Sinonasal Undifferentiated Carcinoma(SNUC)

7/25/2019 Sinonasal Undifferentiated Carcinoma(SNUC)

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Sinonasal UndifferentiatedCarcinoma(SNUC):

the Alberta experience

and literature reviewOleh:

Dr Chrishadi !achmawan


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Definition

Sinonasal undifferentiated carcinoma (SNUC) is a rare"

hi#hl$ a##ressive and clinico%patholo#icall$ distinctive

carcinoma of uncertain histo#enesis


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&he purpose of the stud$

&he purpose of this stud$ was to evaluate survival

outcomes based on treatment of SNUC patients in Alberta

and the literature at lar#e


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'ethods

rovincialchart review

iteraturereview

Statisticalanal$sis


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!O*+NC+AC,A!& !-*+-.

+nclusion Criteria

,istolo#ical dia#nosis ofSNUC

&reatment within Alberta

-xclusion Criteria:

Non%SNUC tumor +ncomplete data

&his method was usin# a s$stematic retrospective medical record

Charts and electronic medical records for all identified patients were thenaccessed and crossreferenced to confirm suspected dia#noses of SNUC


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iterature review

A literature review was underta/en in as$stematic fashion usin#: '-D+N-" -'0AS-"ubmed" and Scopus

&hree reviewers searched for the followin#terms: 1sinonasal undifferentiated carcinoma2"

1SNUC2" 1undifferentiated carcinoma2" and1paranasal sinuses2

-ach stud$ was evaluated for #ender and a#e ofthe patient in the stud$" presentin# s$mptoms"orbital involvement" treatment strate#$" andfollow%up


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Statistical anal$sis

si#nificance

set as p3445

Covariatefactors /nownto influence

survivalincludin# a#e"

#ender and

tumor sta#ewere

incorporatedas potentialconfoundin#

variables

Statisticalanal$sis wasconductedusin# SSS

674


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!esults

*ariable &otal Number (8)

atients 94

'ales 6 (;4)


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!esults

*ariables Number of patients (

atients 6=4

'ales 64@ (@=)

> (9>)

'ean a#e" $ears (ran#e) 595 (;%;=)

&N' Sta#e Sta#e +* 649 (@97)

Sta#e +++ 65 (64@)

Sta#e ++ 66 (@7)

Not Stated 69 (69=)

'ean follow%up time" months 99

&able 9 atient demo#raphics of SNUC patients in the literature


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!esults

'odalit$ Number of patients (8)

Alberta iterature

No treatment 9 (64) 5 (=)

Sin#le modalit$ @ (>5) =9 (>4)

Chemoradiation = (94) >@ (9)

Sur#er$ AdBuvantradiotherap$

> (65) 99 (6)

Sur#er$ Chemoradiation = (94) >= (9=)

&able > &reatments received b$ SNUC patients


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Discussion

Sinonasal undifferentiated carcinoma is a particularl$ difficult to treat

0enefit

represents a possible newavenue of therap$

imitation

this is a review and pooledanal$sis of an area of the

literature comprisedentirel$ of small tomedium%sied case series

&he data is hetero#eneousand the ualit$ is oftenpoor


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Conclusions

SNUC is a uniue clinico%patholo#ic entit$ that remains a

challen#e to treat despite a##ressive multidisciplinar$

approaches

&here is no evidence that a##ressive sur#er$ and post%operative !& offer an$ survival advanta#e compared toother modalities

&herefore" a search for alternative

therapies is warranted


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Documents

Sinonasal Undifferentiated Carcinoma(SNUC)