Total Energy per glucose A) Cytosol – Glycolysis 2 NADH 2 ATP B) Mitochondrion – Pyruvate dehydrogenase 2 NADH --Krebs 6 NADH 2 FADH 2 2 GTP 1

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    22-Dec-2015

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<ul><li> Slide 1 </li> <li> Total Energy per glucose A) Cytosol Glycolysis 2 NADH 2 ATP B) Mitochondrion Pyruvate dehydrogenase 2 NADH --Krebs 6 NADH 2 FADH 2 2 GTP 1 </li> <li> Slide 2 </li> <li> 2 Abnormalities / Diseases Associated With PDH And The TCA Cycle 1)Genetic Deficiency of Pyruvate Dehydrogenase 2) Genetic Diseases of the TCA Cycle : Fumarase deficiency Succinate dehydrogenase -ketoglutarate dehydrogenase </li> <li> Slide 3 </li> <li> 3 3) Thiamine Deficiency -- classical beriberi, Pyuvate Dehydrogenase -ketoglutarate Dehydrogenase Abnormalities / Diseases Associated With PDH And The TCA Cycle </li> <li> Slide 4 </li> <li> Regulation of the Tricarboxylic Acid Cycle? About half page to be submitted next Wednesday before The class. Students Review Question? Additional questions would be sent through the email on Thursday. </li> <li> Slide 5 </li> <li> After Glycolysis What next after? Glucose 2 Pyruvate Lactate (anaerobic) Acetyl-CoA (TCA cycle) 5 </li> <li> Slide 6 </li> <li> (oxidized) (reduced) 2. Conversion To Lactate (Anaerobic conditions) 6 </li> <li> Slide 7 </li> <li> 7 </li> <li> Slide 8 </li> <li> Lactate can be transported by blood to liver and used in gluconeogenesis Cori cycle 8 Exercising muscles and the Cori Cycle </li> <li> Slide 9 </li> <li> How do cytosolic/cytoplasmic NADH get into the mitochondrial? </li> <li> Slide 10 </li> <li> 1.glycerol 3-phosphateshuttle - NADH as FADH 2.malate-aspartate shuttle- NADH as NADH How do cytosolic/cytoplasmic NADH get into the mitochondrial? </li> <li> Slide 11 </li> <li> 11 The malate-aspartate shuttle. </li> </ul>

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