new trendsPioneering

Ibn e SinaIbn e Sina was born in 980 C.E. in the village of Afshana near Bukhara.He wrote almost 450 treatises on a wide range of subjects, of which around 240 have survived. In particular, 150 of his surviving treatises concentrate on philosophy and 40 of them concentrate on medicine. Ibn e Sina was one of the pioneers in “ISLAMIC DENTISTRY” and dedicated many chapters of The Canon of Medicine to dentistry, dental

restoration. treatment for dental caries.

new trendsPioneeringSERVAZSERVAZ

250 mgCapsule

( A z i t h r o m y c i n d i h y d r a t e )

SUPERIOR MIC AGAINSTODONTOGENIC PATHOGENS

“Azithromycin (Servaz ) have a Triple role in treatment of Resolution of periodontal Disease.”

Ref: J.Periodontal 1999;70:960:966

TRIPLEROLE IN PERIODONTITIS

Ref: J.Periodontal res. 2012

1: Suppressing Periodontal Pathogens2: Anti Inflammatory activity with Macrophages3: Healing with Fibroblast stimulation

Ref: Data on f ile

Peptostreptococus Spp.

Prevotella Intermedia

Porphyromonas Gingivalis

Actinomyecetecomitans

Strep. Viridians

Strep. Pyogenes

Staph: Aureus

CLINDAMYCIN

0.75 µ/ml

0.12 µ/ml

0.16 µ/ml

4 µ/ml

0.12 µ/ml

0.128 µ/ml

0.38 µ/ml

0 µ/ml

0.5 µ/ml

0.16 µ/ml

1.1 µ/ml

2 µ/ml

1.6 µ/ml

0.94 µ/ml

PATHOGEN AMOXICILLINLINCOMYCIN

4 µ/ml

2 µ/ml

0.6 µ/ml

1.6 µ/ml

4 µ/ml

0.8 µ/ml

0.12 µ/ml

SERVAZ

0.5 µ/ml

0.03 µ/ml

0.02 µ/ml

0.25 µ/ml

0.5 µ/ml

0.1 µ/ml

0.023 µ/ml

(Az i th romyc in )

new trendsPioneeringSERVAZSERVAZ

250 mgCapsule

( A z i t h r o m y c i n d i h y d r a t e )

IDEAL ANTIBIOTIC FORPERIODONTITIS

Ref: Pearly white.Dentition.File.Wordpress.Com/2011/01/azithromycin

“ Azithromycin (SERVAZ) is the latest antibiotic for being trialled for treatment of gum & bone disease (periodontitis). Servaz has remarkable results for the treatment of periodontitis.”

EFFICACIOUS INODONTOSTOMATOLOGICAL

INFECTIONS

SUPERIOR TISSUE CONCENTRATIONS

Ref: Minerva stomatol 1998 jan-feb ; 47 ; (1-2);57-62

“ Azithromycin achieved good therpeutic results in odontostomatological infections in terms of both efficacy & tolerability.”

2.6%

1.1%

(Cefadroxil)

2.12%(Cephalexin)

2.0%(Amoxicillin)

(Clindamycin)

4.0%(Azithromycin)

Ref: Data on f ile

new trendsPioneeringSERVAZSERVAZ

250 mgCapsule

( A z i t h r o m y c i n d i h y d r a t e )

SERVAZIS RECOMMENDED FOR

Peri-Implantitis

Pericoronitis

Periodontitis

Periodontal AbscessDento Alveolar Abscess

Maxillo Facial SurgeryPre & Post Operative Prohylaxis

Gingivitis

Extensive Coverage

Sustained high tissue concentration

Short duration of treatment

Better tolerability

Excellent efficacy in multiple indications

DOSAGESUPERIOR HALF LIFE

1Hr

2-3Hrs

5.4Hrs

14Hrs

Amoxicillin ClindamycinLincomycin Azithromycin

B.D For 1 Day&

1 Cap. O.D for4 days

250mgCapsule

250mgCapsule

B.D For 3 Days

R

Ref 1: Revomet (Metronidazoe), prescribing information, file data; Ref 2: Braz Oral Res 2008;2 2(2):145-50; Ref 3: Revomet (Metronidazoe), prescribing information, file data

How

Works 1

Application

Flowability

Fills thePocket

HighlyViscous

gel

Releaseto formthe gel

Preferred Choice InGingivitis Peridontitis

R.C.T Dry Socket

Root Scaling Stomatitis

R

Concentration in GCF shows its avalaibility till 48 hours 2

Metronidazole is absorbed slowly from the dentalgel and the bioavailability is about 70% 3

% C

once

ntra

tion

in G

CF

Time in Hours

6 Hours 24 Hours 48 Hours

78.57%

39.29%

25%

DENTAL PAIN IS INEVITABLE

SUFFERING IS OPTIONAL

PROVIDES SUPERIOR ANALGESIC ACTIONWITH RAPID RELIEF from...from...

95%Bioavailibility

95%Bioavailibility

QuickAbsorptionQuickAbsorption

Cost EffectiveTherapy

Cost EffectiveTherapy

ConvenientB.D DosageConvenientB.D Dosage

Onset of Action

in 15-min

Onset of Action

in 15-min

PAIN IS INEVITABLESUFFERING IS OPTIONAL

The Striking PowerThe Striking Power

500mgCapsules

“Against the most of Infections InvolvingGram +ve & Gram -ve Bacteria”

Spectrum of Activity:

PATHOGENS ACTIVITY

Porphyromonas gingivalis

Fusobacterium nucleatum

Streptococcus mutans

Streptococcus sanguis

Bacteroides forsythus

Antimicrobial agent and Chemotherapy, Feb 1997. P 324-330

The Striking PowerThe Striking Power

PericoronitisPericoronitisPericoronalAbscessPericoronalAbscess

Pre-PestoperativeProphyalaxis

Pre-PostoperativeProphyalaxis

MaxillofacialSurgery

MaxillofacialSurgery

PulpitisPulpitisBroad spectrum antibiotic

Well tolerated

Better safety profile

Convenient B.D dosage

Cost effective therapy