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(c) 2015 Northwest Natural Health A
Specialty Care Clinic
Dan Labriola ND
Lisa Price ND
Tara Stacker ND
Carrie Dennett RD, MPH
Vitamins and Supplements for
Cancer Survivors
Moving Beyond Cancer to Wellness
Fred Hutchinson Cancer Research Center
Northwest Natural Health®
A Specialty Care Clinic
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 2
Objectives
• What is new with nutrition, supplements and cancer
• What works
• What doesn’t work
• How natural medicine can affect your conventional cancer treatment
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 3
Objectives
-Learn how vitamins and supplements
can be a safe, sensible and scientific
addition to your care
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Specialty Care Clinic 5
What’s Really Important?
• Stay strong and healthy
• Avoid interactions with treatment
– Respect the “Protected Zone”
• Prevention for the future
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Specialty Care Clinic 6
A Plan that works
• Maintain quality of life before, during and after treatment in every way
– Overall Health
– Cancer specific issues
• Take back control of your life. Do most or all that you could do prior to being diagnosed
• Control adverse effects from treatment
• Manage Co-morbidities
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 7
Omega 3 Essential Fatty Acids
Important Benefits and Risks
• Omega 3 Essential Fatty Acids are important for almost every body function from immune system to skin
• Not all omega 3 Essential Fatty Acids are the same
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 8
Omega 3 Essential Fatty Acids
Important Benefits and Risks
Potential Benefits
• Reduce cancer risk
• Reduce Triglycerides
• Reduce heart attack risk
• Reduce clot formation
• Slow RA progression
• Help mood (depression and anxiety
• Helped learning impaired children
• Help atopic dermatitis
• Help with autism
Potential Risks
• Increased bleed times
• Reduced glycemic control with diabetics
• Hypervitaminosis A and D
• Rancidify easily
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 9
The Omega 3 - Flaxseed Oil
Debate
• The problems with flax oil (seeds are
OK)
– Very low conversion rate
– Some Carcinogenic results
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 10
EFA Conversion
Delta 6 desaturase
ALA (Flax Oil)
EPA
DHA
Delta 5 desaturase
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 11
Echinacea and cancer
• A great herb with many uses
• Use with caution with cancer
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 12
Echinacea and cancer
• Many species
• White blood cell stimulator
• Microbial considerations
• Unknown effects on immature immune
systems therefore not recommended
below age 14 (or pregnancy or lactation)
• Hepatic metabolism
• Counteracts immune suppression
treatment
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 13
Potential
Echinacea Side Effects
• Allergic including anaphylaxis, asthma
• Thrombocytopenia Purpurea
• Leucopenia
• Disrupted WBC differential
• Abdominal pain
• Dysuria
• Arthralgia
• Myalgia
• Dizziness
• Dry mouth
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 14
Herbal combinations
General Considerations
• Many species, actions, interactions
• Microbial considerations
• Pediatric dosage may not be
proportional to weight
• Unknown effects on metabolism,
immature immune systems,
development. Evaluate each ingredient
• Hepatic metabolism
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Specialty Care Clinic 15
Homeopathics
• Very low dosages, highly diluted
• Immune mediated theory of action
• Minimal evidence
• Extensive anecdotal history
• Experienced, responsible, licensed
provider
More strategies
• Quality control of natural products is
important
• Prevention is more important now than
ever
• Survivorship strategies can change
your life
• Herb and nutrition interactions are
important
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Specialty Care Clinic 16
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 17
Natural Product Quality Control
• DSHEA
• GRAS
• CGMPs
• No microbial or heavy metal rules
• Label accuracy?
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 18
Survivorship Strategies
Avoid Possible interactions
with cancer treatment
• Chemotherapy
• Radiation
• Surgery
• Targeted Therapies
Evidence Overview:
Antioxidants during treatment
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 19
Placebo
Antioxidants
Cancer-free Survival Ref: Bairati et al “A Randomized trial of
Antioxidant Vitamins to Prevent Second
Primary Cancers in Head and Neck Cancer
Patients” Int J Cancer 2006 Nov 1:119(9):2221-4
Years
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Specialty Care Clinic 20
Primary Prevention
Diet and Nutrition
• Vitamin B12
• Folate
• Vitamin D
• Fiber
• Fruits and vegetables
• Fish
• Some antioxidants
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Specialty Care Clinic 21
More Nutritional Treatments
• Vitamin E
• Selenium
• Calcium, vitamin D, phosphorus
• Zinc
• Beta carotene
• Antioxidants in general
• Consider IV delivery
22
(c) 2015 Northwest Natural Health A
Specialty Care Clinic
Frequent Questions
Combining Complementary and
Alternative Medicine with
Conventional Therapy
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Specialty Care Clinic 23
Phytoestrogens
Including
Soy Isoflavones
? Safe Replacement for Hormone Therapy?
Answer: Probably the same risk as HRT
Ask for Patient Briefing Paper
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Specialty Care Clinic 24
Strategies that work
• Maintain quality of life before, during and
after treatment
– Cancer and treatment specific issues that can be
helped even if they existed prior to treatment
• Fatigue
• Hot flashes and other menopausal symptoms
• Gas (belching, flatulence)
• Bloating
• Stomach upset
• Constipation
• Diarrhea and bowel urgency
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 25
Strategies that work
(Continued)
• Maintain quality of life before, during and
after treatment
– Cancer and treatment specific issues that can be
helped
• Urination urgency
• Joint and muscle aches (including fibromyalgia)
• Headaches
• Sleep quality
• Pain
• Weight gain or loss
• Headaches
(c) 2015 Northwest Natural Health A
Specialty Care Clinic 26
Strategies that work
(Continued)
• Maintain quality of life before, during and
after treatment
– Cancer and treatment specific issues that can be
helped:
• Treatment side effects
• Neuropathy
• Muscle cramps
• Restless leg syndrome
• Skin rashes
• Blood sugar metabolism