UMMC Research Bulletin 2008/1

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In this issue :In this issue :In this issue :In this issue :In this issue :

57th Meeting of Nobel

Laureates in Lindau,

Germany

The Malaysian

Delegation to Centres of

Excellence in United

Kingdom

Department of Pharmacy

- Research Activities

Department of Medical

Microbiology

- Research Activities

Awards and Honours :

Promotion to Assoc.

Professor

Promotion to Senior

Lecturer

Succesful Recipient of

FRGS 2007 Grant

Other Awards and

Honours

Research Grants /

Funding

Publication

Upcoming Courses /

Events

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ISSN : 1823 - 4062 ISSUE 2008/1

INTRODUCTIONThe Nobel Prize is inarguably the most prestigiousand recognized award in the academic world.Despite the many achievements of mankind overthe past century, only few men and women havebeen found worthy to receive this award ofdistinction. Alfred Nobel, described variously asscientist, inventor and industrialist, lived duringa time of strife, straddling between war and peace.When he first conceived the idea of donating a largepart of his wealth to promote excellence inacademia and humanitarian efforts, it may be toprove wrong the world’s negative perception ofhim as the inventor of dynamite. Little did he knowthat his gesture would have such a powerfulimpact that for generations to come, the Nobellegacy would be synonymous with greatachievements of benefit to mankind. Since 1901,the prize has honored men and women foroutstanding achievements in physics, chemistry,physiology or medicine, literature, and for worktowards world peace. The laureates were part ofan elitist club whose membership was an object ofenvy and exclusivity, so that few have theprivilege to meet a laureate. It was only slightlyover 50 years ago that the idea of the NobelLaureate Meetings was first conceived to bridgethe gap of young minds of the future to theachievers of the present. In 1951, seven NobelLaureates met in Lindau on Lake Constance,Germany and presented lectures to aninternational audience. Since then a Council hasbeen set up to ensure that this gatheriong of thegreat minds continue on a regular basis with theintention of bonding the hopeful minds of the future

At the meeting: (From left) Mr. Mohd Mokrish Md Ajat (UPM), Dr. Tunku Kamarul Zaman, Prof. Dr.Looi Lai Meng, Mr. Tee Kok Keng, Mrs. Zubaidah Aziz-Lembke (Journalist) and Dr. Chan Yoke Fun

The Malaysian Delegation to the 57th

Meeting of Nobel Laureates in Lindau,

Germany

with the Laureates. Each year since 1953, some500 – 700 top students and young researchers fromuniversities and academic institutions initially inGermany and now increasingly from manycountries all over the world, attend these meetings,upon the invitation by the Council, selected for thequality of their academic performance and researchwork. The young come to Lindau throughrecommendation by their superiors, deans, andmentors on the basis of strict selection criteria putforth by the Council. Today, the “Meeting of NobelPrize Winners with Young Scientists” is held everyyear in Lindau, devoted to Nobel Prize Winners inChemistry, Physics, Physiology or Medicine,Natural Sciences and Economical Sciences byrotation. Because there can only be one meetingeach year and there are five Nobel Prize disciplines,each discipline can only have a meeting every threeyears. Each meeting is a gathering of 20 to 25Nobel Laureates with more than 500 youngscientists from all over the world. The invitedLaureates give lectures of their choice, whilestudents have the opportunity to engage in personaldiscussions with them.

To ensure that Malaysia is not left out fromthe arena of academic achievers, in 2004Academician Datuk Seri Salleh Mohd Nor, FASc.(then Vice-President of the Academy of SciencesMalaysia (ASM) and Chairman of the ASM NationalNobel Laureate Programme Committee) met Dr.N.M. Butt, S.I., the coordinator of the Pakistan

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UMMC RESEARCH BULLETIN

Issue No.1 2008

ABOUT THE UMMC RESEARCH BULLETIN

The UMMC Research Bulletin is a bi-annual electronicpublication of the Faculty of Medicine, Universtiy of Malayawhich could be accessed online at http://www.ummc.edu.myor http://fom.um.edu.my It is devoted to matters concerningresearch and publication as well as activities within thefaculty; and to highlight the achievements, awards andhonours received by our faculty members and theirpublications.

Please convey your comments and suggestions to :

UMMC RESEARCH BULLETINSECRETARIAT

Health Research Development Unit (HeRDU)Faculty of Medicine 50603, Kuala Lumpur

Tel : 603-7967 5748Fax : 603-7967 5769

Email : [email protected] /[email protected]

EDITORIAL BOARD

Prof. Dr. Ikram Shah Ismail

Dean, Faculty of Medicine, University of Malaya

& Director, University of Malaya Medical Center

Prof. Dr. Rosmawati bt. Mohamed

Deputy Dean (Research), Faculty of Medicine,

University of Malaya

Assoc. Prof. Dr. Wong Yut Lin

Head, Health Research Development Unit (HeRDU),

Faculty of Medicine, University of Malaya

Prof. Dr. Low Wah Yun

Dr. Wong Li Ping

Kuhan Krishnan

Health Research Development Unit (HeRDU),Faculty of Medicine, University of Malaya

In this first issue of UMMC research bulletin, readabout our Malaysian delegation to the 57th Meeting ofNobel Laureates in Lindau, Germany as well to Cen-tres of Excellence in United Kingdom. This issue alsohighlights the research activities in the Departmentsof Pharmacy and Medical Microbiology.

2008 marks the 10 th Anniversary of the pioneeringworks on Nipah virus in this Faculty (more about thisin the next issue). Not everyone can be involved ingroundbreaking research but we need to start some-where. As more and more research grants are avail-able, researchers must find ways to tap into the manysources of research funds.

I hope you enjoy this edition of Research Bulletin.

From The Editor’s Desk ...From The Editor’s Desk ...From The Editor’s Desk ...From The Editor’s Desk ...From The Editor’s Desk ...

Prof. Dr. Rosmawati bt. Mohamed

Deputy Dean(Research), Faculty of Medicine,University of Malaya

3

Delegation to the Lindau Meeting and embarked on one of the mostimportant steps in academic ties by linking ASM with the LindauCouncil. Following this fruitful arrangement, Malaysianparticipants for the first time attended this meeting in 2004 with adelegation of five young scientists and one accompanying Professor.The meeting was seen as one of the most successful meetings everconducted and was highly recommended by the delegation. In the

effort to ensure Malaysia’s participation in future Lindau Meetings,Malaysia’s involvement was formalized through the signing of aMemorandum of Understanding between ASM and the LindauCouncil.

As the nation’s pride rests upon the representation of thefew attending the meeting, it was important that the best be selectedfor the delegation. For the 2007 meeting, ASM made a call fornominations of academic achievers in the field of Physiology orMedicine (and its related disciplines) from all Institutions of HigherLearning and Research Institutions in the country (both public andprivate). Upon receiving the long list of nominees, the 2007 ASMLindau Selection Committee, chaired by Y.Bhg. Datuk Seri Dr.Salleh Mohd.Nor FASc, had the daunting task of selecting the few tobe nominated to the Lindau Council. Others members of theSelection Committee were Academician Professor Dr. Looi Lai MengFASc., Professor Dr. Asma Ismail FASc., Professor Dr Mak Joon WahFASc., Professor Dr Helen Nair FASc.and Professor Dr Ismail NoorFASc. Shortlisted applicants were called for an interview and toprovide a short presentation of their academic achievements.Finally only four candidates were selected and nominated to theLindau Council Review Panel. All four nominated by ASM wereawarded a place to participate in the 2007 Lindau Meeting. Theywere: Mr. Mohd Mokrish Md Ajat (Universiti Putra Malaysia), Dr.Tunku Kamarul Zaman, Dr. Chan Yoke Fun and Mr. Tee Kok Keng(all from Faculty of Medicine, University of Malaya). ASM SeniorFellow Academician Prof. Dr. Looi Lai Meng (University of Malaya)was selected to head the Malaysian delegation to Lindau.

MEETING AND LEARNING FROM THE LAUREATES

This year’s meeting was the 57th such Meeting and was devoted toLaureates in Physiology or Medicine. It was held from the 1st to the6th of July 2007. More than 20,000 applications were received fromuniversities, foundations and international research institutesaround the world but only 563 “creme-de-la-creme” from 64different countries passed the stringent multi-stage internationalselection process. 339 of the most talented young scientists fromEurope were there at the meeting. Asia was represented by 104 ofits finest, 81 were from North America attended, while the Arabstates was represented by 18 participants. Latin America, Australiaand Africa had 8, 7 and 6 representatives respectively.

In many ways, going through the selection process was the easierpart of the meeting. Being in the presence of the best and the mosttalented scientists around the world, compounded by the fact thatwe were meeting face-to-face with 17 Nobel Laureates brought muchanxiety and suspense for the Malaysian contingent. Not only was itimportant to portray ourselves as equals and scientists of highcalibre, it was equally important to safeguard the image of thenation as their impressions of us may affect future perceptions ofour country. This 5-day meeting had 13 plenary lectures, threepanel (round-table) discussion sessions and three afternoons ofscientific discussions, all of which required our input andinteractions with our contemporaries and the laureates. Details ofthe meeting are available at the website www.lindau-nobel.de. Alsofor the first time, a scientific bazaar was created: centred on amarketplace concept, researchers were encouraged to “sell theirideas,” creating a unique interactive and informal forum betweenparticipants and the laureates. Special emphasis was also given tothe interaction of science and the humanities to mark the German“Year of Humanities 2007”. One of the highlights of the meetingwas a TV-interview of the Malaysian delegation and one of thelaureates (Professor Tim Hunt) by journalist Mrs. Zubaidah Aziz-Lembke for RTM. The program was intensive, with all of us on ourguard most of the time to ensure that Malaysia was well-represented.In the evenings, various social activities including dinners and aclassical concert on the 4th of July, provided further avenue forinteraction. Formalities were minimal, yet the events ran likeclockwork without fuss. The Family Bernadotte af Wisborg wasclearly a important force behind the organisation, lending apervasive graciousness to all the social occasions (receptions,musical performances and the landmark visit to the Isle of Mainau).

Overall the meeting was very successful, the only downsidebeing the rainy and windy weather. The discussions and exchange

of ideas generated between the young scientists and Nobel Laureateswere not only interesting and also gave new insights to futureresearch directions. Most unique about this meeting were theglimpses into the personal philosophies of the Nobel Laureates, anopportunity not many have a chance to experience. Laureates arenot fictitious heroes created in the minds of writers or heroesdepicted in a movie directed by a Hollywood film producer. Theyare real, and so are their achievements. For some of us it was achance of a lifetime to meet them, many of whom we admire not forwho they are but what they had created. Amongst the favorites atthis meeting was Craig Mello who discovered RNA interference, thelatest addition to the Nobel membership, who was particularly goodin relating to the young researchers. Sir Timothy Hunt whodiscovered cyclin in the cell-cycle process was also an interesting

Making new friends

In a more relaxed mood

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UMMC RESEARCH BULLETIN | 3

person. Despite being so well-known in cancer research, the manhimself was very simple and flamboyant, far from the British tightupper-lip characters we would expect from an English professor.Richard Roberts who discovered introns in eukaryotes and ManfredEigen who proposed the quasispecies model were also much liked bymany for being very approachable and showed no discriminationof age and level of background knowledge. It was quite apparent tous that the laureates had many commonalities amongst themselves:they were passionate about science, committed to their work andperseverant in their research undertakings. They demonstratedclearly the important attributes of a good scientist: passion,dedication, curiosity and hard work. In their lectures, over andover they highlighted important elements of good research i.e.strong fundamentals, good experimental design, good experimentalcontrol and sharing of research findings. Interestingly and veryrevealing, was the importance they place their family life, a valuemost cherished by all of them. Perhaps this is something that weshould look at deeply in our own lives. We should examine our owncore values and appreciate what we may be missing while in searchof fame and glory. On pondering back to the numerous othermeetings and conferences we have attended, this meeting was byfar the best, both in depth, breath and philosophy; this view isshared even by the most senior of us.

From a scientist’s point of view, the meeting was unique andunsurpassable. However, beyond the mere logic of sciences thismeeting also highlighted several philosophical insights:

1. Recognition of the humanitarian aspects of science: itsimpact on people, creativity, culture, ethics, and socialdevelopment, underscoring the importance for scientists to voteand exert their rights in National decisions, to have a wideperspective of life, to have a sense of humour in getting scientificmessages across to the public, to speak up against injustice,breeches of human rights and torture, and to help formulatepolicies on health, gene therapy, scientific research, etc. Prof.Gunter Blobel donated the entire proceeds of his Nobel Prize tothe reconstruction of the Frauenkirche church in Dresden,Germany. Prof Richard Roberts, together with 113 other fellowlaureates have been actively involved in the indictment of 6healthcare workers in the Beghazi case in Libya. It makes uswonder whether we as scientists, busy pursuing our own careers,would have done or are willing to do the same for others.

2. Philosophy of research: Recognition of the importance ofinterdisciplinary and basic research, and developing effectivecommunications based on current needs. Be passionate aboutresearch, be generous with collaboration and not be afraid ofbeing others stealing your ideas. Be humble and accept failureas part of life. Failure is an absolutely necessity in order to gainsuccess. Craig Mello in his talk said,” It is okay to fail… it is notscience if you don’t fail and if you have to go back to the lab overand over again, that is what we called “RE-SEARCH”,

3. Be cognisant of the economics of research: Noting theimportance and impact of drug development, proteomics, geneprofiling and targeted cancer research.

4. Public education: The public are not less intelligent than thescientists; they just do not have the right scientific backgroundor knowledge to understand the subject. It is important forscientists to convey the messages which make understandingof science easier for society. Embryonic stem cell research is agood example of what the public needs to understand in orderto support research in this area.

5. Scientists can’t solve everything, but scientists can help toeducate politicians so that they can have a betterunderstanding of science. They can help to point out and findsolutions in sustainability, environmental management,

overpopulation, energy needs, and the use of geneticallymodified plants.

6. On research governance of grants and the need forpublications and other outcome assessments: There are manydilemmas & practicalities in the system of granting awards.

However it is important for Institutions to allow for creativity,rather than restrict research along strict priority areas andassessment procedures.

7. Recognition of the positive role of women in science.

8. Have a life outside of science. Video games are good. Gamesto solve puzzles are great. Researchers must have enough timeto dream. Don’t work so hard that there is no time to dream.

9. Use science in the right context. A lot of health problems donot require high-powered science, but can be fixed with cleanwater, sewage, public health and food supply.

10. Nobel laureates are no different from other human beings,just lucky with their research.

All good things come to an end, and so did this meeting. While themeeting can only be described as EXCELLENT, but it is noteworthythat the Malaysian delegation too served as excellent ambassadorsfor Malaysia and have gained the respect of their fellow scientists,putting no barriers to the concept of internationalization - this wasconveyed to Professor Looi during the business discussions that tookplace alongside the meeting. We brought back not only newknowledge but much fond memories at the end of the day, not tomention the many new friends we made along the way. There canbe no regrets about attending this meeting and despite thedifficulties that some of us had to endure to arrive at the venue, itwas all worth it and many times over. If there were any regrets itwould be that there is no chance of any of us ever attending the likeagain, owing to the limited number of places available for futuremeetings and the age limit of 35 years for its applicants.

Excelence is...

Report prepared by:

Dr. Chan Yoke Fun, Dr . Tunku Kamarul Zaman*, T ee Kok Keng,Mohd Mokrish Md Ajat**, Prof. Dr . Looi Lai Meng***

Dept. of Medical Microbiology, * Dept. of Orthopaedic Surgery , ***Dept. of Pathology, Faculty of Medicine, University of Malaya,

**Universiti Putra Malaysia


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The prominent headlines “Malaysian varsities fail to make top200 ranking in the Times Higher Education Supplement(THES)-Quacquarelli Symonds (QS) World UniversityRankings” in all the national newspapers recently has been verydisturbing. University Malaya, which was ranked among theworld’s top 100 universities three years ago, was in 169th positionin 2005 and in the 192nd spot last year. It has dropped to the 246thspot this year. In a newspaper interview, Datuk Rafiah Salim saidwith more than 3,000 universities being ranked by THES annually,Malaysian universities have to improve if they want to remain atthe top of the list. So, what will it take for UM and other localinstitutions to be excellent?

Following a week (1-6 July 2007) at the 57th Meeting of NobelLaureates in Lindau, Germany, we had the opportunity to visitvarious Centres of Excellence in the United Kingdom under thesponsorship of the Academy of Sciences Malaysia. These were theCambridge Science Park, Institute of Biotechnology (University ofCambridge), Department of Haematological Medicine, King’s CollegeLondon, Wellcome Trust Sanger Institute, EMBL-EuropeanBioinformatics Institute (EMBL-EBI) and Institute of BiomedicalEngineering in Imperial College London. Prof. Asma Ismail(Director, Institute for Research in Molecular Medicine (INFORMM),Universiti Sains Malaysia), Prof. Dr. Rahman Jamal (Director, UKMMedical Molecular Biology Institute (UMBI) and Prof. Ann Anton(Director, Biotechnology Research Institute, University MalaysiaSabah) were also in London to join us for this visit.

A study visit to centres of excellence in Germany, UK or Europefollowing the Lindau Meeting has been recommended by allprevious Malaysian Delegations to Lindau. Also, this was thepractice of most delegations from other Asian countries such asChina, India and Pakistan. The main objective of the study visitwas to provide a more comprehensive learning experience for theyoung scientists by visiting laboratories at renowned centres ofexcellence and meeting with scientists in these centres. In addition,the visit was to provide an insight on how these centres ofexcellence link research, development and commercialization(R-D-C) and establish a multi-disciplinary research model.

The University of Cambridge was ranked sixth in 2004, thirdin 2005 and subsequently secured the second ranking in the THES-QS World University Ranking. During the trip, we visited theCambridge Science Park and also the Institute of Biotoechnology.At the Science Park, Mr Patrick Horseley briefed us on its history,development, growth, knowledge transfer, business links and itsrelation to the University of Cambridge. Cambridge is at the heartof the fastest growing economic region in the UK, and its success isbuilt on the new economy - on knowledge-based businesses. Itsstrength in technology transfer has also encouraged internationalbusinesses such as BP, Microsoft, Rolls Royce, and AstraZeneca toinvest in research in Cambridge. Now home to over 90 hi-techcompanies and 5,000 personnel, the Cambridge Science Parkcontinues to attract new businesses, from small start-ups and spin-outs to subsidiaries of multinational corporations.

The huge success of the Cambridge Science Park depended to a largeextent on its endowment of a large land bank to the Trinity College,University of Cambridge dating back to King Henry VIII,(which itcould now lease to mature companies at considerable financial gain,thus ensuring financial stability) and the world renownedreputation of the University of Cambridge, which many scientificcompanies feel advantageous to be associated with. In contrast,Malaysian Institutions do not enjoy such generous landendowments, or yet such international reputation as to attachmature and established companies to its science parks. It is necessaryfor Malaysia to adopt a more nurturing approach, with “incubator”functions and incentives for many more years. Notwithstanding,it appears critical that science parks be strongly linked to researchuniversities to provide the academic and research environmentnecessary.

Institute of Biotechnology was established by Prof. ChrisotopherLowe in 1988 to pursue research in the area of biotechnology. Inaddition, the Institute also provides training in biotechnology forhigh quality graduates from the physical, chemical, and biologicalsciences and ensure a rapid and effective transfer of ideas anddevelopments in biological science between the University andIndustry. In the Institute of Biotechnology, strong processes are inplace to facilitate translation of research findings tocommercialization. The share of revenue returns and intellectualproperty of researchers are usually negotiated to encourageresearchers. Researchers appear comfortable with this, in that thereis no sign of discontent. In fact, the researchers are so interested intheir research that they appear not to be too bothered with monetaryreturns from their research pursuits. Prof. Christopher Lowe’sstrong passion for translational research has led to the establishmentof 7 spin-out companies and filing of more than 40 patents. Inaddition, he is also a firm believer of “Publish or Perish” and to datehe has published more 250 publications and 7 monographs.

Imperial College London ranked 14th in 2004, 13th in 2005,ninth in 2006 and this year (2007), gained the sixth position inthe THES-QS World University Ranking. Imperial is dedicated toharnessing its intellectual and technological resources to improvethe health and welfare of people worldwide. By applying technologyto advance the treatment and management of chronic disease theInstitute of Biomedical Engineering is actively pursuing this aim.It emphasizes a multidisciplinary approach to solving researchproblems. This allows the drawing together of diverse expertisefrom scientists, engineers,to clinicians, creating more innovative,cost-effective and realistic solutions to research questions. In thedevelopment of research questions, there is emphasis on those thatare of relevance to healthcare and Society. It was evident that

THE MALAYSIAN DELEGATION TO CENTRES OF EXCELLENCE INUNITED KINGDOM, 7-13 JULY, 2007

Dr. Chan Yoke Fun, Tee Kok Keng, Mohd Mokrish Md Ajat*, Prof. Dr. Looi Lai Meng**

Dept. of Medical Microbiology, **Dept. of Pathology, Faculty of Medicine, University of Malaya, *Universiti Putra Malaysia


The Malaysians at Institute of Biotechnology, University of Cambridge:(From left) Mr. Tee Kok Keng, Prof. Dr. Looi Lai Meng, Dr. Chan YokeFun, Prof. Ann Anton (UMS), Prof. Dr. Rahman Jamal (HUKM), Mr.Mohd Mokrish Md Ajat (UPM), Prof. Asma Ismail (USM) and Ms NitiaSamuel (ASM).

research, whether fundamental or applied, was not for researchsake, but should seek to address problems that were pertinent todisease processes or delivery of healthcare. The Institute is equippedwith all common laboratory equipment and facilities. Emphasis isplaced on proper space and facilities utilisation, maintenance,training in good laboratory practices and mutual respect. Goodlaboratory infrastructure and large laboratory space, thoughessential, were not the main features that contributed to itsexcellence. Instead, its strength lay with the strong team ofscientists from different disciplines who work together to address aspecific medical problem. There is a strong trend for postgraduateprogrammes at the University to emphasize relevance to Societyand market needs, both in terms of training and design of researchquestions. Engagement of industry in University programmes isalso a growing trend.

King’s College London is one of the oldest and largest colleges ofthe University of London and was awarded the highest rating offive for research quality in the last research assessment exercise,demonstrating excellence at an international level. A member ofthe Russell Group, a coalition of the UK’s major research-baseduniversities, King’s has an income from grants and contracts ofmore than £101 million (2004-05) and has an annual turnover of£364 million, placing it in the top group of universities for researchearnings.

The Department of Haematology, led by Professor Ghulam Mufti, isthe largest haematopoietic stem cell transplantation centre in theUK serving as the South East Regional Referral Centre for apopulation of approximately 3.6 million. The wealth of clinicaland pathological material available is optimally capitalised forclinically related and translational research. It works closely withthe Elimination of Leukemia Fund (ELF) in treating leukemia andblood cancer patients and along with ELF Trustees formed the ‘King’sLink Group’ which ensures a close link between the Charity and theDepartment. Staff are based in both the Guy’s and King’s DenmarkHill campuses and research contributes to three of the cross-schoolDivisions; the Division of Cancer Studies, Division of Genetics andDevelopment and the Division of Gene and Cell Based Therapy,headed by Professor Thein Swee Lay, a University of Malaya MedicalAlumnus.

During our visit to the Department of Haematology, King’s CollegeLondon, we were at first surprised at the cramped environmentand came to appreciate that the most prominent hallmark of theDepartment’s success has been the philosophy of recruiting the “bestpeople” for the job. Research leadership and investment in peoplehave been repeated emphasized as a crucial ingredient for researchsuccess. We were also deeply impressed with the number of highlycited publications. Each individual researcher’s and the Centre’sperformance were evaluated approximately every five years. Thecontracts of poor individual performers were not renewed andCentres that performed poorly had reduced funding. Thismeritocracy-based system has kept researchers on their toes all thetime to stay competitive. Compared to Malaysia, there is also lessemphasis on ownership of laboratory space and equipment. King’sCollege notably illustrates that there can be outstandingproductivity with minimal laboratory space.

The Wellcome Trust Sanger Institute is a genome research centreset up in 1992 by the Wellcome Trust and the Medical ResearchCouncil to sequence the human genome. Under the new leadershipof the director, Dr Allan Bradley, the Institute is currently activelyinvolved in large-scale sequencing, informatics and analysis ofgenetic variations of human, mouse, worms and human pathogens.The knowledge will provide further understanding of gene functionin health and disease and generate data and resources of lastingvalue to biomedical research. Right opposite the Sanger Institute isthe European Molecular Biology Laboratory-European

Bioinformatics Institute (EMBL-EBI) that pioneered the work toprovide public biological databases to the research community for

promotion of science. It also serves as an advanced bioinformaticstraining ground to scientists at all levels, and help to disseminatecutting-edge technologies to industry.The Sanger Institute and the European Bioinformatics Instituteare unique borderless centres that can be considered “globaltreasures.” While Malaysia should try to emulate their researchethos, it appears futile to try to duplicate such Institutions inMalaysia, as this would be incredibly costly (both to set-up andmaintain). As both Institutes have an open policy for usage of itsdatabases and facilities, it is more expedient that Malaysia becomesa global player by directly tapping on these resources. Malaysianresearch funding agencies should allow Malaysian researchers tospend time at or buy services from these Institutes and allow thecost to be factored into the research funding. In the long run, this ismore cost-effective than establishing duplicate Institutes inMalaysia.

Creating a research culture

We feel challenged to share the research culture which we haveexperienced during this visit . Much still needs to be done in ourhomeground towards building a research culture that isperformance-based, establishing and accepting truly sharedresearch facilities, fully optimizing the usage of facilities andequipment, and developing and nurturing the genuine attitude ofusing science for the benefit and well-being of mankind. The ethosof accountability and healthy competition appears to be animportant drive for achievement and excellence in all the centreswe visited. It is noteworthy that the big five (King’s, UCL, Imperial,Oxford and Cambridge) have been recently asked to form a megaconsortium of academic and research excellence to synergize theirresearch strengths and compete globally. In contrast, in Malaysiaall the universities are pitched against each other in competitionto become the Apex university!

Finally, in all the five centres, the holistic development of individualsduring research training and in the working environment iscontinually emphasized. In this, care is taken to provide a pleasingand conducive working environment. The Institutions are designedto facilitate staff interaction with one another, promote healthyrecreational activities (fitness centres) and appreciation of thehumanities (art, music, etc). In our pursuit of research excellence,we should not forget that an productive mind also needs a healthybody!

The group posing together with rows of DNA sequencers in theWellcome Trust Sanger Institute


7

Department of Pharmacy

Department al Research Activities (1)

Use of palm oil and palm kernel oil blends as drug deliverysystem (2001 – ongoing). Five bases for the use in rectal deliveryhave been developed and tested in humans (approved by UMMCEthic Committee). Further studies are ongoing to make the samebases suitable for semi-solid pharmaceutical dosage formsformulation.

Modification of local sago starch for table manufacturing(2003 – 2007). Outcome expected is formulation of tablet usinglocal excipients comparable to imported starches.

Formulation of anti-infectives for otorhinolaryngologyapplication (2002 – 2004). Commercially viable new anti-infectives using ‘halal’ ingredients have been formulated andpatented. Future works on human subjects are planned for.

Formulation of artificial saliva (2005– 2007). New artificialsaliva preparations and saliva stimulating tablets have beenformulated and are undergoing stability study.

Development of a novel polymeric gemcitabine derivativefor breast cancer treatment (2003-2006). A novel poly-L-glutamic acid-gemcitabine has been successfully synthesized,characterized, and evaluated using in vitro and in vivo breastcancer models.

Self-targeting novel polymeric drug delivery system forcancer treatment (2007-2009). This is a continuation of theabove project aimed to improve the modelling efficiency of thepolymeric drug conjugate, poly-L-glutamic acid-gemcitabine.

Novel pH sensitive biopolymer systems for drug delivery(2006-2010). Surface chemistry of biopolymers will be modifiedto improve the acid resistance. These polymers will then beevaluated as delivery systems for oral peptide-based drugs.

Isolation and characterization of CNS active compoundsfrom plants (2005-2007). Several medium throughput G-protein coupled receptor and enzyme assays were optimized andvalidated for bioactivity guided fractionation and isolation ofplant based compounds. Several moderately active templateswere identified and currently used for lead optimization studies.

Characterization of anti-inflammatory flavanoids,chalcones and their analogues (2007-2009). The aim is to

“University Malaya has made history by its success in developing an excellent course in Pharmacy that is at par with any institution in Europeoffering a similar course. “Professor J.W.Gorrod University of Essex, U.K (External examiner 2001-2003)

The Department of Pharmacy was established in 1995 for the purpose of meeting the nation’s requirement of pharmacists.Apart from undergraduate teachings and providing hospital services, the department is also actively involved inseveral research areas including Pharmaceutical Formulations Research, Chemistry and Natural Products Research,Health Outcome Research.

characterize the anti-inflammatory profiles of some naturalflavonoids isolated from plants and analogues from the syntheticroutes.

Synthesis and investigation of the structure-activityrelationships of some muscarinic active flavonoidcompounds (2007-2008). The aim of this study is to synthesise aseries of flavonoid compounds, to assay their activity at themuscarinic acetylcholine receptor and to identify any structure-activity relationships.

Structure-based design and synthesis of muscarinic receptoractive compounds as potential therapeutic drugs (2007-2008). Molecular modeling of the interaction between activecompounds and the muscarinic acetylcholine receptor to explaintheir activity and to design novel synthetic compounds with greateractivity and selectivity are studied.

Erythrocarpines A-E, new cytotoxic limonoids fromChisocheton erythrocarpus (2006-2007). The study on theextract of bark Chisocheton erythrocarpus Heirn (Meliaceae) hasled to the production of five new limonoids, erythrocarpines A-E.

Economic analysis of drug expenditure and drug utilizationtrends in University Malaya Medical Centre (UMMC) (2005 –ongoing). This study aims to investigate how the drug formularycan be managed efficiently through policy changes and with theincorporation of pharmaco-economic principles.

Study on the use and cost of antibiotics in children withrespiratory infections (2007 – 2009). To identify current patternof antibiotic usage in children with respiratory infections lookingat both the types of organisms involved and also concordance toantibiotic guidelines.

Respiratory virus infections in chronically ill paediatricpatients (2007 – 2008). The study aims to investigate theprevalence of respiratory viruses and atypical pathogens found inrespiratory secretions obtained from routine medical practice.

These research activities have been funded by IRPA, FELDA grants,FRGS, eScience, Science, SAGA funds, F Vote, Fundamental Vote,and Grant-in-Aid for Scientific Research from the Ministry ofEducation, Culture, Sport, Science and Technology of Japan andthe Research Foundation for Pharmaceutical Sciences.

Current Research Activities


Department of Medical Microbiology

Over the years, the Department of Medical Microbiology has had astrong tradition of research. In training our students, we strive toinstill values essential for research, in particular enjoyment,integrity, and creativity. These values have helped the departmentto develop its acknowledged research strengths in dengue, Nipah,enterovirus 71, melioidosis, HIV, mycology, antimicrobialresistance, proteomics, and vaccinology. We also aim to translateresearch ideas into products useful in diagnostics, therapeutics, andvaccines.

The department has two other core functions: clinical diagnosticservices and teaching, which are closely integrated with ourresearch activities. Surveillance is also an important function, bothat national and international level. The department providesinfluenza and enterovirus surveillance for the states of Selangorand Melaka, participates in the WHO Western-Pacific GonococcalAntimicrobial Susceptibility Program, and the ARTEMIS GlobalAntifungal Surveillance Program; and is a WHO CollaboratingCentre for Arbovirus Reference and Research (Dengue and DengueHaemorrhagic Fever), and a WHO National Influenza Centre. Thereis active collaboration with other local and overseas universities,industry, and institutions, such as the Malaysia Genome Institute,and the National Institute for Pharmaceuticals and Nutraceuticals.We also provide research consultancy services for industry.

The department has 13 academic staff (5 Professors, 3 AssociateProfessors, 2 Senior Lecturers, 2 Lecturers, and 1 Senior ResearchFellow), of which 9 (69%) are principal investigators on grantstotaling RM 4.68 million. There are currently 13 PhD students, 25non-clinical Masters students, and 5 clinical Masters studentsattached to the department on a full-time basis. From 2006 untilthe time of writing (August 2007), the department published, orhas had accepted for publication, a total of 66 papers, including 48which are Science Citation Index-linked with a cumulative impactfactor of 101.7. During this time, five patents have been filed.

n Dengue and other Arthropod-borne infections (Assessmentof risk factors in severe dengue; Dynamics of dengue virusevolution in hosts; Role of cross-reacting antibody responsesin dengue; Identification of dengue Specific T & B cell epitopes;Development of small interfering RNAs as therapeutic agentsfor dengue; Molecular epidemiology and diagnostic assaysfor Chikungunya virus; Arthropod-borne bacterialinfections)

n Respiratory viruses (Molecular diagnosis and haemagglutinintyping of influenza A; Pan-respiratory virus moleculardiagnostic screen; Trends of antibiotic usage in respiratoryinfections in children; Molecular epidemiology of RSV;Clinical features of inpatients with laboratory-confirmedinfluenza)

n Nipah virus (Epidemiology and evolution; Development ofnovel vaccines, antivirals, and diagnostics)

n HIV (Evolution of resistant HIV strains followingantiretroviral therapy; Characterization of unique HIV-1recombinants emerging in Malaysia; Proteomic approachesto study biomarkers for HIV disease progression and non-progression)

n Enterovirus 71 (Proteomic approaches for identifying diseaseassociated proteins in enterovirus 71 infection; Mapping ofgene sequences involved in the virulence of enterovirus 71and coxsackievirus A16)

n Antimicrobial susceptibility (Tigecycline susceptibilitytesting of various organisms; Epidemiology of multisensitiveMRSA; Effects of space flight on antibiotic-resistancemechanisms and gene expression profiles of Acinetobacterbaumannii; Identification of novel antibiotic resistancetargets and development of antimicrobial peptides toStreptococcus pneumoniae)

n Melioidosis (Molecular epidemiology and pathogenesis)

n Mycology (Molecular basis of antifungal resistance;Characterisation of melanin production in fungi)

n Evaluation of Palm tocotrienol on immune function

n Screening and discovery of lead compounds with antiviralproperties

n Gene chips for diagnosis and prognosis of familialhypercholesterolaemias

We are constantly looking for students and collaborators who shareour enthusiasm and passion for research in the exciting field ofmicrobiology. Our future aims are to produce internationally-recognised work and well-trained students, and ultimately tocontribute to the study and control of infectious diseases. Therefore,the department views the granting of Research University statusto UM as a great opportunity to achieve these goals.

For further information on our department, please visit

http://www.ummc.edu.my/index.php?option=com_content&task=view&id=345&Itemid=429

Current Research Activities

“It is important that students bring a certain ragamuffin, barefoot, irreverence to their studies; they are not here to worship what isknown, but to question it.”

- Jacob Bronowski, The Ascent of Man (1974)

Department al Research Activities (2)Department al Research Activities (2)

Dr. Jamal I-Ching Sam


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Promotion to Associate Professor

The Faculty wishes to congratulate the following academicians on their promotion to the post ofAssociate Professor and Senior Lecturer with a sincere hope that they will continue the tradition of

excellence in academics and research. Congratulations All.

Awards and Honours

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Awards and Honours


Promotion to Senior Lecturer

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Succesful Recipients of FRGS 2007

Researcher Department Research Title

Prof. Dr. Fatimah Harun Department of PediatricGrowth and Vitamin D Status of Exclusively Breast F ed Babies

Prof. Dr. G Suresh KumarDepartment ofParasitology

Studies On The Correlation Between Biochemical And MolecularAspects Of Blastocysts With Fundamental Immunopatho logicalMechanisms During In Vitro And In Vivo Infections

Prof. Dr. Mohd Rais MustafaDepartment ofPharmacology

Effect of Chronic Treatment of Angiotensin Peptides in theDevelopment of Type 2 Diabetes Mellitus in Goto-Kak izaki Rats

Prof. Dr. Nor Azizan Abdullah Department ofPharmacology

Development of Novel Drug Delivery System: Applicat ion for RenalDrug Targetting

Prof. Dr. Rohana binti YusofDepartment of Molecular

Medicine

Modulation of MHC Class 1 Promoter Gene Expression by HumanPapillomavirus Protein

Assoc. Prof. Dr. Junedah Sanusi Department of AnatomyMesenchymal Stromal Cells Implantation: Implication s on Treatmentfor Acute Spinal Cord Injury in Rats

Assoc. Prof. Dr. M.S. KanthimathiDepartment of Molecular

Medicine

Mechanism of Action of Bioactive Compounds from Mar ineOrganisms

Assoc. Prof. Dr. Maude ElviraPhipps

Department of MolecularMedicine

Fundamental Analysis of Human Genomic Diversity and Bioethicsin Indigenous Populations of Malaysia for Elucidati on of NovelVariants, Evolutionary History and Health

Dr. Chan Yoke FunDepartment of Medical

Microbiology

Evaluation of Effects of Small Interfering RNA for ChikungunyaVirus Infection

Dr. Lian Lay HoongDepartment of Molecular

Medicine

Screening of Single Nucleotide Polymorphisms (SNPs) Found inthe Human CD28 and CTLA-4 Genes in Malaysia Patient s withSystemic Lupus Erythematosus (SLE)

Dr. Sarni Mat JunitDepartment of Molecular

Medicine

Mutational Analyses of Genes Associated with Congen italHypothyroidism in a Cohort of Unrelated Patients an d Their FamilyMembers

1st National AIDS Conference - Oral Presentation Award

Dr Wong Li Ping, Health Research Development Unit(HeRDU) has won the award for the best oral presentationat the first 1st National AIDS Conference (30th Nov-2nd Dec, 2007) held at Legend Hotel, Kuala Lumpur. Thepresentation entitled “HIV/AIDS related stigma, discrimination and negative attitudes: Findings from a na-tionwide HIV/AIDS survey” highlighted some deep-rooted fears, anxieties and social rejection of people livingwith HIV (PLHIV) among Malaysia public. The survey was funded by Division of Health Education, Ministry ofHealth Malaysia.

More Awards and Honours


Southeast Asian W estern Pacific Regional Meeting ofPharmacologists (SEA WP-RMP) - Poster Award

Ms. Vijaya Letchimi Raj, a PhD candidate at Department of Pharmachologyhas won the SEAWP-RMP Award(runners up) for herposter titled “Association of Beta2-Andrenoceptor Polymor “ in the poster section of the recently concluded joint meeting of 10th

Southeast Asian Western Pacific Regional Meeting of Pharmacologists (SEAWP-RMP) and 41st Annual Scientific Meeting of theAustralasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) at Adelaide, 2-6 December,2007.

British Invention Show 2007

International T rade Fair Ideas-Inventions-New Products (IENA 2007)

√ Researchers : Dr. Chua Kek Heng

Invention: Development of PCR Based Beta-haemolysin GeneDetection System for Aeromonas Using In Silico Approach

Medal: Gold******

√ Researchers : Dr. Chua Kek Heng (Principal Researcher), Dr. Ng ChingChing, Dr. Ida Hilmi, Prof. Dato’ Goh Khean Lee

Invention: Giobs - A Variant / Mutation Screening System For Crohn’sDisease

Medal: Gold

Congratulation to the following members of our faculty for winning four out of five Gold medals at the International Trade Fair Ideas-Inventions-New Products (IENA 2007) which was held at Nurnberg Messezentrum, Germany from 1-4 November 2007.

Dr. Chua Kek Heng receivinghis gold medal at the awardceremony

√ Researchers : Dr. Mohamed Ibrahim Noordin (Principal Researcher),

Assoc. Prof. Dr. Chung Lip Yung, Daniel Chung Weng Seng.

Invention : Robust Semi-solid Pharmaceutical Bases From LocalPalm Oil Resources

Medal: Gold******

√ Researchers : Dr. Mohamed Ibrahim Noordin (Principal Researcher),Assoc. Prof. Dr. Chung Lip Yung.

Invention: Thermostable Suppository Bases from Palm Kernel Oil

Medal: Gold

Dr. Mohamed Ibrahim receivinghis gold medal at the awardceremony


The team of Dr. Noor Azuan Abu Osman, Herman Shah Abd. Rahman, Prof.Dato’ Dr. Tunku Sara Tunku Ahmad Yahya (Dept. of Orthopedics Surgery), Prof.Dr. Ir. Wan Abu Bakar Wan Abas, Dr. Ng Eng Seng, Syuhaida Yahud won a Goldmedal for their invention “Development of A New External Finger Fixator toCorrect Flexion Deformity” at the British Invention Show 2007 (BIS) which washeld at the Alexandra Palace, Wood Green, London from 17 - 20 October 2007.

The device is used for correction of rigid soft tissue deformities of the hand andpost-operative observation have showed that the effected finger can extend up

to 75% from the initial range of motion with the application of the device.

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2007 Malaysia T oray Science Foundation Programme’ sScience & T echnology Research Grant

We are delighted to announce that two academic staff of the Faculty has been selected as recipients of this year’sMalaysia Toray Science Foundation Programme’s Science Technology Research Grant. They are:

Dr. Tai Cheh Chin - Lecturer, Department of Orthopedic SurgeryResearch Project: Detecting and Monitoring Haemotogenous Pathogens in Peri- ProstheticInfection of Hip and Knee Joints

Mr. Lee Lin Kiat - PhD candidate, Department of PathologyResearch Project: Epstein-Barr Virus Latent Membrane Proteins in Hodgkin’s LymphomaImmunology and Survival

Malaysian Psychiatric Association’ sPsychiatric Clinical Case Presentation Competition

Amer Siddiq AN, SK Pillai. “Clozapine in Adolescents: A Case Report” won 2nd prize inPsychiatric Clinical Case Presentation Competition organised by Malaysian Psychiatric

Association which was held at Putrajaya Marriot from 3-5 August 2007.

Two Master of Medical Physics student s won the best student present ations awards at the recently held meeting “5 th SoutheastAsian Congress of Medical Physics (SEACOMP)”, Manila, Phillipine 21-23 November 2007.

v Mah YH, Wong JHD, Ng KH, Abdullah BJJ, Kwek KH. Radiofrequency Ablationo Using Cool-Tip System:Characterization of ablation size in ex vivo bovine liver.

v Ismail WH, Nizam MS, Tan LK, Lee CC, Ng KH. An evaluation of image quality, entrance surface air Kerma and

entrance dose rate of a flat panel detector Angiography System.

5th South East Asia Congress of Medical Physics (SEACOMP)- Presentation Award

More Highlight s on Awards and Honours

Research Grant s / FundingsCharcot Grant ProgrammeThe French Ministry of Foreign Affair is offering the Charcot Grant programme for young researchers and PhD students in the field ofmedical, pharmaceutical, veterinary sciences to pursue their studies in France for 1 year.

Deadline for the application is April 15, 2008. For more information, contact :Arnaud GauffierScientific AttacheEmbassy of France in MalaysiaTel: 03-2053 5534Fax: 03-2053 5531


Publications - Books

1. Abdul-Rahman PS, Lim BK, Hashim OH. Expression of highabundance proteins in sera of patients with endometrial andcervical cancers: analysis using two-dimensional gelelectrophoresis with silver staining and lectin detectionmethods. Electrophoresis. 2007; 28:1989-1996.

2. Agarwal G, Pradeep PV, Aggarwal V, Yip CH, Cheung PS.Spectrum of breast cancer in Asian women. World J Surg. 2007;31:1031-40.

3. Ajay M, Chai HJ, Mustafa AM, Gilani AH, Mustafa MR.Mechanisms of the anti-hypertensive effect Hibiscus sabdariffaL. calyces. J. Ethnopharmacol. 2007; 109:388-393.

4. Amer S, Koh OH, Nor Zuraida Z, Gill JS. PhenomenologicalEthnic Differences in first episode schizophrenia spectrumdisorder patients. Aust N Z J Psychiatry. 2007; 41:487.

5. Amer S, Ng CG Koh OH, Aida SA, Gill JS, Jambunathan ST,Habil H. Early intervention center (EIC) in the screening forbipolar disorder in Malaysia. Bipolar Disord. 2008; 10:30-31.

6. Appanna R, Huat TL, See LL, Tan PL, Vadivelu J, Devi S. Cross-reactive T-cell responses to the nonstructural regions of dengueviruses among dengue fever and dengue hemorrhagic feverpatients in Malaysia. Clinical Vaccine Immunology. 2007;14:969-977.

7. Azad HR. Bacillus Calmette-Guerin and Bladder Cancer. AsianJ Surg. 2007; 30:302-309.

8. Baskaran ND, Gan GG, Adeeba K, Sam IC. Bacteremia inpatients with febrile neutropenia after chemotherapy at auniversity medical center in Malaysia. Int J Infect Dis. 2007;11:513.

9. Bister M, Yap CS, Ng KH, Tok CH. Increasing the speed ofmedical image processing in MatLab®. Biomed Imaging IntervJ. 2007; 3:e9.

10. Chin LC, Achike FI, Mustafa MR. Hydrogen peroxide modulatesangiotensin II-induced contraction of mesenteric arteries fromstreptozotocin diabetic rats. Vascul Pharmacol. 2007; 46:223-228.

11. Chua KH, Norzulaani K, Rofina YO. Expression of a functionalanti-cucumber mosaic virus single-chain variable fragmentantibody in tobacco plants (nacotiana tabacum). J. PlantBiotechnol. 2007; 8:9-14.

12. Chua KH, Rofina YO. Development of a single chain variablefragment antibody combinatorial library through a simple threefragment ligation strategy. J Biol Sci. 2007; 7:323-1330.

13. Chua KH, Suzita MN, Tan SY, Rofina YO. Biopanning for bananastreak virus (BSV) binding peptide by phage display peptidelibrary. J. Biol. Sci. 2007; 7:382-1387.

14. Chuah KH, Thong CL, Krishnan H, Lucy Chan. Low doseunilateral spinal anaesthesia for lower limb amputation incritically ill patients. Med J Malaysia. 2007;62:81-2.

15. Desa MN, Sekaran SD, Vadivelu J, Parasakthi N. Distributionof CBP genes in Streptococcus pneumoniae isolates inrelation to vaccine types, penicillin susceptibility and clinicalsite. Epidemiol Infect. 2007; 3:-3.

16. Doorslaer E, O’Donnell O, Rannan-Eliya R P, Somanathan A,Adhikari S R, Garg C C, Harbianto D, Herrin A N, Huq M N,Ibragimova S, Karan A, Lee T, Leung G M, Lu R J F, Ng CW,Pande B R, Racelis R, Tao S, Tin K, Tisayaticom K, TrisnantoroL, Vasasvid C, Zhao Y. Catastrophic payments for health carein Asia. Health Econ. 2007; 16:1159-1184.

17. Fong MY, Lau YL, Zulqarnain M. Characterization of secretedrecombinant Toxoplasma gondii surface antigen 2 (SAG2)heterologously expressed by the yeast Pichia pastoris.Biotechnol Lett. 2007. (in press)

18. Gan GC, Abdullah BJJ, Kumar G, Bux SI, Goh KL, VijeyasingamR. Comparison of Resovist-enhanced MR Imaging with 5 phaseCT of the Liver in the Imaging of Liver Lesions. J Hong KongCollege of Radiology. 2007; 8:244-249.

19. Hasniza ZHi, Yeap SM, Rokiah P. Episodes of hypoglycaemiaand hyperglycaemia during the use of sliding scale insulin inhospitalized diabetes patients. Asian Biomedicine. 2007; 1:307-311.

20. Jamaiyah H, Anita D, Lim TO, Chen WS, Noraihan MN, SanjayR, Safiah B, Muralitharan G, Kumar Iswaran KK, Zaki MoradMZ. Anemia in pregnancy in Malaysia: a cross-sectional survey.Asia Pac J Clin Nutr. 2007; 16:527-536.

21. Jes GK, Ryan MT, Shamala D, Ramesh A. Dengue virus infectionand immune response in humanized RAG2-/-ãc-/- (RAG-hu)mice. Virology. 2007 (in press)

Publications - Journal / Proceeding / Abstract

Title: Study on the Imp act of HIV on People Living with HIV , Their Families andCommunity in Malaysia

Authors: Siti Norazah Zulkifli, Mary Huang Soo Lee, Low Wah Yun, Wong Yut LinISBN: 983-3904-04-4Publisher: United Nations Country Team, MalaysiaYear Published: 2007

This book brings to light the impact of HIV on people living with HIV, their families and community inMalaysia. The main objective of this project was to strengthen the national policy and programmes onHIV/AIDS in Malaysia by assessing the impact of HIV/AIDS on people infected by the disease toprovide an information base on PLHIV(People Living with HIV) and the communities affected.


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22. Kamarul TZ, Razif A, Elina R, Azura M, Chan KY. Normal anteriorcruciate ligament laxity in the Malaysian Population. MalaysianOrthopaedic J. 2007; 1:11-16.

23. Kartini R, Tok CH, Gnana K. Cementoossifying Fibroma of theParanasal Sinuses.A Review of two cases. European Journalof Radiology Extra. 2007; 63:101-104.

24. Kartini R, Wastie ML, Abdullah BJJ. Primary bone lymphoma:Report of a case with multifocal skeletal involvement. BIIJ.2007;3:e52.

25. Karunakaran R, Sam IC. Mutations in gyrA and parC inciprofloxacin-resistant Neisseria gonorrhoeae in KualaLumpur, Malaysia. J Antimicrob Chemother. 2007; 59:803-804.

26. Kasthoori JJ, Gnana K. It is not just constipation- Duplicationcyst and spinal anomaly- A case report. European J RadiologyExtra. 2007; 64:35-38.

27. Kasthoori JJ. Left lobe amoebic liver abscess mimicking aperforated gastric tumour - a case report. Eur J Radiol. 2008(in press).

28. Khalit M. Erythrocarpines A-E, new cytotoxicity limonoids fromChisocheton erythrocarpus. Bioorg Med Chem. 2007; 15:5997-600.

29. Khalit M, Mat Ropi M. New alkaloids from Phoebe scortechinii.Nat Prod Res. 2007; 21:704-709.

30. Koh OH, Hashim NA, Gill JS. Post Stroke Mania: A Case Report.Bipolar Disord. 2008; 10(1):48.

31. Kwan MK, Khoo EM, Chua YP, Mansor A. Isolated displacedfracture of humeral Trochlea: A report of two rare cases. Injury.2007; 38:461-465.

32. Lee CY, Sim, SM, Cheng, HM. Systemic absorption ofantioxidants from mulberry (Morus alba L.) leaf extracts usingan in situ rat intestinal preparation. Nutr Res. 2007;27:492-497.

33. Lekhraj R, Sanjay R, Geok LK, Azhar MZ, Shafie O, Ramlee R,Sirajoon NG, Jayanthi K. A national study on the prevalence ofobesity among 16,127 Malaysians. Asia Pac J Clin Nutr. 2007;16: 561-566.

34. Lim LH, Lee WS, Parasakthi N. Childhood invasivepneumococcal disease: a hospital-based study from Malaysia.J Paediatr Child Health. 2007; 43:366-369.

35. Lim SS, Shireene V, Vijay A, Tan TBA, Rokiah P, Chan SP.Carbimazole-related agranulocytosis in pregnancy-case reportJUMMEC. 2007;10;34-38.

36. Lim Yal, Rohela M, Muhamat Shukri M. Cryptosporidiosisamong birds and bird handlers at Zoo Negara, Malaysia.Southeast Asian J Trop Med Public Health. 2007 ;38(Suppl):1-4.

37. Lim YAL; Wan Hafiz WI, Nissapatorn V. Reduction ofCryptosporidium and Giardia by sewage treatment processes.Trop Biomed. 2007; 24: 95-104.

38. Loh SY, Packer T, Yip CH, Low WY. Perceived barriers to self-management in Malaysian women with breast cancer. AsiaPac J Public Health. 2007; 19:52-57.

39. Low WY, Ng CJ, Fadzil KS, Ang ES. 2007. Sexual Issues: Let ushear it from the Malaysian boys. J Men Health Gender. 2007 (inpress).

40. Lucy Chan. Myths of URTI in children for elective surgery. AseanJ Anaesthesiology. 2007;8:4-8.

41. Maslinda M, Fatimah H, Sarni MJ. Molecular analysis of thethyroid stimulating hormone receptor gene in unrelated patientswith congenital hypothyroidism. Mal J Biochem Mol Biol. 2007;15:8-18.

42. Mohamed Ibrahim N, Chung LY. Robustness of palm kernel oilblend in suppository preparation using Acetaminophen asmodule drug. J Pharmacy Technology. 2007; 23:339-343.

43. Mohammed Mahdy AK, Lim YAL, Wan KL, Hesham Al-MekhlafiMS, Johari S. Risk factors for endemic giardiasis-highlightingthe association with contaminated water and food. Trans RSoc Trop Med Hyg. 2007 (in press).

44. Mustafa AM, Malintan AM, Seelan S, Zhan Z, Mohamed Z,Hassan J, Pendek R, Hussain R, Ito R. Phytoestrogens levelsdetermination in the cord blood from Malaysia rural and urbanpopulations. Toxicol Appl Pharmacol. 2007; 222:25-32.

45. Naidu M, Kuan CYK, Wei-Lun L, Raza MT, A Mak NK, Wong RN,Keynes R. Neuroscience. 2007; 148:915-924.

46. Ng CF, Lum LC, Ismail NA, Tan LH, Tan CP. Clinicians’diagnostic practice of dengue infections. J Clin Virol. 2007;40:202-206.

47. O’Donnell O, Doorslaer E, Rannan-Eliya RP, Somanathan A,Adhikari SR, Garg Hanvoravongchai P, CC, Harbianto D, HuqMN, Karan A, Leung GM, Ng CW, Pande BR, Tin K, TisayaticomK, Trisnantoro L, Zhang Y, Zhao Y. The incidence of publicspending on health care: comparative analysis from Asia. WorldBank Economic Review. 2007; 21:93-123.

48. O’Sullivan M, Tai CC, Richards S, Skyme A, Walter WL, WalterWK. Iliopsoas Tendinitis. A complication after total hiparthroplasty. J arthroplasty. 2007 (in press).

49. Valliyappan NV, Tan PC, Vallikkannu N, Suguna S, Quek KF,Jamiyah H. Transvaginal sonography measurement of cervicallength versus Bishop score in labour induction at term:Tolerability and prediction of Caesarean section.UltrasoundObstet Gynecol. 2007; 29:568-573.

50. Puah SM, Lian LH, Chew CH, Chua KH, Tan SY. A study ofassociation of the complement C4 mutations with systemiclupus erythematosus in the Malaysian population. Lupus 2007;16:750-754.

51. Ranganathan S, Faridah Y, Ng KH. Moving into the digital era: anovel experience into the first full-field digital mammographysystem in Malaysia. Singapore Med J. 2007; 48:804-807.

52. Ravindra L Mehta, John A Kellum, Sudhir V Shah, Bruce AMolitoris, Claudio Ronco, David G Warnock, Adeera Levin, et.al. Acute Kidney Injury Network: report of an initiative to improveoutcomes in acute kidney injury. Critical Care. 2007; 11:31.http://ccforum.com/content/11/2/R31

53. Ravindran T, Tan LH, Lucy Lum CS, Christina Tan PL, Nor S,Rohana Y, Shamala D. The use of two-dimensionelectrophoresis to identify serum biomarkers from patientswith dengue haemorrhagic fever. Trans R Soc Trop Med Hyg.2007 (in press).


54. Reddy SC, Tajunisah Begam MI. Chemical injuries of eye- areview of 75 cases from West Malaysia-Int J Ophthalmology.2007;7:327-330.

55. Sabet NS, Subramaniam G, Parasakthi N, Shamala D.Detection of methicillin and aminoglycoside resistant genesand simultaneous identification of S. aureus using a triplexReal Time PCR. J Microbiol Methods. 2007;68:157-162.

56. Sabet NS, Subramaniam G, Parasakthi N, Shamala D.Detection of mecA, ermA genes and simultaneously identifiedS aureus using triplex real time PCR from Malaysian S aureusstrains collection. Int J Antimicrob Agents. 2007;29:582-595.

57. Sajaratulnisah O, Noor Azmi A. Management of domesticviolence in Malaysia: A survey on health care providers. AsiaPacific Journal of Family Medicine. 2008 (in press).

58. Sam IC, Puthucheary SD. Melioidosis and rainfall in KualaLumpur, Malaysia. J Infect. 2007; 54:519-520.

59. Tai CC, Walter WL, Walter WK, Zicat B. A minimum five yearsfollow-up study of alumina ceramic bearing for total hiparthroplasty. J Bone Joint Surg Am 2007 (in press).

60. Tajunisah Begam MI, Reddy SC, Fathilah J. Diurnal variation ofintraocular pressure in suspected glaucoma patients and theiroutcome. Graefes Arch Clin Exp Ophthalmol. 2007 (in press).

61. Tajunisah Begam MI, Reddy SC, Mas-Ayu S. A study of theindications and changing trends of Enucleation andEvisceration in West Malaysia. Int J Ophthalmology. 2007; 7:27-30.

62. Tajunisah Begam MI, Reddy SC, Tan LH. Acute retinal necrosisby CMV in an Immunocompetent adult- a case report and reviewof literature. Int Ophthalmol. 2007 (in press)

63. Tajunisah Begam MI. ARN arising following chicken poxinfection-A case report and review of literature. Ann Ophthalmol.2007;39:57-62.

64. Tajunisah Begam MI. Malignant melanoma arising in acaruncle-a case report. Asian J Ophthalmology. 2007;8:156-158.

65. Tan CPL, Nor MA Azila. Improving OSCE examiner skills in aMalaysian setting. Med Educ. 2007;41:517.

66. Tan HM, Low WY, Ng CJ, Chen KK, Sugita M, Ishii N, Marumo K,Lee SW, Fisher W, Sand M. Prevalence and correlateds oferectile dysfunction (ED) and treatment seeking for ED in AsianMen: The Asian Men’s Attitudes to Life Events and Sexulaity(Asian MALES) Study. J Sexual Med. 2007; 4:1582-1592.

67. Tan LP, Ng BK, Balraj P, Poh BH, Lim PKC, Peh SC. Molecularanalysis of sporadic colorectal carcinoma in Malaysian patients:mutator pathway is not the dominant pathway for colorectalcarcinogenesis in the left-sided disease. Pathology. 2007;39:228-234.

68. Tan PC, Rajasingam G, S Devi, Omar SZ. Dengue infection inpregnancy: Prevalence, vertical transmission and pregnancyoutcome. Obstet Gynecol. 2008 (in press).

69. Tan PC, Valiapan SD, Tay PYS, Omar SZ. Concurrent oxytocinwith dinoprostone pessary versus dinoprostone pessary inlabour induction of nulliparas with an unfavourable cervix: Arandomised placebo controlled trial. Brit J Obstet Gynaec. 2007;114:824-832.

70. Tan PC, Yow CM, Omar SZ. Effect of Coital activity on onset oflabor in women scheduled for labor induction: A randomizedcontrolled trial. Obstet Gynecol. 2007; 110:820-826.

71. Valliyappan NV, Tan PC, Suguna S, Vallikkannu N, Jamiyah H.Predictors of newborn admission after labour induction at term:Bishop score, preinduction ultrasound and clinical risk factors.Singapore Med J. 2007 (in press).

72. Veeranoot N, Lee CKC, Lim YAL, Tan KS, Jamaiah I, Rohela M.Toxoplasmosis: A silent opportunistic infection in HIV/AIDSpatients. Research J Parasitology. 2007;2:23-31.

73. Visvaraja S. A new parameter of ultrasonic measurement forfollow-up of choroidal metastasis. Int J Ophthalmology. 2007;7:609-612.

74. Visvaraja S. Acute angle closure glaucoma resulting frommyelodysplasia. Med J Malaysia. 2007;62:259-260.

75. Visvaraja S. Improved quality of vision with an anterior surfacemodified prolate intraocular lens: A prospective study. Int JOphthalmology. 2007; 7:918-920.

76. Wei L, Sun S, Xu C, Zhang J, Xu Y, Zhu H, Peh SC, Korteweg C,McNutt M, Gu J. Pathology of the thyroid in severe acuterespiratory syndrome. Hum Pathol. 2007;38:95-102.

77. Wong LP, Sam IC. Current issues facing the introduction ofhuman Papillomavirus vaccine in Malaysia. Malaysian FamilyPhysician. 2007;2:2-8.

79. Wong LP, Wong YL, Low WY, Khoo EM, Shuib R. Cervical cancerscreening attitudes and beliefs of Malaysian women who havenever had a Pap smear: A qualitative study. Int J Behav Med.2008 (in press).

80. Wong LP. Focus group discussion: A tool for health and medicalresearch. Singapore Med J. 2008; 49(2):1-6.

81. Wong LP. Systematic review and meta-analysis: A glossary.JUMMEC. 2007; 10:1-8.

82. Wong LP. Data analysis in Health-related Qualitative Research.Singapore Med J. 2008 (in press).

83. Wong ST, Sazaly AB, Zamberi S, Rozita R. DNA vaccineconstructs against enterovirus 71 elicit immune response inmice. Genet Vaccines Ther. 2007;5:6.

84. Wong YL, Sajaratulnisah O. Early detection and prevention ofdomestic violence using the Women Abuse Screening Tool(WAST) in primary health care clinics in Malaysia. Asia Pac JPublic Health. 2008; 20(2)

85. Yaiw KC , Crammert G, Wang L, Chong HT, Chua B, Tan CT,Goh KJ, Shamala D , Wong KT. Serological evidence of possiblehuman infection with Timan virus, a newly describedparamyxovirus of bat origin.J Virol Methods. 2007;143(2):140-146.

86. Ye H, Shahrul K, Poi JH. The views of older Malaysians onadvanced directive and advanced care planning: a qualitativestudy. Asia Pac J Public Health. 2007 (in press).

87. Yeap SS, Mohd A, Kumar G, Kong KF, Chow SK, Goh EML,Phipps ME. The association between HLA genes andradiological erosions in Malaysian patients with rheumatoidarthritis. Autoimmunity. 2007; 40:187-190.

88. Yip CH, Anderson BO. The breast health global initiatives:clinical practice guidelines for the management of breast cancerin low and middle income countries. Expert Rev AnticancerTher. 2007;7:095-1104.


17

HeRDU’s Professional Development SeriesHeRDU’s Professional Development SeriesHeRDU’s Professional Development SeriesHeRDU’s Professional Development SeriesHeRDU’s Professional Development Series

Basic SPSS Skills WBasic SPSS Skills WBasic SPSS Skills WBasic SPSS Skills WBasic SPSS Skills Worororororkkkkkshopshopshopshopshop

Upcoming Courses /

Event s

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Date:Date:Date:Date:Date: 29 & 30 April 2008

Venue:Venue:Venue:Venue:Venue:

MD 1 Computer LabFaculty of Medicine,University of Malaya

SPEAKER:

Professor Dr. Siow Heng LokeFaculty of Education,University of Malaya

Often users of SPSS have inadequate knowledge about thebasic operation of the SPSS program. Basic knowledge onSPSS is vitally essential for all users before they proceed todata analyses.

This one-day workshop is for beginner with little or noexperience in SPSS for Windows who want to acquire theskills and knowledge on getting started with SPSS. It is partof a series of SPSS workshops; each forms the prerequisites tomore advanced statistical procedures. This is a very much a‘how to’ workshop, in that we provide hands-on activities inpreparing, editing and transforming data files. The basicessential skills that will be imparted in this workshop includethe preparation of code book and data files; opening, readingand saving data files; editing data; transforming data; filehandling and working outputs.

This workshop does NOT include performing data analysis.

For More Information, Contact:

Workshop Secretariat,Health Research Development Unit(HeRDU),Faculty of Medicine, UMPhone : 03 -79675739 / 5748Fax : 03 - 7967 5769Email : [email protected]

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Documents

UMMC Research Bulletin 2008/1