Lupus criteria

• For the purpose of identifying patients in clinical studies, a person has SLE if 4 or more of the 11 criteria are present, serially or simultaneously, during any interval of observation.

• It is important to remember that a patient may have SLE and not have 4 criteria.

Lupus criteria (pneumonic)

M D S O A P B R A I N

Lupus criteria (pneumonic)

MD

S

O

A

P

B

R

A

I

N

Malarrash

Malarrash

Lupus criteria (pneumonic)

M

DS

O

A

P

B

R

A

I

N

Discoidrash

Discoidrash

Discoidrash

Lupus criteria (pneumonic)

M

D

SO

A

P

B

R

A

I

N

Lupus criteria (pneumonic)

Serositis

• Pleuritis, pleural effusion

• Pericarditis, pericardial effusion

• Ascites

Lupus criteria (pneumonic)

M

D

S

OA

P

B

R

A

I

N

Oralulcers

Lupus criteria (pneumonic)

M

D

S

O

AP

B

R

A

I

N

Arthritis (with swelling)

Arthritis (Jaccoud’s)

Lupus criteria (pneumonic)

M

D

S

O

A

P

B

R

A

I

N

Photosensitivity

Lupus criteria (pneumonic)

M

D

S

O

A

P

BR

A

I

N

Blood abnormalities

• Leukocytopenia (< 4000 on 2 + occasions)

• Lymphopenia (< 1500 on 2 + occasions)

• Hemolytic anemia

• Thrombocytopenia (<100, 000)

Lupus criteria (pneumonic)

M

D

S

O

A

P

B

RA

I

N

Renal: A) Proteinuria (>500 mg/24hrs)B) Cellular casts

Lupus criteria (pneumonic)

M

D

S

O

A

P

B

R

AI

N

Anti-nuclear antibodies (ANA)Rim

Nucleolar

Diffuse

Speckled

Lupus pneumonic (criteria)

M

D

S

O

A

P

B

R

A

IN

Immune abnormalities

• Smith antibody

• Anti-ds DNA antibody

• Anti-phospholipid antibody (1997 modification)

• Anti-cardiolipin antibody (IgG or IgM)

• Biologic false positive VDRL (> 6 months)

• Lupus anticoagulant

Lupus criteria (pneumonic)

M

D

S

O

A

P

B

R

A

I

N

Neurologic: A) Seizure B) Psychosis

Lupus criteria (pneumonic)

Malar rash

Discoid lupus

Serositis

Oral ulcers

Arthritis

Photosensitivity

Blood abnormalities

Renal

ANA

Immune

Neurologic