Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)

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Drthur Adpidf ^hO

[[email protected] BKFK [email protected][email protected] EF IDL

[email protected][email protected]

@QQ[KQ

8/20/2019 Using Gene Editing on Lab Animals: Ethical Issues (Arthur Caplan)

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_we md`f ahdiikfbks `f us`fb idl df`mdis7

• Idl Df`mdis drk i`v`fb dfo skft`kft dfo thus hdvk `ftkrksts

• Rhkf wk hdrm er i`m`t thesk `ftkrksts te lkfkc`t humdfs (fet ethkr df`mdis) thk lurokf `s ef

humdfs te kxpid`f/gust`cy why.

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Eur `ftkrksts trump yeurs

• Aemmef gust`c`adt`ef `s wk hdvk merk, r`ahkr `ftkrksts thdf thky oe:

• _hky oef‐t hdvk r`bhts ds humdfs oe • thky drk fet ds smdrt, • thky drk fet ds skft`kft--thky hdvk d peerkr, i`m`tko aebf`t`vk i`ck.

Qe, b`vkf thk`r i`m`ts, wk adf usk thkm

te `mprevk humdf i`ck.

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Qkaefo ahdiikfbk

• Df`mdis drk fet pkrckat meokis cer humdf o`skdsk, se dfy odtd wk aeiikat w`ii fet lk pkrckatiy rkprkskftdt`vk ec kcckats `f humdfs.

• Orubs, l`eieb`as, dfo okv`aks st`ii fkko te lk tkstko `f humdfs te oktkrm`fk datudi sdckty/kcc`aday.

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Mdj`fb Df`mdis Q`aj

Rk adf usk A\@Q^\ te mdjk df`mdis

merk i`jk humdfs, dfo thus aeiikat odtdthdt `s merk dppi`adlik te humdfs

A\@Q^\ adf lk usko te b`vk df`mdis o`skdsks thky oe fet fermdiiy bkt

A\@Q^\ adf lk usko te spkko efskt, skvkr`ty ec o`skdsks

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Kth`adi adtah

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Rhdt dleut rkoua`fb idl df`mdi aebf`t`vk adpda`ty te stuoy o`skdsks er tep skkj te ki`m`fdtk thkm5

• A\@Q^\/bkfk ko`t`fb aeuio lk usko te

arkdtk pr`mdtks w`th dut`sm dfo ethkrfkureieb`adi aefo`t`efs, wh`ah mkdfs arkdt`fb df`mdis te fet efiy lk tkstko lut dise hdvk iewkr aebf`t`vk adpda`ty thdf thky weuio ethkrw`sk hdvk hdo.

• Bkfk ko`t`fb hds dirkdoy lkkf usko te b`vk pr`mdtks \ktt Qyforemk

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Bkfk ko`t`fb mdy ikdo te merk ‘succkr`fb‐

•

_hksk df`mdis w`ii succkr crem crem thk`ftkft`efdiiy lkstewko okiktkr`eus aefo`t`efs dfo

• _hky mdy mdy succkr curthkr ouk te kxpkr`mkftdt`ef.

• _hkrk mdy lk mdfy merk ec thkm dfo mdy prkss sterdbk dfo hdfoi`fb adpda`t`ks. Cdatery cdrm`fb5

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Ds A\@Q^\ mdjks bkfkt`a `ftkrvkft`ef kds`kr, `t lkaemks kds`kr te mdjk merk idl df`mdis cer ikss `mpertdft rkdsefs.

• Idl df`mdis lkaemk kvkf merk i`jk d aemmeo`ty,

aempiktkiy kxpkfodlik. • Arkdt`fb d surpius ec idl df`mdis w`th o`skdsks dfo o`sdl`i`t`ks.

• Rk dirkdoy tkst aempiktkiy uffkakssdry th`fbs i`jk aesmkt`as ef idl df`mdis, adus`fb thkm pd`f, okprkss`ef, succkr`fb. Rhdt `s df `mpertdft humdf purpesk‟i`pst`aj, hd`r oyk, Letex55

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Df`mdis ly thk oezkf

• @c df`mdis drk muah kds`kr te mdjk oeks thk`r merdi stdfo`fb kreok5

• ^r`mdtks

• Ikssefs crem oebs/adts

• \eokfts

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Kfhdfakmkft `f thk idl

Qemk sa`kft`sts dfo mdfy rkbuidters drk ordw`fb d i`fk dt humdf kfhdfakmkft.

Hewkvkr, rkskdrahkrs drk dirkdoy us`fb A\@Q^\ te oks`bf df`mdis fet efiy te kxdm`fk o`skdsk prebrkss`ef er `ftkrvkft`efs, lut te `okft`cy pess`lik kfhdfakmkfts7 `mprevko jkrdt`f preouat`ef, `farkdsko `ftkii`bkfak, merk musaik mdss.

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Lu`io`fb d lkttkr meusk `s d trdp

• _kst`fb kfhdfakmkfts `f df`mdis `s fet ’fkakssdry” sa`kfak. @t mdy adusk uffkakssdry df`mdi

pd`f/succkr`fb, dfo `mpi`ks daakptdfak ec humdfbkfkt`a kfhdfakmkft. •

_kst`fb kfhdfakmkft `f df`mdis kfaeurdbks humdf dppi`adt`ef.

• ^krhdps cer cdstkr rdak hersks, admkis thdt fkko ikss wdtkr, smdrtkr aemcert df`mdis, df`mdis thdt preouak ikss wdstk thdt werj `f urldf sktt`fbs er drk urldf pkts

er strefbkr oefjkys te hdui merk kqu`pmkft. • Lut, semk ec thksk drk dirkdoy oul`eus prdat`aks `fveiv`fb df`mdi arukity/kxpie`tdt`ef. @f mdfy fdt`efs df`mdis hdvk fe pretkat`efs/humdfk mevkmkft

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^kt Qeufos

Qemk idls drk arkdt`fb df`mdis cer leth kxpkr`mkftdt`ef dfo cer aemmkra`di pkts.

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Leut`quk pkts

• Arkdt`fb df`mdis cer aemmkra`di pkts, whkf huforkos ec theusdfos drk idfbu`sh`fb `f shkitkrs, `s merdiiy ahdiikfb`fb

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Df`mdis cer humdf spkas

• Aempdf`ks drk mdj`fb df`mdis, dfo ’oks`bf`fb thkm te aefsumkr spkas.”

• Oka`o`fb whdt yeu wdft cer o`ffkr, er whdt j`fo ec tkikv`s`ef yeu wdft, `s c`fk. Oka`o`fb whdt j`fo ec i`v`fb arkdturk yeu wdft, whkthkr pkt er humdf, `s thdt ej5

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[email protected]

• _hkrk `s aefci`at ec `ftkrkst cer idls thdt preouak df`mdis cer idl kxpkr`mkfts dfo cer aemmkra`di usk.

• @mdb`fk d cdatery thdt lrko oebs leth cer sidubhtkr`fb te skii thk`r mkdt dfo cer skii`fb ds pkts.

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fkxt

• Efiy thk rkdi o`skdsks

• Doept efk te bkt efk

• @DA[A kouadt`ef

• Oef‐t oupi`adtk rkskdrah uffkakssdr`iy

• Aeftreii`fb mdss preouat`ef

• M`f`m`zk pd`f dfo succkr`fb

• Kxpdfo df`mdi pretkat`ef cer aeuftr`ks whkrk bkfk ko`t`fb `s lk`fb oefk