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  • Edited by Alexander W. Kusnecov and Hymie Anisman



  • The Wiley-Blackwell Handbook of


  • The Wiley-Blackwell Handbook of


    Edited by

    Alexander W. Kusnecov and Hymie Anisman

    A John Wiley & Sons, Ltd., Publication

  • This edition first published 2014 C© 2014 John Wiley & Sons, Ltd

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    Library of Congress Cataloging-in-Publication Data

    The Wiley-Blackwell handbook of psychoneuroimmunology / edited by Alexander W. Kusnecov And Hymie Anisman.

    pages cm Includes bibliographical references and index. ISBN 978-1-119-97951-7 (cloth)

    1. Psychoneuroimmunology. 2. Nervous system–Diseases–Immunological aspects. I. Kusnecov, Alexander W., editor of compilation. II. Anisman, Hymie., editor of compilation.

    QP356.47.W55 2013 612.8′233–dc23


    A catalogue record for this book is available from the British Library.

    Cover image: Blood cells, SEM. C© Power and Syred / Science Photo Library Cover design by Cyan Design

    Typeset in 10/12.5pt Galliard by Aptara Inc., New Delhi, India

    1 2014

  • Contents

    Preface ix Alexander W. Kusnecov and Hymie Anisman

    Foreword xiii Robert Ader and Nicholas Cohen

    List of Contributors xvii

    1 Basic Principles in Immunology: Relevance for Studies in Psychoneuroimmunology 1 Sarah M. Clark, Kerry C. Michael, Achsah D. Keegan, and Leonardo H. Tonelli

    2 Innervation of the Immune System 24 Denise L. Bellinger, Dwight M. Nance, and Dianne Lorton

    3 In Vitro and In Vivo Assessment of Immune System Modulation of Brain Function and Neurochemistry 73 Michael O. Poulter and Zul Merali

    4 Control and Contributions of the Blood–Brain Barriers to Cytokine Levels in the CNS 88 William A. Banks

    5 The Immune–Neuroendocrine Network in Health and Disease 99 Adriana del Rey and Hugo O. Besedovsky

    6 Neural Functions of Hematopoietic-derived Cells 120 Noël C. Derecki and Jonathan Kipnis

    7 Immunoregulatory Neuropeptides 144 Doina Ganea and Mario Skarica

    8 Regulation of Immune Cell Activity by Norepinephrine and �2-Adrenergic Receptor Engagement 161 Caroline J. Padro, Jaclyn W. McAlees, and Virginia M. Sanders

  • vi Contents

    9 Immune-to-Brain Communication in Pain: Historical Perspectives, New Directions 176 Peter M. Grace, Linda R. Watkins, and Mark R. Hutchinson

    10 Stress and Neuroendocrine–Immune Interaction: A Therapeutic Role for �-endorphin 198 Olivia Wynne and Dipak K. Sarkar

    11 Assessing Neuroendocrine-Mediated Modulation of Immunity to Infection in Animals: Caveats and Methodological Issues 212 Jodi L. Yorty and Robert H. Bonneau

    12 Approaches to Assessing Stressor-Induced Cytokine and Endocrine Changes in Humans 234 Kim Matheson and Hymie Anisman

    13 Stress and Immune Function in Humans: A Life-Course Perspective 251 Jan A. Moynihan, Kathi L. Heffner, Mary T. Caserta, and Thomas G. O’Connor

    14 Predicting Health: The Role of the Early-Life Environment 266 Luba Sominsky, Adam K. Walker, and Deborah M. Hodgson

    15 Microglia and Neurodevelopment: Programming of Cognition throughout the Lifespan 296 Jaclyn M. Schwarz and Staci D. Bilbo

    16 Aging and the Immune System 313 Ashley M. Fenn, Angela W. Corona, and Jonathan P. Godbout

    17 Peripheral Pro-inflammatory Cytokines and Cognitive Aging: The Role of Metabolic Risk 330 Alvin Lim and Anna Marsland

    18 Immune Stimulation and Cognitive Function: Defining the Deficits and Avoiding the Pitfalls 347 Colm Cunningham

    19 The Role of NF-�B in Behavioral and Neural Plasticity 365 Elyse M. Mallimo and Alexander W. Kusnecov

    20 Inflammatory Roads to Neurodegeneration: A Focus on Parkinson’s and Alzheimer’s Disease 393 Shawn Hayley and Darcy Litteljohn

    21 The Psychotic Face of the Immune System: Inflammation and Schizophrenia 411 Urs Meyer

    22 Neuroimmune Mechanisms in Autism 425 Veronica M. Miller, Rachael Racine, and Steven S. Zalcman

    23 Depression, Inflammation and Tryptophan Metabolism 448 Robert H. McCusker, Annemieke Kavelaars, Cobi J. Heijnen, Robert Dantzer, and Keith W. Kelley

  • Contents vii

    24 An Inflammatory Perspective of Stress and Human Depressive Disorder 469 M.-C. Audet, S. Jacobson-Pick, R. McQuaid, and Hymie Anisman

    25 Interaction Between Immune and Energy-Balance Signals in the Regulation of Feeding and Metabolism 488 Alfonso Abizaid, Giamal Luheshi, and Barbara C. Woodside

    26 Psychoneuroimmunological Processes in Coronary Artery Disease and Heart Failure 504 Willem J. Kop and Paula M.C. Mommersteeg

    Index 525

  • Preface Alexander W. Kusnecov1 and Hymie Anisman2

    1Department of Psychology, Behavioral Neuroscience Program, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA

    2Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada

    During the past decade the biological and behavioral sciences have become increasingly inter- twined, as research continues to reinforce the notion that physical and psychological health are a function of interactive biological systems. Mental ill-health as a reflection of deficits in neural functions is potentially precipitated and/or perpetuated by systemic factors engineered by immunological processes; for these are now understood to be modulators of neural activ- ity, and ultimately the cognitive and emotional life of the organism. Similarly, environmental and physiological events, both prior to and after birth, can impact neurodevelopmental and behavioral processes, as well as endocrine and immunological functions. These circumstances serve as the basis for immunological theories for the formation of autistic spectrum disor- ders and schizophrenia, as well as potential vulnerabilities that set the stage for how later life events influence physiological and psychological adaptation during adult life and the age- ing process. Debilitating neuropathological conditions, such as Alzheimer’s like dementia and Parkinsons’s disease, in which neurodegeneration progressively destroys the motoric, cognitive and emotional lives of the individual, have resurrected and redefined the meaning of “neu- roinflammation.” This is a hotly pursued process that involves parenchymal glial cells of the brain, as well as the contributions of systemic inflammatory processes that emanate from the immune system. This area has increased attention on the biological functions of astrocytes and microglial cells, and the recognition that they are as much a part of brain function, as oligdendrocytes, the myelinating cells that expedite communication between neurons. Finally, it has also become clear that nutritional, metabolic and cardiovascular health are intimately linked to inflammatory and/or immunological activities, emphasizing the importance of the immune system as both a contributor and reflection of health status across different provinces of physiological function.

    In protecting the organism against infectious disease, the hematopoetic cells that give rise to the heterogeneity of lymphocytes, monocytes and other cellular forms – in short, the immune system – are intimately linked to the activities of the central nervous system. This now is an established fact, as the contents of this handbook ma