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Melbourne • Shanghai • San Diego • Cambridge
SYNlibrary Kinome Hosted by
Compound Cloud
The SYNlibrary Kinome Kinase Inhibitor Library contains 187 kinase inhibitors recognising
more than 130 kinase targets. This library provides excellent coverage of the human kinome
and is a great kinome mapping tool.
SDF file can be downloaded from: https://goo.gl/jfWDaG
Format
Supplied in one 384-well v-bottom polypropylene plate.
Each well contains 2uL of 2mM Inhibitor in 100% DMSO.
Can be reformatted to different volumes/concentrations or plate types/layouts for an
additional fee.
Melbourne • Shanghai • San Diego • Cambridge
Kinome Mapping – Main Inhibitor Activity
1 10 100 1000 10000 1000002 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9
IC50 (nM)
J AK1~b
J AK2~b
TYK2~b
J AK3~b
Lmr1
Lmr2
Lmr3
TYK2
J AK1J AK2J AK3
AC K TN K1
H ER3
H ER4EGFR
H ER2
TIE1TIE2
PDGFRαPDGFRβ
FLT3
FMSKIT
VEGFR1VEGFR2
FLT4
RETFGFR4
FGFR1
FGFR2
FGFR3
RYK
RON
MET
Axl Mer
Sk y
ROR1 ROR2
C C K4
Trk CTrk B
Trk A
MUSK
DDR1DDR2
InsRIGF1R
IRR
ROS
ALK
LTK
FAKPYK2
Syk
Zap70
SURTK106
FES
FER
Abl2
Abl
C TK
C SK
BTKEtk
TEC
TXK
ITK
Brk
Srm
FRK
BLK
Lc k
H C KLyn
Fgr
Fyn
Src Yes
EphB1
EphB2
EphB3
EphB4
EphA5 EphA3
EphA4
EphA6
EphA7
EphA8
EphA2
EphA1
EphA6
EphA10
TK
TKL
ALK4
TGFβR1
ALK7
BMPR1A
BMPR1B
ALK1
ALK2AC TR2
AC TR2B
TGFβR2MISR2
BMPR2KSR2
KSR
ARafC Raf
BRaf
MLK3
MLK1
MLK4
MLK2
DLK
LZK
ZAK
ILK
TAK1
H H 498
LIMK1
LIMK2
TESK1
TESK2RIPK1
RIPK3
RIPK2
AN KRD3
SgK288
LRRK1
LRRK2
IRAK4
IRAK2
IRAK3
IRAK1
PBK
SgK496
MOS
MLKL
STE
MAP2K5
MAP2K7
MKK3
MKK6 MAP2K4
MEK1
MEK2
GC N 2~b
N IKTpl2
PAK6
PAK5
PAK4
PAK1
PAK3
PAK2
MEKK1
MAP3K4
MAP3K8
MEKK2
MEKK3 ASK1
MAP3K7
MEKK6
SLKLOK
OSR1
STLK3
STRAD
STLK6
TAO1
TAO2
TAO3
MYO3A
MYO3B
N RK
TN IKMIN K
H GK
YSK1
MST4MST3
MST1
MST2
H PK1
GC K
KH S2
KH S1
ASK3
VRK2
VRK1
VRK3
Bub1
BubR1
PRPK
Wee1Wee1B
MYT1
C K1δC K1ε
C K1α1C Kaα2
C K1γ2
C K1γ1C K1γ3
TTBK1TTBK2
CK1
PKCβ PKCα
PKCγ
PKCη
PKCε
PKCθ
PKCδ
PKCζ
PKCι
PKN 1
PKN 2
SGK1SGK3
SGK2 Ak t3
Ak t2
Ak t1
MSK1
MSK2
P70S6K
P70S6Kβ
RSK3
RSK4
RSK2
RSK1
RSKL1
RSKL2
SGK494
PDK1
GRK7
BARK1
BARK2
RH ODK
GRK6
GRK4GRK5
PRKYPRKX
PKAγ
PKAαPKAβ
YAN K1
YAN K2YAN K3
AurA
AurBAurC
MASTL
MAST3
MAST2
MAST1MAST4
LATS2
LATS1
N DR1
N DR2
C RIKROC K2
ROC K1
DMPKDMPK2
MRC Kα
MRC Kβ
PKG1PKG2
AGC
PKN 3
C aMKIδ
C aMKIγC AMKIIβ
C AMKIα
C aMKIν
VAC AMKL
PSKH 1
PSKH 2
DC AMKL3
DC AMKL1
DC AMKL2
C hk 2
C ASK
PH Kγ1
PH Kγ2
C aMKIIα
C aMKIIγ
C aMKIIδ
C aMKIIβ
MN K1
MN K2
MAPKAPK5
MAPKAPK2
MAPKAPK3
RSK2~b RSK3~b
MSK2~b
MSK1~bRSK4~b
RSK1~b
PDK1
PDK3
PDK2
Pim1
Pim2
Pim3
SGK495
Trb3
Trb2Trb1
Tr io
Trad
Obsc n~b
SPEG~b
OBSC N
SPEG
TTN
smMLC K
SKMLC K
SGK085
C aMLC K
DRAK2
DRAK1
DAKP1
DAPK3
DAPK2
TSSK4SSTK
TSSK3TSSK1
TSSK2
H UN KSN RK
N IM1MELK
N uaK2
N uaK1
QSKSIK
QIK
MARK4
MARK3
MARK1
MARK2
AMPKα2AMPKα1
BRSK1BRSK2
C hk 1
CAMK
CGMC
C K2a1
C K2a2
PRP4
DYRK3
DYRK4
DYRK2
DYRK1A
DYRK1B
H IPK4
H IPK3
H IPK1
H IPK2
SRPK1
SRPK2
MSSK1
C LK2
C LK3C LK1
C LK4
C DKL3C DKL2
C DKL1
C DKL4
C DKL5
GSK3αGSK3β
MAKIC K
MOK
ERK7
ERK3ERK4
N LKERK5
ERK1ERK2
p38γ
p38δ
p38α
p38β
J N K1
J N K2
J N K3
C DK8
C DK11
C C RK C DK9
C RK7
C H ED
C DK7
C DK9
C DK10
C DK4
C DK6
C DK5
C DK1
C DK3
C DK2
PFTAIRE2
PFTAIRE1
PC TAIRE2
PC TAIRE1
PC TAIRE3
Other
H SER
AN Pα
AN Pβ
GUC Y2DGUC Y2F
SGK307
SGK424
N ek 1
N ek 5N ek 3N ek 4N ek 11N ek 9
N ek 2
N ek 8
N ek 7
N ek 6
N ek 10
SC YL2
SC YL1SC YL3
ULK3
ULK4Fused
ULK2
ULK1
PLK3
PLK1
PLK2
PLK4
TLK1
TLK2
PERK
PRK
GC N
H RI
TBC KSBK
SgK110
SgK069
IKKα
IKKβ
IKKε
TBK1
PIN K1
SgK269
SGK223
C DC 7
PIK3R4
BIKEAAK1GAK
MPSK1
N RBP1N RBP2
W N K4 W N K2
W N K3
W N K1
Slob
C AMKK1
C AMKK2
H asp in
PI4B
TIF1β
TIF1γ
TIF1α
RIOK3
RIOK1
RIOK2
mTOR
SMG1
DNAPK
TRRAPBrdT
Brd4
Brd3
Brd2
PCKDK
PDHK4
PDHK1
PDHK3
PDHK2
ChaK1
ChaK2
AlphaK3
EEF2K
AlphaK2
AlphaK1
ADCK1
ADCK5
ADCK3 ADCK4
ADCK2
ABC1
TIF1
RIO
ALPHA
PDHK
Brd
PIKK
PIKfyveATR
ATM
PI4K2A
PI4K2B
PI4KAP2
PI4KA
PI3KC2γ
PI3KC2α
PI3KC2β
PI3Kγ
PI3Kα
PI3Kδ
PI3KβPI3KC3
Melbourne • Shanghai • San Diego • Cambridge
Compound Table
Code Name Alt. Name CAS No.
SYN-1002 Linifanib ABT-869, AL-39324, RG3635
796967-16-3
SYN-1003 Quizartinib AC220 950769-58-1
SYN-1004 AG13958 AG13958 319460-94-1
SYN-1005 Akt-I-1 Akt-I-1,AktI1 473382-39-7
SYN-1006 Akt-I-1,2 HCl Akt-I-1,2 HCl 473382-50-2
SYN-1008 AMG-Tie2-1 AMG-Tie2-1 870223-96-4
SYN-1009 AS-252424 AS252424 900515-16-4
SYN-1010 AT-7519 HCl AT-7519 HCl 902135-91-5
SYN-1011 AT9283 AT9283 896466-04-9
SYN-1012 AV-412 MP412, AV412, MP-412 451492-95-8
SYN-1013 Tivozanib Tivozanib, AV-951 475108-18-0
SYN-1014 Axitinib AG013736 319460-85-0
SYN-1017 AZD7762 HCl AZD7762 HCl 1246094-78-9
SYN-1018 BEZ-235 NVP-BEZ235, BEZ235 915019-65-7
SYN-1019 (R)-BI-2536 (R)-BI-2536 755038-02-9
SYN-1020 BI-D1870 BID1870 501437-28-1
SYN-1021 Bisindoylmaleimide X HCl
RO 31-8425 145317-11-9
SYN-1022 BMS-2 BMS2 888719-03-7
SYN-1024 BMS-5 BMS5 1338247-35-0
SYN-1025 Bosutinib SKI-606 380843-75-4
SYN-1028 CC-401 HCl CC401 1438391-30-0
SYN-1031 CI-1040 PD184352, CI1040 212631-79-3
SYN-1032 Tofacitinib CP690550 - Xeljanz 477600-75-2
SYN-1033 CP-724714 CP724714 383432-38-0
SYN-1034 CYC116 CYC116 693228-63-6
SYN-1035 Momelotinib CYT387, Momelotinib 1056634-68-4
SYN-1036 Dasatinib BMS-354825, Sprycel 302962-49-8
SYN-1037 Dianilinopyrimidine_01 CZC8004 916603-07-1
SYN-1038 E7080 E7080 417716-92-8
SYN-1039 Erlotinib HCl OSI774, CP-358774, Tarceva, NSC718781
183319-69-9
SYN-1041 GDC-0941 GDC0941 957054-30-7
SYN-1042 Gefitinib ZD1839, Iressa 184475-35-2
SYN-1043 GSK-690693 GSK690693 937174-76-0
SYN-1044 GW441756 GW441756 504433-23-2
SYN-1045 IC87114 IC87114 371242-69-2
SYN-1046 Imatinib mesylate CGP54148, ST1571, Gleevec,Glivec,Imatinib mesylate
220127-57-1
SYN-1048 JNJ-7706621 JNJ7706621 443797-96-4
SYN-1052 Lapatinib GW-572016, Tykerb 231277-92-2
SYN-1053 Masatinib AB1010, Masivet 790299-79-5
SYN-1055 Motesanib AMG706 453562-69-1
Melbourne • Shanghai • San Diego • Cambridge
SYN-1056 Amuvatinib MP-470 850879-09-3
SYN-1059 PD0325901 PD0325901 391210-10-9
SYN-1060 PF04217903 PF04217903 956905-27-4
SYN-1061 PD173955 PD173955 260415-63-2
SYN-1062 PD173955-Analog1 PD-173955-Analog1 185039-99-0
SYN-1063 PF431396 PF431396 717906-29-1
SYN-1064 PF-562271 PF562271 717907-75-0
SYN-1065 PI103 PI103 371935-74-9
SYN-1066 PIK-93 PIK93 593960-11-3
SYN-1067 PIK-75 PIK75 372196-67-3
SYN-1068 PIK-90 PIK90 677338-12-4
SYN-1069 PLX4720 PLX4720 918505-84-7
SYN-1070 Purvalanol B NG95 212844-54-7
SYN-1071 GSK429286A GSK429286A, RHO-15 864082-47-3
SYN-1072 RWJ-67657 RWJ67657 215303-72-3
SYN-1073 SB202190 SB202190 152121-30-7
SYN-1073A SB202190 HCl SB202190 HCl 350228-36-3
SYN-1074 SB203580 RWJ 64809, PB 203580 152121-47-6
SYN-1075 SB-216763 SB216763 280744-09-4
SYN-1076 SB-242235 SB242235 193746-75-7
SYN-1077 SB590885 SB590885 405554-55-4
SYN-1078 SD-06 SD06 271576-80-8
SYN-1079 SD169 SD169 1670-87-7
SYN-1081 SNS-314 SNS314 1057249-41-8
SYN-1083 SR3677 SR3677 1072959-67-1
SYN-1086 Sunitinib malate SU11248 341031-54-7
SYN-1087 TAK-715 TAK715 303162-79-0
SYN-1089 TGX221 TGX-221 663619-89-4
SYN-1090 Vandetanib ZD6474, Zactima, Vandetanib
443913-73-3
SYN-1091 Intedanib Intedanib,BIBF 1120, Vargatef
656247-17-5
SYN-1092 Tozasertib MK-0457, VX-680 639089-54-6
SYN-1094 YM201636 HCl YM201636 371942-69-7 (free base)
SYN-1095 Danusertib PHA-739358 827318-97-8
SYN-1098 PIK-294 PIK294 900185-02-6
SYN-1099 ZSTK474 ZSTK474 475110-96-4
SYN-1100 Afatinib Tovok, BIBW-2992 439081-18-2
SYN-1103 TG101209 TG101209 936091-14-4
SYN-1104 TG101348 SAR-302503 936091-26-8
SYN-1105 TG100115 TG100115 677297-51-7
SYN-1107 TG-89 TG89 936091-56-4
SYN-1108 LY294002 LY294002 154447-36-6
SYN-1109 CX-4945 CX4945 1009820-21-6
SYN-1110 A-674563 HCl A674563 552325-73-2 (free base)
SYN-1111 AMG-51 AMG51 890019-63-3
Melbourne • Shanghai • San Diego • Cambridge
SYN-1112 Mubritinib TAK-165 366017-09-6
SYN-1113 SMI-4a SMI4a 438190-29-5
SYN-1114 GNE-490 GNE490 1033739-92-2
SYN-1115 GNE-493 GNE493 1033735-94-2
SYN-1116 Ponatinib AP24534 943319-70-8
SYN-1117 Baricitinib phosphate LY3009104, INCB-28050 1187595-84-1
SYN-1119 S-99 S99 1124381-69-6
SYN-1120 Ruxolitinib INCB018424 941678-49-5
SYN-1121 R406 R406 841290-80-0
SYN-1122 R788 disodium Fostamatinib, FosD, tamatinib fosdium, R788
1025687-58-4
SYN-1123 VX745 VX745 209410-46-8
SYN-1124 GSK-25 GSK25 874119-56-9
SYN-1125 AMG-25 AMG25 1003311-62-3
SYN-1126 GSK2126458 HYR-582 1086062-66-9
SYN-1128 RO495 RO495 1258296-60-4
SYN-1129 Foretinib GSK1363089, Foretinib, EXEL-2880, XL880
849217-64-7
SYN-1131 R428 R428 1037624-75-1
SYN-1132 S6K-18 S6K18 1265789-88-5
SYN-1133 JNJ-38158471 JNJ38158471 951151-97-6
SYN-1136 NVP-BSK805 2HCl NVP-BSK805, BSK-805 1092499-93-8
SYN-1137 XL765 SAR245409 1349796-36-6
SYN-1138 Cabozantinib XL184, BMS-907351 849217-68-1
SYN-1139 Crizotinib PF-02341066 877399-52-5
SYN-1140 Neratinib HKI-272 698387-09-6
SYN-1141 Pelitinib EKB-569 257933-82-7
SYN-1142 BMS-599626 AC480, BMS599626, AC-480
714971-09-2
SYN-1143 AMG-1 AMG1 913376-84-8
SYN-1145 NIBR-17 NIBR17 944396-88-7
SYN-1146 CH5132799 CH5132799 1007207-67-1
SYN-1147 Bentamapimod Bentamapimod, AS-602801 848344-36-5
SYN-1148 GNE 477 GNE 477 1032754-81-6
SYN-1149 MK-2461 MK2461 917879-39-1
SYN-1150 RG7422 RG7422, GDC0980 1032754-93-0
SYN-1152 NVP-BGJ398 NVP-BGJ398, BGJ-398 872511-34-7
SYN-1153 TAK-285 TAK285 871026-44-7
SYN-1155 SGX523 SGX523 1072116-01-8
SYN-1157 MLN0128 MLN0128, INK-128 1224844-38-5
SYN-1158 GLPG0634 GLPG0634 1206161-97-8
SYN-1159 TAE684 TAE684, NVP-TAE684 761439-42-3
SYN-1160 AZD-26 AZD26 1357158-81-6
SYN-1161 PLX4032 Vemurafenib, RG7204, Zelboraf, RO5185426
918504-65-1
SYN-1162 MK-2206 2HCl MK-2206 2HCl 1032350-13-2
SYN-1163 PF4618433 PF-4618433 1166393-85-6
SYN-1164 GCI1746 G-182 910232-84-7
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SYN-1165 SAR131675 SAR131675 1092539-44-0
SYN-1166 AZD8055 CCG 168 1009298-09-2
SYN-1167 AZD2014 AZD2014 1009298-59-2
SYN-1168 Takeda-6d Takeda-6d 1125632-93-0
SYN-1169 Regorafenib BAY 73-4506 755037-03-7
SYN-1170 GSK1120212 JTP-74057, GSK212, Trametinib
871700-17-3
SYN-1171 Ibrutinib PCI-32765 936563-96-1
SYN-1172 Ruboxistaurin HCl LY333531 169939-93-9
SYN-1173 SCH 900776 SCH 900776 891494-63-6
SYN-1174 PF0477736 PF0477736 952021-60-2
SYN-1175 IPI 145 IPI 145 1201438-56-3
SYN-1176 PD-0173074 PD0173074 219580-11-7
SYN-1177 PF-04708671 PF04708671 1255517-76-0
SYN-1178 BGT-226 maleate BGT226 1245537-68-1
SYN-1179 Bafetinib NS-187, INNO-406 859212-16-1
SYN-1180 Palbociclib 2HCl PD-0332991 571189-11-2
SYN-1180A Palbociclib Isethionate PD-0332991 827022-33-3
SYN-1181 PP242 PP242 1092351-67-1
SYN-1182 CX6258 CX6258 1202916-90-2
SYN-1183 GNF-5837 GNF5837 1033769-28-6
SYN-1185 Rapamycin Sirolimus - AY-22989 - WY-090217
53123-88-9
SYN-1186 XL388 XL388 1251156-08-7
SYN-1187 MPI0479605 HCl MPI0479605 1246529-32-7 (free base)
SYN-1188 CH4987655 CH4987655 874101-00-5
SYN-1189 SAR020106 SAR020106 1184843-57-9
SYN-1190 AS703026 AS703026 1236699-92-5
SYN-1191 XL019 XL019 945750-13-0
SYN-1193 SGI-1776 SGI1776 1025065-69-3
SYN-1194 PF-04979064 PF04979064 1220699-06-8
SYN-1195 AZD8330 AZD8330 1204531-17-8
SYN-1196 LY2784544 LY2784544 1229236-86-5
SYN-1197 BLZ-945 BLZ945 953769-46-5
SYN-1198 GDC-046 GDC046 1258292-64-6
SYN-1199 LDK378 LDK378 1032900-25-6
SYN-1200 BKM120 BKM120 944396-07-0
SYN-1201 GSK2606414 GSK2606414 1337531-36-8
SYN-1202 GDC-0032 GDC0032 1282512-48-4
SYN-1203 TAK632 TAK632 1228591-30-7
SYN-1205 KW-2449 HCl KW2449 1038395-65-1
SYN-1207 CFI-400437 N/A N/A
SYN-1208 TASP0415914 TASP0415914 1292300-75-4
SYN-1210 AST-487 NVP-AST 487, AST487 630124-46-8
SYN-1211 URMC-099 URMC099 1229582-33-5
SYN-1212 SP2509 SP2509, SP-2509 1423715-09-6
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SYN-1213 LEE011 LEE-011 1211441-98-3
SYN-1214 AZD1208 AZD-1208 1204144-28-4
SYN-1215 GW806742X GW806742X, AC1NS7PT, AGN-PC-0LQ49Y
N/A
SYN-1216 CCT244747 CCT244747 1404095-34-6
SYN-1217 S49076 HCl S-49076 1265965-19-2
SYN-1219 GSK-A1 GSKA1 1416334-69-4
SYN-1220 GSK-F1 GSKF1 1402345-92-9
SYN-1221 H1152 H-1152 871543-07-6
SYN-1222 LY2801653 LY-2801653 1206799-15-6
SYN-1225 BBT594 NVP-BBT594 882405-89-2
SYN-1226 BGG463 NVP-BGG463 890129-26-7
SYN-1227 MBP146-78 MBP146-78 188343-77-3
SYN-1228 BIX02565 BIX-02565 1311367-27-7
SYN-1229 Selonsertib Hydrochloride
Selonsertib, GS-4997 1448428-05-4
SYN-1230 Alpelisib BYL719 , NVP-BYL719 1217486-61-7
Shipping and Storage Temperature
Shipping:
SYNlibrary Kinome can be shipped anywhere within 3 weeks of a purchase order being
received under normal business conditions and is handed over to our carrier in a
36cmx36cmx36cm box containing dry ice to preserve the samples.
Storage:
-4°C: 1 Month
-80°C: 6 Months
Product Datasheet (Rev. 1.1)