=1610 YBD=2458 YHG=2421>plasma, " XBD=1857 XHG=1804 YBD=2457 YHG=2421>by " XBD=2036 XHG=1892 YBD=2457 YHG=2421>mixing " XBD=2225 XHG=2072 YBD=2457 YHG=2430>enzyme " XBD=2442 XHG=2262 YBD=2451 YHG=2420>solutions " XBD=2516 XHG=2476 YBD=2449 YHG=2419>of

different " XBD=1852 XHG=1538 YBD=2495 YHG=2460>concentrations, " XBD=1949 XHG=1872 YBD=2488 YHG=2459>and " XBD=2010 XHG=1971 YBD=2489 YHG=2460>in " XBD=2138 XHG=2030 YBD=2489 YHG=2460>other " XBD=2268 XHG=2152 YBD=2498 YHG=2469>ways, " XBD=2324 XHG=2290 YBD=2489 YHG=2460>it " XBD=2410 XHG=2342 YBD=2489 YHG=2459>has " XBD=2513 XHG=2425 YBD=2489 YHG=2459>been" XBD=1484 XHG=1341 YBD=2536 YHG=2498>proved " XBD=1615 XHG=1528 YBD=2528 YHG=2499>that " XBD=1735 XHG=1659 YBD=2529 YHG=2499>this " XBD=1856 XHG=1770 YBD=2529 YHG=2499>unit " XBD=1992 XHG=1891 YBD=2536 YHG=2499>gives " XBD=2052 XHG=2029 YBD=2528 YHG=2508>a " XBD=2313 XHG=2088 YBD=2536 YHG=2490>sufficiently " XBD=2513 XHG=2347 YBD=2528 YHG=2500>accurate" XBD=1516 XHG=1342 YBD=2568 YHG=2539>estimate Tof " XBD=1687 XHG=1621 YBD=2568 YHG=2539>the " XBD=2018 XHG=1719 YBD=2575 YHG=2538>histaminolytic " XBD=2176 XHG=2051 YBD=2575 YHG=2547>power " XBD=2253 XHG=2209 YBD=2568 YHG=2538>of " XBD=2345 XHG=2280 YBD=2568 YHG=2530>the " XBD=2513 XHG=2378 YBD=2568 YHG=2538>human" XBD=1487 XHG=1341 YBD=2614 YHG=2578>plasma " XBD=1619 XHG=1509 YBD=2612 YHG=2577>(from " XBD=1754 XHG=1635 YBD=2607 YHG=2577>about 0.005 " XBD=1939 XHG=1898 YBD=2607 YHG=2578>to " XBD=2076 XHG=1957 YBD=2607 YHG=2578>about " XBD=2137 XHG=2096 YBD=2606 YHG=2577>12 Mg/ml. " XBD=2376 XHG=2311 YBD=2614 YHG=2587>per " XBD=2512 XHG=2396 YBD=2611 YHG=2578>hour)." XBD=1684 XHG=1390 YBD=2652 YHG=2616>Investigations " XBD=1755 XHG=1712 YBD=2646 YHG=2616>of " XBD=1843 XHG=1779 YBD=2648 YHG=2617>the " XBD=2117 XHG=1871 YBD=2646 YHG=2616>histaminase " XBD=2301 XHG=2146 YBD=2646 YHG=2618>content " XBD=2371 XHG=2329 YBD=2645 YHG=2617>of " XBD=2513 XHG=2395 YBD=2650 YHG=2616>blood," XBD=1486 XHG=1343 YBD=2685 YHG=2655>carried " XBD=1576 XHG=1508 YBD=2685 YHG=2656>out " XBD=1652 XHG=1598 YBD=2691 YHG=2655>by " XBD=1749 XHG=1673 YBD=2684 YHG=2655>this " XBD=1940 XHG=1772 YBD=2691 YHG=2655>method, " XBD=2068 XHG=1964 YBD=2686 YHG=2656>show " XBD=2112 XHG=2089 YBD=2685 YHG=2665>a " XBD=2368 XHG=2136 YBD=2686 YHG=2655>destruction " XBD=2432 XHG=2391 YBD=2685 YHG=2656>of " XBD=2513 XHG=2450 YBD=2685 YHG=2655>less" XBD=1438 XHG=1341 YBD=2725 YHG=2695>than " XBD=1532 XHG=1451 YBD=2724 YHG=2694>0-02 /g/ml. " XBD=1758 XHG=1693 YBD=2731 YHG=2703>per " XBD=1956 XHG=1770 YBD=2725 YHG=2695>hour-as " XBD=1992 XHG=1969 YBD=2724 YHG=2704>a " XBD=2085 XHG=2006 YBD=2724 YHG=2695>rule " XBD=2169 XHG=2099 YBD=2724 YHG=2695>less " XBD=2278 XHG=2183 YBD=2724 YHG=2696>than " XBD=2368 XHG=2292 YBD=2724 YHG=2695>0-01 " XBD=2512 XHG=2389 YBD=2734 YHG=2695>pg/ml." XBD=1408 XHG=1342 YBD=2770 YHG=2742>per " XBD=1613 XHG=1428 YBD=2763 YHG=2734>hour-in " XBD=1692 XHG=1627 YBD=2763 YHG=2734>the " XBD=1796 XHG=1713 YBD=2763 YHG=2742>case " XBD=1860 XHG=1817 YBD=2763 YHG=2734>of " XBD=2157 XHG=1878 YBD=2771 YHG=2735>non-pregnant " XBD=2327 XHG=2170 YBD=2763 YHG=2743>women. " XBD=2515 XHG=2379 YBD=2770 YHG=2734>During" XBD=1569 XHG=1342 YBD=2810 YHG=2781>pregnancy, " XBD=1775 XHG=1592 YBD=2807 YHG=2773>however, " XBD=1821 XHG=1798 YBD=2801 YHG=2782>a " XBD=2098 XHG=1844 YBD=2802 YHG=2772>considerable " XBD=2284 XHG=2121 YBD=2802 YHG=2773>increase " XBD=2349 XHG=2308 YBD=2802 YHG=2773>of " XBD=2514 XHG=2365 YBD=2810 YHG=2780>enzyme" XBD=1505 XHG=1342 YBD=2848 YHG=2811>activity " XBD=1556 XHG=1525 YBD=2840 YHG=2812>is " XBD=1760 XHG=1578 YBD=2840 YHG=2810>observed " XBD=1878 XHG=1780 YBD=2840 YHG=2811>from " XBD=2018 XHG=1899 YBD=2841 YHG=2812>about " XBD=2104 XHG=2039 YBD=2842 YHG=2813>the " XBD=2193 XHG=2127 YBD=2841 YHG=2813>7th " XBD=2318 XHG=2214 YBD=2841 YHG=2812>week " XBD=2435 XHG=2338 YBD=2841 YHG=2812>after " XBD=2515 XHG=2454 YBD=2841 YHG=2813>the" XBD=1418 XHG=1343 YBD=2880 YHG=2851>last " XBD=1723 XHG=1435 YBD=2880 YHG=2851>menstruation. " XBD=1825 XHG=1774 YBD=2880 YHG=2851>As " XBD=1975 XHG=1845 YBD=2880 YHG=2851>shown " XBD=2032 XHG=1992 YBD=2880 YHG=2851>in " XBD=2110 XHG=2051 YBD=2888 YHG=2851>fig. " XBD=2164 XHG=2133 YBD=2889 YHG=2852>1, " XBD=2335 XHG=2182 YBD=2888 YHG=2860>enzyme " XBD=2515 XHG=2361 YBD=2887 YHG=2851>activity" XBD=1526 XHG=1343 YBD=2919 YHG=2890>increases " XBD=1644 XHG=1552 YBD=2926 YHG=2898>very " XBD=1841 XHG=1668 YBD=2926 YHG=2889>rapidly ; " XBD=2034 XHG=1881 YBD=2927 YHG=2889>already " XBD=2158 XHG=2059 YBD=2920 YHG=2886>after " XBD=2253 XHG=2184 YBD=2919 YHG=2899>one " XBD=2411 XHG=2277 YBD=2920 YHG=2891>month it " XBD=2515 XHG=2483 YBD=2919 YHG=2885>is" XBD=1463 XHG=1344 YBD=2958 YHG=2929>about " XBD=1552 XHG=1487 YBD=2957 YHG=2929>100 " XBD=1685 XHG=1574 YBD=2957 YHG=2928>times " XBD=1862 XHG=1707 YBD=2965 YHG=2930>greater. " XBD=1992 XHG=1915 YBD=2958 YHG=2930>The " XBD=2177 XHG=2014 YBD=2958 YHG=2929>increase " XBD=2228 XHG=2198 YBD=2958 YHG=2930>is " XBD=2290 XHG=2250 YBD=2958 YHG=2939>so " XBD=2415 XHG=2313 YBD=2966 YHG=2930>great " XBD=2515 XHG=2435 YBD=2959 YHG=2929>that" XBD=1480 XHG=1345 YBD=3003 YHG=2967>during " XBD=1588 XHG=1512 YBD=2996 YHG=2967>this " XBD=1750 XHG=1620 YBD=3003 YHG=2966>period " XBD=1813 XHG=1782 YBD=2997 YHG=2967>it " XBD=1876 XHG=1845 YBD=2997 YHG=2968>is " XBD=2079 XHG=1918 YBD=3004 YHG=2968>possible " XBD=2152 XHG=2112 YBD=2997 YHG=2969>to " XBD=2440 XHG=2187 YBD=2997 YHG=2968>demonstrate " XBD=2516 XHG=2469 YBD=2997 YHG=2963>an" XBD=1509 XHG=1344 YBD=3035 YHG=3007>increase " XBD=1624 XHG=1526 YBD=3034 YHG=3006>from " XBD=1712 XHG=1635 YBD=3035 YHG=3015>-one " XBD=1806 XHG=1731 YBD=3042 YHG=3007>day " XBD=1864 XHG=1823 YBD=3036 YHG=3007>to " XBD=2052 XHG=1882 YBD=3036 YHG=3007>another. " XBD=2183 XHG=2103 YBD=3043 YHG=3006>Fig. " XBD=2223 XHG=2203 YBD=3035 YHG=3007>2 " XBD=2362 XHG=2244 YBD=3036 YHG=3007>shows " XBD=2464 XHG=2381 YBD=3036 YHG=3008>that " XBD=2515 XHG=2480 YBD=3035 YHG=3007>in" XBD=1519 XHG=1345 YBD=3074 YHG=3044>different " XBD=1693 XHG=1548 YBD=3073 YHG=3053>women " XBD=1786 XHG=1722 YBD=3074 YHG=3045>the " XBD=1979 XHG=1816 YBD=3074 YHG=3045>increase " XBD=2038 XHG=2008 YBD=3075 YHG=3046>is " XBD=2314 XHG=2068 YBD=3082 YHG=3046>remarkably. " XBD=2513 XHG=2336 YBD=3075 YHG=3047>constant." XBD=1491 XHG=1346 YBD=3120 YHG=3083>During " XBD=1577 XHG=1512 YBD=3112 YHG=3083>the " XBD=1695 XHG=1599 YBD=3112 YHG=3083>later " XBD=1805 XHG=1716 YBD=3121 YHG=3085>part " XBD=1861 XHG=1819 YBD=3113 YHG=3084>of " XBD=2093 XHG=1879 YBD=3120 YHG=3093>pregnancy " XBD=2172 XHG=2107 YBD=3113 YHG=3084>the " XBD=2516 XHG=2196 YBD=3120 YHG=3085>enzyme activity" XBD=1489 XHG=1345 YBD=3152 YHG=3122>attains " XBD=1622 XHG=1502 YBD=3152 YHG=3122>about " XBD=1828 XHG=1644 YBD=3152 YHG=3123>500-1000 " XBD=1962 XHG=1852 YBD=3152 YHG=3123>times " XBD=2041 XHG=1977 YBD=3152 YHG=3123>the " XBD=2220 XHG=2063 YBD=3158 YHG=3124>normal, " XBD=2393 XHG=2236 YBD=3159 YHG=3124>varying " XBD=2514 XHG=2406 YBD=3153 YHG=3132>some-" XBD=1450 XHG=1348 YBD=3191 YHG=3162>what " XBD=1569 XHG=1469 YBD=3190 YHG=3161>from " XBD=1659 XHG=1590 YBD=3190 YHG=3171>one " XBD=1829 XHG=1680 YBD=3191 YHG=3170>woman " XBD=1890 XHG=1849 YBD=3191 YHG=3162>to " XBD=2082 XHG=1910 YBD=3191 YHG=3162>another." XBD=1441 XHG=1396 YBD=3230 YHG=3201>In " XBD=1611 XHG=1468 YBD=3229 YHG=3200>certain " XBD=1889 XHG=1636 YBD=3237 YHG=3200>pathological " XBD=2127 XHG=1915 YBD=3229 YHG=3200>conditions " XBD=2287 XHG=2154 YBD=3236 YHG=3200>during " XBD=2516 XHG=2313 YBD=3236 YHG=3207>pregnancy" XBD=1412 XHG=1346 YBD=3268 YHG=3240>the " XBD=1587 XHG=1433 YBD=3274 YHG=3247>enzyme " XBD=1771 XHG=1607 YBD=3269 YHG=3239>behaves " XBD=2160 XHG=1792 YBD=3274 YHG=3239>characteristically. " XBD=2333 XHG=2212 YBD=3268 YHG=3239>When " XBD=2517 XHG=2351 YBD=3268 YHG=3239>abortion" XBD=1378 XHG=1347 YBD=3307 YHG=3278>is " XBD=1596 XHG=1398 YBD=3307 YHG=3278>imminent " XBD=1681 XHG=1616 YBD=3308 YHG=3279>the " XBD=1865 XHG=1700 YBD=3307 YHG=3278>increase " XBD=1923 XHG=1885 YBD=3306 YHG=3277>in " XBD=2008 XHG=1944 YBD=3306 YHG=3278>the " XBD=2326 XHG=2027 YBD=3313 YHG=3278>histaminolytic " XBD=2464 XHG=2345 YBD=3314 YHG=3287>power " XBD=2521 XHG=2483 YBD=3307 YHG=3277>of" XBD=1413 XHG=1348 YBD=3346 YHG=3317>the " XBD=1544 XHG=1431 YBD=3347 YHG=3316>blood " XBD=1592 XHG=1562 YBD=3346 YHG=3317>is " XBD=1680 XHG=1610 YBD=3347 YHG=3317>less " XBD=1818 XHG=1698 YBD=3352 YHG=3316>rapid, " XBD=1912 XHG=1836 YBD=3345 YHG=3316>and " XBD=1996 XHG=1932 YBD=3345 YHG=3317>the " XBD=2145 XHG=2015 YBD=3352 YHG=3316>degree " XBD=2206 XHG=2164 YBD=3345 YHG=3317>of " XBD=2419 XHG=2220 YBD=3346 YHG=3316>inhibition " XBD=2516 XHG=2435 YBD=3352 YHG=3324>may" XBD=1394 XHG=1348 YBD=3384 YHG=3356>be " XBD=1470 XHG=1420 YBD=3385 YHG=3365>an " XBD=1560 XHG=1496 YBD=3385 YHG=3356>aid " XBD=1626 XHG=1585 YBD=3385 YHG=3357>to " XBD=1858 XHG=1652 YBD=3392 YHG=3355>prognosis. " XBD=1987 XHG=1910 YBD=3383 YHG=3355>The " XBD=2143 XHG=2014 YBD=3384 YHG=3355>slower " XBD=2233 XHG=2169 YBD=3384 YHG=3355>the " XBD=2432 XHG=2260 YBD=3390 YHG=3356>increase, " XBD=2516 XHG=2457 YBD=3384 YHG=3356>the" XBD=1495 XHG=1349 YBD=3431 YHG=3396>greater " XBD=1547 XHG=1516 YBD=3423 YHG=3395>is " XBD=1635 XHG=1571 YBD=3423 YHG=3395>the " XBD=1888 XHG=1657 YBD=3430 YHG=3393>probability " XBD=1956 XHG=1912 YBD=3422 YHG=3393>of " XBD=2174 XHG=1973 YBD=3427 YHG=3393>abortion ; " XBD=2282 XHG=2212 YBD=3423 YHG=3393>but " XBD=2328 XHG=2305 YBD=3422 YHG=3403>a " XBD=2418 XHG=2348 YBD=3422 YHG=3394>rise " XBD=2515 XHG=2440 YBD=3422 YHG=3402>con-" XBD=1497 XHG=1348 YBD=3470 YHG=3433>tinuing " XBD=1652 XHG=1517 YBD=3469 YHG=3433>during " XBD=1693 XHG=1670 YBD=3461 YHG=3442>a " XBD=1858 XHG=1713 YBD=3466 YHG=3432>uterine |>" XBD=2130 XHG=1877 YBD=3467 YHG=3432>haemorrhage " XBD=2181 XHG=2150 YBD=3461 YHG=3431>is " XBD=2428 XHG=2200 YBD=3461 YHG=3432>favourable. In

407

" XBD=227 XHG=157 YBD=219 YHG=183>ng. " XBD=259 XHG=244 YBD=212 YHG=184>1 " XBD=350 XHG=276 YBD=212 YHG=184>two " XBD=508 XHG=365 YBD=219 YHG=182>typical " XBD=620 XHG=519 YBD=214 YHG=191>cases " XBD=695 XHG=632 YBD=211 YHG=191>are " XBD=897 XHG=709 YBD=211 YHG=182>recorded. " XBD=1041 XHG=932 YBD=212 YHG=182>With " XBD=1171 XHG=1057 YBD=218 YHG=183>slight " XBD=1341 XHG=1183 YBD=212 YHG=183>albumi-" XBD=274 XHG=170 YBD=253 YHG=222>nuria " XBD=365 XHG=294 YBD=250 YHG=221>due " XBD=425 XHG=385 YBD=250 YHG=223>to " XBD=658 XHG=445 YBD=257 YHG=229>pregnancy " XBD=857 XHG=680 YBD=250 YHG=221>toxsemia " XBD=981 XHG=876 YBD=250 YHG=222>there " XBD=1031 XHG=999 YBD=250 YHG=221>is " XBD=1101 XHG=1051 YBD=249 YHG=230>an " XBD=1284 XHG=1120 YBD=252 YHG=222>increase " XBD=1347 XHG=1304 YBD=250 YHG=222>of" XBD=420 XHG=169 YBD=293 YHG=260>histaminase, " XBD=519 XHG=444 YBD=288 YHG=259>and " XBD=582 XHG=542 YBD=289 YHG=260>in " XBD=837 XHG=603 YBD=294 YHG=260>hydatiform " XBD=957 XHG=859 YBD=288 YHG=259>mole " XBD=1084 XHG=979 YBD=288 YHG=259>there " XBD=1170 XHG=1107 YBD=287 YHG=268>are " XBD=1341 XHG=1192 YBD=288 YHG=261>charac-" XBD=308 XHG=169 YBD=329 YHG=299>teristic " XBD=464 XHG=324 YBD=326 YHG=298>values. " XBD=593 XHG=516 YBD=326 YHG=297>The " XBD=759 XHG=610 YBD=333 YHG=297>highest " XBD=928 XHG=773 YBD=333 YHG=297>reading " XBD=963 XHG=945 YBD=325 YHG=297>I " XBD=1077 XHG=980 YBD=325 YHG=297>have " XBD=1161 XHG=1093 YBD=332 YHG=299>yet " XBD=1344 XHG=1176 YBD=326 YHG=297>found-" XBD=332 XHG=169 YBD=373 YHG=336>showing " XBD=368 XHG=346 YBD=365 YHG=346>a " XBD=617 XHG=384 YBD=365 YHG=336>destruction " XBD=675 XHG=632 YBD=364 YHG=336>of " XBD=792 XHG=689 YBD=365 YHG=345>more " XBD=902 XHG=807 YBD=364 YHG=336>than " XBD=961 XHG=919 YBD=363 YHG=335>15 " XBD=1105 XHG=979 YBD=373 YHG=335>p,gfml. " XBD=1188 XHG=1122 YBD=372 YHG=344>per " XBD=1345 XHG=1201 YBD=365 YHG=336>hour-" XBD=243 XHG=170 YBD=406 YHG=385>was " XBD=301 XHG=262 YBD=404 YHG=376>in " XBD=342 XHG=319 YBD=404 YHG=384>a " XBD=446 XHG=364 YBD=404 YHG=384>case " XBD=509 XHG=466 YBD=403 YHG=374>of " XBD=737 XHG=524 YBD=410 YHG=375>premature " XBD=984 XHG=757 YBD=411 YHG=374>parturition " XBD=1046 XHG=1004 YBD=403 YHG=374>at " XBD=1130 XHG=1065 YBD=403 YHG=374>the " XBD=1346 XHG=1145 YBD=410 YHG=373>beginning" XBD=213 XHG=170 YBD=444 YHG=408>of " XBD=289 XHG=224 YBD=444 YHG=415>the " XBD=375 XHG=308 YBD=443 YHG=414>8th " XBD=537 XHG=392 YBD=442 YHG=413>month." XBD=266 XHG=216 YBD=482 YHG=454>As " XBD=441 XHG=312 YBD=481 YHG=453>shown " XBD=533 XHG=480 YBD=487 YHG=451>by " XBD=704 XHG=573 YBD=480 YHG=452>earlier " XBD=1051 XHG=750 YBD=487 YHG=451>investigations, " XBD=1157 XHG=1091 YBD=480 YHG=451>the " XBD=1347 XHG=1202 YBD=495 YHG=451>human" XBD=340 XHG=170 YBD=528 YHG=492>placenta " XBD=526 XHG=355 YBD=519 YHG=490>contains " XBD=564 XHG=542 YBD=519 YHG=499>a " XBD=835 XHG=580 YBD=519 YHG=489>considerable " XBD=1010 XHG=851 YBD=518 YHG=490>amount " XBD=1068 XHG=1025 YBD=517 YHG=489>of " XBD=1345 XHG=1085 YBD=518 YHG=484>histaminase." XBD=335 XHG=171 YBD=560 YHG=530>Animals " XBD=441 XHG=348 YBD=558 YHG=529>with " XBD=477 XHG=453 YBD=558 YHG=538>a " XBD=580 XHG=490 YBD=565 YHG=528>high " XBD=890 XHG=593 YBD=564 YHG=528>histaminolytic " XBD=1028 XHG=904 YBD=564 YHG=537>power " XBD=1081 XHG=1041 YBD=556 YHG=528>in " XBD=1159 XHG=1094 YBD=557 YHG=528>the " XBD=1348 XHG=1173 YBD=565 YHG=528>placenta" XBD=400 XHG=175 YBD=605 YHG=567>(guineapigs " XBD=496 XHG=420 YBD=597 YHG=568>and " XBD=609 XHG=515 YBD=602 YHG=568>rats) " XBD=738 XHG=625 YBD=602 YHG=568>show, " XBD=829 XHG=756 YBD=596 YHG=567>like " XBD=946 XHG=844 YBD=602 YHG=576>man, " XBD=1013 XHG=963 YBD=596 YHG=576>an " XBD=1222 XHG=1031 YBD=596 YHG=566>increased " XBD=1347 XHG=1233 YBD=596 YHG=567>blood" XBD=409 XHG=170 YBD=637 YHG=607>histaminase " XBD=561 XHG=427 YBD=643 YHG=606>during " XBD=803 XHG=576 YBD=643 YHG=615>pregnancy, " XBD=983 XHG=819 YBD=636 YHG=606>whereas " XBD=1080 XHG=1000 YBD=635 YHG=608>cats " XBD=1174 XHG=1097 YBD=635 YHG=605>and " XBD=1347 XHG=1189 YBD=640 YHG=605>rabbits," XBD=408 XHG=170 YBD=682 YHG=646>having low " XBD=626 XHG=438 YBD=681 YHG=645>placental " XBD=924 XHG=666 YBD=679 YHG=645>histaminase, " XBD=1005 XHG=958 YBD=673 YHG=644>do " XBD=1125 XHG=1045 YBD=674 YHG=645>not. " XBD=1345 XHG=1190 YBD=680 YHG=644>Experi-" XBD=290 XHG=170 YBD=714 YHG=685>ments " XBD=409 XHG=316 YBD=713 YHG=684>with " XBD=514 XHG=435 YBD=713 YHG=685>rats " XBD=620 XHG=542 YBD=713 YHG=683>also " XBD=751 XHG=648 YBD=713 YHG=684>show " XBD=801 XHG=778 YBD=712 YHG=693>a " XBD=1053 XHG=829 YBD=713 YHG=683>correlation " XBD=1251 XHG=1079 YBD=713 YHG=683>between " XBD=1343 XHG=1277 YBD=712 YHG=683>the" XBD=411 XHG=170 YBD=753 YHG=723>histaminase " XBD=483 XHG=443 YBD=751 YHG=723>in " XBD=580 XHG=515 YBD=752 YHG=723>the " XBD=788 XHG=613 YBD=758 YHG=722>placenta " XBD=897 XHG=820 YBD=752 YHG=722>and " XBD=970 XHG=929 YBD=751 YHG=723>in " XBD=1067 XHG=1002 YBD=751 YHG=722>the " XBD=1225 XHG=1100 YBD=751 YHG=722>blood. " XBD=1344 XHG=1277 YBD=752 YHG=722>We" XBD=279 XHG=172 YBD=791 YHG=762>know " XBD=379 XHG=292 YBD=791 YHG=762>that " XBD=432 XHG=393 YBD=790 YHG=762>in " XBD=589 XHG=447 YBD=791 YHG=762>certain " XBD=761 XHG=603 YBD=790 YHG=761>animals " XBD=977 XHG=775 YBD=791 YHG=761>histamine " XBD=1060 XHG=991 YBD=790 YHG=762>has " XBD=1097 XHG=1074 YBD=789 YHG=769>a " XBD=1348 XHG=1112 YBD=797 YHG=761>contracting" XBD=280 XHG=173 YBD=829 YHG=800>effect " XBD=339 XHG=292 YBD=829 YHG=809>on " XBD=423 XHG=358 YBD=830 YHG=801>the " XBD=566 XHG=436 YBD=829 YHG=801>uterus " XBD=671 XHG=588 YBD=835 YHG=800>(less " XBD=926 XHG=685 YBD=836 YHG=800>pronounced " XBD=1082 XHG=948 YBD=836 YHG=800>during " XBD=1346 XHG=1103 YBD=836 YHG=800>pregnancy)," XBD=245 XHG=172 YBD=874 YHG=838>and " XBD=355 XHG=266 YBD=868 YHG=839>thus " XBD=440 XHG=376 YBD=868 YHG=839>the " XBD=583 XHG=462 YBD=868 YHG=838>above " XBD=858 XHG=598 YBD=869 YHG=839>observations " XBD=994 XHG=874 YBD=869 YHG=840>throw " XBD=1237 XHG=1015 YBD=876 YHG=839>interesting " XBD=1347 XHG=1251 YBD=875 YHG=839>light" XBD=221 XHG=173 YBD=908 YHG=887>on " XBD=305 XHG=241 YBD=907 YHG=878>the " XBD=551 XHG=330 YBD=915 YHG=877>physiology " XBD=615 XHG=572 YBD=907 YHG=878>of " XBD=704 XHG=638 YBD=907 YHG=878>the " XBD=911 XHG=725 YBD=915 YHG=878>placenta. " XBD=1065 XHG=963 YBD=914 YHG=878>They " XBD=1166 XHG=1077 YBD=908 YHG=877>-also " XBD=1295 XHG=1184 YBD=907 YHG=878>make " XBD=1348 XHG=1316 YBD=907 YHG=878>it" XBD=267 XHG=173 YBD=946 YHG=917>clear " XBD=368 XHG=282 YBD=946 YHG=917>that " XBD=501 XHG=388 YBD=946 YHG=916>blood " XBD=760 XHG=515 YBD=947 YHG=917>histaminase " XBD=811 XHG=779 YBD=947 YHG=918>is " XBD=882 XHG=831 YBD=947 YHG=926>an " XBD=1081 XHG=895 YBD=946 YHG=917>indicator " XBD=1145 XHG=1101 YBD=946 YHG=917>of " XBD=1350 XHG=1160 YBD=953 YHG=917>placental" XBD=423 XHG=172 YBD=985 YHG=955>histaminase. " XBD=553 XHG=475 YBD=985 YHG=956>The " XBD=801 XHG=578 YBD=985 YHG=956>correlation " XBD=994 XHG=824 YBD=986 YHG=956>between " XBD=1207 XHG=1018 YBD=992 YHG=956>placental " XBD=1348 XHG=1230 YBD=986 YHG=956>hista-" XBD=310 XHG=172 YBD=1029 YHG=995>minase " XBD=397 XHG=322 YBD=1024 YHG=994>and " XBD=581 XHG=410 YBD=1031 YHG=995>strength " XBD=787 XHG=593 YBD=1030 YHG=995>of labour, " XBD=1083 XHG=801 YBD=1024 YHG=994>demonstrated " XBD=1148 XHG=1095 YBD=1032 YHG=995>by " XBD=1349 XHG=1160 YBD=1024 YHG=995>Danforth" XBD=308 XHG=177 YBD=1069 YHG=1028>(1939), " XBD=439 XHG=328 YBD=1063 YHG=1033>could " XBD=550 XHG=460 YBD=1064 YHG=1030>thus " XBD=624 XHG=579 YBD=1063 YHG=1033>be " XBD=853 XHG=649 YBD=1066 YHG=1034>confirmed " XBD=928 XHG=875 YBD=1071 YHG=1034>by " XBD=1016 XHG=950 YBD=1064 YHG=1035>the " XBD=1153 XHG=1036 YBD=1071 YHG=1033>study " XBD=1218 XHG=1175 YBD=1064 YHG=1035>of " XBD=1349 XHG=1236 YBD=1064 YHG=1034>blood" XBD=423 XHG=173 YBD=1105 YHG=1072>histaminase. " XBD=522 XHG=476 YBD=1102 YHG=1074>In " XBD=623 XHG=547 YBD=1102 YHG=1071>this " XBD=732 XHG=647 YBD=1110 YHG=1082>way " XBD=825 XHG=758 YBD=1103 YHG=1082>our " XBD=1066 XHG=850 YBD=1110 YHG=1073>knowledge " XBD=1126 XHG=1084 YBD=1103 YHG=1074>of " XBD=1214 XHG=1148 YBD=1103 YHG=1074>the " XBD=1349 XHG=1238 YBD=1103 YHG=1073>effect" XBD=216 XHG=174 YBD=1141 YHG=1111>of " XBD=379 XHG=222 YBD=1149 YHG=1111>changes " XBD=429 XHG=389 YBD=1141 YHG=1112>in " XBD=900 XHG=439 YBD=1143 YHG=1112>histamine-histaminase " XBD=1149 XHG=911 YBD=1143 YHG=1113>metabolism " XBD=1208 XHG=1158 YBD=1143 YHG=1122>on " XBD=1351 XHG=1218 YBD=1148 YHG=1113>labpur" XBD=292 XHG=173 YBD=1188 YHG=1150>might " XBD=352 XHG=305 YBD=1180 YHG=1151>be " XBD=545 XHG=365 YBD=1181 YHG=1152>widened.

REFERENCES

Best, C. H. and McHenry, E. W. (1930) J. Physiol. 70, 349.Danforth, D. N. (1939) Proc. Soc. exp. Biol., N.Y. 40, 319.Marcou, I. and Athanasiu-Vergu, E. (1937) Bull. Acad. Med. Roum.

3, 319.Neumann and Ebbinge (1942) Ned. Tijdschr. Verlosk. 45, 3.Werle, E. and Effkemann, G. (1940) Arch. Gyn&auml;k. 170, 82.Zeller, E. A., Birkh&auml;user, H. (1940) Schweiz. med. Wschr. 70, 975.

ACUTE DIFFUSE PERITONITISTREATED WITH SULPHATHIAZOLE SUSPENSION

JUDSON T. CHESTERMAN, MRCP, FRCS, FACSRESIDENT SURGEON CITY GENERAL HOSPITAL, SHEFFIELD

" XBD=255 XHG=222 YBD=1740 YHG=1711>A " XBD=405 XHG=270 YBD=1740 YHG=1718>SERIES " XBD=463 XHG=420 YBD=1740 YHG=1710>of " XBD=542 XHG=474 YBD=1739 YHG=1710>789 " XBD=796 XHG=559 YBD=1740 YHG=1710>consecutive " XBD=913 XHG=811 YBD=1740 YHG=1719>cases " XBD=971 XHG=928 YBD=1740 YHG=1711>of " XBD=1091 XHG=981 YBD=1740 YHG=1711>acute " XBD=1355 XHG=1105 YBD=1747 YHG=1710>appendicitis" XBD=322 XHG=176 YBD=1780 YHG=1750>treated " XBD=391 XHG=338 YBD=1786 YHG=1750>by " XBD=468 XHG=408 YBD=1779 YHG=1759>me " XBD=659 XHG=485 YBD=1779 YHG=1749>included " XBD=722 XHG=678 YBD=1779 YHG=1749>95 " XBD=834 XHG=740 YBD=1779 YHG=1750>with " XBD=960 XHG=850 YBD=1779 YHG=1750>acute " XBD=1112 XHG=979 YBD=1779 YHG=1749>diffuse " XBD=1354 XHG=1129 YBD=1787 YHG=1749>peritonitis." XBD=224 XHG=179 YBD=1819 YHG=1790>In " XBD=295 XHG=245 YBD=1819 YHG=1790>all " XBD=360 XHG=316 YBD=1819 YHG=1790>of " XBD=483 XHG=377 YBD=1819 YHG=1789>these " XBD=571 XHG=505 YBD=1819 YHG=1789>the " XBD=743 XHG=595 YBD=1826 YHG=1789>general " XBD=973 XHG=764 YBD=1819 YHG=1789>treatment " XBD=1070 XHG=994 YBD=1819 YHG=1798>was " XBD=1160 XHG=1094 YBD=1818 YHG=1789>the " XBD=1309 XHG=1182 YBD=1819 YHG=1798>same :" XBD=410 XHG=223 YBD=1876 YHG=1839>Operation " XBD=503 XHG=432 YBD=1867 YHG=1847>was " XBD=726 XHG=526 YBD=1866 YHG=1839>immediate " XBD=874 XHG=750 YBD=1875 YHG=1841>except " XBD=934 XHG=897 YBD=1866 YHG=1839>in " XBD=1051 XHG=958 YBD=1867 YHG=1847>cases " XBD=1229 XHG=1075 YBD=1874 YHG=1838>showing " XBD=1356 XHG=1251 YBD=1867 YHG=1839>much" XBD=418 XHG=179 YBD=1915 YHG=1879>dehydration, " XBD=548 XHG=447 YBD=1906 YHG=1878>when " XBD=639 XHG=575 YBD=1906 YHG=1881>not " XBD=763 XHG=668 YBD=1905 YHG=1887>more " XBD=880 XHG=793 YBD=1911 YHG=1878>than " XBD=978 XHG=908 YBD=1906 YHG=1881>two " XBD=1123 XHG=1007 YBD=1906 YHG=1877>hours’ " XBD=1257 XHG=1154 YBD=1913 YHG=1878>delay " XBD=1356 XHG=1285 YBD=1906 YHG=1887>was" XBD=329 XHG=177 YBD=1945 YHG=1918>allowed. " XBD=510 XHG=376 YBD=1946 YHG=1918>Gastric " XBD=716 XHG=541 YBD=1945 YHG=1917>retention " XBD=817 XHG=746 YBD=1945 YHG=1926>was " XBD=987 XHG=848 YBD=1944 YHG=1917>treated " XBD=1066 XHG=1018 YBD=1953 YHG=1917>by " XBD=1242 XHG=1097 YBD=1952 YHG=1917>lavage ; " XBD=1357 XHG=1288 YBD=1945 YHG=1918>and" XBD=312 XHG=179 YBD=1985 YHG=1957>suction " XBD=477 XHG=325 YBD=1992 YHG=1956>through " XBD=536 XHG=491 YBD=1984 YHG=1965>an " XBD=696 XHG=550 YBD=1992 YHG=1957>in-lying " XBD=883 XHG=710 YBD=1984 YHG=1956>duodenal " XBD=981 XHG=896 YBD=1983 YHG=1956>tube " XBD=1065 XHG=994 YBD=1984 YHG=1965>was " XBD=1268 XHG=1080 YBD=1984 YHG=1956>continued " XBD=1359 XHG=1280 YBD=1984 YHG=1957>well" XBD=250 XHG=178 YBD=2023 YHG=1997>into " XBD=339 XHG=278 YBD=2023 YHG=1996>the " XBD=626 XHG=367 YBD=2032 YHG=1995>postoperative " XBD=775 XHG=655 YBD=2031 YHG=1995>period " XBD=834 XHG=804 YBD=2022 YHG=1995>if " XBD=1032 XHG=859 YBD=2031 YHG=1995>vomiting " XBD=1240 XHG=1058 YBD=2031 YHG=1995>persisted. " XBD=1359 XHG=1286 YBD=2023 YHG=1996>The" XBD=312 XHG=178 YBD=2063 YHG=2035>routine " XBD=537 XHG=333 YBD=2063 YHG=2036>anaesthetic " XBD=627 XHG=557 YBD=2073 YHG=2044>was " XBD=739 XHG=649 YBD=2070 YHG=2044>open " XBD=869 XHG=759 YBD=2067 YHG=2034>ether, " XBD=1027 XHG=891 YBD=2070 YHG=2034>though " XBD=1135 XHG=1047 YBD=2062 YHG=2034>local " XBD=1226 XHG=1156 YBD=2062 YHG=2034>and " XBD=1359 XHG=1247 YBD=2070 YHG=2034>spinal" XBD=382 XHG=179 YBD=2102 YHG=2074>anaesthesia " XBD=502 XHG=414 YBD=2102 YHG=2084>were " XBD=765 XHG=536 YBD=2109 YHG=2068>occasionally " XBD=991 XHG=799 YBD=2110 YHG=2073>employed. " XBD=1358 XHG=1037 YBD=2110 YHG=2073>Appendicectomy" XBD=247 XHG=179 YBD=2142 YHG=2123>was " XBD=458 XHG=262 YBD=2150 YHG=2113>performed " XBD=510 XHG=474 YBD=2140 YHG=2113>in " XBD=573 XHG=527 YBD=2141 YHG=2104>all " XBD=747 XHG=588 YBD=2153 YHG=2112>patients " XBD=884 XHG=761 YBD=2149 YHG=2115>except " XBD=966 XHG=902 YBD=2140 YHG=2121>one " XBD=1065 XHG=982 YBD=2140 YHG=2121>man " XBD=1121 XHG=1082 YBD=2140 YHG=2113>of " XBD=1177 XHG=1136 YBD=2140 YHG=2113>68 " XBD=1270 XHG=1193 YBD=2140 YHG=2112>who " XBD=1357 XHG=1287 YBD=2140 YHG=2121>was" XBD=314 XHG=178 YBD=2181 YHG=2153>treated " XBD=382 XHG=334 YBD=2190 YHG=2153>by " XBD=565 XHG=403 YBD=2188 YHG=2153>drainage " XBD=680 XHG=587 YBD=2188 YHG=2152>only, " XBD=789 XHG=702 YBD=2180 YHG=2145>with " XBD=975 XHG=810 YBD=2180 YHG=2152>eventual " XBD=1169 XHG=994 YBD=2187 YHG=2160>recovery. " XBD=1288 XHG=1215 YBD=2180 YHG=2152>The " XBD=1358 XHG=1309 YBD=2180 YHG=2153>in-" XBD=284 XHG=180 YBD=2220 YHG=2193>cision " XBD=368 XHG=298 YBD=2220 YHG=2201>was " XBD=421 XHG=383 YBD=2220 YHG=2195>as " XBD=556 XHG=435 YBD=2228 YHG=2193>nearly " XBD=609 XHG=570 YBD=2220 YHG=2201>as " XBD=833 XHG=622 YBD=2228 YHG=2191>practicable " XBD=931 XHG=849 YBD=2219 YHG=2201>over " XBD=1006 XHG=945 YBD=2219 YHG=2191>the " XBD=1101 XHG=1022 YBD=2219 YHG=2200>area " XBD=1156 XHG=1117 YBD=2219 YHG=2191>of " XBD=1359 XHG=1167 YBD=2219 YHG=2191>maximum" XBD=387 XHG=179 YBD=2260 YHG=2232>tenderness. " XBD=616 XHG=444 YBD=2267 YHG=2232>Drainage " XBD=701 XHG=632 YBD=2259 YHG=2240>was " XBD=805 XHG=718 YBD=2259 YHG=2231>used " XBD=851 XHG=821 YBD=2258 YHG=2231>if " XBD=1078 XHG=864 YBD=2259 YHG=2230>hsemostasis " XBD=1165 XHG=1095 YBD=2258 YHG=2240>was " XBD=1358 XHG=1182 YBD=2264 YHG=2231>doubtful," XBD=208 XHG=179 YBD=2298 YHG=2270>if " XBD=328 XHG=232 YBD=2298 YHG=2271>there " XBD=426 XHG=357 YBD=2298 YHG=2280>was " XBD=508 XHG=447 YBD=2297 YHG=2270>the " XBD=726 XHG=529 YBD=2306 YHG=2270>possibility " XBD=787 XHG=748 YBD=2297 YHG=2270>of " XBD=826 XHG=805 YBD=2297 YHG=2278>a " XBD=1000 XHG=847 YBD=2298 YHG=2270>fseoolith " XBD=1060 XHG=1021 YBD=2297 YHG=2279>or " XBD=1231 XHG=1079 YBD=2297 YHG=2270>necrotic " XBD=1360 XHG=1252 YBD=2297 YHG=2270>tissue" XBD=280 XHG=180 YBD=2345 YHG=2309>being " XBD=365 XHG=301 YBD=2337 YHG=2310>left " XBD=526 XHG=386 YBD=2343 YHG=2309>behind, " XBD=587 XHG=550 YBD=2336 YHG=2318>or " XBD=639 XHG=610 YBD=2336 YHG=2309>if " XBD=719 XHG=658 YBD=2337 YHG=2309>the " XBD=851 XHG=741 YBD=2338 YHG=2309>bowel " XBD=952 XHG=872 YBD=2336 YHG=2309>wall " XBD=1111 XHG=973 YBD=2337 YHG=2308>showed " XBD=1230 XHG=1133 YBD=2337 YHG=2318>areas " XBD=1291 XHG=1252 YBD=2336 YHG=2309>of " XBD=1360 XHG=1310 YBD=2336 YHG=2309>in-" XBD=394 XHG=180 YBD=2376 YHG=2348>flammation " XBD=522 XHG=409 YBD=2376 YHG=2348>which " XBD=650 XHG=537 YBD=2384 YHG=2348>might " XBD=744 XHG=666 YBD=2376 YHG=2348>lead " XBD=798 XHG=760 YBD=2375 YHG=2351>to " XBD=933 XHG=814 YBD=2375 YHG=2348>fistula " XBD=1148 XHG=950 YBD=2376 YHG=2348>formation. " XBD=1279 XHG=1194 YBD=2375 YHG=2348>Free " XBD=1360 XHG=1295 YBD=2383 YHG=2356>pus" XBD=249 XHG=181 YBD=2416 YHG=2397>was " XBD=436 XHG=262 YBD=2424 YHG=2387>aspirated " XBD=487 XHG=450 YBD=2415 YHG=2397>as " XBD=554 XHG=501 YBD=2414 YHG=2387>far " XBD=605 XHG=567 YBD=2415 YHG=2396>as " XBD=766 XHG=617 YBD=2424 YHG=2387>possible " XBD=895 XHG=779 YBD=2415 YHG=2387>before " XBD=1041 XHG=910 YBD=2415 YHG=2387>closure " XBD=1094 XHG=1055 YBD=2414 YHG=2387>of " XBD=1163 XHG=1102 YBD=2415 YHG=2387>the " XBD=1359 XHG=1177 YBD=2415 YHG=2386>abdomen." XBD=275 XHG=229 YBD=2466 YHG=2437>In " XBD=340 XHG=296 YBD=2467 YHG=2435>75 " XBD=464 XHG=363 YBD=2466 YHG=2445>cases " XBD=534 XHG=486 YBD=2464 YHG=2445>no " XBD=844 XHG=557 YBD=2473 YHG=2434>sulphonamide " XBD=960 XHG=866 YBD=2472 YHG=2435>drug " XBD=1057 XHG=981 YBD=2466 YHG=2445>was " XBD=1359 XHG=1079 YBD=2465 YHG=2434>administered." XBD=229 XHG=183 YBD=2505 YHG=2475>In " XBD=312 XHG=246 YBD=2505 YHG=2476>the " XBD=442 XHG=334 YBD=2505 YHG=2476>other " XBD=501 XHG=457 YBD=2504 YHG=2475>20 |>" XBD=547 XHG=522 YBD=2504 YHG=2482>a; " XBD=867 XHG=569 YBD=2512 YHG=2475>sulphathiazole " XBD=1101 XHG=881 YBD=2512 YHG=2475>suspension " XBD=1131 XHG=1115 YBD=2494 YHG=2477>* " XBD=1223 XHG=1147 YBD=2504 YHG=2484>was " XBD=1360 XHG=1245 YBD=2505 YHG=2474>intro-" XBD=614 XHG=499 YBD=2567 YHG=2547>TABLE " XBD=1035 XHG=638 YBD=2567 YHG=2547>I-MORTALITY-RATES

" XBD=305 XHG=186 YBD=2927 YHG=2898>duced " XBD=401 XHG=320 YBD=2928 YHG=2899>into " XBD=484 XHG=419 YBD=2929 YHG=2900>the " XBD=709 XHG=501 YBD=2935 YHG=2899>peritoneal " XBD=866 XHG=727 YBD=2936 YHG=2899>cavity. " XBD=1044 XHG=926 YBD=2928 YHG=2890>These " XBD=1106 XHG=1062 YBD=2929 YHG=2899>20 " XBD=1250 XHG=1124 YBD=2929 YHG=2899>would " XBD=1364 XHG=1266 YBD=2928 YHG=2899>have" XBD=279 XHG=184 YBD=2965 YHG=2936>been " XBD=546 XHG=310 YBD=2967 YHG=2938>consecutive " XBD=648 XHG=576 YBD=2967 YHG=2938>but " XBD=718 XHG=679 YBD=2966 YHG=2937>in " XBD=819 XHG=749 YBD=2966 YHG=2946>one " XBD=934 XHG=851 YBD=2967 YHG=2947>case " XBD=1032 XHG=966 YBD=2967 YHG=2938>the " XBD=1158 XHG=1064 YBD=2974 YHG=2939>drug " XBD=1265 XHG=1187 YBD=2967 YHG=2947>was " XBD=1365 XHG=1296 YBD=2967 YHG=2939>not" XBD=368 XHG=185 YBD=3005 YHG=2976>available " XBD=431 XHG=389 YBD=3006 YHG=2977>at " XBD=659 XHG=452 YBD=3013 YHG=2976>operation. " XBD=816 XHG=712 YBD=3012 YHG=2976>(This " XBD=987 XHG=836 YBD=3014 YHG=2975>patient " XBD=1234 XHG=1006 YBD=3011 YHG=2976>recovered.) " XBD=1364 XHG=1286 YBD=3006 YHG=2976>The" XBD=496 XHG=185 YBD=3052 YHG=3015>mortality-rates " XBD=579 XHG=517 YBD=3045 YHG=3025>are " XBD=731 XHG=602 YBD=3045 YHG=3015>shown " XBD=792 XHG=752 YBD=3044 YHG=3015>in " XBD=909 XHG=806 YBD=3044 YHG=3015>table " XBD=950 XHG=925 YBD=3045 YHG=3022>I." XBD=310 XHG=235 YBD=3083 YHG=3053>The " XBD=434 XHG=333 YBD=3085 YHG=3063>cases " XBD=605 XHG=455 YBD=3084 YHG=3055>treated " XBD=719 XHG=624 YBD=3084 YHG=3054>with " XBD=1038 XHG=741 YBD=3091 YHG=3054>sulphathiazole " XBD=1280 XHG=1060 YBD=3093 YHG=3055>suspension " XBD=1363 XHG=1301 YBD=3083 YHG=3063>are" XBD=430 XHG=185 YBD=3123 YHG=3093>summarised " XBD=490 XHG=450 YBD=3122 YHG=3093>in " XBD=614 XHG=511 YBD=3122 YHG=3093>table " XBD=678 XHG=635 YBD=3126 YHG=3100>ti." XBD=464 XHG=235 YBD=3161 YHG=3131>Instillation " XBD=529 XHG=486 YBD=3161 YHG=3132>of " XBD=613 XHG=548 YBD=3161 YHG=3132>the " XBD=856 XHG=636 YBD=3167 YHG=3131>suspension " XBD=972 XHG=878 YBD=3160 YHG=3127>adds " XBD=1019 XHG=995 YBD=3160 YHG=3140>a " XBD=1113 XHG=1041 YBD=3160 YHG=3131>few " XBD=1300 XHG=1135 YBD=3161 YHG=3132>minutes " XBD=1363 XHG=1322 YBD=3160 YHG=3131>to" XBD=251 XHG=186 YBD=3198 YHG=3169>the " XBD=459 XHG=268 YBD=3206 YHG=3169>operative " XBD=580 XHG=475 YBD=3205 YHG=3170>time, " XBD=657 XHG=598 YBD=3199 YHG=3170>for " XBD=695 XHG=676 YBD=3199 YHG=3170>9 " XBD=899 XHG=715 YBD=3206 YHG=3177>grammes " XBD=1117 XHG=917 YBD=3199 YHG=3164>contained " XBD=1174 XHG=1134 YBD=3198 YHG=3170>in " XBD=1236 XHG=1191 YBD=3199 YHG=3170>60 " XBD=1361 XHG=1255 YBD=3198 YHG=3168>c.cm." XBD=252 XHG=185 YBD=3237 YHG=3207>has " XBD=314 XHG=273 YBD=3237 YHG=3209>to " XBD=382 XHG=335 YBD=3238 YHG=3208>be " XBD=535 XHG=403 YBD=3246 YHG=3209>placed " XBD=686 XHG=556 YBD=3245 YHG=3208>slowly " XBD=787 XHG=706 YBD=3238 YHG=3209>into " XBD=875 XHG=809 YBD=3237 YHG=3209>the " XBD=1035 XHG=895 YBD=3238 YHG=3206>wound " XBD=1131 XHG=1055 YBD=3237 YHG=3208>and " XBD=1234 XHG=1152 YBD=3237 YHG=3208>well " XBD=1363 XHG=1254 YBD=3243 YHG=3216>away" XBD=282 XHG=185 YBD=3275 YHG=3246>from " XBD=385 XHG=311 YBD=3283 YHG=3256>any " XBD=703 XHG=407 YBD=3284 YHG=3241>drainage-tube. " XBD=941 XHG=754 YBD=3276 YHG=3246>Provided " XBD=1029 XHG=964 YBD=3276 YHG=3247>the " XBD=1272 XHG=1052 YBD=3282 YHG=3247>suspension " XBD=1361 XHG=1293 YBD=3275 YHG=3247>has" XBD=280 XHG=186 YBD=3315 YHG=3284>been " XBD=390 XHG=298 YBD=3322 YHG=3285>kept " XBD=577 XHG=408 YBD=3322 YHG=3286>airtight, " XBD=703 XHG=599 YBD=3316 YHG=3287>there " XBD=753 XHG=722 YBD=3314 YHG=3285>is " XBD=822 XHG=773 YBD=3314 YHG=3295>no " XBD=1027 XHG=843 YBD=3322 YHG=3285>difficulty " XBD=1086 XHG=1047 YBD=3314 YHG=3285>in " XBD=1286 XHG=1104 YBD=3320 YHG=3284>handling " XBD=1360 XHG=1304 YBD=3320 YHG=3284>it ; |>" XBD=1360 XHG=1352 YBD=3320 YHG=3294>;" XBD=199 XHG=185 YBD=3362 YHG=3347>* " XBD=265 XHG=217 YBD=3372 YHG=3348>An " XBD=421 XHG=282 YBD=3376 YHG=3353>aqueous " XBD=720 XHG=437 YBD=3377 YHG=3348>microcrystalline " XBD=923 XHG=737 YBD=3376 YHG=3348>suspension " XBD=1130 XHG=947 YBD=3374 YHG=3347>containing " XBD=1217 XHG=1149 YBD=3374 YHG=3347>15% " XBD=1364 XHG=1237 YBD=3375 YHG=3346>sulpha-" XBD=402 XHG=262 YBD=3401 YHG=3377>thiazole. " XBD=513 XHG=420 YBD=3400 YHG=3377>made " XBD=679 XHG=543 YBD=3402 YHG=3378>isotonic " XBD=782 XHG=704 YBD=3401 YHG=3377>with " XBD=935 XHG=811 YBD=3401 YHG=3377>sodium " XBD=1101 XHG=964 YBD=3400 YHG=3376>chloride " XBD=1269 XHG=1131 YBD=3405 YHG=3376>(Menley " XBD=1364 XHG=1299 YBD=3399 YHG=3375>and" XBD=372 XHG=264 YBD=3431 YHG=3407>James " XBD=488 XHG=389 YBD=3432 YHG=3405>Ltd.).

" XBD=1517 XHG=1402 YBD=211 YHG=192>TABLE " XBD=1722 XHG=1541 YBD=211 YHG=192>II&horbar;&horbar;OASES " XBD=1900 XHG=1734 YBD=211 YHG=191>TREATED " XBD=2010 XHG=1914 YBD=211 YHG=191>WITH " XBD=2339 XHG=2023 YBD=212 YHG=191>SULPHATHIAZOLE " XBD=2585 XHG=2361 YBD=212 YHG=191>SUSPENSION

" XBD=1655 XHG=1626 YBD=1535 YHG=1510>A " XBD=1704 XHG=1678 YBD=1529 YHG=1520>= " XBD=2026 XHG=1717 YBD=1540 YHG=1510>appendicectomy ; " XBD=2080 XHG=2054 YBD=1534 YHG=1510>D " XBD=2131 XHG=2106 YBD=1529 YHG=1521>= " XBD=2308 XHG=2147 YBD=1537 YHG=1510>drainage." XBD=1498 XHG=1457 YBD=1570 YHG=1546>In " XBD=1555 XHG=1511 YBD=1570 YHG=1546>all " XBD=1628 XHG=1568 YBD=1570 YHG=1546>but " XBD=1703 XHG=1642 YBD=1570 YHG=1552>one " XBD=1797 XHG=1725 YBD=1570 YHG=1552>case " XBD=1859 XHG=1813 YBD=1576 YHG=1547>(in " XBD=1977 XHG=1873 YBD=1571 YHG=1546>which " XBD=2047 XHG=1990 YBD=1571 YHG=1547>the " XBD=2224 XHG=2062 YBD=1575 YHG=1547>appendix " XBD=2302 XHG=2237 YBD=1572 YHG=1552>was " XBD=2529 XHG=2317 YBD=1576 YHG=1547>gangrenous) " XBD=2602 XHG=2543 YBD=1571 YHG=1546>the" XBD=1628 XHG=1416 YBD=1604 YHG=1576>appendicitis " XBD=1708 XHG=1643 YBD=1600 YHG=1581>was " XBD=1847 XHG=1725 YBD=1604 YHG=1577>proved " XBD=1908 XHG=1863 YBD=1604 YHG=1575>by " XBD=2158 XHG=1922 YBD=1604 YHG=1576>microscopical " XBD=2400 XHG=2173 YBD=1601 YHG=1576>examination.

" XBD=1636 XHG=1419 YBD=1668 YHG=1630>experience " XBD=1700 XHG=1656 YBD=1659 YHG=1630>of " XBD=1766 XHG=1716 YBD=1659 YHG=1630>its " XBD=1852 XHG=1785 YBD=1660 YHG=1639>use " XBD=1914 XHG=1873 YBD=1660 YHG=1631>in |>" XBD=2216 XHG=1932 YBD=1668 YHG=1631>thoracoplasty " XBD=2409 XHG=2235 YBD=1661 YHG=1631>incisions " XBD=2601 XHG=2431 YBD=1668 YHG=1631>suggests" XBD=1506 XHG=1418 YBD=1700 YHG=1670>that " XBD=1627 XHG=1521 YBD=1699 YHG=1670>there " XBD=1674 XHG=1642 YBD=1699 YHG=1670>is " XBD=1739 XHG=1690 YBD=1699 YHG=1679>no " XBD=1943 XHG=1755 YBD=1707 YHG=1669>tendency " XBD=2038 XHG=1958 YBD=1699 YHG=1670>to &dquo; " XBD=2228 XHG=2057 YBD=1707 YHG=1670>caking,&dquo; " XBD=2321 XHG=2246 YBD=1701 YHG=1669>and " XBD=2442 XHG=2336 YBD=1700 YHG=1671>there " XBD=2534 XHG=2457 YBD=1700 YHG=1679>was " XBD=2600 XHG=2550 YBD=1701 YHG=1678>no" XBD=1596 XHG=1420 YBD=1739 YHG=1708>evidence " XBD=1674 XHG=1630 YBD=1738 YHG=1710>of " XBD=1840 XHG=1704 YBD=1746 YHG=1709>caking " XBD=1913 XHG=1872 YBD=1739 YHG=1709>in " XBD=2010 XHG=1944 YBD=1739 YHG=1709>the " XBD=2115 XHG=2045 YBD=1738 YHG=1718>one " XBD=2336 XHG=2148 YBD=1739 YHG=1709>abdomen " XBD=2492 XHG=2368 YBD=1739 YHG=1709>which " XBD=2601 XHG=2523 YBD=1740 YHG=1718>was" XBD=1607 XHG=1419 YBD=1786 YHG=1748>reopened " XBD=1667 XHG=1617 YBD=1777 YHG=1758>on " XBD=1745 XHG=1679 YBD=1778 YHG=1748>the " XBD=1874 XHG=1761 YBD=1778 YHG=1749>128th " XBD=2168 XHG=1885 YBD=1785 YHG=1749>postoperative " XBD=2276 XHG=2190 YBD=1786 YHG=1748>day. " XBD=2433 XHG=2331 YBD=1784 YHG=1749>(This " XBD=2604 XHG=2448 YBD=1785 YHG=1749>patient" XBD=1496 XHG=1420 YBD=1818 YHG=1798>was " XBD=1592 XHG=1514 YBD=1818 YHG=1788>also " XBD=1677 XHG=1610 YBD=1817 YHG=1788>the " XBD=1784 XHG=1694 YBD=1825 YHG=1788>only " XBD=1872 XHG=1803 YBD=1817 YHG=1797>one " XBD=2001 XHG=1890 YBD=1825 YHG=1787>given " XBD=2095 XHG=2018 YBD=1825 YHG=1797>any " XBD=2191 XHG=2113 YBD=1818 YHG=1789>oral " XBD=2507 XHG=2208 YBD=1825 YHG=1788>sulphonamide, " XBD=2603 XHG=2527 YBD=1817 YHG=1788>and" XBD=1508 XHG=1420 YBD=1858 YHG=1828>that " XBD=1607 XHG=1530 YBD=1858 YHG=1837>was " XBD=1732 XHG=1630 YBD=1858 YHG=1836>some " XBD=1862 XHG=1756 YBD=1858 YHG=1828>three " XBD=2038 XHG=1884 YBD=1858 YHG=1828>months " XBD=2161 XHG=2061 YBD=1858 YHG=1828>after " XBD=2249 XHG=2183 YBD=1857 YHG=1828>the " XBD=2354 XHG=2272 YBD=1858 YHG=1828>first " XBD=2604 XHG=2378 YBD=1865 YHG=1827>operation.)" XBD=1480 XHG=1422 YBD=1896 YHG=1867>No " XBD=1682 XHG=1496 YBD=1896 YHG=1867>reactions " XBD=1951 XHG=1697 YBD=1897 YHG=1866>attributable " XBD=2007 XHG=1966 YBD=1896 YHG=1867>to " XBD=2089 XHG=2024 YBD=1896 YHG=1867>the " XBD=2200 XHG=2105 YBD=1903 YHG=1867>drug " XBD=2308 XHG=2214 YBD=1898 YHG=1868>were " XBD=2451 XHG=2323 YBD=1896 YHG=1866>noted." XBD=1547 XHG=1468 YBD=1936 YHG=1906>The " XBD=1792 XHG=1570 YBD=1944 YHG=1901>impression " XBD=1835 XHG=1816 YBD=1936 YHG=1907>I " XBD=1956 XHG=1858 YBD=1936 YHG=1907>have " XBD=2115 XHG=1981 YBD=1943 YHG=1906>gained " XBD=2236 XHG=2137 YBD=1936 YHG=1908>from " XBD=2337 XHG=2259 YBD=1937 YHG=1907>this " XBD=2469 XHG=2360 YBD=1936 YHG=1906>small " XBD=2605 XHG=2493 YBD=1936 YHG=1906>series" XBD=1453 XHG=1421 YBD=1975 YHG=1946>is " XBD=1572 XHG=1484 YBD=1976 YHG=1946>that " XBD=1914 XHG=1603 YBD=1982 YHG=1946>intraperitoneal " XBD=2243 XHG=1944 YBD=1982 YHG=1946>sulphathiazole " XBD=2309 XHG=2278 YBD=1975 YHG=1946>is " XBD=2531 XHG=2344 YBD=1983 YHG=1945>probably " XBD=2611 XHG=2567 YBD=1975 YHG=1946>of" XBD=1533 XHG=1422 YBD=2014 YHG=1985>value " XBD=1596 XHG=1556 YBD=2014 YHG=1985>in " XBD=1685 XHG=1619 YBD=2014 YHG=1986>the " XBD=1915 XHG=1707 YBD=2015 YHG=1986>treatment " XBD=1982 XHG=1939 YBD=2015 YHG=1985>of " XBD=2135 XHG=2001 YBD=2015 YHG=1984>diffuse " XBD=2382 XHG=2158 YBD=2022 YHG=1985>peritonitis, " XBD=2552 XHG=2406 YBD=2022 YHG=1984>though " XBD=2607 XHG=2574 YBD=2014 YHG=1984>it" XBD=1525 XHG=1422 YBD=2053 YHG=2025>must " XBD=1597 XHG=1549 YBD=2054 YHG=2024>be " XBD=1779 XHG=1620 YBD=2054 YHG=2024>realised " XBD=1892 XHG=1804 YBD=2054 YHG=2025>that " XBD=2019 XHG=1917 YBD=2054 YHG=2033>some " XBD=2088 XHG=2045 YBD=2054 YHG=2025>of " XBD=2174 XHG=2108 YBD=2054 YHG=2025>the " XBD=2366 XHG=2198 YBD=2054 YHG=2024>bacteria " XBD=2606 XHG=2391 YBD=2060 YHG=2024>commonly" XBD=1576 XHG=1423 YBD=2100 YHG=2064>causing " XBD=1675 XHG=1597 YBD=2093 YHG=2063>this " XBD=1891 XHG=1697 YBD=2093 YHG=2063>condition " XBD=1975 XHG=1912 YBD=2093 YHG=2073>are " XBD=2488 XHG=1996 YBD=2100 YHG=2063>sulphonamide-resistant." XBD=1484 XHG=1466 YBD=2135 YHG=2108>I " XBD=1584 XHG=1498 YBD=2136 YHG=2108>wish " XBD=1635 XHG=1598 YBD=2136 YHG=2111>to " XBD=1763 XHG=1649 YBD=2136 YHG=2108>thank " XBD=1837 XHG=1775 YBD=2136 YHG=2108>the " XBD=1999 XHG=1851 YBD=2136 YHG=2108>Medical " XBD=2186 XHG=2012 YBD=2137 YHG=2108>Research " XBD=2343 XHG=2200 YBD=2136 YHG=2107>Council " XBD=2410 XHG=2356 YBD=2135 YHG=2108>for " XBD=2608 XHG=2423 YBD=2144 YHG=2108>arranging" XBD=1483 XHG=1422 YBD=2175 YHG=2148>the " XBD=1624 XHG=1498 YBD=2184 YHG=2148>supply " XBD=1679 XHG=1639 YBD=2175 YHG=2148>of " XBD=1963 XHG=1689 YBD=2184 YHG=2147>sulphathiazole " XBD=2179 XHG=1978 YBD=2184 YHG=2148>suspension " XBD=2392 XHG=2195 YBD=2182 YHG=2147>(sterilised) " XBD=2457 XHG=2409 YBD=2183 YHG=2147>by " XBD=2607 XHG=2471 YBD=2175 YHG=2146>Messrs." XBD=1560 XHG=1423 YBD=2223 YHG=2186>Menley " XBD=1653 XHG=1583 YBD=2215 YHG=2187>and " XBD=1817 XHG=1677 YBD=2220 YHG=2187>James ; " XBD=1926 XHG=1855 YBD=2215 YHG=2187>also " XBD=2011 XHG=1950 YBD=2216 YHG=2188>Dr. " XBD=2069 XHG=2036 YBD=2215 YHG=2187>J. " XBD=2238 XHG=2094 YBD=2220 YHG=2187>Rennie, " XBD=2409 XHG=2261 YBD=2214 YHG=2186>medical " XBD=2547 XHG=2432 YBD=2215 YHG=2186>officer " XBD=2610 XHG=2570 YBD=2214 YHG=2186>of" XBD=1555 XHG=1422 YBD=2259 YHG=2226>health, " XBD=1651 XHG=1580 YBD=2254 YHG=2226>and " XBD=1736 XHG=1674 YBD=2254 YHG=2227>Dr. " XBD=1796 XHG=1762 YBD=2254 YHG=2227>J. " XBD=1935 XHG=1822 YBD=2260 YHG=2226>Clark, " XBD=2106 XHG=1959 YBD=2254 YHG=2227>medical " XBD=2429 XHG=2131 YBD=2262 YHG=2226>superintendent, " XBD=2508 XHG=2453 YBD=2253 YHG=2226>for " XBD=2606 XHG=2530 YBD=2262 YHG=2234>per-" XBD=1564 XHG=1423 YBD=2293 YHG=2266>mission " XBD=1625 XHG=1587 YBD=2292 YHG=2268>to " XBD=1789 XHG=1648 YBD=2302 YHG=2265>publish " XBD=1910 XHG=1812 YBD=2293 YHG=2266>these " XBD=2070 XHG=1934 YBD=2294 YHG=2266>results. " XBD=2274 XHG=2116 YBD=2301 YHG=2265>Especial " XBD=2427 XHG=2297 YBD=2293 YHG=2265>thanks " XBD=2509 XHG=2450 YBD=2293 YHG=2274>are " XBD=2605 XHG=2533 YBD=2292 YHG=2265>also" XBD=1492 XHG=1424 YBD=2332 YHG=2304>due " XBD=1548 XHG=1510 YBD=2332 YHG=2307>to " XBD=1664 XHG=1568 YBD=2333 YHG=2304>Prof. " XBD=1813 XHG=1681 YBD=2333 YHG=2305>Wilson " XBD=1948 XHG=1833 YBD=2333 YHG=2305>Smith " XBD=2036 XHG=1967 YBD=2332 YHG=2305>and " XBD=2117 XHG=2056 YBD=2332 YHG=2305>Dr. " XBD=2184 XHG=2137 YBD=2332 YHG=2303>H. " XBD=2246 XHG=2204 YBD=2332 YHG=2305>E. " XBD=2425 XHG=2266 YBD=2339 YHG=2304>Harding " XBD=2497 XHG=2443 YBD=2331 YHG=2304>for " XBD=2608 XHG=2515 YBD=2331 YHG=2304>their" XBD=1558 XHG=1424 YBD=2378 YHG=2346>reports " XBD=1611 XHG=1575 YBD=2370 YHG=2343>in " XBD=1863 XHG=1627 YBD=2379 YHG=2343>bacteriology " XBD=1948 XHG=1880 YBD=2370 YHG=2344>and " XBD=2140 XHG=1966 YBD=2379 YHG=2343>histology " XBD=2395 XHG=2156 YBD=2379 YHG=2343>respectively.

New Inventions

INTERMITTENT PENICILLIN DRIP APPARATUS

" XBD=1561 XHG=1475 YBD=2609 YHG=2580>THE " XBD=1810 XHG=1575 YBD=2615 YHG=2580>advantages " XBD=1875 XHG=1832 YBD=2608 YHG=2579>of " XBD=1957 XHG=1892 YBD=2608 YHG=2579>the " XBD=2197 XHG=1973 YBD=2609 YHG=2579>continuous " XBD=2502 XHG=2212 YBD=2609 YHG=2579>intramuscular " XBD=2607 XHG=2523 YBD=2616 YHG=2579>drip " XBD=2641 XHG=2628 YBD=2602 YHG=2597>--" XBD=1583 XHG=1426 YBD=2648 YHG=2617>method " XBD=1652 XHG=1609 YBD=2647 YHG=2618>of " XBD=1959 XHG=1674 YBD=2654 YHG=2617>administering " XBD=2173 XHG=1984 YBD=2654 YHG=2618>penicillin " XBD=2295 XHG=2196 YBD=2647 YHG=2618>have " XBD=2489 XHG=2321 YBD=2654 YHG=2618>recently " XBD=2610 XHG=2514 YBD=2648 YHG=2619>been" XBD=1667 XHG=1428 YBD=2687 YHG=2656>established. " XBD=1811 XHG=1732 YBD=2686 YHG=2657>The " XBD=1998 XHG=1842 YBD=2693 YHG=2656>original " XBD=2185 XHG=2028 YBD=2687 YHG=2656>method " XBD=2259 XHG=2216 YBD=2686 YHG=2656>of " XBD=2422 XHG=2295 YBD=2694 YHG=2657>giving " XBD=2608 XHG=2455 YBD=2693 YHG=2658>100,000" XBD=1530 XHG=1426 YBD=2726 YHG=2696>units " XBD=1588 XHG=1548 YBD=2725 YHG=2696>in " XBD=1675 XHG=1608 YBD=2725 YHG=2696>540 " XBD=1801 XHG=1696 YBD=2725 YHG=2705>c.cm. " XBD=1925 XHG=1822 YBD=2732 YHG=2694>daily " XBD=2079 XHG=1943 YBD=2725 YHG=2695>caused " XBD=2380 XHG=2098 YBD=2733 YHG=2696>water-logging " XBD=2441 XHG=2397 YBD=2725 YHG=2696>of " XBD=2521 XHG=2454 YBD=2726 YHG=2697>the " XBD=2609 XHG=2539 YBD=2733 YHG=2696>leg," XBD=1609 XHG=1427 YBD=2771 YHG=2735>resulting " XBD=1669 XHG=1629 YBD=2764 YHG=2735>in " XBD=1927 XHG=1688 YBD=2771 YHG=2735>irregularity " XBD=1990 XHG=1947 YBD=2764 YHG=2735>of " XBD=2091 XHG=2006 YBD=2765 YHG=2734>flow " XBD=2155 XHG=2112 YBD=2764 YHG=2735>of " XBD=2238 XHG=2172 YBD=2764 YHG=2735>the " XBD=2355 XHG=2259 YBD=2772 YHG=2735>drip. " XBD=2445 XHG=2406 YBD=2770 YHG=2735>If " XBD=2611 XHG=2462 YBD=2765 YHG=2735>smaller" XBD=1597 XHG=1428 YBD=2803 YHG=2774>volumes " XBD=1718 XHG=1625 YBD=2803 YHG=2774>such " XBD=1788 XHG=1746 YBD=2803 YHG=2782>as " XBD=1885 XHG=1819 YBD=2803 YHG=2774>100 " XBD=2021 XHG=1916 YBD=2802 YHG=2783>c.cm. " XBD=2114 XHG=2052 YBD=2802 YHG=2783>are " XBD=2236 XHG=2142 YBD=2803 YHG=2772>used " XBD=2295 XHG=2261 YBD=2803 YHG=2774>it " XBD=2354 XHG=2321 YBD=2804 YHG=2775>is " XBD=2609 XHG=2382 YBD=2804 YHG=2768>difficult * to" XBD=1574 XHG=1429 YBD=2842 YHG=2812>control " XBD=1654 XHG=1589 YBD=2842 YHG=2813>the " XBD=1754 XHG=1669 YBD=2842 YHG=2812>flow " XBD=1811 XHG=1768 YBD=2842 YHG=2813>at " XBD=1845 XHG=1821 YBD=2841 YHG=2822>a " XBD=2080 XHG=1856 YBD=2848 YHG=2812>sufficiently " XBD=2182 XHG=2092 YBD=2842 YHG=2813>slow " XBD=2286 XHG=2192 YBD=2842 YHG=2812>rate. The " XBD=2609 XHG=2422 YBD=2851 YHG=2813>Eudrip’

apparatus " XBD=1854 XHG=1643 YBD=2889 YHG=2851>1 attempts " XBD=1906 XHG=1865 YBD=2881 YHG=2852>to " XBD=2111 XHG=1918 YBD=2881 YHG=2861>overcome " XBD=2202 XHG=2127 YBD=2881 YHG=2851>this " XBD=2385 XHG=2217 YBD=2889 YHG=2852>problem " XBD=2450 XHG=2400 YBD=2888 YHG=2852>by " XBD=2573 XHG=2464 YBD=2889 YHG=2852>using " XBD=2611 XHG=2587 YBD=2881 YHG=2862>a" XBD=1747 XHG=1430 YBD=2926 YHG=2889>delicate. though " XBD=2009 XHG=1762 YBD=2927 YHG=2890>complicated " XBD=2175 XHG=2031 YBD=2919 YHG=2890>control " XBD=2234 XHG=2195 YBD=2919 YHG=2890>of " XBD=2319 XHG=2255 YBD=2920 YHG=2890>the " XBD=2399 XHG=2343 YBD=2920 YHG=2891>air " XBD=2547 XHG=2419 YBD=2920 YHG=2891>intake " XBD=2609 XHG=2568 YBD=2920 YHG=2891>to" XBD=1492 XHG=1427 YBD=2958 YHG=2928>the " XBD=1721 XHG=1504 YBD=2966 YHG=2929>apparatus, " XBD=1810 XHG=1733 YBD=2958 YHG=2928>and " XBD=1910 XHG=1820 YBD=2957 YHG=2928>thus " XBD=2080 XHG=1923 YBD=2958 YHG=2929>delivers " XBD=2113 XHG=2089 YBD=2957 YHG=2938>a " XBD=2230 XHG=2122 YBD=2958 YHG=2929>small " XBD=2387 XHG=2240 YBD=2959 YHG=2930>volume " XBD=2436 XHG=2397 YBD=2958 YHG=2930>of " XBD=2610 XHG=2447 YBD=2959 YHG=2930>solution" XBD=1694 XHG=1429 YBD=3004 YHG=2967>continuously " XBD=1762 XHG=1720 YBD=2996 YHG=2967>to " XBD=1855 XHG=1790 YBD=2996 YHG=2967>the " XBD=2042 XHG=1884 YBD=3004 YHG=2967>patient. " XBD=2164 XHG=2087 YBD=2996 YHG=2967>The " XBD=2382 XHG=2192 YBD=3004 YHG=2968>following " XBD=2611 XHG=2407 YBD=3005 YHG=2968>apparatus" XBD=1556 XHG=1429 YBD=3035 YHG=3006>differs " XBD=1667 XHG=1569 YBD=3035 YHG=3005>from " XBD=1745 XHG=1681 YBD=3034 YHG=3005>the " XBD=1880 XHG=1760 YBD=3035 YHG=3006>above " XBD=1935 XHG=1894 YBD=3035 YHG=3006>in " XBD=2036 XHG=1947 YBD=3035 YHG=3005>that " XBD=2081 XHG=2049 YBD=3035 YHG=3006>it " XBD=2125 XHG=2094 YBD=3035 YHG=3006>is " XBD=2317 XHG=2141 YBD=3043 YHG=3005>designed " XBD=2372 XHG=2332 YBD=3035 YHG=3007>to " XBD=2609 XHG=2388 YBD=3035 YHG=3006>administer" XBD=1451 XHG=1428 YBD=3074 YHG=3054>a " XBD=1563 XHG=1461 YBD=3074 YHG=3038>fixed " XBD=1683 XHG=1574 YBD=3073 YHG=3044>small " XBD=1842 XHG=1694 YBD=3074 YHG=3045>volume " XBD=1891 XHG=1853 YBD=3074 YHG=3045>of " XBD=2091 XHG=1901 YBD=3081 YHG=3044>penicillin " XBD=2276 XHG=2102 YBD=3079 YHG=3045>solution, " XBD=2610 XHG=2289 YBD=3081 YHG=3045>discontinuously" XBD=1517 XHG=1427 YBD=3113 YHG=3092>over " XBD=1555 XHG=1532 YBD=3111 YHG=3092>a " XBD=1696 XHG=1569 YBD=3114 YHG=3083>stated " XBD=1852 XHG=1710 YBD=3120 YHG=3083>period. " XBD=1935 XHG=1895 YBD=3112 YHG=3083>It " XBD=2019 XHG=1950 YBD=3112 YHG=3092>can " XBD=2087 XHG=2041 YBD=3112 YHG=3083>be " XBD=2349 XHG=2109 YBD=3113 YHG=3083>constructed " XBD=2467 XHG=2369 YBD=3112 YHG=3084>from " XBD=2607 XHG=2487 YBD=3120 YHG=3083>pieces" XBD=1464 XHG=1427 YBD=3150 YHG=3122>of " XBD=1685 XHG=1480 YBD=3157 YHG=3122>apparatus " XBD=1849 XHG=1706 YBD=3158 YHG=3121>readily " XBD=2084 XHG=1869 YBD=3151 YHG=3121>obtainable " XBD=2145 XHG=2106 YBD=3150 YHG=3123>in " XBD=2189 XHG=2167 YBD=3150 YHG=3131>a " XBD=2373 XHG=2209 YBD=3158 YHG=3121>hospital " XBD=2609 XHG=2391 YBD=3157 YHG=3121>laboratory" XBD=1503 XHG=1426 YBD=3189 YHG=3159>and " XBD=1548 XHG=1516 YBD=3187 YHG=3160>it " XBD=1593 XHG=1562 YBD=3188 YHG=3159>is " XBD=1727 XHG=1608 YBD=3196 YHG=3160>easily " XBD=1925 XHG=1739 YBD=3196 YHG=3160>managed " XBD=1988 XHG=1936 YBD=3196 YHG=3159>by " XBD=2065 XHG=2000 YBD=3189 YHG=3159>the " XBD=2233 XHG=2079 YBD=3196 YHG=3160>nursing " XBD=2346 XHG=2247 YBD=3188 YHG=3159>staff." XBD=1553 XHG=1418 YBD=3234 YHG=3198>The " XBD=1749 XHG=1568 YBD=3234 YHG=3198>principle " XBD=1796 XHG=1763 YBD=3227 YHG=3198>is " XBD=1996 XHG=1811 YBD=3234 YHG=3198>simple. A " XBD=2234 XHG=2054 YBD=3227 YHG=3198>reservoir " XBD=2407 XHG=2250 YBD=3227 YHG=3197>delivers " XBD=2486 XHG=2423 YBD=3226 YHG=3197>via " XBD=2524 XHG=2501 YBD=3226 YHG=3206>a " XBD=2607 XHG=2539 YBD=3233 YHG=3197>tap" XBD=1449 XHG=1425 YBD=3270 YHG=3246>a " XBD=1576 XHG=1474 YBD=3265 YHG=3236>fixed " XBD=1760 XHG=1601 YBD=3266 YHG=3237>amount " XBD=1848 XHG=1791 YBD=3271 YHG=3237>(10 " XBD=1999 XHG=1877 YBD=3271 YHG=3237>c.cm.) " XBD=2069 XHG=2026 YBD=3266 YHG=3237>of " XBD=2279 XHG=2091 YBD=3273 YHG=3236>penicillin " XBD=2468 XHG=2304 YBD=3265 YHG=3235>solution " XBD=2609 XHG=2494 YBD=3272 YHG=3243>every" XBD=1447 XHG=1427 YBD=3304 YHG=3276>3 " XBD=1586 XHG=1471 YBD=3304 YHG=3275>hours " XBD=1691 XHG=1610 YBD=3304 YHG=3275>into " XBD=1739 XHG=1717 YBD=3304 YHG=3284>a " XBD=1981 XHG=1764 YBD=3305 YHG=3274>distensible " XBD=2209 XHG=2006 YBD=3309 YHG=3275>container, " XBD=2357 XHG=2235 YBD=3303 YHG=3274>which " XBD=2489 XHG=2380 YBD=3303 YHG=3274>when " XBD=2608 XHG=2511 YBD=3310 YHG=3273>fully" XBD=1624 XHG=1426 YBD=3350 YHG=3313>expanded " XBD=1715 XHG=1641 YBD=3343 YHG=3314>will " XBD=1822 XHG=1731 YBD=3343 YHG=3313>hold " XBD=1929 XHG=1840 YBD=3350 YHG=3314>only " XBD=2033 XHG=1945 YBD=3343 YHG=3314>that " XBD=2230 XHG=2052 YBD=3349 YHG=3313>quantity " XBD=2290 XHG=2247 YBD=3341 YHG=3313>of " XBD=2477 XHG=2302 YBD=3341 YHG=3312>solution. " XBD=2608 XHG=2529 YBD=3341 YHG=3312>The

1. See McAdam, I. W. J., Duguid, J. P. and Challinor, S. W. Lancet,Sept. 9, 1944, p. 336.