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Slamf1 -/- [BALB/c.129] wt BALB/c 1000 2000 3000 4000 IgM IgG1 IgG2a IgG2b IgG3 IgA 250 500 750 1000 IgM IgG1 IgG2a IgG2b IgG3 IgA Slamf2 -/- [BALB/c.129] wt BALB/c toimmunity in Slamf1-/- and Slamf2-/- mice pplement Fig S1A

Slamf1 -/- [ BALB/c.129]

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Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1A. 4000. 3000. Slamf1 -/- [ BALB/c.129]. 2000. wt BALB/c. 1000. IgM IgG1 IgG2a IgG2b IgG3 IgA. 1000. Slamf2 -/- [ BALB/c.129]. 750. wt BALB/c. 500. 250. IgM IgG1 IgG2a IgG2b IgG3 IgA. - PowerPoint PPT Presentation

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Page 1: Slamf1 -/-  [ BALB/c.129]

Slamf1-/- [BALB/c.129]wt BALB/c

1000

2000

3000

4000

IgM IgG1 IgG2a IgG2b IgG3 IgA

250

500

750

1000

IgM IgG1 IgG2a IgG2b IgG3 IgA

Slamf2-/- [BALB/c.129]wt BALB/c

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1A

Page 2: Slamf1 -/-  [ BALB/c.129]

Slamf1-/- [B6.129]wt B6

500

1000

1500

2000

1 mo 2 mo 3 mo 6 mo

IgM

250

500

750

1000

1 mo 2 mo 3 mo 6 mo

IgG1

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1B

Page 3: Slamf1 -/-  [ BALB/c.129]

F M0

25

50

75

100

% a

utoa

ntibo

dy +

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S2

Page 4: Slamf1 -/-  [ BALB/c.129]

B6

CD244

SlamfHaplotype 1

SlamfHaplotype 2

Sle1bSlamf2-/- [B6.129]

Slamf1/- [B6.129]

1.2598.8

72.627.4

1.0399

93.66.42

0.7199.3

7129

84.415.6

0.399.7

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S3

Page 5: Slamf1 -/-  [ BALB/c.129]

CD4-PE+

PNA-FITC

CD4-PE+

B220-FITC

wt BALB/c

Slamf2-/- [BALB/c.129]

Slamf1-/- [BALB/c.129]

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S4

Page 6: Slamf1 -/-  [ BALB/c.129]

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S5A

p < 0.001

3 months 6 months

Slamf2-/- [B6.129]

Slamf2-/- [B6.129]

B6 B6

Page 7: Slamf1 -/-  [ BALB/c.129]

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S5B

3 months 6 months

Slamf2-/- [B6.129]

Slamf2-/- [B6.129]

B6 B6

Page 8: Slamf1 -/-  [ BALB/c.129]

B6.129chr1b (26)

B6.Sle1b (13)

129/NZW allele

B6 allele

Slamf2-/- [B6.129]

recombinant region

10Mb

Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S6