Transdermal Glyceryl Trinitrate Significantly Improves Exercise Capacity But there Is no difference between low and high doses in patients with angina pectoris In a double-blind crossover study, 15 men with stable effort angina randomly received placebo patches or single applications of transderma/ glycery/ Irinitrate [nitroglycerin] 2Ocm2 or 4Ocm 2 (releasing 10 and 20 mg/24 hours, respectively). Patches remained in place IOf 24 hours and there was a 24-hour washout period between each application. During bicycle exercise 4 and 24 hours after patch application, both glyceryt trrnitrate doses significantly increased heart rate and rate-pressure product compared with placebo. The 2 active doses also significantly prolonged exercise duration and time to 1mm ST-segment depression and improved maximal workload and total work performed 4 and 24 hours after patch application. There was no significant difference between the 2 glyceryl trinitrate doses in any of the variables measured. Headache was reported in 11 patients (8 after both active doses and 3 only after the higher dose) an average of 2.6 hours after patch application, and lasting 14.9 (range 1·24) hours. Thus, single applications of either transdermal glyceryl trinitrate 200m 2 or 400m 2 prolong exercise duration and time to 1 mm S1 depression for 24 hours, in patients with stable eflorl angina. ScaKJ; . S .. Pivolll. F.. FOI"Ida. F . Pandullc. c.. Cos/em : M. el '1.: American Hellrl Journ.1 t to: 546-551 (SeP 1985) 0156_2703/85/1005-0008/0$01.00/0 00 AOIS pren

Transdermal Glyceryl Trinitrate Significantly Improves Exercise Capacity

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Transdermal Glyceryl Trinitrate Significantly Improves Exercise Capacity But there Is no difference between low and high doses in patients with angina pectoris

In a double-blind crossover study, 15 men with stable effort angina randomly received placebo patches or single applications of transderma/ glycery/ Irinitrate [nitroglycerin] 2Ocm2 or 4Ocm2 (releasing 10 and 20 mg/24 hours, respectively). Patches remained in place IOf 24 hours and there was a 24-hour washout period between each application.

During bicycle exercise 4 and 24 hours after patch application , both glyceryt trrnitrate doses significantly increased heart rate and rate-pressure product compared with placebo. The 2 active doses also significantly prolonged exercise duration and time to 1 mm ST-segment depression and improved maximal workload and total work performed 4 and 24 hours after patch application. There was no significant difference between the 2 glyceryl trinitrate doses in any of the variables measured.

Headache was reported in 11 patients (8 after both active doses and 3 only after the higher dose) an average of 2.6 hours after patch application, and lasting 14.9 (range 1·24) hours. Thus, single applications of either transdermal glyceryl trinitrate 200m2 or 400m2 prolong exercise duration and time to 1 mm S1 depression for 24 hours , in patients with stable eflorl angina. ScaKJ;. S .. Pivolll. F .. FOI"Ida. F . Pandullc. c.. Cos/em: M. el '1.: American Hellrl Journ.1 t to: 546-551 (SeP 1985)

0156_2703/85/1005-0008/0$01.00/0 00 AOIS pren