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8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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Drthur Adpidf ^hO
[Q@FB BKFKKO@_@FB EF IDL
DF@MDIQ7K_H@ADI
@QQ[KQ
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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_we md`f ahdiikfbks `f us`fb idl df`mdis7
• Idl Df`mdis drk i`v`fb dfoskft`kft dfo thus hdvk `ftkrksts
• Rhkf wk hdrm er i`m`t thesk`ftkrksts te lkfkc`t humdfs (fetethkr df`mdis) thk lurokf `s ef
humdfs te kxpid`f/gust`cy why.
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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1
Eur `ftkrksts trump yeurs
• Aemmef gust`c`adt`ef `s wk hdvk merk, r`ahkr`ftkrksts thdf thky oe:
• _hky oef‐t hdvk r`bhts ds humdfs oe• thky drk fet ds smdrt,• thky drk fet ds skft`kft--thky hdvk d peerkr,i`m`tko aebf`t`vk i`ck.
Qe, b`vkf thk`r i`m`ts, wk adf usk thkm
te `mprevk humdf i`ck.
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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?
Qkaefo ahdiikfbk
• Df`mdis drk fet pkrckat meokis cer humdfo`skdsk, se dfy odtd wk aeiikat w`ii fet lkpkrckatiy rkprkskftdt`vk ec kcckats `f humdfs.
• Orubs, l`eieb`as, dfo okv`aks st`ii fkko te lktkstko `f humdfs te oktkrm`fk datudisdckty/kcc`aday.
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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;
Mdj`fb Df`mdis Q`aj
Rk adf usk A\@Q^\ te mdjk df`mdis
merk i`jk humdfs, dfo thus aeiikat odtdthdt `s merk dppi`adlik te humdfs
A\@Q^\ adf lk usko te b`vk df`mdiso`skdsks thky oe fet fermdiiy bkt
A\@Q^\ adf lk usko te spkko efskt,skvkr`ty ec o`skdsks
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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3
Kth`adi adtah <<
thk merk jky humdf dttr`lutks wkb`vk te df`mdis -- brkdtkr`ftkii`bkfak, skfs`t`v`ty te pd`f,o`skdsks thdt efiy eaaur `fhumdfs, succkr`fb thk iess ec dfeccspr`fb -- thk merk wk ufokrm`fk
thk prkm`sk thdt thky drk ikss thdfhumdf, o`cckrkft crem us--wh`ah `sthk lds`s cer gust`cy`fb
kxpkr`mkft`fb ef thkm.
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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Rhdt dleut rkoua`fb idl df`mdi aebf`t`vk adpda`ty te stuoyo`skdsks er tep skkj te ki`m`fdtk thkm5
• A\@Q^\/bkfk ko`t`fb aeuio lk usko te
arkdtk pr`mdtks w`th dut`sm dfo ethkrfkureieb`adi aefo`t`efs, wh`ah mkdfsarkdt`fb df`mdis te fet efiy lk tkstkolut dise hdvk iewkr aebf`t`vk adpda`tythdf thky weuio ethkrw`sk hdvk hdo.
• Bkfk ko`t`fb hds dirkdoy lkkf usko teb`vk pr`mdtks \ktt Qyforemk
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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Bkfk ko`t`fb mdy ikdo te merk ‘succkr`fb‐
•
_hksk df`mdis w`ii succkr crem crem thk`ftkft`efdiiy lkstewko okiktkr`eusaefo`t`efs dfo
• _hky mdy mdy succkr curthkr ouk tekxpkr`mkftdt`ef.
• _hkrk mdy lk mdfy merk ec thkm dfomdy prkss sterdbk dfo hdfoi`fbadpda`t`ks. Cdatery cdrm`fb5
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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0
Ds A\@Q^\ mdjks bkfkt`a `ftkrvkft`ef kds`kr, `t lkaemkskds`kr te mdjk merk idl df`mdis cer ikss `mpertdft rkdsefs.
• Idl df`mdis lkaemk kvkf merk i`jk d aemmeo`ty,
aempiktkiy kxpkfodlik.• Arkdt`fb d surpius ec idl df`mdis w`th o`skdsks dfoo`sdl`i`t`ks.
• Rk dirkdoy tkst aempiktkiy uffkakssdry th`fbs i`jkaesmkt`as ef idl df`mdis, adus`fb thkm pd`f,okprkss`ef, succkr`fb. Rhdt `s df `mpertdft humdfpurpesk‟i`pst`aj, hd`r oyk, Letex55
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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4>
Df`mdis ly thk oezkf
• @c df`mdis drk muah kds`kr te mdjk oeks thk`rmerdi stdfo`fb kreok5
• ^r`mdtks
• Ikssefs crem oebs/adts
• \eokfts
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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44
Kfhdfakmkft `f thk idl
Qemk sa`kft`sts dfo mdfy rkbuidters drk ordw`fb d i`fk dt humdfkfhdfakmkft.
Hewkvkr, rkskdrahkrs drk dirkdoy us`fb A\@Q^\ te oks`bf df`mdis fetefiy te kxdm`fk o`skdsk prebrkss`ef er `ftkrvkft`efs, lut te `okft`cypess`lik kfhdfakmkfts7 `mprevko jkrdt`f preouat`ef, `farkdsko`ftkii`bkfak, merk musaik mdss.
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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4<
Lu`io`fb d lkttkr meusk `s d trdp
• _kst`fb kfhdfakmkfts `f df`mdis `s fet ’fkakssdry”sa`kfak. @t mdy adusk uffkakssdry df`mdi
pd`f/succkr`fb, dfo `mpi`ks daakptdfak ec humdfbkfkt`a kfhdfakmkft.•
_kst`fb kfhdfakmkft `f df`mdis kfaeurdbks humdfdppi`adt`ef.
• ^krhdps cer cdstkr rdak hersks, admkis thdt fkko iksswdtkr, smdrtkr aemcert df`mdis, df`mdis thdt preouakikss wdstk thdt werj `f urldf sktt`fbs er drk urldf pkts
er strefbkr oefjkys te hdui merk kqu`pmkft.• Lut, semk ec thksk drk dirkdoy oul`eus prdat`aks`fveiv`fb df`mdi arukity/kxpie`tdt`ef. @f mdfy fdt`efsdf`mdis hdvk fe pretkat`efs/humdfk mevkmkft
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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41
^kt Qeufos
Qemk idls drk arkdt`fb df`mdis cer leth kxpkr`mkftdt`ef dfo ceraemmkra`di pkts.
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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4?
Leut`quk pkts
• Arkdt`fb df`mdis cer aemmkra`di pkts, whkf huforkos ec theusdfosdrk idfbu`sh`fb `f shkitkrs, `s merdiiy ahdiikfb`fb
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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4;
Df`mdis cer humdf spkas
• Aempdf`ks drk mdj`fb df`mdis, dfo ’oks`bf`fb thkm te aefsumkrspkas.”
• Oka`o`fb whdt yeu wdft cer o`ffkr, er whdt j`fo ec tkikv`s`ef yeuwdft, `s c`fk. Oka`o`fb whdt j`fo ec i`v`fb arkdturk yeu wdft, whkthkrpkt er humdf, `s thdt ej5
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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43
AE@
• _hkrk `s aefci`at ec `ftkrkst cer idls thdt preouak df`mdis cer idlkxpkr`mkfts dfo cer aemmkra`di usk.
• @mdb`fk d cdatery thdt lrko oebs leth cer sidubhtkr`fb te skii thk`rmkdt dfo cer skii`fb ds pkts.
8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)
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fkxt
• Efiy thk rkdi o`skdsks
• Doept efk te bkt efk
• @DA[A kouadt`ef
• Oef‐t oupi`adtk rkskdrah uffkakssdr`iy
• Aeftreii`fb mdss preouat`ef
• M`f`m`zk pd`f dfo succkr`fb
• Kxpdfo df`mdi pretkat`ef cer aeuftr`ks whkrk bkfk ko`t`fb `slk`fb oefk
