7
Melbourne Shanghai San Diego Cambridge SYNlibrary Kinome Hosted by Compound Cloud The SYNlibrary Kinome Kinase Inhibitor Library contains 187 kinase inhibitors recognising more than 130 kinase targets. This library provides excellent coverage of the human kinome and is a great kinome mapping tool. SDF file can be downloaded from: https://goo.gl/jfWDaG Format Supplied in one 384-well v-bottom polypropylene plate. Each well contains 2uL of 2mM Inhibitor in 100% DMSO. Can be reformatted to different volumes/concentrations or plate types/layouts for an additional fee.

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Page 1: SYNlibrary Kinome Hosted by Compound Cloud - … · SYNlibrary Kinome Hosted by Compound Cloud ... Masivet 790299-79-5 SYN-1055 Motesanib AMG706 453562-69-1 . Melbourne • Shanghai

Melbourne • Shanghai • San Diego • Cambridge

SYNlibrary Kinome Hosted by

Compound Cloud

The SYNlibrary Kinome Kinase Inhibitor Library contains 187 kinase inhibitors recognising

more than 130 kinase targets. This library provides excellent coverage of the human kinome

and is a great kinome mapping tool.

SDF file can be downloaded from: https://goo.gl/jfWDaG

Format

Supplied in one 384-well v-bottom polypropylene plate.

Each well contains 2uL of 2mM Inhibitor in 100% DMSO.

Can be reformatted to different volumes/concentrations or plate types/layouts for an

additional fee.

Page 2: SYNlibrary Kinome Hosted by Compound Cloud - … · SYNlibrary Kinome Hosted by Compound Cloud ... Masivet 790299-79-5 SYN-1055 Motesanib AMG706 453562-69-1 . Melbourne • Shanghai

Melbourne • Shanghai • San Diego • Cambridge

Kinome Mapping – Main Inhibitor Activity

1 10 100 1000 10000 1000002 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9 2 3 4 5 6 7 8 9

IC50 (nM)

J AK1~b

J AK2~b

TYK2~b

J AK3~b

Lmr1

Lmr2

Lmr3

TYK2

J AK1J AK2J AK3

AC K TN K1

H ER3

H ER4EGFR

H ER2

TIE1TIE2

PDGFRαPDGFRβ

FLT3

FMSKIT

VEGFR1VEGFR2

FLT4

RETFGFR4

FGFR1

FGFR2

FGFR3

RYK

RON

MET

Axl Mer

Sk y

ROR1 ROR2

C C K4

Trk CTrk B

Trk A

MUSK

DDR1DDR2

InsRIGF1R

IRR

ROS

ALK

LTK

FAKPYK2

Syk

Zap70

SURTK106

FES

FER

Abl2

Abl

C TK

C SK

BTKEtk

TEC

TXK

ITK

Brk

Srm

FRK

BLK

Lc k

H C KLyn

Fgr

Fyn

Src Yes

EphB1

EphB2

EphB3

EphB4

EphA5 EphA3

EphA4

EphA6

EphA7

EphA8

EphA2

EphA1

EphA6

EphA10

TK

TKL

ALK4

TGFβR1

ALK7

BMPR1A

BMPR1B

ALK1

ALK2AC TR2

AC TR2B

TGFβR2MISR2

BMPR2KSR2

KSR

ARafC Raf

BRaf

MLK3

MLK1

MLK4

MLK2

DLK

LZK

ZAK

ILK

TAK1

H H 498

LIMK1

LIMK2

TESK1

TESK2RIPK1

RIPK3

RIPK2

AN KRD3

SgK288

LRRK1

LRRK2

IRAK4

IRAK2

IRAK3

IRAK1

PBK

SgK496

MOS

MLKL

STE

MAP2K5

MAP2K7

MKK3

MKK6 MAP2K4

MEK1

MEK2

GC N 2~b

N IKTpl2

PAK6

PAK5

PAK4

PAK1

PAK3

PAK2

MEKK1

MAP3K4

MAP3K8

MEKK2

MEKK3 ASK1

MAP3K7

MEKK6

SLKLOK

OSR1

STLK3

STRAD

STLK6

TAO1

TAO2

TAO3

MYO3A

MYO3B

N RK

TN IKMIN K

H GK

YSK1

MST4MST3

MST1

MST2

H PK1

GC K

KH S2

KH S1

ASK3

VRK2

VRK1

VRK3

Bub1

BubR1

PRPK

Wee1Wee1B

MYT1

C K1δC K1ε

C K1α1C Kaα2

C K1γ2

C K1γ1C K1γ3

TTBK1TTBK2

CK1

PKCβ PKCα

PKCγ

PKCη

PKCε

PKCθ

PKCδ

PKCζ

PKCι

PKN 1

PKN 2

SGK1SGK3

SGK2 Ak t3

Ak t2

Ak t1

MSK1

MSK2

P70S6K

P70S6Kβ

RSK3

RSK4

RSK2

RSK1

RSKL1

RSKL2

SGK494

PDK1

GRK7

BARK1

BARK2

RH ODK

GRK6

GRK4GRK5

PRKYPRKX

PKAγ

PKAαPKAβ

YAN K1

YAN K2YAN K3

AurA

AurBAurC

MASTL

MAST3

MAST2

MAST1MAST4

LATS2

LATS1

N DR1

N DR2

C RIKROC K2

ROC K1

DMPKDMPK2

MRC Kα

MRC Kβ

PKG1PKG2

AGC

PKN 3

C aMKIδ

C aMKIγC AMKIIβ

C AMKIα

C aMKIν

VAC AMKL

PSKH 1

PSKH 2

DC AMKL3

DC AMKL1

DC AMKL2

C hk 2

C ASK

PH Kγ1

PH Kγ2

C aMKIIα

C aMKIIγ

C aMKIIδ

C aMKIIβ

MN K1

MN K2

MAPKAPK5

MAPKAPK2

MAPKAPK3

RSK2~b RSK3~b

MSK2~b

MSK1~bRSK4~b

RSK1~b

PDK1

PDK3

PDK2

Pim1

Pim2

Pim3

SGK495

Trb3

Trb2Trb1

Tr io

Trad

Obsc n~b

SPEG~b

OBSC N

SPEG

TTN

smMLC K

SKMLC K

SGK085

C aMLC K

DRAK2

DRAK1

DAKP1

DAPK3

DAPK2

TSSK4SSTK

TSSK3TSSK1

TSSK2

H UN KSN RK

N IM1MELK

N uaK2

N uaK1

QSKSIK

QIK

MARK4

MARK3

MARK1

MARK2

AMPKα2AMPKα1

BRSK1BRSK2

C hk 1

CAMK

CGMC

C K2a1

C K2a2

PRP4

DYRK3

DYRK4

DYRK2

DYRK1A

DYRK1B

H IPK4

H IPK3

H IPK1

H IPK2

SRPK1

SRPK2

MSSK1

C LK2

C LK3C LK1

C LK4

C DKL3C DKL2

C DKL1

C DKL4

C DKL5

GSK3αGSK3β

MAKIC K

MOK

ERK7

ERK3ERK4

N LKERK5

ERK1ERK2

p38γ

p38δ

p38α

p38β

J N K1

J N K2

J N K3

C DK8

C DK11

C C RK C DK9

C RK7

C H ED

C DK7

C DK9

C DK10

C DK4

C DK6

C DK5

C DK1

C DK3

C DK2

PFTAIRE2

PFTAIRE1

PC TAIRE2

PC TAIRE1

PC TAIRE3

Other

H SER

AN Pα

AN Pβ

GUC Y2DGUC Y2F

SGK307

SGK424

N ek 1

N ek 5N ek 3N ek 4N ek 11N ek 9

N ek 2

N ek 8

N ek 7

N ek 6

N ek 10

SC YL2

SC YL1SC YL3

ULK3

ULK4Fused

ULK2

ULK1

PLK3

PLK1

PLK2

PLK4

TLK1

TLK2

PERK

PRK

GC N

H RI

TBC KSBK

SgK110

SgK069

IKKα

IKKβ

IKKε

TBK1

PIN K1

SgK269

SGK223

C DC 7

PIK3R4

BIKEAAK1GAK

MPSK1

N RBP1N RBP2

W N K4 W N K2

W N K3

W N K1

Slob

C AMKK1

C AMKK2

H asp in

PI4B

TIF1β

TIF1γ

TIF1α

RIOK3

RIOK1

RIOK2

mTOR

SMG1

DNAPK

TRRAPBrdT

Brd4

Brd3

Brd2

PCKDK

PDHK4

PDHK1

PDHK3

PDHK2

ChaK1

ChaK2

AlphaK3

EEF2K

AlphaK2

AlphaK1

ADCK1

ADCK5

ADCK3 ADCK4

ADCK2

ABC1

TIF1

RIO

ALPHA

PDHK

Brd

PIKK

PIKfyveATR

ATM

PI4K2A

PI4K2B

PI4KAP2

PI4KA

PI3KC2γ

PI3KC2α

PI3KC2β

PI3Kγ

PI3Kα

PI3Kδ

PI3KβPI3KC3

Page 3: SYNlibrary Kinome Hosted by Compound Cloud - … · SYNlibrary Kinome Hosted by Compound Cloud ... Masivet 790299-79-5 SYN-1055 Motesanib AMG706 453562-69-1 . Melbourne • Shanghai

Melbourne • Shanghai • San Diego • Cambridge

Compound Table

Code Name Alt. Name CAS No.

SYN-1002 Linifanib ABT-869, AL-39324, RG3635

796967-16-3

SYN-1003 Quizartinib AC220 950769-58-1

SYN-1004 AG13958 AG13958 319460-94-1

SYN-1005 Akt-I-1 Akt-I-1,AktI1 473382-39-7

SYN-1006 Akt-I-1,2 HCl Akt-I-1,2 HCl 473382-50-2

SYN-1008 AMG-Tie2-1 AMG-Tie2-1 870223-96-4

SYN-1009 AS-252424 AS252424 900515-16-4

SYN-1010 AT-7519 HCl AT-7519 HCl 902135-91-5

SYN-1011 AT9283 AT9283 896466-04-9

SYN-1012 AV-412 MP412, AV412, MP-412 451492-95-8

SYN-1013 Tivozanib Tivozanib, AV-951 475108-18-0

SYN-1014 Axitinib AG013736 319460-85-0

SYN-1017 AZD7762 HCl AZD7762 HCl 1246094-78-9

SYN-1018 BEZ-235 NVP-BEZ235, BEZ235 915019-65-7

SYN-1019 (R)-BI-2536 (R)-BI-2536 755038-02-9

SYN-1020 BI-D1870 BID1870 501437-28-1

SYN-1021 Bisindoylmaleimide X HCl

RO 31-8425 145317-11-9

SYN-1022 BMS-2 BMS2 888719-03-7

SYN-1024 BMS-5 BMS5 1338247-35-0

SYN-1025 Bosutinib SKI-606 380843-75-4

SYN-1028 CC-401 HCl CC401 1438391-30-0

SYN-1031 CI-1040 PD184352, CI1040 212631-79-3

SYN-1032 Tofacitinib CP690550 - Xeljanz 477600-75-2

SYN-1033 CP-724714 CP724714 383432-38-0

SYN-1034 CYC116 CYC116 693228-63-6

SYN-1035 Momelotinib CYT387, Momelotinib 1056634-68-4

SYN-1036 Dasatinib BMS-354825, Sprycel 302962-49-8

SYN-1037 Dianilinopyrimidine_01 CZC8004 916603-07-1

SYN-1038 E7080 E7080 417716-92-8

SYN-1039 Erlotinib HCl OSI774, CP-358774, Tarceva, NSC718781

183319-69-9

SYN-1041 GDC-0941 GDC0941 957054-30-7

SYN-1042 Gefitinib ZD1839, Iressa 184475-35-2

SYN-1043 GSK-690693 GSK690693 937174-76-0

SYN-1044 GW441756 GW441756 504433-23-2

SYN-1045 IC87114 IC87114 371242-69-2

SYN-1046 Imatinib mesylate CGP54148, ST1571, Gleevec,Glivec,Imatinib mesylate

220127-57-1

SYN-1048 JNJ-7706621 JNJ7706621 443797-96-4

SYN-1052 Lapatinib GW-572016, Tykerb 231277-92-2

SYN-1053 Masatinib AB1010, Masivet 790299-79-5

SYN-1055 Motesanib AMG706 453562-69-1

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Melbourne • Shanghai • San Diego • Cambridge

SYN-1056 Amuvatinib MP-470 850879-09-3

SYN-1059 PD0325901 PD0325901 391210-10-9

SYN-1060 PF04217903 PF04217903 956905-27-4

SYN-1061 PD173955 PD173955 260415-63-2

SYN-1062 PD173955-Analog1 PD-173955-Analog1 185039-99-0

SYN-1063 PF431396 PF431396 717906-29-1

SYN-1064 PF-562271 PF562271 717907-75-0

SYN-1065 PI103 PI103 371935-74-9

SYN-1066 PIK-93 PIK93 593960-11-3

SYN-1067 PIK-75 PIK75 372196-67-3

SYN-1068 PIK-90 PIK90 677338-12-4

SYN-1069 PLX4720 PLX4720 918505-84-7

SYN-1070 Purvalanol B NG95 212844-54-7

SYN-1071 GSK429286A GSK429286A, RHO-15 864082-47-3

SYN-1072 RWJ-67657 RWJ67657 215303-72-3

SYN-1073 SB202190 SB202190 152121-30-7

SYN-1073A SB202190 HCl SB202190 HCl 350228-36-3

SYN-1074 SB203580 RWJ 64809, PB 203580 152121-47-6

SYN-1075 SB-216763 SB216763 280744-09-4

SYN-1076 SB-242235 SB242235 193746-75-7

SYN-1077 SB590885 SB590885 405554-55-4

SYN-1078 SD-06 SD06 271576-80-8

SYN-1079 SD169 SD169 1670-87-7

SYN-1081 SNS-314 SNS314 1057249-41-8

SYN-1083 SR3677 SR3677 1072959-67-1

SYN-1086 Sunitinib malate SU11248 341031-54-7

SYN-1087 TAK-715 TAK715 303162-79-0

SYN-1089 TGX221 TGX-221 663619-89-4

SYN-1090 Vandetanib ZD6474, Zactima, Vandetanib

443913-73-3

SYN-1091 Intedanib Intedanib,BIBF 1120, Vargatef

656247-17-5

SYN-1092 Tozasertib MK-0457, VX-680 639089-54-6

SYN-1094 YM201636 HCl YM201636 371942-69-7 (free base)

SYN-1095 Danusertib PHA-739358 827318-97-8

SYN-1098 PIK-294 PIK294 900185-02-6

SYN-1099 ZSTK474 ZSTK474 475110-96-4

SYN-1100 Afatinib Tovok, BIBW-2992 439081-18-2

SYN-1103 TG101209 TG101209 936091-14-4

SYN-1104 TG101348 SAR-302503 936091-26-8

SYN-1105 TG100115 TG100115 677297-51-7

SYN-1107 TG-89 TG89 936091-56-4

SYN-1108 LY294002 LY294002 154447-36-6

SYN-1109 CX-4945 CX4945 1009820-21-6

SYN-1110 A-674563 HCl A674563 552325-73-2 (free base)

SYN-1111 AMG-51 AMG51 890019-63-3

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Melbourne • Shanghai • San Diego • Cambridge

SYN-1112 Mubritinib TAK-165 366017-09-6

SYN-1113 SMI-4a SMI4a 438190-29-5

SYN-1114 GNE-490 GNE490 1033739-92-2

SYN-1115 GNE-493 GNE493 1033735-94-2

SYN-1116 Ponatinib AP24534 943319-70-8

SYN-1117 Baricitinib phosphate LY3009104, INCB-28050 1187595-84-1

SYN-1119 S-99 S99 1124381-69-6

SYN-1120 Ruxolitinib INCB018424 941678-49-5

SYN-1121 R406 R406 841290-80-0

SYN-1122 R788 disodium Fostamatinib, FosD, tamatinib fosdium, R788

1025687-58-4

SYN-1123 VX745 VX745 209410-46-8

SYN-1124 GSK-25 GSK25 874119-56-9

SYN-1125 AMG-25 AMG25 1003311-62-3

SYN-1126 GSK2126458 HYR-582 1086062-66-9

SYN-1128 RO495 RO495 1258296-60-4

SYN-1129 Foretinib GSK1363089, Foretinib, EXEL-2880, XL880

849217-64-7

SYN-1131 R428 R428 1037624-75-1

SYN-1132 S6K-18 S6K18 1265789-88-5

SYN-1133 JNJ-38158471 JNJ38158471 951151-97-6

SYN-1136 NVP-BSK805 2HCl NVP-BSK805, BSK-805 1092499-93-8

SYN-1137 XL765 SAR245409 1349796-36-6

SYN-1138 Cabozantinib XL184, BMS-907351 849217-68-1

SYN-1139 Crizotinib PF-02341066 877399-52-5

SYN-1140 Neratinib HKI-272 698387-09-6

SYN-1141 Pelitinib EKB-569 257933-82-7

SYN-1142 BMS-599626 AC480, BMS599626, AC-480

714971-09-2

SYN-1143 AMG-1 AMG1 913376-84-8

SYN-1145 NIBR-17 NIBR17 944396-88-7

SYN-1146 CH5132799 CH5132799 1007207-67-1

SYN-1147 Bentamapimod Bentamapimod, AS-602801 848344-36-5

SYN-1148 GNE 477 GNE 477 1032754-81-6

SYN-1149 MK-2461 MK2461 917879-39-1

SYN-1150 RG7422 RG7422, GDC0980 1032754-93-0

SYN-1152 NVP-BGJ398 NVP-BGJ398, BGJ-398 872511-34-7

SYN-1153 TAK-285 TAK285 871026-44-7

SYN-1155 SGX523 SGX523 1072116-01-8

SYN-1157 MLN0128 MLN0128, INK-128 1224844-38-5

SYN-1158 GLPG0634 GLPG0634 1206161-97-8

SYN-1159 TAE684 TAE684, NVP-TAE684 761439-42-3

SYN-1160 AZD-26 AZD26 1357158-81-6

SYN-1161 PLX4032 Vemurafenib, RG7204, Zelboraf, RO5185426

918504-65-1

SYN-1162 MK-2206 2HCl MK-2206 2HCl 1032350-13-2

SYN-1163 PF4618433 PF-4618433 1166393-85-6

SYN-1164 GCI1746 G-182 910232-84-7

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SYN-1165 SAR131675 SAR131675 1092539-44-0

SYN-1166 AZD8055 CCG 168 1009298-09-2

SYN-1167 AZD2014 AZD2014 1009298-59-2

SYN-1168 Takeda-6d Takeda-6d 1125632-93-0

SYN-1169 Regorafenib BAY 73-4506 755037-03-7

SYN-1170 GSK1120212 JTP-74057, GSK212, Trametinib

871700-17-3

SYN-1171 Ibrutinib PCI-32765 936563-96-1

SYN-1172 Ruboxistaurin HCl LY333531 169939-93-9

SYN-1173 SCH 900776 SCH 900776 891494-63-6

SYN-1174 PF0477736 PF0477736 952021-60-2

SYN-1175 IPI 145 IPI 145 1201438-56-3

SYN-1176 PD-0173074 PD0173074 219580-11-7

SYN-1177 PF-04708671 PF04708671 1255517-76-0

SYN-1178 BGT-226 maleate BGT226 1245537-68-1

SYN-1179 Bafetinib NS-187, INNO-406 859212-16-1

SYN-1180 Palbociclib 2HCl PD-0332991 571189-11-2

SYN-1180A Palbociclib Isethionate PD-0332991 827022-33-3

SYN-1181 PP242 PP242 1092351-67-1

SYN-1182 CX6258 CX6258 1202916-90-2

SYN-1183 GNF-5837 GNF5837 1033769-28-6

SYN-1185 Rapamycin Sirolimus - AY-22989 - WY-090217

53123-88-9

SYN-1186 XL388 XL388 1251156-08-7

SYN-1187 MPI0479605 HCl MPI0479605 1246529-32-7 (free base)

SYN-1188 CH4987655 CH4987655 874101-00-5

SYN-1189 SAR020106 SAR020106 1184843-57-9

SYN-1190 AS703026 AS703026 1236699-92-5

SYN-1191 XL019 XL019 945750-13-0

SYN-1193 SGI-1776 SGI1776 1025065-69-3

SYN-1194 PF-04979064 PF04979064 1220699-06-8

SYN-1195 AZD8330 AZD8330 1204531-17-8

SYN-1196 LY2784544 LY2784544 1229236-86-5

SYN-1197 BLZ-945 BLZ945 953769-46-5

SYN-1198 GDC-046 GDC046 1258292-64-6

SYN-1199 LDK378 LDK378 1032900-25-6

SYN-1200 BKM120 BKM120 944396-07-0

SYN-1201 GSK2606414 GSK2606414 1337531-36-8

SYN-1202 GDC-0032 GDC0032 1282512-48-4

SYN-1203 TAK632 TAK632 1228591-30-7

SYN-1205 KW-2449 HCl KW2449 1038395-65-1

SYN-1207 CFI-400437 N/A N/A

SYN-1208 TASP0415914 TASP0415914 1292300-75-4

SYN-1210 AST-487 NVP-AST 487, AST487 630124-46-8

SYN-1211 URMC-099 URMC099 1229582-33-5

SYN-1212 SP2509 SP2509, SP-2509 1423715-09-6

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Melbourne • Shanghai • San Diego • Cambridge

SYN-1213 LEE011 LEE-011 1211441-98-3

SYN-1214 AZD1208 AZD-1208 1204144-28-4

SYN-1215 GW806742X GW806742X, AC1NS7PT, AGN-PC-0LQ49Y

N/A

SYN-1216 CCT244747 CCT244747 1404095-34-6

SYN-1217 S49076 HCl S-49076 1265965-19-2

SYN-1219 GSK-A1 GSKA1 1416334-69-4

SYN-1220 GSK-F1 GSKF1 1402345-92-9

SYN-1221 H1152 H-1152 871543-07-6

SYN-1222 LY2801653 LY-2801653 1206799-15-6

SYN-1225 BBT594 NVP-BBT594 882405-89-2

SYN-1226 BGG463 NVP-BGG463 890129-26-7

SYN-1227 MBP146-78 MBP146-78 188343-77-3

SYN-1228 BIX02565 BIX-02565 1311367-27-7

SYN-1229 Selonsertib Hydrochloride

Selonsertib, GS-4997 1448428-05-4

SYN-1230 Alpelisib BYL719 , NVP-BYL719 1217486-61-7

Shipping and Storage Temperature

Shipping:

SYNlibrary Kinome can be shipped anywhere within 3 weeks of a purchase order being

received under normal business conditions and is handed over to our carrier in a

36cmx36cmx36cm box containing dry ice to preserve the samples.

Storage:

-4°C: 1 Month

-80°C: 6 Months

Product Datasheet (Rev. 1.1)