Università Politecnica delle Marche Istituto di Biologia e Genetica

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Universit Politecnica delle Marche Istituto di Biologia e Genetica. Lo splicing dellRNA definizione importanza predizione. Francesco Piva. Struttura tipica dei geni umani. esoni. introni. esone1. introne1. esone2. introne2. esone3. GT. AG. GT. AG. SPLICING. - PowerPoint PPT Presentation

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<ul><li><p>Universit Politecnica delle Marche</p><p>Istituto di Biologia e GeneticaLo splicing dellRNA definizione importanza predizioneFrancesco Piva</p></li><li><p>Struttura tipica dei geni umaniesoniintroni</p></li><li><p>esone1introne1esone2introne2esone3esone1esone1introne1esone2esone2introne2esone3esone3SPLICINGeliminazione introniunione esoniGTGTAGAG</p></li><li><p>Lo splicing avviene in tutto il trascritto, anche nelle zone non codificanti</p></li><li><p>attggaaaccgaaacccgttggtcacctctgcaatagccctccctccctcacttctacaattttgtgacagtggtcttgttttctgcattctctgcttcacgtgcttgttttgttggagcgcgtttgcatgctgctttaaattctgaaatattaaaaaaatttcgaagtttttcagcacatgggatgggagttttgaatttcaattttttaaaaacatttttctgtgattagtgccgtcgtggcacggctgttagccgcctatccggtttattcgatactttGTGAGTTTTTTGTAACTTTATGGTCGTCGAAATGGGAAAACTTGGCCACCAATATAAGTTTGGAAAACAATTTCCTAAAAATAAAATAATTGAACTTTTCCGATGAATAAAAAAATCGATCAGATATTCTGGAAAAAAAATCGATAAATTAATCGATTTTCTTGGAAAATACATCGAAAAATTGAGAAAAATAGAAAAATGAATGTTTTTCGATTACCGATTTATTGATTTTTCGTGAAAACTGAGTTCAGATAATTTTAAAAGCAATGTTTTTCATTTTTCAAATCAGAATCACTATAGTTTTGAAAAATCAATAATTAATTTATTGATTTTTCAATATAATTTTTTGGAAAAAATAGAAAAATCCCTTTCTAAAAGTTTTAAATTTCCAAGAAAAATTCATTTTCAAAATCACCAACGCGCTCTATAGAGTAGTCGATGAAAATCTCCGTTAAGGGTGCATGGGCAAAACGCGCTCGAACGACAATTGTTATTGTATGTTTGGTCTTGCAACGAAAAGTTTGAAAAATTGAAAAAAAGTTGTGTCTGATACATTTTTTTTTGGCATTTTCTGCTATTTTACACCAGAAAAAATTTAATAAACATAAAAAATCGAAATTTTTCAAGTTGGACAATTTTCAGtgagcatcttatccatcctagttctcagttcaggacttgtgcacattcgtttagagccagatattcgcaaagccttttcaccggatgattcagatgctggataGTAAGTGACTACTGACCTTGAAGCCTCCTTCCTCCACCAGTCAGAAATAACACGTTTTTTCGCAATGTTTTTCTTTTTCTAATTCGATTTCCCTTTCTCCCTTTCTTATTGTGATTTGGTCAATGTTTGGTTGACTGGGAAGAAAATTGAATTTTTTTGGAATTCCACTTGAAGTTAAAAAACCCAAAATAAATATTTGATCAAAAATAAATAAGAAAAAAAAGAAAACTTTAAAGCAAATGAAAATTTCGTTCGTAACTATTTTGTTAATTTTTTTAAAACTCCTATTTTAAATATATGCTTTTTGCGGAAATTTCTATAAATTTTTTTACATTTTTCAGtgaaacccgtgtctggctggaatactacggactcgacatctatccggaacgagcattctgtatttttaccgccaagcgcgaaaattccagtattctccaggaaggcgcactggcagacGTAAGTTGATTCTCCGTCACGCCCACTTTTCTGGCGGGAATTTAAAAAATTTCAGatttatactgtggacaatcgactatcggcggcagttggctaccaagatggggatggacgaaaaaattgcgatccactctgcgacttgaacagcccctttcacttgttagcgGTAGGTGGTGGTCTAGGGTGTCATTTTTCGATTTTTTCAATTATTCGATGTTTTTAGTGAAAATCGAAAAATCTAAAAATTGAAAATCGAAAAATGAAAGAAACATTGTTTTTTGGGGACCAAACATCTTAATGAATTTAACAACAGGGAAAACTGAACAGAAACCTGGACGGTCTTATCCCATTTATCTATATTCTTAAAATGAATGATGGAGAAAAAAGTTAAAATAAAAACATTATCAGCTTTTTGTAAGTTTTTCTCAAAAATTGTTCGATTTTTCGATTTTCTAAAAAGTCGAAAAACCGAAACCCTTGGTGGTGGTGGTGGTGGACTAGAAAACTCTTCAACGACCACATGGCAATTTTCAGaatttgacgcggagaaacaatggtaccacaagtgtattcacctatccggatatgccatatagcggactggatattttcctgggacttcacttgagtaatgcggattttggtaagattttttttgaaatgttaaatgaaaagttgaaaaatagtttttatgatttagccactttccagttaaaatttcatttttttaactataaaaagttctggaaaaatg</p></li><li><p>aatttctAGgccgccgatcctaaaAGTgcaccatttcgcAGaAGTacGTacAGTttcccatctatccctAGTgGTcttGTtttctgcattctctgcttcacGTgcttGTtttGTtggAGcgcGTttgcatgctgctttaaattctgaaatattaaaaaaatttcgaAGTttttcAGcacatgggatgggAGTtttgaatttcaattttttaaaaacatttttctGTgattAGTgccGTcGTggcacggctGTtAGccgcctatccgGTttattcgatactttGTGAGTTTTTTGTAACTTTATGGTCGTCGAAATGGGAAAACTTGGCCACCAATATAAGTTTGGAAAACAATTTCCTAAAAATAAAATAATTGAACTTTTCCGATGAATAAAAAAATCGATCAGATATTCTGGAAAAAAAATCGATAAATTAATCGATTTTCTTGGAAAATACATCGAAAAATTGAGAAAAATAGAAAAATGAATGTTTTTCGATTACCGATTTATTGATTTTTCGTGAAAACTGAGTTCAGATAATTTTAAAAGCAATGTTTTTCATTTTTCAAATCAGAATCACTATAGTTTTGAAAAATCAATAATTAATTTATTGATTTTTCAATATAATTTTTTGGAAAAAATAGAAAAATCCCTTTCTAAAAGTTTTAAATTTCCAAGAAAAATTCATTTTCAAAATCACCAACGCGCTCTATAGAGTAGTCGATGAAAATCTCCGTTAAGGGTGCATGGGCAAAACGCGCTCGAACGACAATTGTTATTGTATGTTTGGTCTTGCAACGAAAAGTTTGAAAAATTGAAAAAAAGTTGTGTCTGATACATTTTTTTTTGGCATTTTCTGCTATTTTACACCAGAAAAAATTTAATAAACATAAAAAATCGAAATTTTTCAAGTTGGACAATTTTCAGtgAGcatcttatccatcctAGTtctcAGTtcAGgacttGTgcacattcGTttAGAGccAGatattcgcaaAGccttttcaccggatgattcAGatgctggatAGTAAGTGACTACTGACCTTGAAGCCTCCTTCCTCCACCAGTCAGAAATAACACGTTTTTTCGCAATGTTTTTCTTTTTCTAATTCGATTTCCCTTTCTCCCTTTCTTATTGTGATTTGGTCAATGTTTGGTTGACTGGGAAGAAAATTGAATTTTTTTGGAATTCCACTTGAAGTTAAAAAACCCAAAATAAATATTTGATCAAAAATAAATAAGAAAAAAAAGAAAACTTTAAAGCAAATGAAAATTTCGTTCGTAACTATTTTGTTAATTTTTTTAAAACTCCTATTTTAAATATATGCTTTTTGCGGAAATTTCTATAAATTTTTTTACATTTTTCAGTgaaacccGTGTctggctggaatactacggactcgacatctatccggaacgAGcattctGTatttttaccgccaAGcgcgaaaattccAGTattctccAGgaAGgcgcactggcAGacGTAAGTTGATTCTCCGTCACGCCCACTTTTCTGGCGGGAATTTAAAAAATTTCAGatttatactGTggacaatcgactatcggcggcAGTtggctaccaAGatggggatggacgaaaaaattgcgatccactctgcgacttgaacAGcccctttcacttGTtAGcgGTAGGTGGTGGTCTAGGGTGTCATTTTTCGATTTTTTCAATTATTCGATGTTTTTAGTGAAAATCGAAAAATCTAAAAATTGAAAATCGAAAAATGAAAGAAACATTGTTTTTTGGGGACCAAACATCTTAATGAATTTAACAACAGGGAAAACTGAACAGAAACCTGGACGGTCTTATCCCATTTATCTATATTCTTAAAATGAATGATGGAGAAAAAAGTTAAAATAAAAACATTATCAGCTTTTTGTAAGTTTTTCTCAAAAATTGTTCGATTTTTCGATTTTCTAAAAAGTCGAAAAACCGAAACCCTTGGTGGTGGTGGTGGTGGACTAGAAAACTCTTCAACGACCACATGGCAATTTTCAGaatttgacgcggAGaaacaatgGTaccacaAGTGTattcacctatccggatatgccatatAGcggactggatattttcctgggacttcacttgAGTaatgcggattttgGTaAGattttttttgaaatGTtaaatgaaaAGTtgaaaaatAGTttttatgatttAGccactttccAGTtaaaatttcatttttttaactataaaaAGTtctggaaaaatG</p></li><li><p>Segnali per il riconoscimento degli introniMotivi conservati</p></li><li><p>I segnali dei siti di splicing sono ben conservati tra le specieprobabilmente la comparsa del meccanismo di splicing molto antica</p></li><li><p>Grafico1</p><p>0.0062022901</p><p>0.0025445293</p><p>0.00206743</p><p>0.0050890585</p><p>0.0012722646</p><p>0.0011132316</p><p>0.0007951654</p><p>0.0027035623</p><p>0.0006361323</p><p>0.0006361323</p><p>0.0001590331</p><p>0.0011132316</p><p>0.0050890585</p><p>0.0028625954</p><p>0.0025445293</p><p>0.010019084</p><p>0.0012722646</p><p>0.0012722646</p><p>0.0001590331</p><p>0.0012722646</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0006361323</p><p>0.0011132316</p><p>0.0006361323</p><p>0</p><p>0.0001590331</p><p>0.0006361323</p><p>0.00206743</p><p>0.0006361323</p><p>0.0011132316</p><p>0.0041348601</p><p>0.0200381679</p><p>0.003975827</p><p>0.0066793893</p><p>0.0213104326</p><p>0.0063613232</p><p>0.0041348601</p><p>0.0033396947</p><p>0.0136768448</p><p>0.0054071247</p><p>0.0030216285</p><p>0.0023854962</p><p>0.0052480916</p><p>0.024173028</p><p>0.0122455471</p><p>0.0233778626</p><p>0.1032124682</p><p>0.0046119593</p><p>0.0022264631</p><p>0.0006361323</p><p>0.0030216285</p><p>0.0007951654</p><p>0.0009541985</p><p>0.0011132316</p><p>0.0022264631</p><p>0.0011132316</p><p>0.0011132316</p><p>0.0007951654</p><p>0.0007951654</p><p>0.0054071247</p><p>0.0027035623</p><p>0.0052480916</p><p>0.0154262087</p><p>0.0009541985</p><p>0</p><p>0</p><p>0.0007951654</p><p>0.0003180662</p><p>0.0003180662</p><p>0</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0.0006361323</p><p>0.00206743</p><p>0.0007951654</p><p>0.0004770992</p><p>0.0019083969</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0003180662</p><p>0.0004770992</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0.0006361323</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0014312977</p><p>0.0003180662</p><p>0.0011132316</p><p>0.0012722646</p><p>0.0003180662</p><p>0.0003180662</p><p>0.0003180662</p><p>0.0007951654</p><p>0.0009541985</p><p>0.0003180662</p><p>0.0009541985</p><p>0.0012722646</p><p>0.0023854962</p><p>0.0017493639</p><p>0.0019083969</p><p>0.0068384224</p><p>0.0006361323</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0006361323</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0009541985</p><p>0.0011132316</p><p>0.0006361323</p><p>0.0007951654</p><p>0.0015903308</p><p>0.0011132316</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0009541985</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0.0004770992</p><p>0.0006361323</p><p>0.0011132316</p><p>0.0006361323</p><p>0.0003180662</p><p>0.0012722646</p><p>0.0004770992</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0041348601</p><p>0.0004770992</p><p>0.0006361323</p><p>0.0033396947</p><p>0.0014312977</p><p>0.0004770992</p><p>0.0012722646</p><p>0.0023854962</p><p>0.0009541985</p><p>0.0009541985</p><p>0.0007951654</p><p>0.0009541985</p><p>0.0033396947</p><p>0.0025445293</p><p>0.00206743</p><p>0.0116094148</p><p>0.0003180662</p><p>0</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0.0003180662</p><p>0.0007951654</p><p>0.0003180662</p><p>0.0012722646</p><p>0.0022264631</p><p>0.0009541985</p><p>0.0007951654</p><p>0.0003180662</p><p>0.0017493639</p><p>0.0004770992</p><p>0.0003180662</p><p>0</p><p>0.0003180662</p><p>0.0007951654</p><p>0.0006361323</p><p>0.0001590331</p><p>0.0007951654</p><p>0.0009541985</p><p>0.0006361323</p><p>0.0001590331</p><p>0.0036577608</p><p>0.0006361323</p><p>0.0003180662</p><p>0</p><p>0.0011132316</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0.0003180662</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0.0009541985</p><p>0.0038167939</p><p>0.0014312977</p><p>0.0017493639</p><p>0.0025445293</p><p>0.0017493639</p><p>0.0009541985</p><p>0.0004770992</p><p>0.0017493639</p><p>0.0012722646</p><p>0.0006361323</p><p>0.0012722646</p><p>0.0019083969</p><p>0.0041348601</p><p>0.0022264631</p><p>0.0054071247</p><p>0.0205152672</p><p>0.0015903308</p><p>0.0007951654</p><p>0.0003180662</p><p>0.0022264631</p><p>0.0009541985</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0011132316</p><p>0.0014312977</p><p>0.0003180662</p><p>0.0003180662</p><p>0.0011132316</p><p>0.0022264631</p><p>0.0006361323</p><p>0.0011132316</p><p>0.0079516539</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0009541985</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0014312977</p><p>0.0006361323</p><p>0.0003180662</p><p>0.0047709924</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0004770992</p><p>0.0019083969</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0012722646</p><p>0.0009541985</p><p>0.0001590331</p><p>0</p><p>0.0011132316</p><p>0.0003180662</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0030216285</p><p>0.0006361323</p><p>0.0011132316</p><p>0.0022264631</p><p>0.0003180662</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0004770992</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0003180662</p><p>0</p><p>0.0003180662</p><p>0.0007951654</p><p>0.0128816794</p><p>0.0041348601</p><p>0.0034987277</p><p>0.0095419847</p><p>0.0050890585</p><p>0.0027035623</p><p>0.0014312977</p><p>0.0068384224</p><p>0.0028625954</p><p>0.0009541985</p><p>0.0009541985</p><p>0.0023854962</p><p>0.0211513995</p><p>0.0106552163</p><p>0.0131997455</p><p>0.0901717557</p><p>0.0007951654</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0001590331</p><p>0</p><p>0.0003180662</p><p>0.0003180662</p><p>0</p><p>0.0003180662</p><p>0</p><p>0.0001590331</p><p>0.0011132316</p><p>0.0004770992</p><p>0</p><p>0.0034987277</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0007951654</p><p>0</p><p>0</p><p>0</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0007951654</p><p>0.0001590331</p><p>0</p><p>0.0027035623</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0004770992</p><p>0</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0003180662</p><p>0.0009541985</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0012722646</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0003180662</p><p>0</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0007951654</p><p>0.0004770992</p><p>0</p><p>0</p><p>0</p><p>0.0014312977</p><p>0.0007951654</p><p>0.0015903308</p><p>0.0055661578</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0007951654</p><p>0.0003180662</p><p>0.0004770992</p><p>0.0009541985</p><p>0.0007951654</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0012722646</p><p>0.0001590331</p><p>0.0011132316</p><p>0.0028625954</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0004770992</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0006361323</p><p>0.0012722646</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0004770992</p><p>0</p><p>0</p><p>0.0006361323</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0012722646</p><p>0.0006361323</p><p>0.0001590331</p><p>0.00206743</p><p>0.0003180662</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0006361323</p><p>0.00206743</p><p>0.0011132316</p><p>0.0012722646</p><p>0.0034987277</p><p>0.0009541985</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0015903308</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0.0006361323</p><p>0.0076335878</p><p>0.0036577608</p><p>0.0054071247</p><p>0.028148855</p><p>0.0003180662</p><p>0.0006361323</p><p>0</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0003180662</p><p>0</p><p>0.0001590331</p><p>0.0004770992</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0004770992</p><p>0.0009541985</p><p>0.0023854962</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0006361323</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0.0004770992</p><p>0.0007951654</p><p>0.0004770992</p><p>0.0006361323</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0014312977</p><p>0.0001590331</p><p>0.0019083969</p><p>0.0046119593</p><p>0.0004770992</p><p>0</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0004770992</p><p>0.0012722646</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0004770992</p><p>0.0003180662</p><p>0.0001590331</p><p>0</p><p>0.0001590331</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0006361323</p><p>0</p><p>0.0004770992</p><p>0.0004770992</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0.0001590331</p><p>0.0014312977</p><p>0.0003180662</p><p>0.0003180662</p><p>0.0007951654</p><p>0.0004770992</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0.0003180662</p><p>0.0014312977</p><p>0.0006361323</p><p>0.0014312977</p><p>0.0063613232</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0001590331</p><p>0</p><p>0.0003180662</p><p>0.0001590331</p><p>0.0006361323</p><p>0.0011132316</p><p>0.0001590331</p><p>0</p><p>0.0007951654</p><p>0.0001590331</p><p>0</p><p>0</p><p>0.0003180662</p><p>0</p><p>0</p><p>0</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0.0003180662</p><p>0.0011132316</p><p>0.0003180662</p><p>0</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0003180662</p><p>0</p><p>0</p><p>0.0004770992</p><p>0</p><p>0</p><p>0</p><p>0</p><p>0.0004770992</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0007951654</p><p>0.0031806616</p><p>0.0006361323</p><p>0.0006361323</p><p>0.0022264631</p><p>0.0014312977</p><p>0.0006361323</p><p>0</p><p>0.0012722646</p><p>0.0015903308</p><p>0.0004770992</p><p>0.0006361323</p><p>0.0011132316</p><p>0.0063613232</p><p>0.0027035623</p><p>0.003975827</p><p>0.0090648855</p><p>0.0006361323</p><p>0.0003180662</p><p>0.0007951654</p><p>0.0004770992</p><p>0.0004770992</p><p>0.0001590331</p><p>0.0001590331</p><p>0.0003180662</p><p>0.0009541985</p><p>0.0001590331</p><p>0</p><p>0.0003180662</p><p>0.0027035623</p><p>0.0007951654</p><p>0.0007951654</p><p>0.003975827</p><p>basi</p><p>frequenze</p><p>Sequenze in testa negli introni di C.elegans</p><p>TESTE</p><p>gtaaaaa390.006gtaagtt0.103occorrep(a)C*D</p><p>gtaaaac160.003gtgagtt0.090log(1/p(a))</p><p>gtaaaag130.002gttagtt0.028a35030.5570.8440.470</p><p>gtaaaat

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