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that patients with ADHD display is not so much a problem of the simple inhibition of a prepotent response (response inhibition in the No-Go Task). The problem with response inhibition becomes manifested especially when a Go response is to be negatively effected and downregulateddue to the existence of negative contextual cues (e.g. the red No-Go stimulus) in the environment. Reference Karakas, S., et al., 2006. A multidiciplinary and multitechnological approach to attention decit hyperactivity disorder. (Project 2006K-120-640-06-08 funded by Hacettepe University, Center for Scientic Studies, Ankara, Turkey). doi:10.1016/j.ijpsycho.2008.05.274 How manic phase affects performance on neuropsychological tests? A. Doruk, N. Yazihan Torun, A. Balikci Gьlhane Military Medical Academy, Faculty of Medicine, Department of Psychiatry, Ankara, Turkey Previous studies indicate that mania affects ones' ability to concentrate, reason, remember, and think. The extent and nature of these changes are less clear. The aim of this study was to investigate the cognitive characteristics of patients who are in the manic phase and compare them to those who are in the euthymic phase. The diagnosis of Bipolar I disorder and manic episode were made using SCID-I (according to DSM-IV). The sample consisted of 32 males, 16 of which were in the manic phase at the time of testing (the mean of Young Mania Scale score: 28.77), sixteen have been in the euthymic phase for minimal 3 months (Hamilton Depression Scale score: 5.09, Young Mania Scale: 4.0). The manic group had a mean age of 24.12 years (2034); euthymic group 25.93 years (2040). The mean years of education completed were 11.75 years (817) for the manic group and 12.87 years (816) for the euthymic group. Cognitive functions were measured through 53 scores that the following tests yielded: Stroop Test TBAG Form (ST); Verbal and Nonverbal Cancellation Tests (CT), Serial Digit Learning Test (SDLT), Auditory Verbal Learning Test (AVLT). Data were analysed using One- Way Multivariate Analysis of Covariance (MANCOVA), where age was used as the covariate. The effect of group variablewas found to be signicant (Wilks lambda: F (1, 29) = 248.469, p = .05). The effect was obtained for the completion time for the 4 subtests of STP and the 4 subtests of CT; SDLT score; number of correct and incorrect responses in subtests of CT; learning and free recall, immediate recall, delayed recall and retroactive interference scores in AVLT. The patients in the manic phase had a slower psychomotor speed (they completed the STP and CT tasks in longer times), lower learning capacity (they had lower scores on SDLT and AVLT), lower performance on different types of memory (lower performance on immediate memory and delayed memory). A controlled study such as the present one should be replicated in the future using a larger sample of participants in the manic and euthymic phases. doi:10.1016/j.ijpsycho.2008.05.275 Slow oscillatory responses to tactile stimuli A. Oniz, C. Guducu, B. Aydin, M. Ozgoren Dokuz Eylul University, Faculty of Medicine, Biophysics Department, Izmir, Turkey The objective of this study was to investigate the delta and theta oscillatory responses to tactile stimuli by using oddball paradigm. The measurements were performed with eighteen sub- jects (21.39±2.75 ages; 12 male). Single type of tactile stimuli was applied to two ngers on the right hand: frequent (non-target) tactile stimuli and targets. The target (25%) stimuli were presented on index nger and non-target stimuli (75%) were presented on middle nger randomly. Subjects counted the target stimuli mental- ly. The electroencephalogram (EEG) was recorded from 64 chan- nels,14 of which (F3, F4, FZ, CZ, C3, C4, T7, T8, P3, P4, P7, P8, O1, O2) were primarily analyzed. Peak-to-peak maximum amplitudes and prolongations of delta (0.53.5 Hz) and theta (47 Hz) were measured in 1000 ms following stimuli. The repeated measures ANOVA test was used for statistical analysis. In this present study, increases in delta (0.53.5 Hz) responses in distributed scalp locations and theta in parietal areas were observed. Delta responses to target stimuli were higher than to non-target stimuli at F3, F4, FZ, CZ, C3, T7, P3, P4, P7, P8 and O2 recording sites (p b 0.05, for each comparison). Furthermore, theta responses to target stimuli were higher than to non-target stimuli at P4, P7, and P8 (p b 0.05, for each comparison). In this tactile oddball paradigm, delta responses to the both stimuli were highly distributed on the scalp. Conse- quently, delta and theta oscillations have been differentiated for the target and non-target stimuli and the results point to working memory during oddball paradigm. The relative simplicity of the paradigm as well as its non-invasiveness can enable further clinical applications. doi:10.1016/j.ijpsycho.2008.05.276 Modied MMN and Dichotic Listening paradigm applied in schizophrenia patients A. Oniz a , M. Ozgoren a , S. Taslica a , C. Guducu a , A. Aktener b , B. Akdede b , K. Alptekin b a Dokuz Eylul University, Faculty of Medicine, Department of Biophysics, Izmir, Turkey b Dokuz Eylul University, Faculty of Medicine, Department of Psychiatry, Izmir, Turkey The research studies aiming to elucidate the cognitive functions both in healthy individuals and pathologies require adaptation of various new paradigms. Incorporating these experimental setups into a reliable measurement design would be of greater importance for especially the clinical applications. Accordingly, in our laboratory we utilized such a paradigm that presents a modied MMN and Dichotic Listening (DL). Recently, the mismatch negativity has attracted a number of scientists in the clinical research area. Furthermore, in schizophrenia patients, sensitivity to assess the electrophysiological abnormality both in early and later stages of the disease was addressed. Additionally, the DL paradigm has a proven value for the schizophrenia. Therefore a battery of electrophysiological tests was constituted for obtaining optimal recording parameters and make use of cross-domain data to elucidate possible mechanisms from different features. Fifteen patients (age 2349 years, mean 34.1) with schizophrenia (DSM-IV criteria)/15 healthy control subjects (age 2248 years, mean age 30.2) for the DL and 12 patients (age mean 35.2)/12 healthy control subjects (mean age 30.8) were recruited and underwent 64-channel EEG recording. The stimuli consisted of auditory stimuli with duration, intensity, frequency and location deviants for the MMN and Dichotic Syllables (CV) for the DL. The preliminary MMN analysis revealed frequency and duration devia- tions to be decreased in schizophrenia patients in comparison 293 Posters session 3 / International Journal of Psychophysiology 69 (2008) 276316

Slow oscillatory responses to tactile stimuli

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that patients with ADHD display is not so much a problem of the simpleinhibition of a prepotent response (response inhibition in the No-GoTask). The problem with response inhibition becomes manifestedespecially when a Go response is to be negatively effected and“downregulated” due to the existence of negative contextual cues (e.g.the red No-Go stimulus) in the environment.

Reference

Karakas, S., et al., 2006. Amultidiciplinary andmultitechnological approach to attentiondeficit hyperactivity disorder. (Project 2006K-120-640-06-08 funded by HacettepeUniversity, Center for Scientific Studies, Ankara, Turkey).

doi:10.1016/j.ijpsycho.2008.05.274

How manic phase affects performance on neuropsychologicaltests?

A. Doruk, N. Yazihan Torun, A. BalikciGьlhane Military Medical Academy, Faculty of Medicine,Department of Psychiatry, Ankara, Turkey

Previous studies indicate that mania affects ones' ability toconcentrate, reason, remember, and think. The extent and nature ofthese changes are less clear.

The aim of this study was to investigate the cognitive characteristicsof patients who are in themanic phase and compare them to thosewhoare in the euthymic phase. The diagnosis of Bipolar I disorder andmanicepisode were made using SCID-I (according to DSM-IV). The sampleconsisted of 32males,16 ofwhichwere in themanic phase at the time oftesting (themean of YoungMania Scale score: 28.77), sixteen have beenin theeuthymicphase forminimal 3months (HamiltonDepressionScalescore: 5.09, YoungMania Scale: 4.0). Themanic group had amean age of24.12 years (20–34); euthymic group 25.93 years (20–40). The meanyears of education completed were 11.75 years (8–17) for the manicgroup and 12.87 years (8–16) for the euthymic group.

Cognitive functions were measured through 53 scores that thefollowing tests yielded: Stroop Test TBAG Form (ST); Verbal andNonverbal Cancellation Tests (CT), Serial Digit Learning Test (SDLT),Auditory Verbal Learning Test (AVLT). Data were analysed using One-Way Multivariate Analysis of Covariance (MANCOVA), where age wasused as the covariate. The effect of “group variable” was found to besignificant (Wilks lambda: F(1, 29)=248.469, p= .05).

The effect was obtained for the completion time for the 4 subtestsof STP and the 4 subtests of CT; SDLT score; number of correct andincorrect responses in subtests of CT; learning and free recall,immediate recall, delayed recall and retroactive interference scoresin AVLT. The patients in the manic phase had a slower psychomotorspeed (they completed the STP and CT tasks in longer times), lowerlearning capacity (they had lower scores on SDLT and AVLT), lowerperformance on different types of memory (lower performance onimmediate memory and delayed memory).

A controlled study such as the present one should be replicatedin the future using a larger sample of participants in the manic andeuthymic phases.

doi:10.1016/j.ijpsycho.2008.05.275

Slow oscillatory responses to tactile stimuli

A. Oniz, C. Guducu, B. Aydin, M. OzgorenDokuz Eylul University, Faculty of Medicine, Biophysics Department,Izmir, Turkey

The objective of this study was to investigate the delta andtheta oscillatory responses to tactile stimuli by using oddballparadigm. The measurements were performed with eighteen sub-jects (21.39±2.75 ages; 12 male). Single type of tactile stimuli wasapplied to two fingers on the right hand: frequent (non-target)tactile stimuli and targets. The target (25%) stimuli were presentedon index finger and non-target stimuli (75%) were presented onmiddle finger randomly. Subjects counted the target stimuli mental-ly. The electroencephalogram (EEG) was recorded from 64 chan-nels, 14 of which (F3, F4, FZ, CZ, C3, C4, T7, T8, P3, P4, P7, P8, O1, O2)were primarily analyzed. Peak-to-peak maximum amplitudesand prolongations of delta (0.5–3.5 Hz) and theta (4–7 Hz) weremeasured in 1000 ms following stimuli. The repeated measuresANOVA test was used for statistical analysis. In this present study,increases in delta (0.5–3.5 Hz) responses in distributed scalplocations and theta in parietal areas were observed. Delta responsesto target stimuli were higher than to non-target stimuli at F3, F4,FZ, CZ, C3, T7, P3, P4, P7, P8 and O2 recording sites (pb0.05, foreach comparison). Furthermore, theta responses to target stimuliwere higher than to non-target stimuli at P4, P7, and P8 (pb0.05, foreach comparison). In this tactile oddball paradigm, delta responsesto the both stimuli were highly distributed on the scalp. Conse-quently, delta and theta oscillations have been differentiated for thetarget and non-target stimuli and the results point to workingmemory during oddball paradigm. The relative simplicity of theparadigm as well as its non-invasiveness can enable further clinicalapplications.

doi:10.1016/j.ijpsycho.2008.05.276

Modified MMN and Dichotic Listening paradigm applied inschizophrenia patients

A. Oniza, M. Ozgorena, S. Taslicaa, C. Guducua, A. Aktenerb,B. Akdedeb, K. Alptekinb

a Dokuz Eylul University, Faculty of Medicine, Department of Biophysics,Izmir, TurkeybDokuz Eylul University, Faculty of Medicine, Department of Psychiatry,

Izmir, Turkey

The research studies aiming to elucidate the cognitive functionsboth in healthy individuals and pathologies require adaptation ofvarious new paradigms. Incorporating these experimental setups intoa reliable measurement design would be of greater importance forespecially the clinical applications. Accordingly, in our laboratory weutilized such a paradigm that presents a modified MMN and DichoticListening (DL). Recently, the mismatch negativity has attracted anumber of scientists in the clinical research area. Furthermore, inschizophrenia patients, sensitivity to assess the electrophysiologicalabnormality both in early and later stages of the disease wasaddressed. Additionally, the DL paradigm has a proven value for theschizophrenia. Therefore a battery of electrophysiological tests wasconstituted for obtaining optimal recording parameters and make useof cross-domain data to elucidate possible mechanisms from differentfeatures.

Fifteen patients (age 23–49 years, mean 34.1) with schizophrenia(DSM-IV criteria)/15 healthy control subjects (age 22–48 years,mean age 30.2) for the DL and 12 patients (age mean 35.2)/12healthy control subjects (mean age 30.8) were recruited andunderwent 64-channel EEG recording. The stimuli consisted ofauditory stimuli with duration, intensity, frequency and locationdeviants for the MMN and Dichotic Syllables (CV) for the DL. Thepreliminary MMN analysis revealed frequency and duration devia-tions to be decreased in schizophrenia patients in comparison

293Posters session 3 / International Journal of Psychophysiology 69 (2008) 276–316